PROSITE documentation PDOC51503HIG1 domain profile
The hypoxia induced gene 1 (HIG1) or hypoglycemia/hypoxia inducible mitochondrial protein (HIMP1) is up-regulated by stresses of the microenvironment such as low oxygen or low glucose conditions. HIG1 is a mitochondrial inner membrane protein, which is ubiquitously expressed. It is predicted to be an integral membrane protein consisting of two hydrophobic helices, 21-23 residues in length that might tend to form a hairpin-like loop across the bilayer. HIG1 could be implied in apoptotic or cytoprotective signals. HIG1 is a member of a well conserved eukaryote protein family. The predicted transmembrane helice (TMH) and loop regions represent the most highly conserved regions in these proteins [1,2].
The profile we developed covers the predicted TMH and loop regions.
Last update:August 2010 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Bedo G. Vargas M. Ferreiro M.-J. Chalar C. Agrati D. |
| Title | Characterization of hypoxia induced gene 1: expression during rat central nervous system maturation and evidence of antisense RNA expression. | |
| Source | Int. J. Dev. Biol. 49:431-436(2005). | |
| PubMed ID | 15968589 | |
| DOI | 10.1387/ijdb.041901gb |
| 2 | Authors | Wang J. Cao Y. Chen Y. Chen Y. Gardner P. Steiner D.F. |
| Title | Pancreatic beta cells lack a low glucose and O2-inducible mitochondrial protein that augments cell survival. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 103:10636-10641(2006). | |
| PubMed ID | 16815968 | |
| DOI | 10.1073/pnas.0604194103 |
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