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PROSITE documentation PDOC51425
Stromalin conservative (SCD) domain profile


Description

The stromal antigens or stromalins are a group of highly conserved nuclear proteins, originally identified from a murine bone marrows stromal cell line. Stromalins are represented in several organisms from yeast to humans and are characterized by the stromalin conservative domain (SCD), an 86 amino acid motif found in all proteins of the family described to date [1].

Some proteins known to contain a SCD domain are listed below:

  • Vertebrate cohesin subunits SA-1, -2 and -3 (Stag1, 2 and 3), components of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication.
  • Human STAG3-like protein.
  • Yeast cohesin subunit SCC3, a component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication.
  • Fission yeast meiotic recombination protein rec11.

The profile we developed covers the entire SCD domain.

Last update:

January 2009 / First entry.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

SCD, PS51425; Stromalin conservative (SCD) domain profile  (MATRIX)


Reference

1AuthorsPezzi N. Prieto I. Kremer L. Perez Jurado L.A. Valero C. Del Mazo J. Martinez-A. C. Barbero J.L.
TitleSTAG3, a novel gene encoding a protein involved in meiotic chromosome pairing and location of STAG3-related genes flanking the Williams-Beuren syndrome deletion.
SourceFASEB J. 14:581-592(2000).
PubMed ID10698974



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