PROSITE documentation PDOC52003OCA domain profile
The 23 amino acid OCA domain, which binds to class II POU domain-containing transcription factors (TFs) and a DNA octamer motif in a bivalent manner, are found in the POU2AF family of coactivators [1,2]:
- Vertebrate POU2AF1 (OBF-1, Bob1, OCA-B), a B-cell specific coactivator of class II POU TFs POU2F1 (Oct-1) and POU2F2 (Oct-2).
- Vertebrate POU2AF2 (C11orf53, OCA-T1), a tuft cell specific coactivator of class II POU TF POU2F3 (Oct-11).
- Vertebrate POU2AF3 (COLCA2, OCA-T2), a tuft cell specific coactivator of class II POU TF POU2F3 (Oct-11).
An OCA domain is also found in another family of cofactors, the nuclear factor (NF)-kappaB inhibitor zeta (IkappaBzeta) proteins, NF-kappaB regulators which function not only as repressors but also as activators of a selective subset of NF-kappaB target genes [3].
The OCA domain is made of a N-terminal extended polypeptide strand and a C-terminal two-turn α helix (see <PDB:1CQT>) [1].
The profile we developed covers the entire OCA domain.
Last update:July 2022 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Chasman D. Cepek K. Sharp P.A. Pabo C.O. |
| Title | Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface. | |
| Source | Genes. Dev. 13:2650-2657(1999). | |
| PubMed ID | 10541551 | |
| DOI | 10.1101/gad.13.20.2650 |
| 2 | Authors | Wu X.S. He X.-Y. Ipsaro J.J. Huang Y.-H. Preall J.B. Ng D. Shue Y.T. Sage J. Egeblad M. Joshua-Tor L. Vakoc C.R. |
| Title | OCA-T1 and OCA-T2 are coactivators of POU2F3 in the tuft cell lineage. | |
| Source | Nature 607:169-175(2022). | |
| PubMed ID | 35576971 | |
| DOI | 10.1038/s41586-022-04842-7 |
| 3 | Authors | Mueller A. Hennig A. Lorscheid S. Grondona P. Schulze-Osthoff K. Hailfinger S. Kramer D. |
| Title | IkappaBzeta is a key transcriptional regulator of IL-36-driven psoriasis-related gene expression in keratinocytes. | |
| Source | Proc. Natl. Acad. Sci. U. S. A. 115:10088-10093(2018). | |
| PubMed ID | 30224457 | |
| DOI | 10.1073/pnas.1801377115 |
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