The NRL (for NPH3/RPT2-Like) family is formed by signaling molecules specific
to higher plant. Several regions of sequence and predicted structural
conservation define members of the NRL family, with three domains being most
notable: an N-terminal BTB domain (see <PDOC50097>), a centrally located NPH3
domain, and a C-terminal coiled coil domain. The function of the NPH3 domain
is not yet known [1,2,3,4,5,6,7,8].
Some proteins known to contain a NPH3 domain are listed below:
Arabidopsis non-phototropic hypocotyl 3 (NPH3), may function as an adapter
or scaffold protein in plants.
Arabidopsis root-phototropisme 2 (RPT2), a signal transducer involved in
phototropic response and stomatal opening in association with phototropin 1
Oriza coleoptile phototropism 1 (CPT1), the rice ortholog of NPH3. It is
required for phototropism of coleoptiles and lateral translocation of
The profile we developed covers the entire NPH3 domain.
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