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PROSITE documentation PDOC51389

Xin repeat profile





Description

Xin (which means heart in Chinese) repeats are 16 amino acid tandem repeats found in all vertebrates, including mammals, birds, amphibians and fishes. They are present in at least two different muscle proteins, Xin and the closely related Xin-repeat protein 2 (XIRP2). The Xin repeat is an actin-binding motif, capable of binding to actin filaments and organizing microfilaments into loose networks. A minimum of 3 Xin repeats is required for the binding to actin filaments. The consensus sequence of the Xin repeats is G-D-V-[KQRS]-x(2)-[RKT]-W-L-F-E-T-[QRKT]-P-L-D [1,2,3,4].

The profile we developed covers the entire Xin repeat.

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html --------------------------------------------------------------------------------.

Last update:

June 2008 / First entry.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

XIN, PS51389; Xin repeat profile  (MATRIX)


References

1AuthorsWang D.-Z. Reiter R.S. Lin J.L.-C. Wang Q. Williams H.S. Krob S.L. Schultheiss T.M. Evans S. Lin J.J.-C.
TitleRequirement of a novel gene, Xin, in cardiac morphogenesis.
SourceDevelopment 126:1281-1294(1999).
PubMed ID10021346

2AuthorsPacholsky D. Vakeel P. Himmel M. Loewe T. Stradal T. Rottner K. Fuerst D.O. van der Ven P.F.M.
TitleXin repeats define a novel actin-binding motif.
SourceJ. Cell Sci. 117:5257-5268(2004).
PubMed ID15454575
DOI10.1242/jcs.01406

3AuthorsLin J.J.-C. Gustafson-Wagner E.A. Sinn H.W. Choi S. Jaacks S.M. Wang D.-Z. Evans S. Li-Chun Lin J.L.-C.
TitleStructure, Expression, and Function of a Novel Intercalated Disc Protein, Xin.
SourceJ. Med. Sci. 25:215-222(2005).
PubMed ID16708114
DOI10.1901/jaba.2005.25-215

4AuthorsHuang H.-T. Brand O.M. Mathew M. Ignatiou C. Ewen E.P. McCalmon S.A. Naya F.J.
TitleMyomaxin is a novel transcriptional target of MEF2A that encodes a Xin-related alpha-actinin-interacting protein.
SourceJ. Biol. Chem. 281:39370-39379(2006).
PubMed ID17046827
DOI10.1074/jbc.M603244200



PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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