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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00041


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PURL: https://purl.expasy.org/prosite/signature/PS00041

Direct ScanProsite submission
General information about the entry

Entry name [info] HTH_ARAC_FAMILY_1
Accession [info] PS00041
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00040

Name and characterization of the entry

Description [info] Bacterial regulatory proteins, araC family signature.
Pattern [info] 
[KRQ]-[LIVMA]-x(2)-[GSTALIV]-{FYWPGDN}-x(2)-[LIVMSA]-x(4,9)-[LIVMF]-x-
{PLH}-[LIVMSTA]-[GSTACIL]-{GPK}-{F}-x-[GANQRF]-[LIVMFY]-x(4,5)-[LFY]-
x(3)-[FYIVA]-{FYWHCM}-{PGVI}-x(2)-[GSADENQKR]-x-[NSTAPKL]-[PARL].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 330 in 328 different sequences
Number of true positive hits 221 in 219 different sequences
Number of 'unknown' hits 1
Number of false positive hits 108 in 108 different sequences
Number of false negative sequences 47
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 67.17 %
Recall (true positives / (true positives + false negatives)) 82.46 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 2
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 219 sequences 

AARP_PROST  (P43463), ADAA_BACSU  (P19219), ADA_ECOLI   (P06134), 

ADA_SALTY   (P26189), ADIY_ECOLI  (P33234), AGGR_ECOLX  (P43464), 
ALKA_MYCTO  (P9WJW2), ALKA_MYCTU  (P9WJW3), ALKR_ACIAD  (O31249), 
ANDR_BURCE  (Q84BZ4), APPY_ECOLI  (P05052), ARACL_STRAT (Q03320), 
ARACL_STRLI (P35319), ARAC_CITFR  (P11765), ARAC_DICCH  (P07642), 
ARAC_ECO57  (P0A9E1), ARAC_ECOLI  (P0A9E0), ARAC_SALTY  (P03022), 
ARGR_PSEAE  (G3XCU2), BTR_BACSU   (P40408), CAF1R_YERPE (P26950), 
CDHR_PSEAE  (Q9HTH5), CFAD_ECOLX  (P25393), CHBR_ECOLI  (P17410), 
CSVR_ECOLX  (P43460), ENVY_ECOLI  (P10805), EUTR_ECOLI  (P36547), 
EUTR_SALTY  (Q9ZFU7), EXSA_PSEAE  (P26993), FAPR_ECOLX  (P23774), 
GADW_ECO57  (P63202), GADW_ECOL6  (Q8FCI7), GADW_ECOLI  (P63201), 
GADW_SHIFL  (P63203), GADX_ECO27  (Q9EYV5), GADX_ECO57  (P58230), 
GADX_ECOL6  (Q8FCI6), GADX_ECOLI  (P37639), GADX_SHIFL  (Q83PR0), 
GBDR_PSEAB  (A0A0H2ZIC3), GBDR_PSEAE  (Q9HTI4), GLXA_RHIME  (O87389), 
HILD_SALTS  (E1WAC0), HILD_SALTY  (P0CL08), HRPB_RALN1  (P31778), 
INVF_SALTI  (P69342), INVF_SALTY  (P69343), LACR_STAXY  (O33813), 
LCRF_YERPE  (P28808), LUMQ_PHOLE  (Q51872), MARA_ECO57  (P0ACH6), 
MARA_ECOLI  (P0ACH5), MARA_SALEN  (P0A2S6), MARA_SALTI  (P0A2S5), 
MARA_SALTY  (P0A2S4), MARA_SHIFL  (P0ACH7), MELR_ECOL6  (P0ACH9), 
MELR_ECOLI  (P0ACH8), MMSR_PSEAE  (P28809), MSMR_STRMU  (Q00753), 
MXIE_SHIFL  (P0A2S7), MXIE_SHISO  (P0A2S8), NIMR_ECOLI  (P76241), 
NPHR_RHOSO  (B1Q2A8), PCHR_PSEAE  (P40883), PERA_ECO27  (P43459), 
PLH4_FORAG  (T2KMF4), POCR_SALTY  (Q05587), PQRA_PROVU  (Q52620), 
RAFR_PEDPE  (P43465), RAMA_KLEPH  (A0A0H3GPK2), RAMA_KLEPN  (Q48413), 
RAMA_SALTY  (H9L484), RHAR_CROS8  (A7ML57), RHAR_ECO24  (A7ZUB8), 
RHAR_ECO57  (Q8X7B3), RHAR_ECOBW  (C5A074), RHAR_ECOHS  (A8A710), 
RHAR_ECOK1  (A1AI83), RHAR_ECOL5  (Q0TAF7), RHAR_ECOL6  (Q8FBD7), 
