We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC51335ELMO domain profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC51335
Description
Regulatory GTPases in the Ras superfamily employ a cycle of alternating GTP binding and hydrolysis, controlled by guanine nucleotide exchange factors and GTPase-activating proteins (GAPs), as essential features of their actions in cells. Within the Ras superfamily, the Arf family is composed of 30 members, including 22 Arf-like (Arl) proteins. The ELMO (for EnguLfment and cell MOtility) domain has been proposed to be a GAP domain for ARL2 and other members of the Arf family [1].
The profile we developed covers the entire ELMO domain.
Last update:October 2007 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
Reference
| 1 | Authors | Bowzard J.B. Cheng D. Peng J. Kahn R.A. |
| Title | ELMOD2 is an Arl2 GTPase-activating protein that also acts on Arfs. | |
| Source | J. Biol. Chem. 282:17568-17580(2007). | |
| PubMed ID | 17452337 | |
| DOI | 10.1074/jbc.M701347200 |
Copyright
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.