PROSITE documentation PDOC51649NPH3 domain profile
Description
The NRL (for NPH3/RPT2-Like) family is formed by signaling molecules specific to higher plant. Several regions of sequence and predicted structural conservation define members of the NRL family, with three domains being most notable: an N-terminal BTB domain (see <PDOC50097>), a centrally located NPH3 domain, and a C-terminal coiled coil domain. The function of the NPH3 domain is not yet known [1,2,3,4,5,6,7,8].
Some proteins known to contain a NPH3 domain are listed below:
- Arabidopsis non-phototropic hypocotyl 3 (NPH3), may function as an adapter or scaffold protein in plants.
- Arabidopsis root-phototropisme 2 (RPT2), a signal transducer involved in phototropic response and stomatal opening in association with phototropin 1 (phot1).
- Oriza coleoptile phototropism 1 (CPT1), the rice ortholog of NPH3. It is required for phototropism of coleoptiles and lateral translocation of auxin.
The profile we developed covers the entire NPH3 domain.
Last update:July 2012 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Motchoulski A. Liscum E. |
| Title | Arabidopsis NPH3: A NPH1 photoreceptor-interacting protein essential for phototropism. | |
| Source | Science 286:961-964(1999). | |
| PubMed ID | 10542152 |
| 2 | Authors | Sakai T. Wada T. Ishiguro S. Okada K. |
| Title | RPT2. A signal transducer of the phototropic response in Arabidopsis. | |
| Source | Plant Cell 12:225-236(2000). | |
| PubMed ID | 10662859 |
| 3 | Authors | Inada S. Ohgishi M. Mayama T. Okada K. Sakai T. |
| Title | RPT2 is a signal transducer involved in phototropic response and stomatal opening by association with phototropin 1 in Arabidopsis thaliana. | |
| Source | Plant Cell 16:887-896(2004). | |
| PubMed ID | 15031408 | |
| DOI | 10.1105/tpc.019901 |
| 4 | Authors | Haga K. Takano M. Neumann R. Iino M. |
| Title | The Rice COLEOPTILE PHOTOTROPISM1 gene encoding an ortholog of Arabidopsis NPH3 is required for phototropism of coleoptiles and lateral translocation of auxin. | |
| Source | Plant Cell 17:103-115(2005). | |
| PubMed ID | 15598797 | |
| DOI | 10.1105/tpc.104.028357 |
| 5 | Authors | Pedmale U.V. Liscum E. |
| Title | Regulation of phototropic signaling in Arabidopsis via phosphorylation state changes in the phototropin 1-interacting protein NPH3. | |
| Source | J. Biol. Chem. 282:19992-20001(2007). | |
| PubMed ID | 17493935 | |
| DOI | 10.1074/jbc.M702551200 |
| 6 | Authors | Inoue S. Kinoshita T. Takemiya A. Doi M. Shimazaki K. |
| Title | Leaf positioning of Arabidopsis in response to blue light. | |
| Source | Mol. Plant 1:15-26(2008). | |
| PubMed ID | 20031912 | |
| DOI | 10.1093/mp/ssm001 |
| 7 | Authors | Holland J.J. Roberts D. Liscum E. |
| Title | Understanding phototropism: from Darwin to today. | |
| Source | J. Exp. Bot. 60:1969-1978(2009). | |
| PubMed ID | 19357428 | |
| DOI | 10.1093/jxb/erp113 |
| 8 | Authors | Roberts D. Pedmale U.V. Morrow J. Sachdev S. Lechner E. Tang X. Zheng N. Hannink M. Genschik P. Liscum E. |
| Title | Modulation of phototropic responsiveness in Arabidopsis through ubiquitination of phototropin 1 by the CUL3-Ring E3 ubiquitin ligase CRL3(NPH3). | |
| Source | Plant Cell 23:3627-3640(2011). | |
| PubMed ID | 21990941 | |
| DOI | 10.1105/tpc.111.087999 |
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