PROSITE documentation PDOC60031Glutamic acid-rich protein 2 (GARP2) signature
The glutamic acid-rich protein 2 (GARP2 is a soluble retinal protein that exists in rod outer segments but is absent in cones. GARP2 is a product of alternative splicing of the β-subunit of the cGMP-gated ion channel (CNGB1) of rod photoreceptors and contains a unique 8-amino-acid C-terminal extension. It has a high content of proline and glutamate residues. GARP2 has been shown to bind to several retinal proteins including perpherin, and the photoreceptor phosphodiesterase (PDE6) [1,2].
As a signature we used the five last common amino acid and the unique 8-amino-acid C-terminal extension of GARP2.
Expert(s) to contact by email: Last update:March 2015 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Pentia D.C. Hosier S. Cote R.H. |
| Title | The glutamic acid-rich protein-2 (GARP2) is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties. | |
| Source | J. Biol. Chem. 281:5500-5505(2006). | |
| PubMed ID | 16407240 | |
| DOI | 10.1074/jbc.M507488200 |
| 2 | Authors | Gibriel A.A.Y. Tate R.J. Yu Y. Rawson-Lax E. Hammer H.M. Tettey J.N.A. Pyne N.J. Converse C.A. |
| Title | The p.Arg86Gln change in GARP2 (glutamic acid-rich protein-2) is a common West African-related polymorphism. | |
| Source | Gene 515:155-158(2013). | |
| PubMed ID | 23201897 | |
| DOI | 10.1016/j.gene.2012.11.005 |
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