PROSITE documentation PDOC51633CXC domain profile
Polycomb group (Pc-G) proteins ensure the stable inheritance of expression patterns through cell division and regulate the control of cell proliferation. The Enhancer of zeste (E(z))-type of Pc-G proteins includes:
- Drosophila melanogaster Enhancer of zeste E(z).
- Mammalian ENX-1 and ENX-2.
- Arabidopsis thaliana CURLY LEAF (CLF), a transcriptional repressor of floral homeotic gene AGAMOUS.
- Arabidopsis thaliana CLF-like.
- Arabidopsis thaliana MEDEA (MEA), a suppressor of endosperm development.
- Arabidopsis thaliana EZA1.
These proteins contain a SET domain (see <PDOC50280>) at the C-terminus. Unique to them is the presence of a CXC domain, an ~65-residue cys-rich region preceding the SET domain. The spacing of 17 cyteines is conserved. The CXC domain contains three units of C-X(6)-C-X(3)-C-X-C motif, although the most C-terminal unit is reverse-oriented. Because of its evolutionary conservation, the CXC domain is likely to be involved in an important function of E(z)-related proteins [1,2,3].
The CXC domain shows some similarity to the CRC domain found in the tesmin/ TSO1 protein family (see <PDOC51634>) [4].
The profile we developed covers the entire CXC domain.
Last update:January 2012 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Hobert O. Sures I. Ciossek T. Fuchs M. Ullrich A. |
| Title | Isolation and developmental expression analysis of Enx-1, a novel mouse Polycomb group gene. | |
| Source | Mech. Dev. 55:171-184(1996). | |
| PubMed ID | 8861097 |
| 2 | Authors | Hobert O. Jallal B. Ullrich A. |
| Title | Interaction of Vav with ENX-1, a putative transcriptional regulator of homeobox gene expression. | |
| Source | Mol. Cell. Biol. 16:3066-3073(1996). | |
| PubMed ID | 8649418 |
| 3 | Authors | Ogawa M. Hiraoka Y. Taniguchi K. Aiso S. |
| Title | Cloning and expression of a human/mouse Polycomb group gene, ENX-2/Enx-2. | |
| Source | Biochim. Biophys. Acta 1395:151-158(1998). | |
| PubMed ID | 9473645 |
| 4 | Authors | Andersen S.U. Algreen-Petersen R.G. Hoedl M. Jurkiewicz A. Cvitanich C. Braunschweig U. Schauser L. Oh S.-A. Twell D. Jensen E.O. |
| Title | The conserved cysteine-rich domain of a tesmin/TSO1-like protein binds zinc in vitro and TSO1 is required for both male and female fertility in Arabidopsis thaliana. | |
| Source | J. Exp. Bot. 58:3657-3670(2007). | |
| PubMed ID | 18057042 | |
| DOI | 10.1093/jxb/erm215 |
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