PROSITE documentation PDOC51804
Zinc finger C2HC LYAR-type profile


Zinc finger (ZF) proteins are a large family of metalloproteins that utilize zinc for structural purposes. Zinc coordinates to a combination of cysteine thiol and histidine imidazole residues within the ZF polypetide sequence resulting in a folded and functional protein. Ly-1 antibody reactive clone (Lyar), which is known to be expressed abundantly in the testis, encodes a nucleolar protein that contain a LYAR-type C2HC zinc finger motif and three nuclear localization signals. It is a nucleolar protein abundantly expressed in spermatocytes and spermatids, but not sperm. LYAR forms a complex with the nucleolin, which is one of the most abundant proteins in the nucleolus [1,2,3].

The profile we developed covers the entire LYAR-type C2HC zinc finger.

Last update:

June 2016 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

ZF_C2HC_LYAR, PS51804; Zinc finger C2HC LYAR-type profile  (MATRIX)


1AuthorsSu L. Hershberger R.J. Weissman I.L.
TitleLYAR, a novel nucleolar protein with zinc finger DNA-binding motifs, is involved in cell growth regulation.
SourceGenes Dev. 7:735-748(1993).
PubMed ID8491376

2AuthorsLee B. Jin S. Choi H. Kwon J.T. Kim J. Jeong J. Kwon Y.-I. Cho C.
TitleExpression and function of the testis-predominant protein LYAR in mice.
SourceMol. Cells 35:54-60(2013).
PubMed ID23212345

3AuthorsYonezawa K. Sugihara Y. Oshima K. Matsuda T. Nadano D.
TitleLyar, a cell growth-regulating zinc finger protein, was identified to be associated with cytoplasmic ribosomes in male germ and cancer cells.
SourceMol. Cell. Biochem. 395:221-229(2014).
PubMed ID24990247

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