PROSITE documentation PDOC51302
Single-minded C-terminal domain profile


In Drosophila, single-minded (sim) is a transcription factor that acts as the master regulator of neurogenesis. Two mammalian homologs of Sim, Sim1 and Sim2, have been identified. There is a high level of homology among mammalian and Drosophila sim proteins in their amino-terminal half where the conserved bHLH (see <PDOC00038>), PAS (see <PDOC50112>) and HST domains are present. In contrast, the carboxy-terminal parts are only conserved in vertebrates [1]. The Sim1 C-terminus contains a Ser-rich region, whereas the Sim2 C-terminus both contain Ser/Thr-rich regions, Pro/Ser-rich regions, Pro/Ala-rich regions, and positively charged regions. Sim2s, a splice variant of Sim2, still contains the Ser/Thr- and Pro/Ser-rich regions shown to harbor repressive activities, but is missing the Pro/Ala-rich repressor region [1,2,3].

The profile we developed covers the entire single-minded C-terminal domain.

Last update:

March 2007 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

SIM_C, PS51302; Single-minded C-terminal domain profile  (MATRIX)


1AuthorsChrast R. Scott H.S. Chen H. Kudoh J. Rossier C. Minoshima S. Wang Y. Shimizu N. Antonarakis S.E.
TitleCloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region.
SourceGenome Res. 7:615-624(1997).
PubMed ID9199934

2AuthorsCoumailleau P. Penrad-Mobayed M. Lecomte C. Bollerot K. Simon F. Poellinger L. Angelier N.
TitleCharacterization and developmental expression of xSim, a Xenopus bHLH/PAS gene related to the Drosophila neurogenic master gene single-minded.
SourceMech. Dev. 99:163-166(2000).
PubMed ID11091086

3AuthorsMetz R.P. Kwak H.-I. Gustafson T. Laffin B. Porter W.W.
TitleDifferential transcriptional regulation by mouse single-minded 2s.
SourceJ. Biol. Chem. 281:10839-10848(2006).
PubMed ID16484282

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