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PROSITE documentation PDOC51386RINT1/TIP20 domain profile
Description
The following proteins playing a role in anterograde transport from the endoplasmic reticulum (ER) to the Golgi and/or retrograde transport from the Golgi to the ER share sequence similarity:
- Mammalian RINT1 (Rad50-interacting protein 1), which was originally discovered as a checkpoint protein that interacts with Rad50 only during late S and G2/M phases. RINT1 also functions in membrane trafficking from the endoplasmic reticulum (ER) to the Golgi complex in interphase cells [1,2,3].
- Yeast TIP20, which has been reported to be involved in the retrograde transport from the Golgi to the ER [4].
- Arabidopsis thaliana MAIGO2 (MAG2), functions in the transport of storage protein precursors between the ER and Golgi complex in plants [5].
They share a similar domain organization with an N-terminal leucine heptad repeat rich coiled coil and an ~500-residue C-terminal RINT1/TIP20 domain, which might be a protein-protein interaction module necessary for the formation of functional complexes.
The profile we developed covers the entire RINT1/TIP20 domain.
Last update:May 2008 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Xiao J. Liu C.-C. Chen P.-L. Lee W.-H. |
| Title | RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G(2)/M checkpoint control. | |
| Source | J. Biol. Chem. 276:6105-6111(2001). | |
| PubMed ID | 11096100 | |
| DOI | 10.1074/jbc.M008893200 |
| 2 | Authors | Kong L.-J. Meloni A.R. Nevins J.R. |
| Title | The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1. | |
| Source | Mol. Cell 22:63-71(2006). | |
| PubMed ID | 16600870 | |
| DOI | 10.1016/j.molcel.2006.02.016 |
| 3 | Authors | Arasaki K. Taniguchi M. Tani K. Tagaya M. |
| Title | RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex. | |
| Source | Mol. Biol. Cell 17:2780-2788(2006). | |
| PubMed ID | 16571679 | |
| DOI | 10.1091/mbc.E05-10-0973 |
| 4 | Authors | Sweet D.J. Pelham H.R.B. |
| Title | The TIP1 gene of Saccharomyces cerevisiae encodes an 80 kDa cytoplasmic protein that interacts with the cytoplasmic domain of Sec20p. | |
| Source | EMBO J. 12:2831-2840(1993). | |
| PubMed ID | 8334998 |
| 5 | Authors | Li L. Shimada T. Takahashi H. Ueda H. Fukao Y. Kondo M. Nishimura M. Hara-Nishimura I. |
| Title | MAIGO2 is involved in exit of seed storage proteins from the endoplasmic reticulum in Arabidopsis thaliana. | |
| Source | Plant Cell 18:3535-3547(2006). | |
| PubMed ID | 17194767 | |
| DOI | 10.1105/tpc.106.046151 |
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