PROSITE documentation PDOC51302Single-minded C-terminal domain profile
In Drosophila, single-minded (sim) is a transcription factor that acts as the master regulator of neurogenesis. Two mammalian homologs of Sim, Sim1 and Sim2, have been identified. There is a high level of homology among mammalian and Drosophila sim proteins in their amino-terminal half where the conserved bHLH (see <PDOC00038>), PAS (see <PDOC50112>) and HST domains are present. In contrast, the carboxy-terminal parts are only conserved in vertebrates [1]. The Sim1 C-terminus contains a Ser-rich region, whereas the Sim2 C-terminus both contain Ser/Thr-rich regions, Pro/Ser-rich regions, Pro/Ala-rich regions, and positively charged regions. Sim2s, a splice variant of Sim2, still contains the Ser/Thr- and Pro/Ser-rich regions shown to harbor repressive activities, but is missing the Pro/Ala-rich repressor region [1,2,3].
The profile we developed covers the entire single-minded C-terminal domain.
Last update:March 2007 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Chrast R. Scott H.S. Chen H. Kudoh J. Rossier C. Minoshima S. Wang Y. Shimizu N. Antonarakis S.E. |
| Title | Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region. | |
| Source | Genome Res. 7:615-624(1997). | |
| PubMed ID | 9199934 |
| 2 | Authors | Coumailleau P. Penrad-Mobayed M. Lecomte C. Bollerot K. Simon F. Poellinger L. Angelier N. |
| Title | Characterization and developmental expression of xSim, a Xenopus bHLH/PAS gene related to the Drosophila neurogenic master gene single-minded. | |
| Source | Mech. Dev. 99:163-166(2000). | |
| PubMed ID | 11091086 |
| 3 | Authors | Metz R.P. Kwak H.-I. Gustafson T. Laffin B. Porter W.W. |
| Title | Differential transcriptional regulation by mouse single-minded 2s. | |
| Source | J. Biol. Chem. 281:10839-10848(2006). | |
| PubMed ID | 16484282 | |
| DOI | 10.1074/jbc.M508858200 |
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