PROSITE documentation PDOC51492Peptidase family C23 domain profile
βflexiviridae are a family of plant viruses containing a single-stranded positive-sense RNA genome [E1]. The first open reading frame (ORF1) of βflexiviridae encodes a putative replication-associated protein that is autocatalytically processed by a peptidase family C23 domain [E2]. The peptidase family C23 domain is a papain-like proteinase domain with catalytic cysteine and histidine residues [1].
Some proteins known to contain a peptidase family C23 domain are listed below:
- Blueberry scorch virus (BBScV) RNA replication protein.
- Apple stem pitting virus (ASPV) RNA replication protein.
- Potato virus M (PVM) RNA replication protein.
The profile we developed covers the entire peptidase family C23 domain.
Last update:November 2014 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Lawrence D.M. Rozanov M.N. Hillman B.I. |
| Title | Autocatalytic processing of the 223-kDa protein of blueberry scorch carlavirus by a papain-like proteinase. | |
| Source | Virology 207:127-135(1995). | |
| PubMed ID | 7871721 | |
| DOI | 10.1006/viro.1995.1058 |
| E1 | Title | https://viralzone.expasy.org/739?outline=all_by_species |
| E2 | Title | https://www.ebi.ac.uk/merops/cgi-bin/famsum?family=C23 |
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