PROSITE documentation PDOC51708
CHAD domain profile


The CHAD (conserved histidine α-helical domain) is an uncharacterized domain, with a characteristic pattern of conserved histidines and other charged residues. It is predicted to adopt an α-helical fold. The sequence conservation pattern suggests that this domain is likely to contain two repeat units, with at least 4 helices each, at its core. The conserved charged residues could form a strongly polar surface that could participate, either in metal chelation, or act as phosphoacceptors [1].

Some proteins known to contain a CHAD domain are listed below:

  • Escherichia coli uncharacterized protein YgiF.
  • Mycobacterium tuberculosis uncharacterized protein Rv2226/MT2285.

The profile we developed covers the entire CHAD domain.

Last update:

February 2014 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

CHAD, PS51708; CHAD domain profile  (MATRIX)


1AuthorsIyer L.M. Aravind L.
TitleThe catalytic domains of thiamine triphosphatase and CyaB-like adenylyl cyclase define a novel superfamily of domains that bind organic phosphates.
SourceBMC Genomics 3:33-33(2002).
PubMed ID12456267

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