PROSITE documentation PDOC51517
NDT80 DNA-binding domain profile


The NDT80 DNA-binding domain is found in the following proteins, which might all be involved in sensing nutritional status [1]:

  • Yeast meiosis-specific transcription factor NDT80, the key transcription factor that ultimately allows the continuation of meiosis after the successful completion of recombination.
  • Emericella nidulans phoG (xprG), a transcriptional activator involved in the response to nutrient limitation.
  • Emericella nidulans putative uncharacterized protein AN6015.2.
  • Neurospora crassa transcription factor vib-1, involved in the control of heterokaryon incompatibility.
  • Neurospora crassa related to acid phosphatase NCU04729.
  • Neurospora crassa related to meiosis-specific protein NDT80 NCU09915.

The proteolytically resistant core NDT80 DNA-binding domain reveals a central β-sandwich characteristic of an s-type Ig fold (see <PDOC50835>) (see <PDB:1MNN>). The β-sandwich contains a three-stranded sheet composed of strands a, b and e, packed against a four-stranded sheet composed of strands c', c, f and g. Each sheet of the β-sandwich contains an additional β-strand, as well as a variety of peripheral secondary structure elements. The NDT80 DNA-binding domain contains an N-terminal extension, which consists of a β-hairpin and a loop [2].

The profile we developed covers the entire NDT80 DNA-binding domain.

Last update:

January 2011 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

NDT80, PS51517; NDT80 DNA-binding domain profile  (MATRIX)


1AuthorsKatz M.E. Gray K.-A. Cheetham B.F.
TitleThe Aspergillus nidulans xprG (phoG) gene encodes a putative transcriptional activator involved in the response to nutrient limitation.
SourceFungal Genet. Biol. 43:190-199(2006).
PubMed ID16464624

2AuthorsLamoureux J.S. Stuart D. Tsang R. Wu C. Glover J.N.M.
TitleStructure of the sporulation-specific transcription factor Ndt80 bound to DNA.
SourceEMBO J. 21:5721-5732(2002).
PubMed ID12411490

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