PROSITE documentation PDOC51804Zinc finger C2HC LYAR-type profile
Zinc finger (ZF) proteins are a large family of metalloproteins that utilize zinc for structural purposes. Zinc coordinates to a combination of cysteine thiol and histidine imidazole residues within the ZF polypetide sequence resulting in a folded and functional protein. Ly-1 antibody reactive clone (Lyar), which is known to be expressed abundantly in the testis, encodes a nucleolar protein that contain a LYAR-type C2HC zinc finger motif and three nuclear localization signals. It is a nucleolar protein abundantly expressed in spermatocytes and spermatids, but not sperm. LYAR forms a complex with the nucleolin, which is one of the most abundant proteins in the nucleolus [1,2,3].
The profile we developed covers the entire LYAR-type C2HC zinc finger.
Last update:June 2016 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Su L. Hershberger R.J. Weissman I.L. |
| Title | LYAR, a novel nucleolar protein with zinc finger DNA-binding motifs, is involved in cell growth regulation. | |
| Source | Genes Dev. 7:735-748(1993). | |
| PubMed ID | 8491376 |
| 2 | Authors | Lee B. Jin S. Choi H. Kwon J.T. Kim J. Jeong J. Kwon Y.-I. Cho C. |
| Title | Expression and function of the testis-predominant protein LYAR in mice. | |
| Source | Mol. Cells 35:54-60(2013). | |
| PubMed ID | 23212345 | |
| DOI | 10.1007/s10059-013-2271-3 |
| 3 | Authors | Yonezawa K. Sugihara Y. Oshima K. Matsuda T. Nadano D. |
| Title | Lyar, a cell growth-regulating zinc finger protein, was identified to be associated with cytoplasmic ribosomes in male germ and cancer cells. | |
| Source | Mol. Cell. Biochem. 395:221-229(2014). | |
| PubMed ID | 24990247 | |
| DOI | 10.1007/s11010-014-2128-x |
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