We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC51756LXG domain profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC51756
Description
The bacterial LXG domain contains a conserved [LF]-X-G sequence motif and is predicted to assume an α-helical bundle fold. The LXG is predicted to be a secretion signal for the type VII secretion system of Mycobacterium and Bacillus species. It is likely to utilize the ATP-dependent YueA pumps and the potential peptide-binding EsaC domain as partners for extrusion from the producing cell [1,2].
The profile we developed covers the entire LXG domain.
Last update:May 2015 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Zhang D. Iyer L.M. Aravind L. |
| Title | A novel immunity system for bacterial nucleic acid degrading toxins and its recruitment in various eukaryotic and DNA viral systems. | |
| Source | Nucleic Acids Res. 39:4532-4552(2011). | |
| PubMed ID | 21306995 | |
| DOI | 10.1093/nar/gkr036 |
| 2 | Authors | Holberger L.E. Garza-Sanchez F. Lamoureux J. Low D.A. Hayes C.S. |
| Title | A novel family of toxin/antitoxin proteins in Bacillus species. | |
| Source | FEBS Lett. 586:132-136(2012). | |
| PubMed ID | 22200572 | |
| DOI | 10.1016/j.febslet.2011.12.020 |
Copyright
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.