PROSITE documentation PDOC51289Cysteine-rich GLG1 repeat
The Golgi apparatus protein 1 (GLG1), which is located in Golgi cisterns of various cell types, can bind fibroblast growth factor and E-selectin. Sixteen cysteine-rich GLG1 repeats form the core of the protein and are located in the lumen. The C-terminal part of GLG1 is composed of a transmembrane region and a short cytoplasmic tail. The Cys-rich GLG1 repeat is a ~60 amino acid module that contains 4 Cys residues, which can form intrachain disulfide bridges [1,2]. Homologues of the vertebrate GLG1/Golgi sialoglycoprotein MG-160 (Mg160)/E-selectin ligand 1 (ESL1)/cysteine-rich fibroblast growth factor receptor 1 (CFR1)/latent transforming growth factor-β complex protein 1 (LTCP-1) have been found in insects and the nematode Caenorhabditis elegans.
The profile we developed covers the entire cysteine-rich GLG1 repeat.
Last update:January 2007 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Burrus L.W. Zuber M.E. Lueddecke B.A. Olwin B.B. |
| Title | Identification of a cysteine-rich receptor for fibroblast growth factors. | |
| Source | Mol. Cell. Biol. 12:5600-5609(1992). | |
| PubMed ID | 1448090 |
| 2 | Authors | Kawano J. Nakayama T. Kotani T. Matsubayashi H. Yamamoto M.T. Suganuma T. |
| Title | Identification and characterization of an insect homologue of the vertebrate Golgi apparatus protein 1 (MG-160/cysteine-rich fibroblast growth factor receptor/E-selectin ligand-1/latent transforming growth factor-beta complex protein-1) with a Golgi-specific monoclonal antibody. | |
| Source | Histochem. Cell Biol. 117:381-389(2002). | |
| PubMed ID | 12029485 | |
| DOI | 10.1007/s00418-002-0402-6 |
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