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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE documentation PDOC51751
EXPERA domain profile


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PURL: https://purl.expasy.org/prosite/documentation/PDOC51751

Description

The EXPERA (EXPanded EBP superfamilly) domain is conserved among the following protein families:

  • Vertebrate TM6SF1 (Transmembrane 6 Superfamily Member 1).
  • Vertebrate TM6SF2 (Transmembrane 6 Superfamily Member 2).
  • Eukaryotic MAC30 (Meningioma-associated protein 30) also known as TMEM97 (Transmembrane protein 97), mainly localized in the endoplasmic reticulum (ER).
  • Eukaryotic EBP (Emopamil binding protein), an enzyme with a D8, D7 sterol isomerase activity that catalyzes the transposition of a double bond from C8=C9 to C7=C8 in the sterol B-ring.

The EXPERA domain contains four transmembrane regions and is likely to possess a sterol isomerase catalytic activity [1].

The profile we developed covers the entire EXPERA domain.

Last update:

March 2015 / First entry.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

EXPERA, PS51751; EXPERA domain profile  (MATRIX)


Reference

1AuthorsSanchez-Pulido L. Ponting C.P.
TitleTM6SF2 and MAC30, new enzyme homologs in sterol metabolism and common metabolic disease.
SourceFront. Genet. 5:439-439(2014).
PubMed ID25566323
DOI10.3389/fgene.2014.00439



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