PROSITE documentation PDOC51673
SUZ domain profile


The SUZ domain is found in a wide range of eukaryotes including animals, fungi, Dictyostelium, plants, and the apicomplexan Plasmodium falciparum. The SUZ domain shows a strong association with known RNA-binding domains: it is fused with R3H (see <PDOC51061>) and RRM domains and RGG repeats in previously characterized multidomain RNA-binding proteins:

  • Caenorhabditis elegans SZY-20, a putative RNA-binding protein that plays a critical role in limiting centrosome size.
  • Drosophila Encore protein, required for the regulation of germline mitosis, karyosome formation, and establishment of dorsoventral (DS) polarity of the egg and embryo.
  • Maize Dip1 protein.
  • Mammalian R3H domain-containing protein 1 (R3HDM1).

Based on the "syntax" of the domain architecture, the SUZ domain has been predicted to function in connection to RNA-protein complexes. The SUZ domain enrichment in positively charged residues, including four universally conserved positively charged positions, supports a role in direct RNA-binding [1].

The profile we developed covers the entire SUZ domain.

Last update:

April 2013 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

SUZ, PS51673; SUZ domain profile  (MATRIX)


1AuthorsSong M.H. Aravind L. Mueller-Reichert T. O'Connell K.F.
TitleThe conserved protein SZY-20 opposes the Plk4-related kinase ZYG-1 to limit centrosome size.
SourceDev. Cell 15:901-912(2008).
PubMed ID19081077

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