PROSITE documentation PDOC51634
CRC domain profile


The following proteins of the tesmin/TSO1 family contain two cysteines-rich repeats with the consensus C-X-C-X(4)-C-X(3)-Y-C-X-C-X(6)-C-X(3)-C-X-C-X(2)-C separated by a region of variable length containing the short conserved sequence R-N-P-X-A-F-X-P-K:

  • Animal tesmin or MTL5, originally identified by its specific expression in testes, but subsequently it was also detected at specific stages of ovary development.
  • Animal tesmin-like (tesl) or LIN54.
  • Drosophila melanogaster tombola (tomb), a meiotic arrest protein which is expressed specifically in testis.
  • Arabidopsis thaliana TSO1, 'tso' means 'ugly' in Chinese and refers to the appearance of tso1 mutant flowers.
  • Arabidopsis thaliana TSO1-like 1 and 2 (SOL1 and SOL2).
  • Legume Cysteine-rich Polycomb-like Protein 1 (CPP1), a DNA-binding protein acting as a negative regulator of the leghemoglobin gene.

This domain has been named the CRC domain (C1-RNPXAFXPK-C2). It binds zinc and is able to bind DNA [1,2,3,4,5].

The CRC domain shows some similarity to the CXC domain found in the E(z)-type of Polycomb group proteins (see <PDOC51633>) [6]. However, a clear distinction can be made since the CXC domain lacks the RNPXAFXPK motif.

The profile we developed covers the entire CRC domain.

Last update:

January 2012 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

CRC, PS51634; CRC domain profile  (MATRIX)


1AuthorsSong J.-Y. Leung T. Ehler L.K. Wang C. Liu Z.
TitleRegulation of meristem organization and cell division by TSO1, an Arabidopsis gene with cysteine-rich repeats.
SourceDevelopment 127:2207-2217(2000).
PubMed ID10769244

2AuthorsHauser B.A. He J.Q. Park S.O. Gasser C.S.
TitleTSO1 is a novel protein that modulates cytokinesis and cell expansion in Arabidopsis.
SourceDevelopment 127:2219-2226(2000).
PubMed ID10769245

3AuthorsCvitanich C. Pallisgaard N. Nielsen K.A. Hansen A.C. Larsen K. Pihakaski-Maunsbach K. Marcker K.A. Jensen E.O.
TitleCPP1, a DNA-binding protein involved in the expression of a soybean leghemoglobin c3 gene.
SourceProc. Natl. Acad. Sci. U.S.A. 97:8163-8168(2000).
PubMed ID10859345

4AuthorsAndersen S.U. Algreen-Petersen R.G. Hoedl M. Jurkiewicz A. Cvitanich C. Braunschweig U. Schauser L. Oh S.-A. Twell D. Jensen E.O.
TitleThe conserved cysteine-rich domain of a tesmin/TSO1-like protein binds zinc in vitro and TSO1 is required for both male and female fertility in Arabidopsis thaliana.
SourceJ. Exp. Bot. 58:3657-3670(2007).
PubMed ID18057042

5AuthorsJiang J. Benson E. Bausek N. Doggett K. White-Cooper H.
TitleTombola, a tesmin/TSO1-family protein, regulates transcriptional activation in the Drosophila male germline and physically interacts with always early.
SourceDevelopment 134:1549-1559(2007).
PubMed ID17360778

6AuthorsOgawa M. Hiraoka Y. Taniguchi K. Aiso S.
TitleCloning and expression of a human/mouse Polycomb group gene, ENX-2/Enx-2.
SourceBiochim. Biophys. Acta 1395:151-158(1998).
PubMed ID9473645

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