We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC51386RINT1/TIP20 domain profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC51386
Description
The following proteins playing a role in anterograde transport from the endoplasmic reticulum (ER) to the Golgi and/or retrograde transport from the Golgi to the ER share sequence similarity:
- Mammalian RINT1 (Rad50-interacting protein 1), which was originally discovered as a checkpoint protein that interacts with Rad50 only during late S and G2/M phases. RINT1 also functions in membrane trafficking from the endoplasmic reticulum (ER) to the Golgi complex in interphase cells [1,2,3].
- Yeast TIP20, which has been reported to be involved in the retrograde transport from the Golgi to the ER [4].
- Arabidopsis thaliana MAIGO2 (MAG2), functions in the transport of storage protein precursors between the ER and Golgi complex in plants [5].
They share a similar domain organization with an N-terminal leucine heptad repeat rich coiled coil and an ~500-residue C-terminal RINT1/TIP20 domain, which might be a protein-protein interaction module necessary for the formation of functional complexes.
The profile we developed covers the entire RINT1/TIP20 domain.
Last update:May 2008 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Xiao J. Liu C.-C. Chen P.-L. Lee W.-H. |
| Title | RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G(2)/M checkpoint control. | |
| Source | J. Biol. Chem. 276:6105-6111(2001). | |
| PubMed ID | 11096100 | |
| DOI | 10.1074/jbc.M008893200 |
| 2 | Authors | Kong L.-J. Meloni A.R. Nevins J.R. |
| Title | The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1. | |
| Source | Mol. Cell 22:63-71(2006). | |
| PubMed ID | 16600870 | |
| DOI | 10.1016/j.molcel.2006.02.016 |
| 3 | Authors | Arasaki K. Taniguchi M. Tani K. Tagaya M. |
| Title | RINT-1 regulates the localization and entry of ZW10 to the syntaxin 18 complex. | |
| Source | Mol. Biol. Cell 17:2780-2788(2006). | |
| PubMed ID | 16571679 | |
| DOI | 10.1091/mbc.E05-10-0973 |
| 4 | Authors | Sweet D.J. Pelham H.R.B. |
| Title | The TIP1 gene of Saccharomyces cerevisiae encodes an 80 kDa cytoplasmic protein that interacts with the cytoplasmic domain of Sec20p. | |
| Source | EMBO J. 12:2831-2840(1993). | |
| PubMed ID | 8334998 |
| 5 | Authors | Li L. Shimada T. Takahashi H. Ueda H. Fukao Y. Kondo M. Nishimura M. Hara-Nishimura I. |
| Title | MAIGO2 is involved in exit of seed storage proteins from the endoplasmic reticulum in Arabidopsis thaliana. | |
| Source | Plant Cell 18:3535-3547(2006). | |
| PubMed ID | 17194767 | |
| DOI | 10.1105/tpc.106.046151 |
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