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PROSITE documentation PDOC51758 |
Mitochondrial ribosomes synthesize core subunits of the inner membrane respiratory chain complexes. In mitochondria, ribosomes are mainly membrane associated and translation is tightly coupled to the inner mitochondrial membrane. Mdm38/Letm1 is a conserved membrane receptor for mitochondrial ribosomes and specifically involved in respiratory chain biogenesis.
The Letm1 ribosome-binding domain (RBD) is necessary and sufficient for interaction with mitochondrial ribosomes. It exhibits a predominantly α-helical compact fold (see <PDB:3SKQ>) and contains extended, highly charged surface patches. The conserved regions most probably represent interaction sites for ribosomal RNA or protein subunits, or for proteins involved in mitochondrial protein biogenesis [1,2].
The profile we developed covers the entire Letm1 RBD domain.
Last update:May 2015 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Lupo D. Vollmer C. Deckers M. Mick D.U. Tews I. Sinning I. Rehling P. |
Title | Mdm38 is a 14-3-3-like receptor and associates with the protein synthesis machinery at the inner mitochondrial membrane. | |
Source | Traffic 12:1457-1466(2011). | |
PubMed ID | 21718401 | |
DOI | 10.1111/j.1600-0854.2011.01239.x |
2 | Authors | Bauerschmitt H. Mick D.U. Deckers M. Vollmer C. Funes S. Kehrein K. Ott M. Rehling P. Herrmann J.M. |
Title | Ribosome-binding proteins Mdm38 and Mba1 display overlapping functions for regulation of mitochondrial translation. | |
Source | Mol. Biol. Cell 21:1937-1944(2010). | |
PubMed ID | 20427570 | |
DOI | 10.1091/mbc.E10-02-0101 |