PROSITE documentation PDOC51488
KBD domain profile


The c-Kit-binding domain (KBD) composed of about 50 amino acids is found in a family of membrane-bound molecules, Spreds, which contain an EVH1 domain (see <PDOC50229>) in the N-terminus and a Sprouty-related cysteine rich region (SPR domain) (see <PDOC51227>) in the C-terminus [1,2]:

  • Spred-1
  • Spred-2
  • Spred-3. It does not possess a functional KBD domain, since the critical amino acid Arg was replaced with Gly.

Spred proteins function as suppressors of the MAP kinase pathway in various systems. Each member of the Spred family may have a selective function for the regulation of the MAP kinase cascade [1,2].

The profile we developed covers the entire KBD domain.

Last update:

April 2010 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

KBD, PS51488; KBD domain profile  (MATRIX)


1AuthorsWakioka T. Sasaki A. Kato R. Shouda T. Matsumoto A. Miyoshi K. Tsuneoka M. Komiya S. Baron R. Yoshimura A.
TitleSpred is a Sprouty-related suppressor of Ras signalling.
SourceNature 412:647-651(2001).
PubMed ID11493923

2AuthorsKato R. Nonami A. Taketomi T. Wakioka T. Kuroiwa A. Matsuda Y. Yoshimura A.
TitleMolecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation.
SourceBiochem. Biophys. Res. Commun. 302:767-772(2003).
PubMed ID12646235

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