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PROSITE entry PS00058


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General information about the entry

Entry name [info] DNA_MISMATCH_REPAIR_1
Accession [info] PS00058
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
08-NOV-2023 INFO UPDATE.
PROSITE Doc. [info] PDOC00057

Name and characterization of the entry

Description [info] DNA mismatch repair proteins mutL / hexB / PMS1 signature.
Pattern [info] 
G-F-R-G-E-[AG]-L.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2023_05 which contains 570'420 sequence entries.


Total number of hits 461 in 461 different sequences
Number of true positive hits 458 in 458 different sequences
Number of 'unknown' hits 0
Number of false positive hits 3 in 3 different sequences
Number of false negative sequences 10
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 99.35 %
Recall (true positives / (true positives + false negatives)) 97.86 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 458 sequences 

HEXB_STRPN  (P0A3R1), HEXB_STRR6  (P0A3R2), MLH1_ARATH  (Q9ZRV4), 

MLH1_DICDI  (Q54KD8), MLH1_HUMAN  (P40692), MLH1_MOUSE  (Q9JK91), 
MLH1_RAT(P97679), MLH1_SCHPO  (Q9P7W6), MLH1_YEAST  (P38920), 
MLH2_YEAST  (Q07980), MLH3_ARATH  (F4JN26), MLH3_HUMAN  (Q9UHC1), 
MUTL_ACIC5  (C1F876), MUTL_ACICJ  (A5FW68), MUTL_ACTPJ  (B0BTY3), 
MUTL_ACTSZ  (A6VN10), MUTL_AERHH  (A0KGR9), MUTL_AERS4  (A4SR27), 
MUTL_AFIC5  (B6JIV1), MUTL_AGARV  (C4ZA52), MUTL_AGRFC  (Q8UHI3), 
MUTL_AGRRK  (B9JA11), MUTL_AKKM8  (B2ULE2), MUTL_ALIF1  (Q5E2C6), 
MUTL_ALIFM  (B5FBR6), MUTL_ALISL  (B6EMQ9), MUTL_ALKCK  (Q5WFY4), 
MUTL_ALKMQ  (A6TR78), MUTL_ALLAM  (B9JSD6), MUTL_ANADF  (A7HC45), 
MUTL_ANAPZ  (Q2GJE2), MUTL_ANOFW  (B7GIA3), MUTL_AQUAE  (O67518), 
MUTL_AQUPY  (P70754), MUTL_AZOC5  (A8I6D2), MUTL_AZOVD  (C1DLQ0), 
MUTL_BACAA  (C3P5H4), MUTL_BACAC  (C3L823), MUTL_BACAH  (A0RHE0), 
MUTL_BACAN  (Q81WR4), MUTL_BACC0  (B7JJ46), MUTL_BACC1  (Q732V8), 
MUTL_BACC2  (B7ITM0), MUTL_BACC3  (C1ENZ2), MUTL_BACC4  (B7HDP3), 
