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PROSITE documentation PDOC51370 |
Members of the TCP family of transcription factors have so far only been found in plants, where they are implicated in processes related to cell proliferation. It appears that TCP domain (see <PDOC51369>) protein have been recruited during evolution to control cell division and growth in various developmental processes. The TCP proteins fall into two subfamilies, one including CYC and TB1 and the other including the PCFs. Most members of the CYC/TB1 subfamily have an R domain, predicted to form a coiled coil that may mediate protein-protein interactions [1,2].
The R domain is rich in polar residues (arginine, lysine and glutamic acid) and is predicted to form a hydrophilic α-helix [1].
Some proteins known to contain a R domain are listed below:
The profile we developed covers the entire R domain.
Last update:February 2008 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Cubas P. Lauter N. Doebley J. Coen E. |
Title | The TCP domain: a motif found in proteins regulating plant growth and development. | |
Source | Plant J. 18:215-222(1999). | |
PubMed ID | 10363373 |
2 | Authors | Faivre-Rampant O. Bryan G.J. Roberts A.G. Milbourne D. Viola R. Taylor M.A. |
Title | Regulated expression of a novel TCP domain transcription factor indicates an involvement in the control of meristem activation processes in Solanum tuberosum. | |
Source | J. Exp. Bot. 55:951-953(2004). | |
PubMed ID | 14990618 | |
DOI | 10.1093/jxb/erh082 |