PROSITE documentation PDOC51335ELMO domain profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC51335
Description
Regulatory GTPases in the Ras superfamily employ a cycle of alternating GTP binding and hydrolysis, controlled by guanine nucleotide exchange factors and GTPase-activating proteins (GAPs), as essential features of their actions in cells. Within the Ras superfamily, the Arf family is composed of 30 members, including 22 Arf-like (Arl) proteins. The ELMO (for EnguLfment and cell MOtility) domain has been proposed to be a GAP domain for ARL2 and other members of the Arf family [1].
The profile we developed covers the entire ELMO domain.
Last update:October 2007 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
Reference
| 1 | Authors | Bowzard J.B. Cheng D. Peng J. Kahn R.A. |
| Title | ELMOD2 is an Arl2 GTPase-activating protein that also acts on Arfs. | |
| Source | J. Biol. Chem. 282:17568-17580(2007). | |
| PubMed ID | 17452337 | |
| DOI | 10.1074/jbc.M701347200 |
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