PROSITE documentation PDOC51881
Obg C-terminal (OCT) domain profile


Obg subfamily proteins (also known as ObgE, YhbZ and CgtA) are conserved P-loop GTPases, that are involved in a wide range of cellular processes, including sporulation, cellular differentiation, ribosome assembly, DNA replication, chromosome segregation, and stringent response in eubacteria and plant chloroplasts. Obg subfamily proteins have three domains: the Obg fold, the G domain (see <PDOC51710>), and the Obg C-terminal (OCT) domain. A potential role of the OCT domain in the regulation of the nucleotide-binding state has been suggested [1,2,3].

The OCT domain structure contains a four-stranded β sheet and three α helices flanked by an additional β strand (see <PDB:1UDX>) [1].

The profile we developed covers the entire OCT domain.

Last update:

December 2018 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

OCT, PS51881; Obg C-terminal (OCT) domain profile  (MATRIX)


1AuthorsKukimoto-Niino M. Murayama K. Inoue M. Terada T. Tame J.R.H. Kuramitsu S. Shirouzu M. Yokoyama S.
TitleCrystal structure of the GTP-binding protein Obg from Thermus thermophilus HB8.
SourceJ. Mol. Biol. 337:761-770(2004).
PubMed ID15019792

2AuthorsBang W.Y. Chen J. Jeong I.S. Kim S.W. Kim C.W. Jung H.S. Lee K.H. Kweon H.-S. Yoko I. Shiina T. Bahk J.D.
TitleFunctional characterization of ObgC in ribosome biogenesis during chloroplast development.
SourcePlant. J. 71:122-134(2012).
PubMed ID22380942

3AuthorsBang W.Y. Hata A. Jeong I.S. Umeda T. Masuda T. Chen J. Yoko I. Suwastika I.N. Kim D.W. Im C.H. Lee B.H. Lee Y. Lee K.W. Shiina T. Bahk J.D.
TitleAtObgC, a plant ortholog of bacterial Obg, is a chloroplast-targeting GTPase essential for early embryogenesis.
SourcePlant Mol. Biol. 71:379-390(2009).
PubMed ID19636801

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