Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC51503HIG1 domain profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC51503
The hypoxia induced gene 1 (HIG1) or hypoglycemia/hypoxia inducible mitochondrial protein (HIMP1) is up-regulated by stresses of the microenvironment such as low oxygen or low glucose conditions. HIG1 is a mitochondrial inner membrane protein, which is ubiquitously expressed. It is predicted to be an integral membrane protein consisting of two hydrophobic helices, 21-23 residues in length that might tend to form a hairpin-like loop across the bilayer. HIG1 could be implied in apoptotic or cytoprotective signals. HIG1 is a member of a well conserved eukaryote protein family. The predicted transmembrane helice (TMH) and loop regions represent the most highly conserved regions in these proteins [1,2].
The profile we developed covers the predicted TMH and loop regions.
Last update:August 2010 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Bedo G. Vargas M. Ferreiro M.-J. Chalar C. Agrati D. |
| Title | Characterization of hypoxia induced gene 1: expression during rat central nervous system maturation and evidence of antisense RNA expression. | |
| Source | Int. J. Dev. Biol. 49:431-436(2005). | |
| PubMed ID | 15968589 | |
| DOI | 10.1387/ijdb.041901gb |
| 2 | Authors | Wang J. Cao Y. Chen Y. Chen Y. Gardner P. Steiner D.F. |
| Title | Pancreatic beta cells lack a low glucose and O2-inducible mitochondrial protein that augments cell survival. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 103:10636-10641(2006). | |
| PubMed ID | 16815968 | |
| DOI | 10.1073/pnas.0604194103 |
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