PROSITE documentation PDOC51756LXG domain profile
Description
The bacterial LXG domain contains a conserved [LF]-X-G sequence motif and is predicted to assume an α-helical bundle fold. The LXG is predicted to be a secretion signal for the type VII secretion system of Mycobacterium and Bacillus species. It is likely to utilize the ATP-dependent YueA pumps and the potential peptide-binding EsaC domain as partners for extrusion from the producing cell [1,2].
The profile we developed covers the entire LXG domain.
Last update:May 2015 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Zhang D. Iyer L.M. Aravind L. |
| Title | A novel immunity system for bacterial nucleic acid degrading toxins and its recruitment in various eukaryotic and DNA viral systems. | |
| Source | Nucleic Acids Res. 39:4532-4552(2011). | |
| PubMed ID | 21306995 | |
| DOI | 10.1093/nar/gkr036 |
| 2 | Authors | Holberger L.E. Garza-Sanchez F. Lamoureux J. Low D.A. Hayes C.S. |
| Title | A novel family of toxin/antitoxin proteins in Bacillus species. | |
| Source | FEBS Lett. 586:132-136(2012). | |
| PubMed ID | 22200572 | |
| DOI | 10.1016/j.febslet.2011.12.020 |
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