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PROSITE documentation PDOC51306 |
The Shroom (Shrm) protein family is found only in animals. Proteins of this family are predicted to be utilized in multiple morphogenic and developmental processes across animal phyla to regulate cells shape or intracellular architecture in an actin and myosin-dependent manner [1]. While the founding member of the Shrm family is Shrm1 (formerly Apx), it appears that this protein is found only in Xenopus [2]. In mice and humans, the Shrm family of proteins consists of:
This protein family is based on the conservation of a specific arrangement of an N-terminal PDZ domain (see <PDOC50106>), a centrally positionned sequence motif termed ASD1 (Apx/Shrm Domain 1) and a C-terminally positioned motif termed ASD2 [1,2,3]. Shrm2 and Shrm3 contain all three domains, while Shrm4 contains the PDZ and ASD2 domains, but lacks a discernable ASD1 element. To date, the ASD1 and ASD2 elements have only been found in Shrm-related proteins and do not appear in combination with other conserved domains. ASD1 is required for targeting to actin, while ASD2 is capable of eliciting an actomyosin based constriction event [1,2].
ASD2 is the most highly conserved sequence element shared by Shrm1, Shrm2, Shrm3, and Shrm4. It possesses a well conserved series of leucine residues that exhibit spacing consistent with that of a leucine zipper motif [1].
The profiles we developed cover the entire ASD1 and ASD2 domains.
Last update:April 2007 / First entry.
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PROSITE methods (with tools and information) covered by this documentation:
1 | Authors | Dietz M.L. Bernaciak T.M. Vendetti F. Kielec J.M. Hildebrand J.D. |
Title | Differential actin-dependent localization modulates the evolutionarily conserved activity of Shroom family proteins. | |
Source | J. Biol. Chem. 281:20542-20554(2006). | |
PubMed ID | 16684770 | |
DOI | 10.1074/jbc.M512463200 |
2 | Authors | Yoder M. Hildebrand J.D. |
Title | Shroom4 (Kiaa1202) is an actin-associated protein implicated in cytoskeletal organization. | |
Source | Cell Motil. Cytoskeleton 64:49-63(2007). | |
PubMed ID | 17009331 | |
DOI | 10.1002/cm.20167 |
3 | Authors | Hildebrand J.D. Soriano P. |
Title | Shroom, a PDZ domain-containing actin-binding protein, is required for neural tube morphogenesis in mice. | |
Source | Cell 99:485-497(1999). | |
PubMed ID | 10589677 |