PROSITE documentation PDOC51830
FIIND domain profile


The "Function to Find Domain" (FIIND)-containing proteins CARD8 (Cardinal; Tucan) and NLRP1 (NALP1; NAC) are well known components of inflammasomes, multiprotein complexes responsible for activation of caspase-1, a regulator of inflammation and innate immunity. CARD8 and NLRP1 undergo autoproteolytic cleavage at a conserved SF/S motif within the FIIND. The FIIND domain is only present in chordates and consists of a ZU5-like domain (see <PDOC51145>) and a UPA-like domain [1,2,3].

The profile we developed covers the entire FIIND domain.

Last update:

March 2017 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

FIIND, PS51830; FIIND domain profile  (MATRIX)


1AuthorsTschopp J. Martinon F. Burns K.
TitleNALPs: a novel protein family involved in inflammation.
SourceNat. Rev. Mol. Cell Biol. 4:95-104(2003).
PubMed ID12563287

2AuthorsD'Osualdo A. Weichenberger C.X. Wagner R.N. Godzik A. Wooley J. Reed J.C.
TitleCARD8 and NLRP1 undergo autoproteolytic processing through a ZU5-like domain.
SourcePLoS ONE 6:E27396-E27396(2011).
PubMed ID22087307

3AuthorsLiao Y. Pei J. Cheng H. Grishin N.V.
TitleAn ancient autoproteolytic domain found in GAIN, ZU5 and Nucleoporin98.
SourceJ. Mol. Biol. 426:3935-3945(2014).
PubMed ID25451782

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