RHAR_ECOLI  (P09378), RHAR_ECOUT  (Q1R413), RHAR_ENT38  (A4WG90), 
RHAR_KLEP7  (A6TGB0), RHAR_MANSM  (Q65Q30), RHAR_SALA4  (B5F0N0), 
RHAR_SALAR  (A9MI63), RHAR_SALCH  (Q57HG7), RHAR_SALDC  (B5FPP6), 
RHAR_SALEP  (B5QWY5), RHAR_SALHS  (B4TBY4), RHAR_SALNS  (B4SZZ4), 
RHAR_SALPA  (Q5PKG1), RHAR_SALPB  (A9MZC9), RHAR_SALPK  (B5BJG9), 
RHAR_SALSV  (B4TPR0), RHAR_SALTI  (Q8Z2V5), RHAR_SALTY  (P40865), 
RHAR_SHIBS  (Q31U83), RHAR_SHIDS  (Q32A71), RHAR_SHIF8  (Q0SZ96), 
RHAR_SHIFL  (Q83PD9), RHAR_YERP3  (A7FN79), RHAR_YERPA  (Q1C0W2), 
RHAR_YERPB  (B2K1W6), RHAR_YERPE  (Q8ZIZ9), RHAR_YERPG  (A9QYR6), 
RHAR_YERPN  (Q1CEB6), RHAR_YERPP  (A4TRS7), RHAR_YERPS  (Q66FF1), 
RHAR_YERPY  (B1JNC4), RHAS_CITK8  (A8AL27), RHAS_ECO24  (A7ZUB7), 
RHAS_ECO27  (B7UNM6), RHAS_ECO45  (B7MI37), RHAS_ECO55  (B7L9G1), 
RHAS_ECO57  (Q8X897), RHAS_ECO5E  (B5YZ43), RHAS_ECO7I  (B7NUA1), 
RHAS_ECO81  (B7N2P7), RHAS_ECO8A  (B7M6V7), RHAS_ECOBW  (C5A073), 
RHAS_ECODH  (B1XB72), RHAS_ECOHS  (A8A709), RHAS_ECOK1  (A1AI82), 
RHAS_ECOL5  (Q0TAF8), RHAS_ECOL6  (Q8CXW5), RHAS_ECOLC  (B1IVH3), 
RHAS_ECOLI  (P09377), RHAS_ECOLU  (B7NFK3), RHAS_ECOSE  (B6I4P8), 
RHAS_ECOSM  (B1LMU6), RHAS_ECOUT  (Q1R414), RHAS_ENT38  (A4WG91), 
RHAS_KLEP3  (B5XZ49), RHAS_KLEP7  (A6TGA9), RHAS_PECAS  (Q6DA22), 
RHAS_PECCP  (C6DJR4), RHAS_SALA4  (B5F0M9), RHAS_SALAR  (A9MI64), 
RHAS_SALCH  (Q57HG8), RHAS_SALDC  (B5FPP5), RHAS_SALEP  (B5QWY4), 
RHAS_SALG2  (B5RFC3), RHAS_SALHS  (B4TBY3), RHAS_SALNS  (B4SZZ3), 
RHAS_SALPA  (Q5PKG2), RHAS_SALPB  (A9MZC8), RHAS_SALPC  (C0Q3L4), 
RHAS_SALPK  (B5BJG8), RHAS_SALSV  (B4TPQ9), RHAS_SALTI  (P0A2T0), 
RHAS_SALTY  (P0A2S9), RHAS_SHIBS  (Q31U84), RHAS_SHIDS  (Q32A70), 
RHAS_SHIF8  (Q0SZ95), RHAS_SHIFL  (Q83PE0), RHAS_SHISS  (Q3YV71), 
RHAS_YERP3  (A7FN80), RHAS_YERPB  (B2K1W5), RHAS_YERPG  (A9QYR8), 
RHAS_YERPP  (A4TRS8), RHAS_YERPS  (Q66FF2), RHAS_YERPY  (B1JNC5), 
RIPA_CORDI  (Q6NI56), RIPA_COREF  (Q8FQS2), RIPA_CORGL  (Q8NRR3), 
RNS_ECOLX   (P16114), ROB_ECO57   (P0ACI1), ROB_ECOLI   (P0ACI0), 
ROB_SALTY   (Q8ZJU7), ROB_SHIFL   (P0ACI2), SIRC_SALTI  (Q8Z4A6), 
SIRC_SALTS  (E1WAB2), SIRC_SALTY  (P0CL09), SOXS_ECO57  (P0A9E4), 
SOXS_ECOL6  (P0A9E3), SOXS_ECOLI  (P0A9E2), SOXS_SALTY  (Q56143), 
TCPN_VIBC3  (A5F384), TCPN_VIBCH  (P0C6D6), TETD_ECOLX  (P28816), 
THCR_RHOER  (P43462), URER_ECOLX  (P32326), URER_PROMH  (Q02458), 
VIRF_SHIDY  (P0A2T2), VIRF_SHIFL  (P0A2T1), VIRF_SHISO  (P0A2T3), 
VIRF_YERE8  (A1JU91), VIRF_YEREN  (P0C2V5), XYLR_ECO57  (P0ACI5), 
XYLR_ECOL6  (P0ACI4), XYLR_ECOLI  (P0ACI3), XYLR_HAEIN  (P45043), 
XYLS1_PSEPU (Q04710), XYLS2_PSEPU (Q05092), XYLS3_PSEPU (Q05335), 
XYLS4_PSEPU (Q04713), XYLS_PSEPU  (P07859), Y1052_HAEIN (P45008), 
Y3175_SALTY (Q8ZM00), Y4FK_SINFN  (P55449), YCGK_PSEVC  (P43461), 
YDCO_ECOLI  (P76103), YDEC_BACSU  (P96660), YDEE_BACSU  (P96662), 
YDEO_ECO57  (Q8X4Z9), YDEO_ECOL6  (Q8FHG0), YDEO_ECOLI  (P76135), 
YDEO_SHIFL  (Q83RF4), YESS_BACSU  (O31522), YFIF_BACSU  (P54722), 
YIDL_ECOLI  (P31449), YIJO_ECOLI  (P32677), YISR_BACSU  (P40331), 
YMCR_STRLA  (P43458), YOBQ_BACSU  (O34901), YPDC_ECOLI  (P77396)
» more

