PROSITE documentation PDOC51799Zinc finger C2H2 AKAP95-type profile
A-kinase (or PKA)-anchoring protein AKAP95 is a member of the AKAP-family that binds to regulatory subunits of protein kinase A (PKA) and localizes PKA to various distinct locations and structures within cells. AKAP95 is a zinc-finger protein implicated in mitotic chromosome condensation by acting as a targeting molecule for the condensin complex. In addition to anchoring the regulatory subunit (RII) of cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA), AKAP95 binds chromatin at mitosis. It harbours two zinc fingers, designated ZF1 and ZF2. ZF1 mediates the binding of AKAP95 to DNA. ZF2 is dispensable for chromatin binding; however it may substitute for ZF1 when the latter is rendered non-functional by mutation [1,2,3].
The profile we developed covers the entire C2H2 AKAP95-type zinc finger.
Last update:May 2016 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Seki N. Ueki N. Yano K. Saito T. Masuho Y. Muramatsu M. |
| Title | cDNA cloning of a novel human gene NAKAP95, neighbor of A-kinase anchoring protein 95 (AKAP95) on chromosome 19p13.11-p13.12 region. | |
| Source | J. Hum. Genet. 45:31-37(2000). | |
| PubMed ID | 10697960 | |
| DOI | 10.1007/s100380070040 |
| 2 | Authors | Eide T. Carlson C. Tasken K.A. Hirano T. Tasken K. Collas P. |
| Title | Distinct but overlapping domains of AKAP95 are implicated in chromosome condensation and condensin targeting. | |
| Source | EMBO Rep. 3:426-432(2002). | |
| PubMed ID | 11964380 | |
| DOI | 10.1093/embo-reports/kvf089 |
| 3 | Authors | Marstad A. Landsverk O.J. Stromme O. Otterlei M. Collas P. Sundan A. Brede G. |
| Title | A-kinase anchoring protein AKAP95 is a novel regulator of ribosomal RNA synthesis. | |
| Source | FEBS J. 283:757-770(2016). | |
| PubMed ID | 26683827 | |
| DOI | 10.1111/febs.13630 |
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