PROSITE documentation PDOC51492
Peptidase family C23 domain profile


βflexiviridae are a family of plant viruses containing a single-stranded positive-sense RNA genome [E1]. The first open reading frame (ORF1) of βflexiviridae encodes a putative replication-associated protein that is autocatalytically processed by a peptidase family C23 domain [E2]. The peptidase family C23 domain is a papain-like proteinase domain with catalytic cysteine and histidine residues [1].

Some proteins known to contain a peptidase family C23 domain are listed below:

  • Blueberry scorch virus (BBScV) RNA replication protein.
  • Apple stem pitting virus (ASPV) RNA replication protein.
  • Potato virus M (PVM) RNA replication protein.

The profile we developed covers the entire peptidase family C23 domain.

Last update:

November 2014 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

PEPTIDASE_C23, PS51492; Peptidase family C23 domain profile  (MATRIX)


1AuthorsLawrence D.M. Rozanov M.N. Hillman B.I.
TitleAutocatalytic processing of the 223-kDa protein of blueberry scorch carlavirus by a papain-like proteinase.
SourceVirology 207:127-135(1995).
PubMed ID7871721



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