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PROSITE documentation PDOC51488 |
The c-Kit-binding domain (KBD) composed of about 50 amino acids is found in a family of membrane-bound molecules, Spreds, which contain an EVH1 domain (see <PDOC50229>) in the N-terminus and a Sprouty-related cysteine rich region (SPR domain) (see <PDOC51227>) in the C-terminus [1,2]:
Spred proteins function as suppressors of the MAP kinase pathway in various systems. Each member of the Spred family may have a selective function for the regulation of the MAP kinase cascade [1,2].
The profile we developed covers the entire KBD domain.
Last update:April 2010 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Wakioka T. Sasaki A. Kato R. Shouda T. Matsumoto A. Miyoshi K. Tsuneoka M. Komiya S. Baron R. Yoshimura A. |
Title | Spred is a Sprouty-related suppressor of Ras signalling. | |
Source | Nature 412:647-651(2001). | |
PubMed ID | 11493923 | |
DOI | 10.1038/35088082 |
2 | Authors | Kato R. Nonami A. Taketomi T. Wakioka T. Kuroiwa A. Matsuda Y. Yoshimura A. |
Title | Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation. | |
Source | Biochem. Biophys. Res. Commun. 302:767-772(2003). | |
PubMed ID | 12646235 |