PROSITE documentation PDOC51673SUZ domain profile
The SUZ domain is found in a wide range of eukaryotes including animals, fungi, Dictyostelium, plants, and the apicomplexan Plasmodium falciparum. The SUZ domain shows a strong association with known RNA-binding domains: it is fused with R3H (see <PDOC51061>) and RRM domains and RGG repeats in previously characterized multidomain RNA-binding proteins:
- Caenorhabditis elegans SZY-20, a putative RNA-binding protein that plays a critical role in limiting centrosome size.
- Drosophila Encore protein, required for the regulation of germline mitosis, karyosome formation, and establishment of dorsoventral (DS) polarity of the egg and embryo.
- Maize Dip1 protein.
- Mammalian R3H domain-containing protein 1 (R3HDM1).
Based on the "syntax" of the domain architecture, the SUZ domain has been predicted to function in connection to RNA-protein complexes. The SUZ domain enrichment in positively charged residues, including four universally conserved positively charged positions, supports a role in direct RNA-binding [1].
The profile we developed covers the entire SUZ domain.
Last update:April 2013 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Song M.H. Aravind L. Mueller-Reichert T. O'Connell K.F. |
| Title | The conserved protein SZY-20 opposes the Plk4-related kinase ZYG-1 to limit centrosome size. | |
| Source | Dev. Cell 15:901-912(2008). | |
| PubMed ID | 19081077 | |
| DOI | 10.1016/j.devcel.2008.09.018 |
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