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PROSITE documentation PDOC50112 |
The PAS region [1,2] is an approximately 300 amino-acid conserved region who was first isolated in the Drosophila protein period clock (PER), the Ah receptor nuclear translocator (ARNT) and the Drosophila single-minded (SIM). It is composed of two or more imperfect repeats. Within the bHLH/PAS proteins the PAS region is involved in protein dimerization with another protein of the same family. It has also been associated with light reception, light regulation and circadian rhythm regulators (clock). In bacteria, the PAS repeat is usually associated with the input domain of a histidine kinase, or a sensor protein that regulates a histidine kinase.
The PAS repeat is often associated with a PAC motif (PAS-associated C-terminal motif), a conserved region of 40-45 amino acids situated carboxy-terminal to any PAS repeat and which can contribute to the PAS structural domain.
The PAS family can be divided into two groups. The first group contains the PAS domain followed by a PAC motif:
The second group contains a PAS domain alone:
We developed two profiles, one that spans a single PAS repeat and one that covers the whole PAC domain.
Last update:December 2001 / First entry.
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PROSITE methods (with tools and information) covered by this documentation:
1 | Authors | Ponting C.P. Aravind L. |
Title | PAS: a multifunctional domain family comes to light. | |
Source | Curr. Biol. 7:R674-R677(1997). | |
PubMed ID | 9382818 |
2 | Authors | Zhulin I.B. Taylor B.L. Dixon R. |
Title | PAS domain S-boxes in Archaea, Bacteria and sensors for oxygen and redox. | |
Source | Trends Biochem. Sci. 22:331-333(1997). | |
PubMed ID | 9301332 |
3 | Authors | Reyes H. Reisz-Porszasz S. Hankinson O. |
Title | Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor. | |
Source | Science 256:1193-1195(1992). | |
PubMed ID | 1317062 |
4 | Authors | Zelzer E. Wappner P. Shilo B.-Z. |
Title | The PAS domain confers target gene specificity of Drosophila bHLH/PAS proteins. | |
Source | Genes Dev. 11:2079-2089(1997). | |
PubMed ID | 9284047 |
5 | Authors | Zhou Y.D. Barnard M. Tian H. Li X. Ring H.Z. Francke U. Shelton J. Richardson J. Russell D.W. McKnight S.L. |
Title | Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system. | |
Source | Proc. Natl. Acad. Sci. U.S.A. 94:713-718(1997). | |
PubMed ID | 9012850 |
6 | Authors | Tian H. McKnight S.L. Russell D.W. |
Title | Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. | |
Source | Genes Dev. 11:72-82(1997). | |
PubMed ID | 9000051 |