PROSITE documentation PDOC51329C-CAP/cofactor C-like domain profile
The C-CAP/cofactor C-like domain is present in several cytoskeleton-related proteins, which also contain a number of additional domains [1,2,3,4]:
- Eukaryotic cyclase-associated protein (CAP or SRV2) (see <PDOC00835>), a modular actin monomer binding that directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.
- Vertebrate retinitis pigmentosa 2 (XRP2). In human, the protein responsible for X-linked forms of retinitis pigmentosa, a disease characterized by severe retinal degeneration.
- Eukaryotic tubulin-specific chaperone cofactor C (TBCC), a GTPase- activating component of the tubulin-folding supercomplex, which directs the assembly of the α- and β-tubulin heterodimer.
The cyclase-associated protein C-CAP/cofactor C-like domain binds G-actin and is responsible for oligomerization of the entire CAP molecule [1], whereas the XRP2 C-CAP/cofactor C-like domain is required for binding of ADP ribosylation factor-like protein 3 (Arl3) [2].
The central core of the C-CAP/cofactor C-like domain is composed of six coils of right-handed parallel β-helix, termed coils 1-6, which form an elliptical barrel with a tightly packed interior. Each β-helical coil is composed of three relatively short β-strands, designated a-c, separated by sharp turns. Flanking the central β-helical core is an N-terminal β-strand, β0, that packs antiparallel to the core, and strand β7 packs antiparallel to the core near the C-terminal end of the parallel β-helix (see <PDB:1K4Z>) [1,2].
The profile we developed covers the C-CAP/cofactor C-like domain.
Last update:August 2007 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Dodatko T. Fedorov A.A. Grynberg M. Patskovsky Y. Rozwarski D.A. Jaroszewski L. Aronoff-Spencer E. Kondraskina E. Irving T. Godzik A. Almo S.C. |
| Title | Crystal structure of the actin binding domain of the cyclase-associated protein. | |
| Source | Biochemistry 43:10628-10641(2004). | |
| PubMed ID | 15311924 | |
| DOI | 10.1021/bi049071r |
| 2 | Authors | Kuehnel K. Veltel S. Schlichting I. Wittinghofer A. |
| Title | Crystal structure of the human retinitis pigmentosa 2 protein and its interaction with Arl3. | |
| Source | Structure 14:367-378(2006). | |
| PubMed ID | 16472755 | |
| DOI | 10.1016/j.str.2005.11.008 |
| 3 | Authors | Stephan A. Vaughan S. Shaw M.K. Gull K. McKean P.G. |
| Title | An Essential Quality Control Mechanism at the Eukaryotic Basal Body Prior to Intraflagellar Transport. | |
| Source | Traffic 0:0-0(2007). | |
| PubMed ID | 17645436 | |
| DOI | 10.1111/j.1600-0854.2007.00611.x |
| 4 | Authors | Grynberg M. Jaroszewski L. Godzik A. |
| Title | Domain analysis of the tubulin cofactor system: a model for tubulin folding and dimerization. | |
| Source | BMC Bioinformatics 4:46-46(2003). | |
| PubMed ID | 14536023 | |
| DOI | 10.1186/1471-2105-4-46 |
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