PROSITE documentation PDOC51503
HIG1 domain profile


The hypoxia induced gene 1 (HIG1) or hypoglycemia/hypoxia inducible mitochondrial protein (HIMP1) is up-regulated by stresses of the microenvironment such as low oxygen or low glucose conditions. HIG1 is a mitochondrial inner membrane protein, which is ubiquitously expressed. It is predicted to be an integral membrane protein consisting of two hydrophobic helices, 21-23 residues in length that might tend to form a hairpin-like loop across the bilayer. HIG1 could be implied in apoptotic or cytoprotective signals. HIG1 is a member of a well conserved eukaryote protein family. The predicted transmembrane helice (TMH) and loop regions represent the most highly conserved regions in these proteins [1,2].

The profile we developed covers the predicted TMH and loop regions.

Last update:

August 2010 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

HIG1, PS51503; HIG1 domain profile  (MATRIX)


1AuthorsBedo G. Vargas M. Ferreiro M.-J. Chalar C. Agrati D.
TitleCharacterization of hypoxia induced gene 1: expression during rat central nervous system maturation and evidence of antisense RNA expression.
SourceInt. J. Dev. Biol. 49:431-436(2005).
PubMed ID15968589

2AuthorsWang J. Cao Y. Chen Y. Chen Y. Gardner P. Steiner D.F.
TitlePancreatic beta cells lack a low glucose and O2-inducible mitochondrial protein that augments cell survival.
SourceProc. Natl. Acad. Sci. U.S.A. 103:10636-10641(2006).
PubMed ID16815968

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


View entry in original PROSITE document format
View entry in raw text format (no links)