PROSITE documentation PDOC51708CHAD domain profile
The CHAD (conserved histidine α-helical domain) is an uncharacterized domain, with a characteristic pattern of conserved histidines and other charged residues. It is predicted to adopt an α-helical fold. The sequence conservation pattern suggests that this domain is likely to contain two repeat units, with at least 4 helices each, at its core. The conserved charged residues could form a strongly polar surface that could participate, either in metal chelation, or act as phosphoacceptors [1].
Some proteins known to contain a CHAD domain are listed below:
- Escherichia coli uncharacterized protein YgiF.
- Mycobacterium tuberculosis uncharacterized protein Rv2226/MT2285.
The profile we developed covers the entire CHAD domain.
Last update:February 2014 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Iyer L.M. Aravind L. |
| Title | The catalytic domains of thiamine triphosphatase and CyaB-like adenylyl cyclase define a novel superfamily of domains that bind organic phosphates. | |
| Source | BMC Genomics 3:33-33(2002). | |
| PubMed ID | 12456267 |
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