PROSITE documentation PDOC51649
NPH3 domain profile


The NRL (for NPH3/RPT2-Like) family is formed by signaling molecules specific to higher plant. Several regions of sequence and predicted structural conservation define members of the NRL family, with three domains being most notable: an N-terminal BTB domain (see <PDOC50097>), a centrally located NPH3 domain, and a C-terminal coiled coil domain. The function of the NPH3 domain is not yet known [1,2,3,4,5,6,7,8].

Some proteins known to contain a NPH3 domain are listed below:

  • Arabidopsis non-phototropic hypocotyl 3 (NPH3), may function as an adapter or scaffold protein in plants.
  • Arabidopsis root-phototropisme 2 (RPT2), a signal transducer involved in phototropic response and stomatal opening in association with phototropin 1 (phot1).
  • Oriza coleoptile phototropism 1 (CPT1), the rice ortholog of NPH3. It is required for phototropism of coleoptiles and lateral translocation of auxin.

The profile we developed covers the entire NPH3 domain.

Last update:

July 2012 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

NPH3, PS51649; NPH3 domain profile  (MATRIX)


1AuthorsMotchoulski A. Liscum E.
TitleArabidopsis NPH3: A NPH1 photoreceptor-interacting protein essential for phototropism.
SourceScience 286:961-964(1999).
PubMed ID10542152

2AuthorsSakai T. Wada T. Ishiguro S. Okada K.
TitleRPT2. A signal transducer of the phototropic response in Arabidopsis.
SourcePlant Cell 12:225-236(2000).
PubMed ID10662859

3AuthorsInada S. Ohgishi M. Mayama T. Okada K. Sakai T.
TitleRPT2 is a signal transducer involved in phototropic response and stomatal opening by association with phototropin 1 in Arabidopsis thaliana.
SourcePlant Cell 16:887-896(2004).
PubMed ID15031408

4AuthorsHaga K. Takano M. Neumann R. Iino M.
TitleThe Rice COLEOPTILE PHOTOTROPISM1 gene encoding an ortholog of Arabidopsis NPH3 is required for phototropism of coleoptiles and lateral translocation of auxin.
SourcePlant Cell 17:103-115(2005).
PubMed ID15598797

5AuthorsPedmale U.V. Liscum E.
TitleRegulation of phototropic signaling in Arabidopsis via phosphorylation state changes in the phototropin 1-interacting protein NPH3.
SourceJ. Biol. Chem. 282:19992-20001(2007).
PubMed ID17493935

6AuthorsInoue S. Kinoshita T. Takemiya A. Doi M. Shimazaki K.
TitleLeaf positioning of Arabidopsis in response to blue light.
SourceMol. Plant 1:15-26(2008).
PubMed ID20031912

7AuthorsHolland J.J. Roberts D. Liscum E.
TitleUnderstanding phototropism: from Darwin to today.
SourceJ. Exp. Bot. 60:1969-1978(2009).
PubMed ID19357428

8AuthorsRoberts D. Pedmale U.V. Morrow J. Sachdev S. Lechner E. Tang X. Zheng N. Hannink M. Genschik P. Liscum E.
TitleModulation of phototropic responsiveness in Arabidopsis through ubiquitination of phototropin 1 by the CUL3-Ring E3 ubiquitin ligase CRL3(NPH3).
SourcePlant Cell 23:3627-3640(2011).
PubMed ID21990941

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