PROSITE documentation PDOC51890DAZ domain profile
DAZ (Deleted in Azoospermia) proteins are found almost exclusively in germ cells in distant animal species. Deletion or mutations of their encoding genes usually impair either oogenesis or spermatogenesis or both. The family includes three members, Boule (or Boll), Dazl (or Dazla) and DAZ, encoding RNA binding proteins. Boule is the ancestral gene that is conserved from flies to humans, whereas, Dazl arose in the early vertebrate lineage and Daz arrived on Y chromosome during primate evolution. Basically, DAZ family proteins have been proposed to function as adaptors for target mRNA transport and activators of their translation. These proteins have a highly conserved RNA recognition motif (RRM) (see <PDOC00030>) for binding target mRNAs and one (Boule and Dazl) or multiple copies (Daz) of the DAZ domain, a 24 amino acids motif rich in Asn, Tyr, and Gln residues. The function of the DAZ domain is not known, but may be involved in protein-protein interactions [1,2,3,4,5].
The profile we developed covers the entire DAZ domain.
Last update:April 2019 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Fu X.-F. Cheng S.-F. Wang L.-Q. Yin S. De Felici M. Shen W. |
| Title | DAZ Family Proteins, Key Players for Germ Cell Development. | |
| Source | Int. J. Biol. Sci. 11:1226-1235(2015). | |
| PubMed ID | 26327816 | |
| DOI | 10.7150/ijbs.11536 |
| 2 | Authors | Xu E.Y. Moore F.L. Pera R.A.R. |
| Title | A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans. | |
| Source | Proc. Natl. Acad. Sci. U. S. A. 98:7414-7419(2001). | |
| PubMed ID | 11390979 | |
| DOI | 10.1073/pnas.131090498 |
| 3 | Authors | Sekizaki H. Takahashi S. Tanegashima K. Onuma Y. Haramoto Y. Asashima M. |
| Title | Tracing of Xenopus tropicalis germ plasm and presumptive primordial germ cells with the Xenopus tropicalis DAZ-like gene. | |
| Source | Dev. Dyn. 229:367-372(2004). | |
| PubMed ID | 14745962 | |
| DOI | 10.1002/dvdy.10448 |
| 4 | Authors | Xu H. Li Z. Li M. Wang L. Hong Y. |
| Title | Boule is present in fish and bisexually expressed in adult and embryonic germ cells of medaka. | |
| Source | PLoS One. 4:E6097-E6097(2009). | |
| PubMed ID | 19564913 | |
| DOI | 10.1371/journal.pone.0006097 |
| 5 | Authors | Rengaraj D. Zheng Y.H. Kang K.S. Park K.J. Lee B.R. Lee S.I. Choi J.W. Han J.Y. |
| Title | Conserved expression pattern of chicken DAZL in primordial germ cells and germ-line cells. | |
| Source | Theriogenology 74:765-776(2010). | |
| PubMed ID | 20537692 | |
| DOI | 10.1016/j.theriogenology.2010.04.001 |
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