We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC51742PPC domain profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC51742
Description
The Plants and Prokaryotes Conserved (PPC) domain contains a hydrophobic region in the C terminal, and in the case of plants, is often found in several proteins with the AT-hook motif. Proteins with PPC domains are found in Bacteria, Archaea and the plant kingdom [1,2].
The PPC domain has a single α-helix packed against an antiparallel β-sheet, which is formed by five β-strands (see <PDB:2DT4>) [2]:
Some proteins known to contain a PPC domain are listed below:
- Plant AT-hook motif nuclear localized protein 1 (AHL1), a matrix-attachment region (MAR) binding protein involved in positioning chromatin fibers in the nucleus by an AT-hook motif and PPC.
- Pyrococcus horikoshii putative uncharacterized protein PH0802.
- Cyanobacteria bifunctional protein GlmU.
The profile we developed covers the entire PPC domain.
Last update:December 2014 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Fujimoto S. Matsunaga S. Yonemura M. Uchiyama S. Azuma T. Fukui K. |
| Title | Identification of a novel plant MAR DNA binding protein localized on chromosomal surfaces. | |
| Source | Plant Mol. Biol. 56:225-239(2004). | |
| PubMed ID | 15604740 | |
| DOI | 10.1007/s11103-004-3249-5 |
| 2 | Authors | Lin L. Nakano H. Nakamura S. Uchiyama S. Fujimoto S. Matsunaga S. Kobayashi Y. Ohkubo T. Fukui K. |
| Title | Crystal structure of Pyrococcus horikoshii PPC protein at 1.60 A resolution. | |
| Source | Proteins 67:505-507(2007). | |
| PubMed ID | 17295322 | |
| DOI | 10.1002/prot.21270 |
Copyright
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