EndoU is a family of metal-dependent endoribonucleases that is broadly
conserved among eukaryotes [1,2]. EndoU family members have RNA-binding and
endoribonuclease activities and appear to be involved in many aspects of
biology, including small nucleolar RNA biogenesis, endoplasmic reticulum (ER)
network formation, immune response, and neurodegeneration:
Xenopus laevis endoribonuclease XendoU is responsible for processing the
intron encoded U16 and U86 small nucleolar RNAs (snoRNAs) [3,4].
Human EndoU, also known as PP11 (placental protein 11), has an
endoribonuclease activity with placental tissue specificity [5,6].
Drosophila melanogaster CG2145 and DendoU endoribonucleases .
Caenorhabditis elegans endu-2 regulates nucleotide metabolism and germ cell
proliferation in response to nucleotide imbalance and other genotoxic
EndoU family members share a common domain, that carries out a conserved RNA
processing function. The EndoU domain cleaves RNA at uridylates and release
2',3'-cyclic phosphodiester ends.
The EndoU domain is an α+β domain, that contains nine α-helices and
three antiparallel β-sheets; the latter are clustered on one side of the
domain, whereas the α-helices are largely on the other side (see
<PDB:2C1W>) . It contains a conserved trio of catalytic residues, two
histidines and a lysine.
The profile we developed covers the entire EndoU domain.
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