PROSITE documentation PDOC51633
CXC domain profile


Polycomb group (Pc-G) proteins ensure the stable inheritance of expression patterns through cell division and regulate the control of cell proliferation. The Enhancer of zeste (E(z))-type of Pc-G proteins includes:

  • Drosophila melanogaster Enhancer of zeste E(z).
  • Mammalian ENX-1 and ENX-2.
  • Arabidopsis thaliana CURLY LEAF (CLF), a transcriptional repressor of floral homeotic gene AGAMOUS.
  • Arabidopsis thaliana CLF-like.
  • Arabidopsis thaliana MEDEA (MEA), a suppressor of endosperm development.
  • Arabidopsis thaliana EZA1.

These proteins contain a SET domain (see <PDOC50280>) at the C-terminus. Unique to them is the presence of a CXC domain, an ~65-residue cys-rich region preceding the SET domain. The spacing of 17 cyteines is conserved. The CXC domain contains three units of C-X(6)-C-X(3)-C-X-C motif, although the most C-terminal unit is reverse-oriented. Because of its evolutionary conservation, the CXC domain is likely to be involved in an important function of E(z)-related proteins [1,2,3].

The CXC domain shows some similarity to the CRC domain found in the tesmin/ TSO1 protein family (see <PDOC51634>) [4].

The profile we developed covers the entire CXC domain.

Last update:

January 2012 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

CXC, PS51633; CXC domain profile  (MATRIX)


1AuthorsHobert O. Sures I. Ciossek T. Fuchs M. Ullrich A.
TitleIsolation and developmental expression analysis of Enx-1, a novel mouse Polycomb group gene.
SourceMech. Dev. 55:171-184(1996).
PubMed ID8861097

2AuthorsHobert O. Jallal B. Ullrich A.
TitleInteraction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression.
SourceMol. Cell. Biol. 16:3066-3073(1996).
PubMed ID8649418

3AuthorsOgawa M. Hiraoka Y. Taniguchi K. Aiso S.
TitleCloning and expression of a human/mouse Polycomb group gene, ENX-2/Enx-2.
SourceBiochim. Biophys. Acta 1395:151-158(1998).
PubMed ID9473645

4AuthorsAndersen S.U. Algreen-Petersen R.G. Hoedl M. Jurkiewicz A. Cvitanich C. Braunschweig U. Schauser L. Oh S.-A. Twell D. Jensen E.O.
TitleThe conserved cysteine-rich domain of a tesmin/TSO1-like protein binds zinc in vitro and TSO1 is required for both male and female fertility in Arabidopsis thaliana.
SourceJ. Exp. Bot. 58:3657-3670(2007).
PubMed ID18057042

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