MUTL_BACC7  (B7HLA2), MUTL_BACCN  (A7GR98), MUTL_BACCQ  (B9IV58), 
MUTL_BACCR  (Q81A26), MUTL_BACCZ  (Q636Q8), MUTL_BACFN  (Q5L8M5), 
MUTL_BACFR  (Q64NX1), MUTL_BACHK  (Q6HF47), MUTL_BACLD  (Q65JE1), 
MUTL_BACMK  (A9VS12), MUTL_BACP2  (A8FDH4), MUTL_BACSU  (P49850), 
MUTL_BACTN  (Q8A120), MUTL_BACVZ  (A7Z4X6), MUTL_BARBK  (A1UU01), 
MUTL_BARHE  (Q6G4R4), MUTL_BARQU  (Q6G0J4), MUTL_BART1  (A9IN82), 
MUTL_BAUCH  (Q1LSQ2), MUTL_BEII9  (B2II71), MUTL_BORA1  (Q2KX20), 
MUTL_BORAP  (Q0SNV1), MUTL_BORBR  (Q7WG61), MUTL_BORBU  (O51229), 
MUTL_BORDL  (B5RL36), MUTL_BORGP  (Q662F3), MUTL_BORPA  (Q7W4N5), 
MUTL_BORPE  (Q7W0A6), MUTL_BORRA  (B5RR29), MUTL_BORT9  (A1QZ05), 
MUTL_BRADU  (Q89DE6), MUTL_BRASB  (A5ECL8), MUTL_BRASO  (A4Z0Q5), 
MUTL_BRUA1  (B2SD15), MUTL_BRUA2  (Q2YIH2), MUTL_BRUA4  (A6X3F3), 
MUTL_BRUAB  (Q579M7), MUTL_BRUC2  (A9MDX3), MUTL_BRUMB  (C0RKF6), 
MUTL_BRUME  (P65489), MUTL_BRUO2  (A5VTW1), MUTL_BRUSI  (A9WXS2), 
MUTL_BRUSU  (P65490), MUTL_BUCA5  (B8D8D4), MUTL_BUCAI  (P57633), 
MUTL_BUCAP  (Q8K913), MUTL_BUCAT  (B8D891), MUTL_BUCBP  (Q89A38), 
MUTL_CALS4  (Q8RA70), MUTL_CARHZ  (Q3ACA6), MUTL_CAUSK  (B0SWX9), 
MUTL_CAUVC  (P0CAV5), MUTL_CAUVN  (B8H173), MUTL_CELJU  (B3PDC3), 
MUTL_CHESB  (Q11L80), MUTL_CHLAB  (Q5L4T7), MUTL_CHLCH  (Q3AUA2), 
MUTL_CHLCV  (Q821I9), MUTL_CHLFF  (Q256F3), MUTL_CHLL2  (B3EHI9), 
MUTL_CHLL3  (Q3B1F8), MUTL_CHLMU  (Q9PJG5), MUTL_CHLP8  (B3QL59), 
MUTL_CHLPB  (B3EL44), MUTL_CHLPD  (A1BCW2), MUTL_CHLPM  (A4SGM5), 
MUTL_CHLPN  (Q9Z794), MUTL_CHLT2  (B0B8E9), MUTL_CHLT3  (B3QW86), 
MUTL_CHLTA  (Q3KLC2), MUTL_CHLTB  (B0BA28), MUTL_CHLTE  (Q8KAX3), 
MUTL_CHLTR  (O84579), MUTL_CHRFK  (A0LZH8), MUTL_CHRSD  (Q1QY28), 
MUTL_CITBB  (B5EGD4), MUTL_CITK8  (A8AMN1), MUTL_CLOAB  (Q97I20), 
MUTL_CLOB1  (A7FUK9), MUTL_CLOB6  (C3KX34), MUTL_CLOB8  (A6LWJ1), 
MUTL_CLOBB  (B2TIB8), MUTL_CLOBJ  (C1FNT8), MUTL_CLOBK  (B1IM67), 
MUTL_CLOBL  (A7GE44), MUTL_CLOBM  (B1KSA2), MUTL_CLONN  (A0Q0M7), 
MUTL_CLOP1  (Q0TRD5), MUTL_CLOPE  (Q8XL86), MUTL_CLOPS  (Q0STR3), 
