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PROSITE documentation PDOC51983

CUT repeat-like (CUTL) domain profile





Description

SATB (Special AT-rich binding protein) family proteins have emerged as key regulators that integrate higher-order chromatin organization with the regulation of gene expression. SATB family chromatin organizers are involved in long-range enhancer function, extension of chromatin modifications and dynamic tethering of chromatin loops, and play diverse and important roles in regulating the dynamic equilibrium of apoptosis, cell invasion, metastasis, proliferation, angiogenesis, and immune modulation. SATB family proteins consist of an ubiquitin-like domain (ULD) (see <PDOC51982>) and a CUT repeat-like (CUTL) domain at the N terminus, a homeodomain (HD) (see <PDOC00027>) at the C terminus, and tandem CUT domains (see <PDOC51042>) in the center. The DNA binding ability of SATB1 requires the contribution of the CUTL domain, as well as the tandem CUT domains and the homeodomain [1,2].

The profile we developed covers the entire CUTL domain.

Last update:

July 2021 / First entry.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

CUTL, PS51983; CUT repeat-like (CUTL) domain profile  (MATRIX)


References

1AuthorsNaik R. Galande S.
TitleSATB family chromatin organizers as master regulators of tumor progression.
SourceOncogene 38:1989-2004(2019).
PubMed ID30413763
DOI10.1038/s41388-018-0541-4

2AuthorsWang Z. Yang X. Guo S. Yang Y. Su X.-C. Shen Y. Long J.
TitleCrystal structure of the ubiquitin-like domain-CUT repeat-like tandem of special AT-rich sequence binding protein 1 (SATB1) reveals a coordinating DNA-binding mechanism.
SourceJ. Biol. Chem. 289:27376-27385(2014).
PubMed ID25124042
DOI10.1074/jbc.M114.562314



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