UniProtKB/Swiss-Prot
False negative sequences		 47 sequences 

FEAR_ECOLI  (Q47129), HPTR_STAA3  (Q2FK47), HPTR_STAA8  (Q2G1E1), 

HPTR_STAAB  (Q2YV56), HPTR_STAAC  (Q5HJF7), HPTR_STAAM  (Q99X00), 
HPTR_STAAN  (Q7A7X9), HPTR_STAAR  (Q6GK93), HPTR_STAAS  (Q6GCQ3), 
HPTR_STAAW  (Q8NYJ9), MTRA_NEIGO  (Q9WW32), ORUR_PSEAE  (P72171), 
RAMA_ENTCL  (P55922), RCLR_ECOLI  (P77379), RHAR_PECAS  (Q6DA21), 
RHAR_PECCP  (C6DJR5), RHAS_ESCF3  (B7LVD8), RHAS_MANSM  (Q65Q31), 
RHAS_SHIB3  (B2TVP7), RHAS_YERPA  (Q1C0W1), RHAS_YERPE  (Q8ZJ00), 
RHAS_YERPN  (Q1CEB5), RHRA_RHIME  (Q9Z3Q6), VIRS_MYCTO  (P9WMJ2), 
VIRS_MYCTU  (P9WMJ3), VQSM_PSEAE  (Q9I1P2), Y077_STAAW  (Q8NYT6), 
Y078_STAAS  (Q6GD21), Y084_STAAC  (Q5HJR8), Y097_STAAN  (Q7A882), 
Y101_STAAM  (Q99XB1), Y107_STAAR  (Q6GKK1), Y1395_MYCTO (P9WMJ0), 
Y1395_MYCTU (P9WMJ1), Y1430_MYCBO (P68912), Y165_STAES  (Q8CQE3), 
Y1931_MYCTU (P95283), Y2406_STAEQ (Q5HKE0), YBCM_ECOLI  (P77634), 
YBFI_BACSU  (O31449), YBFP_BACSU  (O31456), YDIP_ECOLI  (P77402), 
YHTH1_STAAU (Q936F1), YKGA_ECOLI  (P77601), YNEL_ECOLI  (P76138), 
YQHC_ECOLI  (Q46855), YTDP_BACSU  (O32071)
» more

UniProtKB/Swiss-Prot
'Unknown' sequences		 1 sequence 

MRP7_CAEEL  (Q9U2G5)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			108 sequences
			


