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PROSITE documentation PDOC51375 |
Pentatricopeptide repeat (PPR) proteins are characterized by tandem repeats of a degenerate 35 amino acid motif [1]. Most of PPR proteins have roles in mitochondria or plastid. PPR repeats were discovered while screening Arabidopsis proteins for those predicted to be targeted to mitochondria or chloroplast [1,2]. Some of these proteins have been shown to play a role in post-transcriptional processes within organelles and they are thought to be sequence-specific RNA-binding proteins [3,4,5]. Plant genomes have between one hundred to five hundred PPR genes per genome whereas non-plant genomes encode two to six PPR proteins.
Although no PPR structures are yet known, the motif is predicted to fold into a helix-turn-helix structure similar to those found in the tetratricopeptide repeat (TPR) family (see <PDOC50005>) [1].
The plant PPR protein family has been divided in two subfamilies on the basis of their motif content and organization [6,7]:
Some non-plant PPR proteins are listed below:
The profile we developed covers the entire PPR repeat.
Last update:April 2008 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Small I.D. Peeters N. |
Title | The PPR motif - a TPR-related motif prevalent in plant organellar proteins. | |
Source | Trends Biochem. Sci. 25:46-47(2000). | |
PubMed ID | 10664580 |
2 | Authors | Lurin C. Andres C. Aubourg S. Bellaoui M. Bitton F. Bruyere C. Caboche M. Debast C. Gualberto J. Hoffmann B. Lecharny A. Le Ret M. Martin-Magniette M.L. Mireau H. Peeters N. Renou J.P. Szurek B. Taconnat L. Small I. |
Title | Genome-wide analysis of Arabidopsis pentatricopeptide repeat proteins reveals their essential role in organelle biogenesis. | |
Source | Plant Cell 16:2089-2103(2004). | |
PubMed ID | 15269332 | |
DOI | 10.1105/tpc.104.022236 |
3 | Authors | Meierhoff K. Felder S. Nakamura T. Bechtold N. Schuster G. |
Title | HCF152, an Arabidopsis RNA binding pentatricopeptide repeat protein involved in the processing of chloroplast psbB-psbT-psbH-petB-petD RNAs. | |
Source | Plant Cell 15:1480-1495(2003). | |
PubMed ID | 12782738 |
4 | Authors | Mili S. Pinol-Roma S. |
Title | LRP130, a pentatricopeptide motif protein with a noncanonical RNA-binding domain, is bound in vivo to mitochondrial and nuclear RNAs. | |
Source | Mol. Cell. Biol. 23:4972-4982(2003). | |
PubMed ID | 12832482 |
5 | Authors | Delannoy E. Stanley W.A. Bond C.S. Small I.D. |
Title | Pentatricopeptide repeat (PPR) proteins as sequence-specificity factors in post-transcriptional processes in organelles. | |
Source | Biochem. Soc. Trans. 35:1643-1647(2007). | |
PubMed ID | 18031283 | |
DOI | 10.1042/BST0351643 |
6 | Authors | Lurin C. Andres C. Aubourg S. Bellaoui M. Bitton F. Bruyere C. Caboche M. Debast C. Gualberto J. Hoffmann B. Lecharny A. Le Ret M. Martin-Magniette M.L. Mireau H. Peeters N. Renou J.P. Szurek B. Taconnat L. Small I. |
Title | Genome-wide analysis of Arabidopsis pentatricopeptide repeat proteins reveals their essential role in organelle biogenesis. | |
Source | Plant Cell 16:2089-2103(2004). | |
PubMed ID | 15269332 | |
DOI | 10.1105/tpc.104.022236 |
7 | Authors | Saha D. Prasad A.M. Srinivasan R. |
Title | Pentatricopeptide repeat proteins and their emerging roles in plants. | |
Source | Plant Physiol. Biochem. 45:521-534(2007). | |
PubMed ID | 17560114 | |
DOI | 10.1016/j.plaphy.2007.03.026 |