The NDT80 DNA-binding domain is found in the following proteins, which might all be involved in sensing nutritional status [1]:

• Yeast meiosis-specific transcription factor NDT80, the key transcription factor that ultimately allows the continuation of meiosis after the successful completion of recombination.
• Emericella nidulans phoG (xprG), a transcriptional activator involved in the response to nutrient limitation.
• Emericella nidulans putative uncharacterized protein AN6015.2.
• Neurospora crassa transcription factor vib-1, involved in the control of heterokaryon incompatibility.
• Neurospora crassa related to acid phosphatase NCU04729.
• Neurospora crassa related to meiosis-specific protein NDT80 NCU09915.

The proteolytically resistant core NDT80 DNA-binding domain reveals a central β-sandwich characteristic of an s-type Ig fold (see <PDOC50835>) (see <PDB:1MNN>). The β-sandwich contains a three-stranded sheet composed of strands a, b and e, packed against a four-stranded sheet composed of strands c', c, f and g. Each sheet of the β-sandwich contains an additional β-strand, as well as a variety of peripheral secondary structure elements. The NDT80 DNA-binding domain contains an N-terminal extension, which consists of a β-hairpin and a loop [2].

The profile we developed covers the entire NDT80 DNA-binding domain.