			
AAM_RHOER   (K9NBS6), ABGR_ECOLI  (P77744), AIPS_SACS2  (Q7LXU6), 

			
APY4_ARATH  (Q8H1D8), ARGD_HAEDU  (Q7VMS5), AROB_SYNP6  (Q5N3D4), 
ARSB_YEREN  (P74985), AT21A_ARATH (P0CH01), AUG1_ARATH  (F4IK01), 
BIOC_DECAR  (Q47C02), BPNT1_MOUSE (Q9Z0S1), BRE1A_ORYSI (A2XW69), 
BRE1A_ORYSJ (Q7XU27), CBID_PROM9  (Q31DE8), CHB_SERMA   (Q54468), 
CORA_YERPE  (Q8ZAG5), CORA_YERPS  (Q66FY7), ENPP1_RAT   (Q924C3), 
ERD6_ARATH  (O04036), FABD_HAEIN  (P43712), FKS3_YEAST  (Q04952), 
FTSW_ACIAD  (Q6FFC1), GATB_FRACC  (Q2J6U8), GATB_THEFY  (Q47SC0), 
GRM6_HUMAN  (O15303), GRM6_MOUSE  (Q5NCH9), GRM6_RABIT  (Q863I4), 
GRM6_RAT(P35349), HLDE_HYDCU  (Q31IC2), KDPA_PSEAE  (P57683), 
KDPA_PSEPK  (Q88FD7), KDPA_PSESM  (Q883V6), KUP1_RHIWR  (A5V2F7), 
L2_FOWPN(P15911), LYSO_ECOLI  (P75826), L_CCHFI (Q6TQR6), 
MATK_HELAN  (Q1KXX8), MEND_BACAH  (A0RK76), MEND_BACAN  (Q81K94), 
MEND_BACCN  (A7GU91), MEND_BACCR  (Q816H7), MEND_BACCZ  (Q632I2), 
MEND_BACHK  (Q6HC26), MEND_BACMK  (A9VM77), MEND_BACP2  (A8FGK9), 
MEND_BACSU  (P23970), MEND_BACVZ  (A7Z812), MEND_GEOKA  (Q5KVX6), 
MEND_GEOTN  (A4IS14), MEND_LISIN  (Q92AY5), MEND_LISMF  (Q71YZ2), 
MEND_LISMO  (Q8Y6K9), MEND_LISW6  (A0AJC9), METK_SALRD  (Q2RYY4), 
METN_CHLCV  (Q823C4), MON1_ORYSJ  (Q5JL08), MPRGB_DANRE (Q6DC77), 
MURA1_STRP1 (P65458), MURA1_STRP3 (P0DC44), MURA1_STRP6 (Q5XCX7), 
MURA1_STRP8 (P65459), MURA1_STRPM (Q48UD0), MURA1_STRPQ (P0DC45), 
MUTS_AROAE  (Q5NYP9), NAR1_LODEL  (A5DSI2), NAT12_ARATH (Q3E7D0), 
NHAA2_CLAM3 (A5CTB2), NR5A2_CHICK (O42101), NRPS8_ASPFU (Q4WVN4), 
POL2_CNSV   (Q8QVU9), POPL1_CAEEL (Q11188), PRFB3_ARATH (F4J264), 
PRP28_ASPCL (A1CHL3), PRP28_ASPFU (Q4WPE9), PRP28_ASPNC (A2QIL2), 
PRP28_ASPOR (Q2UH00), PRP28_ASPTN (Q0CLX0), PRP28_BOTFB (A6RJA2), 
PRP28_COCIM (Q1DMX8), PRP28_EMENI (Q5BCU6), PRP28_GIBZE (Q4I7F9), 
PRP28_NEOFI (A1CX72), PRP28_NEUCR (Q7SEL0), PRP28_PHANO (Q0UWC8), 
PRP28_SCLS1 (A7EGG4), PURA_ACIAD  (Q6FCS7), RH1_ARATH   (Q7FGZ2), 
RP54_VIBAN  (O08429), S2610_HUMAN (Q8NG04), S4A10_BOVIN (Q32LP4), 
S4A10_HUMAN (Q6U841), S4A10_MOUSE (Q5DTL9), S4A10_RAT   (Q80ZA5), 
SCTL_SHIFL  (Q99PY0), SELA_HAEDU  (Q7VKC2), SEM4A_HUMAN (Q9H3S1), 
SEM4B_MOUSE (Q62179), SYFB_XANAC  (Q8PJE5), SYG_MYCPA   (Q73Y21), 
SYG_NOCFA   (Q5YZT7), SYV_SCHPO   (O75005), THAQ_BURTA  (Q2T4P1), 
TLR9_BOVIN  (Q5I2M5), TLR9_SHEEP  (Q5I2M4), TM235_HUMAN (A6NFC5), 
UFL1_NEMVE  (A7S2N8), YB95_ARATH  (Q8W487), YKOC_BACSU  (O34572)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			22 PDB
			


			pdb_00001bl0; pdb_00001d5y; pdb_00001u8b; pdb_00001wpk; pdb_00001xs9; pdb_00001zgw; pdb_00002k9s; pdb_00003gbg; pdb_00003mkl; pdb_00004fe4; pdb_00004fe7; pdb_00005suw; 
			
				pdb_00006xiu; pdb_00006xiv; pdb_00007bef; pdb_00007beg; pdb_00007r3w; pdb_00007vwy; pdb_00007vwz; pdb_00007w5w; pdb_00007w5x; pdb_00007w5y
			
			

			» more