MUTL_CLOTE  (Q895H3), MUTL_COLP3  (Q48A24), MUTL_COXB2  (B6J016), 
MUTL_COXBN  (A9KE32), MUTL_COXBR  (A9NCK3), MUTL_COXBU  (Q83CM9), 
MUTL_CROS5  (B1X109), MUTL_CROS8  (A7MMA2), MUTL_DEIRA  (Q9RTR0), 
MUTL_DESAP  (B1I293), MUTL_DESRM  (A4J5Q3), MUTL_DICNV  (A5EXM6), 
MUTL_DICT6  (B5YE42), MUTL_DICTD  (B8E280), MUTL_ECO24  (A7ZV39), 
MUTL_ECO27  (B7UQH9), MUTL_ECO45  (B7MKX4), MUTL_ECO55  (B7LC24), 
MUTL_ECO57  (Q8XDN4), MUTL_ECO5E  (B5Z2H6), MUTL_ECO81  (B7MSY3), 
MUTL_ECO8A  (B7M8T0), MUTL_ECOBW  (C5A1G1), MUTL_ECODH  (B1XDS1), 
MUTL_ECOHS  (A8A7R4), MUTL_ECOK1  (A1AJ76), MUTL_ECOL5  (Q0T9M3), 
MUTL_ECOL6  (Q8FAK9), MUTL_ECOLC  (B1IT36), MUTL_ECOLI  (P23367), 
MUTL_ECOLU  (B7NGA4), MUTL_ECOSE  (B6I274), MUTL_ECOSM  (B1LQJ0), 
MUTL_EDWI9  (C5BDM9), MUTL_EHRCR  (Q2GFV4), MUTL_ELUMP  (B2KB18), 
MUTL_ENDTX  (B1H0C7), MUTL_ENT38  (A4W5R1), MUTL_ERWT9  (B2VCU8), 
MUTL_ESCF3  (B7LLV2), MUTL_EXIS2  (B1YMD8), MUTL_EXISA  (C4L192), 
MUTL_FERNB  (A7HNR3), MUTL_FLAJ1  (A5FNH2), MUTL_FLAPJ  (A6GYR1), 
MUTL_GEMAT  (C1A8L2), MUTL_GEODF  (B9M3N0), MUTL_GEOKA  (Q5L0E4), 
MUTL_GEOSL  (Q74BP0), MUTL_GEOSM  (C6E4L2), MUTL_GEOSW  (C5D9H6), 
MUTL_GEOTN  (A4IMI1), MUTL_GEOUR  (A5GEV5), MUTL_HAEDU  (Q7VN43), 
MUTL_HAEI8  (Q4QPH7), MUTL_HAEIE  (A5UB71), MUTL_HAEIG  (A5UFN4), 
MUTL_HAEIN  (P44494), MUTL_HALH5  (Q9KAC1), MUTL_HALOH  (B8CX97), 
MUTL_HALS3  (B0R2S6), MUTL_HALSA  (Q9HSM6), MUTL_HELMI  (B0TB10), 
MUTL_HERAR  (A4G289), MUTL_HISS1  (Q0I463), MUTL_HISS2  (B0UUU5), 
MUTL_IDILO  (Q5QW89), MUTL_JANMA  (A6SV55), MUTL_KLEP3  (B5Y334), 
MUTL_KLEP7  (A6TH85), MUTL_KORVE  (Q1ILN0), MUTL_KOSOT  (C5CF28), 
MUTL_LACAC  (Q5FLX4), MUTL_LACCB  (B3W9W3), MUTL_LACDA  (Q1G939), 
MUTL_LACDB  (Q048Y5), MUTL_LACGA  (Q045Q4), MUTL_LACH4  (A8YTI0), 
MUTL_LACJO  (Q74KW0), MUTL_LACLA  (Q9CDL1), MUTL_LACLM  (A2RP08), 
MUTL_LACLS  (Q02VS5), MUTL_LACP3  (Q035Z3), MUTL_LACPL  (Q88UZ8), 
MUTL_LEPBA  (B0SB85), MUTL_LEPBJ  (Q04QW2), MUTL_LEPBL  (Q04Z69), 
MUTL_LEPBP  (B0ST13), MUTL_LEPIC  (Q72PF7), MUTL_LEPIN  (Q8F6X4), 
