PROSITE documentation PDOC51386

RINT1/TIP20 domain profile


The following proteins playing a role in anterograde transport from the endoplasmic reticulum (ER) to the Golgi and/or retrograde transport from the Golgi to the ER share sequence similarity:

  • Mammalian RINT1 (Rad50-interacting protein 1), which was originally discovered as a checkpoint protein that interacts with Rad50 only during late S and G2/M phases. RINT1 also functions in membrane trafficking from the endoplasmic reticulum (ER) to the Golgi complex in interphase cells [1,2,3].
  • Yeast TIP20, which has been reported to be involved in the retrograde transport from the Golgi to the ER [4].
  • Arabidopsis thaliana MAIGO2 (MAG2), functions in the transport of storage protein precursors between the ER and Golgi complex in plants [5].

They share a similar domain organization with an N-terminal leucine heptad repeat rich coiled coil and an ~500-residue C-terminal RINT1/TIP20 domain, which might be a protein-protein interaction module necessary for the formation of functional complexes.

The profile we developed covers the entire RINT1/TIP20 domain.

Last update:

May 2008 / First entry.

Technical section

PROSITE method (with tools and information) covered by this documentation:

RINT1_TIP20, PS51386; RINT1/TIP20 domain profile  (MATRIX)


1AuthorsXiao J., Liu C.-C., Chen P.-L., Lee W.-H.
TitleRINT-1, a novel Rad50-interacting protein, participates in radiation-induced G(2)/M checkpoint control.
SourceJ. Biol. Chem. 276:6105-6111(2001).
PubMed ID11096100

2AuthorsKong L.-J., Meloni A.R., Nevins J.R.
TitleThe Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1.
SourceMol. Cell 22:63-71(2006).
PubMed ID16600870

3AuthorsArasaki K., Taniguchi M., Tani K., Tagaya M.
TitleRINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex.
SourceMol. Biol. Cell 17:2780-2788(2006).
PubMed ID16571679

4AuthorsSweet D.J., Pelham H.R.B.
TitleThe TIP1 gene of Saccharomyces cerevisiae encodes an 80 kDa cytoplasmic protein that interacts with the cytoplasmic domain of Sec20p.
SourceEMBO J. 12:2831-2840(1993).
PubMed ID8334998

5AuthorsLi L., Shimada T., Takahashi H., Ueda H., Fukao Y., Kondo M., Nishimura M., Hara-Nishimura I.
TitleMAIGO2 is involved in exit of seed storage proteins from the endoplasmic reticulum in Arabidopsis thaliana.
SourcePlant Cell 18:3535-3547(2006).
PubMed ID17194767

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