PROSITE documentation PDOC51502Stress-response A/B barrel domain profile
The stress-response A/B barrel domain is found in a class of stress-response proteins in plants and in some bacterial fructose-bisphosphate aldolase. The stress-response A/B barrel domain forms a very stable dimer. This dimer belongs to the superfamily of dimeric α+β barrels in which the two β-sheets form a β-barrel. The two molecules in the dimer are related by a 2-fold axis parallel to helix H1 and β-strands B3 and B4. The outer surface of the β-sheets of the two molecules forms a β-barrel-like structure defining a central pore. The function of the stress-response A/B barrel domain is unknown [1,2,3].
The stress-response A/B barrel domain has an α/β structure consisting of a four-stranded antiparallel β-sheet and three α-helices, arranged in a β-α-β-β-α-α-β topology (see <PDB:1Q4R>). Two sheets join at their edges to form an oblong β-barrel, flanked by four helices on each of the opposing faces. C-terminal residues extending from the β4 strand of each monomer wrap around and connect with the β2 strand and α1 helix of the opposing monomer to form the dimer interface [1,2,3].
Some proteins known to contain a stress response A/B barrel domain are listed below:
- Arabidopsis thaliana At3g17210
- Arabidopsis thaliana At5g22580
- Populus tremula stable protein 1 (SP-1) (also known as Pop3 in other Populus species), a thermostable stress-responsive protein.
- Pseudomonas hydrogenothermophila fructose 1,6-bisphosphate aldolase (cbbA).
The profile we developed covers the entire stress-response A/B barrel domain.
Last update:August 2010 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Lytle B.L. Peterson F.C. Qiu S.H. Luo M. Zhao Q. Markley J.L. Volkman B.F. |
| Title | Solution structure of a ubiquitin-like domain from tubulin-binding cofactor B. | |
| Source | J. Biol. Chem. 279:46787-46793(2004). | |
| PubMed ID | 15364906 | |
| DOI | 10.1074/jbc.M409422200 |
| 2 | Authors | Cornilescu G. Cornilescu C.C. Zhao Q. Frederick R.O. Peterson F.C. Thao S. Markley J.L. |
| Title | Solution structure of a homodimeric hypothetical protein, At5g22580, a structural genomics target from Arabidopsis thaliana. | |
| Source | J. Biomol. NMR 29:387-390(2004). | |
| PubMed ID | 15213437 | |
| DOI | 10.1023/B:JNMR.0000032525.70677.16 |
| 3 | Authors | Dgany O. Gonzalez A. Sofer O. Wang W. Zolotnitsky G. Wolf A. Shoham Y. Altman A. Wolf S.G. Shoseyov O. Almog O. |
| Title | The structural basis of the thermostability of SP1, a novel plant (Populus tremula) boiling stable protein. | |
| Source | J. Biol. Chem. 279:51516-51523(2004). | |
| PubMed ID | 15371455 | |
| DOI | 10.1074/jbc.M409952200 |
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