MUTL_LEUCK  (B1N024), MUTL_LEVBA  (Q03R34), MUTL_LIGS1  (Q1WT16), 
MUTL_LIMF3  (B2GB18), MUTL_LIMRD  (A5VIX0), MUTL_LIMRJ  (B2G6E6), 
MUTL_LISIN  (Q92BV2), MUTL_LISMC  (C1L2W0), MUTL_LISMF  (Q71ZR6), 
MUTL_LISMH  (B8DFS3), MUTL_LISMO  (Q8Y788), MUTL_LISW6  (A0AIK6), 
MUTL_MACCJ  (B9EBI5), MUTL_MAGSA  (Q2VYV5), MUTL_MANSM  (Q65SD7), 
MUTL_METLZ  (A2SSN1), MUTL_METMJ  (A3CWX7), MUTL_METSB  (B8ETE4), 
MUTL_METTP  (A0B977), MUTL_MICAN  (B0JS91), MUTL_NEIG1  (Q5F8M6), 
MUTL_NEIG2  (B4RLX4), MUTL_NEIM0  (A9M0G1), MUTL_NEIMA  (Q9JTS2), 
MUTL_NEIMB  (Q9JYT2), MUTL_NEIMF  (A1KUP6), MUTL_NEOSM  (Q2GDF7), 
MUTL_NITHX  (Q1QIP3), MUTL_NITWN  (Q3SPJ0), MUTL_NOSP7  (B2IYW1), 
MUTL_NOSS1  (Q8YSM9), MUTL_OPITP  (B1ZZY2), MUTL_PARD8  (A6LEJ8), 
MUTL_PASMU  (P57886), MUTL_PECAS  (Q6D065), MUTL_PECCP  (C6DFJ9), 
MUTL_PEDPA  (Q03EQ8), MUTL_PELPB  (B4SGC3), MUTL_PELPD  (A1AT89), 
MUTL_PELTS  (A5D2K5), MUTL_PERMH  (C0QSY6), MUTL_PETMO  (A9BJB9), 
MUTL_PHEZH  (B4RA70), MUTL_PHOLL  (Q7MYT9), MUTL_PHOV8  (A6KXH3), 
MUTL_PORG3  (B2RL29), MUTL_PORGI  (Q7MX15), MUTL_PROA2  (B4S3X8), 
MUTL_PROMH  (B4F203), MUTL_PSEA7  (A6VD59), MUTL_PSEA8  (B7V209), 
MUTL_PSEAB  (Q02F72), MUTL_PSEAE  (Q9HUL8), MUTL_PSEE4  (Q1I447), 
MUTL_PSEFS  (C3KDW1), MUTL_PSELT  (A8F560), MUTL_PSEPG  (B0KKZ7), 
MUTL_PSEPK  (Q88DD1), MUTL_PSEPW  (B1JAD6), MUTL_PSESM  (Q87VJ2), 
MUTL_PSET1  (Q3IDU0), MUTL_PSYIN  (A1SZL2), MUTL_RALN1  (Q8XWB1), 
MUTL_RHIE6  (B3PRD9), MUTL_RHIEC  (Q2KBX7), MUTL_RHIL3  (Q1MKU7), 
MUTL_RHILO  (Q983L2), MUTL_RHILW  (B5ZS00), MUTL_RHIME  (Q92RP4), 
MUTL_RHIWR  (A5V3J3), MUTL_RHOP2  (Q2ISE2), MUTL_RHOP5  (Q07RR2), 
MUTL_RHOPA  (Q6N1N4), MUTL_RHOPB  (Q219I5), MUTL_RHOPS  (Q131I8), 
MUTL_RHOPT  (B3Q7Y9), MUTL_RHORT  (Q2RQ52), MUTL_RICAE  (C3PM22), 
MUTL_RICAH  (A8GQA9), MUTL_RICB8  (A8GY89), MUTL_RICBR  (Q1RGP6), 
MUTL_RICCK  (A8F0A4), MUTL_RICCN  (Q92FW6), MUTL_RICFE  (Q4UJQ1), 
MUTL_RICPR  (Q9ZC88), MUTL_RICPU  (C4K2Y5), MUTL_RICRO  (B0BVP7), 
MUTL_RICRS  (A8GU58), MUTL_RICTY  (Q68VN4), MUTL_RIPO1  (B7JY11), 
