PROSITE documentation PDOC51634CRC domain profile
The following proteins of the tesmin/TSO1 family contain two cysteines-rich repeats with the consensus C-X-C-X(4)-C-X(3)-Y-C-X-C-X(6)-C-X(3)-C-X-C-X(2)-C separated by a region of variable length containing the short conserved sequence R-N-P-X-A-F-X-P-K:
- Animal tesmin or MTL5, originally identified by its specific expression in testes, but subsequently it was also detected at specific stages of ovary development.
- Animal tesmin-like (tesl) or LIN54.
- Drosophila melanogaster tombola (tomb), a meiotic arrest protein which is expressed specifically in testis.
- Arabidopsis thaliana TSO1, 'tso' means 'ugly' in Chinese and refers to the appearance of tso1 mutant flowers.
- Arabidopsis thaliana TSO1-like 1 and 2 (SOL1 and SOL2).
- Legume Cysteine-rich Polycomb-like Protein 1 (CPP1), a DNA-binding protein acting as a negative regulator of the leghemoglobin gene.
This domain has been named the CRC domain (C1-RNPXAFXPK-C2). It binds zinc and is able to bind DNA [1,2,3,4,5].
The CRC domain shows some similarity to the CXC domain found in the E(z)-type of Polycomb group proteins (see <PDOC51633>) [6]. However, a clear distinction can be made since the CXC domain lacks the RNPXAFXPK motif.
The profile we developed covers the entire CRC domain.
Last update:January 2012 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Song J.-Y. Leung T. Ehler L.K. Wang C. Liu Z. |
| Title | Regulation of meristem organization and cell division by TSO1, an Arabidopsis gene with cysteine-rich repeats. | |
| Source | Development 127:2207-2217(2000). | |
| PubMed ID | 10769244 |
| 2 | Authors | Hauser B.A. He J.Q. Park S.O. Gasser C.S. |
| Title | TSO1 is a novel protein that modulates cytokinesis and cell expansion in Arabidopsis. | |
| Source | Development 127:2219-2226(2000). | |
| PubMed ID | 10769245 |
| 3 | Authors | Cvitanich C. Pallisgaard N. Nielsen K.A. Hansen A.C. Larsen K. Pihakaski-Maunsbach K. Marcker K.A. Jensen E.O. |
| Title | CPP1, a DNA-binding protein involved in the expression of a soybean leghemoglobin c3 gene. | |
| Source | Proc. Natl. Acad. Sci. U.S.A. 97:8163-8168(2000). | |
| PubMed ID | 10859345 | |
| DOI | 10.1073/pnas.090468497 |
| 4 | Authors | Andersen S.U. Algreen-Petersen R.G. Hoedl M. Jurkiewicz A. Cvitanich C. Braunschweig U. Schauser L. Oh S.-A. Twell D. Jensen E.O. |
| Title | The conserved cysteine-rich domain of a tesmin/TSO1-like protein binds zinc in vitro and TSO1 is required for both male and female fertility in Arabidopsis thaliana. | |
| Source | J. Exp. Bot. 58:3657-3670(2007). | |
| PubMed ID | 18057042 | |
| DOI | 10.1093/jxb/erm215 |
| 5 | Authors | Jiang J. Benson E. Bausek N. Doggett K. White-Cooper H. |
| Title | Tombola, a tesmin/TSO1-family protein, regulates transcriptional activation in the Drosophila male germline and physically interacts with always early. | |
| Source | Development 134:1549-1559(2007). | |
| PubMed ID | 17360778 | |
| DOI | 10.1242/dev.000521 |
| 6 | Authors | Ogawa M. Hiraoka Y. Taniguchi K. Aiso S. |
| Title | Cloning and expression of a human/mouse Polycomb group gene, ENX-2/Enx-2. | |
| Source | Biochim. Biophys. Acta 1395:151-158(1998). | |
| PubMed ID | 9473645 |
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