PROSITE documentation PDOC51389Xin repeat profile
Xin (which means heart in Chinese) repeats are 16 amino acid tandem repeats found in all vertebrates, including mammals, birds, amphibians and fishes. They are present in at least two different muscle proteins, Xin and the closely related Xin-repeat protein 2 (XIRP2). The Xin repeat is an actin-binding motif, capable of binding to actin filaments and organizing microfilaments into loose networks. A minimum of 3 Xin repeats is required for the binding to actin filaments. The consensus sequence of the Xin repeats is G-D-V-[KQRS]-x(2)-[RKT]-W-L-F-E-T-[QRKT]-P-L-D [1,2,3,4].
The profile we developed covers the entire Xin repeat.
Last update:June 2008 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Wang D.-Z. Reiter R.S. Lin J.L.-C. Wang Q. Williams H.S. Krob S.L. Schultheiss T.M. Evans S. Lin J.J.-C. |
| Title | Requirement of a novel gene, Xin, in cardiac morphogenesis. | |
| Source | Development 126:1281-1294(1999). | |
| PubMed ID | 10021346 |
| 2 | Authors | Pacholsky D. Vakeel P. Himmel M. Loewe T. Stradal T. Rottner K. Fuerst D.O. van der Ven P.F.M. |
| Title | Xin repeats define a novel actin-binding motif. | |
| Source | J. Cell Sci. 117:5257-5268(2004). | |
| PubMed ID | 15454575 | |
| DOI | 10.1242/jcs.01406 |
| 3 | Authors | Lin J.J.-C. Gustafson-Wagner E.A. Sinn H.W. Choi S. Jaacks S.M. Wang D.-Z. Evans S. Li-Chun Lin J.L.-C. |
| Title | Structure, Expression, and Function of a Novel Intercalated Disc Protein, Xin. | |
| Source | J. Med. Sci. 25:215-222(2005). | |
| PubMed ID | 16708114 | |
| DOI | 10.1901/jaba.2005.25-215 |
| 4 | Authors | Huang H.-T. Brand O.M. Mathew M. Ignatiou C. Ewen E.P. McCalmon S.A. Naya F.J. |
| Title | Myomaxin is a novel transcriptional target of MEF2A that encodes a Xin-related alpha-actinin-interacting protein. | |
| Source | J. Biol. Chem. 281:39370-39379(2006). | |
| PubMed ID | 17046827 | |
| DOI | 10.1074/jbc.M603244200 |
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