Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC51302Single-minded C-terminal domain profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC51302
In Drosophila, single-minded (sim) is a transcription factor that acts as the master regulator of neurogenesis. Two mammalian homologs of Sim, Sim1 and Sim2, have been identified. There is a high level of homology among mammalian and Drosophila sim proteins in their amino-terminal half where the conserved bHLH (see <PDOC00038>), PAS (see <PDOC50112>) and HST domains are present. In contrast, the carboxy-terminal parts are only conserved in vertebrates [1]. The Sim1 C-terminus contains a Ser-rich region, whereas the Sim2 C-terminus both contain Ser/Thr-rich regions, Pro/Ser-rich regions, Pro/Ala-rich regions, and positively charged regions. Sim2s, a splice variant of Sim2, still contains the Ser/Thr- and Pro/Ser-rich regions shown to harbor repressive activities, but is missing the Pro/Ala-rich repressor region [1,2,3].
The profile we developed covers the entire single-minded C-terminal domain.
Last update:March 2007 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Chrast R. Scott H.S. Chen H. Kudoh J. Rossier C. Minoshima S. Wang Y. Shimizu N. Antonarakis S.E. |
| Title | Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region. | |
| Source | Genome Res. 7:615-624(1997). | |
| PubMed ID | 9199934 |
| 2 | Authors | Coumailleau P. Penrad-Mobayed M. Lecomte C. Bollerot K. Simon F. Poellinger L. Angelier N. |
| Title | Characterization and developmental expression of xSim, a Xenopus bHLH/PAS gene related to the Drosophila neurogenic master gene single-minded. | |
| Source | Mech. Dev. 99:163-166(2000). | |
| PubMed ID | 11091086 |
| 3 | Authors | Metz R.P. Kwak H.-I. Gustafson T. Laffin B. Porter W.W. |
| Title | Differential transcriptional regulation by mouse single-minded 2s. | |
| Source | J. Biol. Chem. 281:10839-10848(2006). | |
| PubMed ID | 16484282 | |
| DOI | 10.1074/jbc.M508858200 |
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