We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC51830FIIND domain profile
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PURL: https://purl.expasy.org/prosite/documentation/PDOC51830
Description
The "Function to Find Domain" (FIIND)-containing proteins CARD8 (Cardinal; Tucan) and NLRP1 (NALP1; NAC) are well known components of inflammasomes, multiprotein complexes responsible for activation of caspase-1, a regulator of inflammation and innate immunity. CARD8 and NLRP1 undergo autoproteolytic cleavage at a conserved SF/S motif within the FIIND. The FIIND domain is only present in chordates and consists of a ZU5-like domain (see <PDOC51145>) and a UPA-like domain [1,2,3].
The profile we developed covers the entire FIIND domain.
Last update:March 2017 / First entry.
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Technical section
PROSITE method (with tools and information) covered by this documentation:
References
| 1 | Authors | Tschopp J. Martinon F. Burns K. |
| Title | NALPs: a novel protein family involved in inflammation. | |
| Source | Nat. Rev. Mol. Cell Biol. 4:95-104(2003). | |
| PubMed ID | 12563287 | |
| DOI | 10.1038/nrm1019 |
| 2 | Authors | D'Osualdo A. Weichenberger C.X. Wagner R.N. Godzik A. Wooley J. Reed J.C. |
| Title | CARD8 and NLRP1 undergo autoproteolytic processing through a ZU5-like domain. | |
| Source | PLoS ONE 6:E27396-E27396(2011). | |
| PubMed ID | 22087307 | |
| DOI | 10.1371/journal.pone.0027396 |
| 3 | Authors | Liao Y. Pei J. Cheng H. Grishin N.V. |
| Title | An ancient autoproteolytic domain found in GAIN, ZU5 and Nucleoporin98. | |
| Source | J. Mol. Biol. 426:3935-3945(2014). | |
| PubMed ID | 25451782 | |
| DOI | 10.1016/j.jmb.2014.10.011 |
Copyright
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.