We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC51649NPH3 domain profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC51649
Description
The NRL (for NPH3/RPT2-Like) family is formed by signaling molecules specific to higher plant. Several regions of sequence and predicted structural conservation define members of the NRL family, with three domains being most notable: an N-terminal BTB domain (see <PDOC50097>), a centrally located NPH3 domain, and a C-terminal coiled coil domain. The function of the NPH3 domain is not yet known [1,2,3,4,5,6,7,8].
Some proteins known to contain a NPH3 domain are listed below:
- Arabidopsis non-phototropic hypocotyl 3 (NPH3), may function as an adapter or scaffold protein in plants.
- Arabidopsis root-phototropisme 2 (RPT2), a signal transducer involved in phototropic response and stomatal opening in association with phototropin 1 (phot1).
- Oriza coleoptile phototropism 1 (CPT1), the rice ortholog of NPH3. It is required for phototropism of coleoptiles and lateral translocation of auxin.
The profile we developed covers the entire NPH3 domain.
Last update:July 2012 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Motchoulski A. Liscum E. |
| Title | Arabidopsis NPH3: A NPH1 photoreceptor-interacting protein essential for phototropism. | |
| Source | Science 286:961-964(1999). | |
| PubMed ID | 10542152 |
| 2 | Authors | Sakai T. Wada T. Ishiguro S. Okada K. |
| Title | RPT2. A signal transducer of the phototropic response in Arabidopsis. | |
| Source | Plant Cell 12:225-236(2000). | |
| PubMed ID | 10662859 |
| 3 | Authors | Inada S. Ohgishi M. Mayama T. Okada K. Sakai T. |
| Title | RPT2 is a signal transducer involved in phototropic response and stomatal opening by association with phototropin 1 in Arabidopsis thaliana. | |
| Source | Plant Cell 16:887-896(2004). | |
| PubMed ID | 15031408 | |
| DOI | 10.1105/tpc.019901 |
| 4 | Authors | Haga K. Takano M. Neumann R. Iino M. |
| Title | The Rice COLEOPTILE PHOTOTROPISM1 gene encoding an ortholog of Arabidopsis NPH3 is required for phototropism of coleoptiles and lateral translocation of auxin. | |
| Source | Plant Cell 17:103-115(2005). | |
| PubMed ID | 15598797 | |
| DOI | 10.1105/tpc.104.028357 |
| 5 | Authors | Pedmale U.V. Liscum E. |
| Title | Regulation of phototropic signaling in Arabidopsis via phosphorylation state changes in the phototropin 1-interacting protein NPH3. | |
| Source | J. Biol. Chem. 282:19992-20001(2007). | |
| PubMed ID | 17493935 | |
| DOI | 10.1074/jbc.M702551200 |
| 6 | Authors | Inoue S. Kinoshita T. Takemiya A. Doi M. Shimazaki K. |
| Title | Leaf positioning of Arabidopsis in response to blue light. | |
| Source | Mol. Plant 1:15-26(2008). | |
| PubMed ID | 20031912 | |
| DOI | 10.1093/mp/ssm001 |
| 7 | Authors | Holland J.J. Roberts D. Liscum E. |
| Title | Understanding phototropism: from Darwin to today. | |
| Source | J. Exp. Bot. 60:1969-1978(2009). | |
| PubMed ID | 19357428 | |
| DOI | 10.1093/jxb/erp113 |
| 8 | Authors | Roberts D. Pedmale U.V. Morrow J. Sachdev S. Lechner E. Tang X. Zheng N. Hannink M. Genschik P. Liscum E. |
| Title | Modulation of phototropic responsiveness in Arabidopsis through ubiquitination of phototropin 1 by the CUL3-Ring E3 ubiquitin ligase CRL3(NPH3). | |
| Source | Plant Cell 23:3627-3640(2011). | |
| PubMed ID | 21990941 | |
| DOI | 10.1105/tpc.111.087999 |
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