PROSITE documentation PDOC51756
LXG domain profile


The bacterial LXG domain contains a conserved [LF]-X-G sequence motif and is predicted to assume an α-helical bundle fold. The LXG is predicted to be a secretion signal for the type VII secretion system of Mycobacterium and Bacillus species. It is likely to utilize the ATP-dependent YueA pumps and the potential peptide-binding EsaC domain as partners for extrusion from the producing cell [1,2].

The profile we developed covers the entire LXG domain.

Last update:

May 2015 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

LXG, PS51756; LXG domain profile  (MATRIX)


1AuthorsZhang D. Iyer L.M. Aravind L.
TitleA novel immunity system for bacterial nucleic acid degrading toxins and its recruitment in various eukaryotic and DNA viral systems.
SourceNucleic Acids Res. 39:4532-4552(2011).
PubMed ID21306995

2AuthorsHolberger L.E. Garza-Sanchez F. Lamoureux J. Low D.A. Hayes C.S.
TitleA novel family of toxin/antitoxin proteins in Bacillus species.
SourceFEBS Lett. 586:132-136(2012).
PubMed ID22200572

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