MUTL_SALA4  (B5F385), MUTL_SALAR  (A9MFP2), MUTL_SALCH  (Q57GM1), 
MUTL_SALDC  (B5FRM6), MUTL_SALEP  (B5R0N7), MUTL_SALG2  (B5R9B7), 
MUTL_SALHS  (B4TFA4), MUTL_SALNS  (B4T2R5), MUTL_SALPA  (Q5PL49), 
MUTL_SALPB  (A9N4Y4), MUTL_SALPC  (C0Q6C7), MUTL_SALPK  (B5BKH9), 
MUTL_SALSV  (B4TSF0), MUTL_SALTI  (Q8Z187), MUTL_SALTY  (P14161), 
MUTL_SERP5  (A8G8U7), MUTL_SHEAM  (A1SA23), MUTL_SHEB5  (A3D022), 
MUTL_SHEB8  (A6WSV4), MUTL_SHEB9  (A9L3W1), MUTL_SHEDO  (Q12J93), 
MUTL_SHEFN  (Q07XW5), MUTL_SHEHH  (B0TU66), MUTL_SHELP  (A3QAD8), 
MUTL_SHEON  (Q8EJ70), MUTL_SHEPA  (A8H8G8), MUTL_SHEPW  (B8CIX3), 
MUTL_SHESA  (A0KSR5), MUTL_SHESH  (A8FRD3), MUTL_SHESM  (Q0HMP1), 
MUTL_SHESR  (Q0HR40), MUTL_SHEWM  (B1KHV0), MUTL_SHIB3  (B2TY45), 
MUTL_SHIBS  (Q31TA0), MUTL_SHIDS  (Q328E9), MUTL_SHIF8  (Q0SXB2), 
MUTL_SHIFL  (Q83P35), MUTL_SHISS  (Q3YUH3), MUTL_SINFN  (C3MGW0), 
MUTL_SINMW  (A6U6K5), MUTL_SOLUE  (Q01QW7), MUTL_SPHAL  (Q1GSN3), 
MUTL_STAA1  (A7X1T8), MUTL_STAA2  (A6U1B5), MUTL_STAA3  (Q2FHE2), 
MUTL_STAA8  (Q93T05), MUTL_STAAC  (Q5HGD5), MUTL_STAAE  (A6QGJ5), 
MUTL_STAAM  (P65491), MUTL_STAAN  (P65492), MUTL_STAAR  (Q6GHD9), 
MUTL_STAAS  (Q6G9R7), MUTL_STAAT  (A8Z1W7), MUTL_STAAW  (Q8NWX9), 
MUTL_STACT  (B9DPC0), MUTL_STAEQ  (Q5HPP4), MUTL_STAES  (Q8CPE9), 
MUTL_STAS1  (Q49X89), MUTL_STRA1  (Q3JYM6), MUTL_STRA3  (Q8E2R5), 
MUTL_STRE4  (C0MAS4), MUTL_STREM  (B4U0J7), MUTL_STRMU  (Q8DRX0), 
MUTL_STRP1  (Q99XN7), MUTL_STRP2  (Q04MR4), MUTL_STRP3  (P0DC58), 
MUTL_STRP4  (B5E6C5), MUTL_STRP6  (Q5X9H5), MUTL_STRP8  (Q8NZ25), 
MUTL_STRPB  (Q1J9C2), MUTL_STRPC  (Q1JJH1), MUTL_STRPG  (A2RGV3), 
MUTL_STRPI  (B1I8F2), MUTL_STRPJ  (B8ZKC9), MUTL_STRPQ  (P0DC59), 
MUTL_STRPS  (B2IS10), MUTL_STRPZ  (B5XJ09), MUTL_STRS7  (C0MGC4), 
MUTL_STRT1  (Q5M1Y6), MUTL_STRT2  (Q5M6H7), MUTL_STRTD  (Q03MY0), 
MUTL_STRU0  (B9DW70), MUTL_STRZJ  (C1CBX8), MUTL_STRZP  (C1CI68), 
MUTL_STRZT  (C1CP43), MUTL_STUS1  (A4VQP2), MUTL_SYMTH  (Q67NL0), 
MUTL_SYNAS  (Q2LUR5), MUTL_SYNC1  (Q3A504), MUTL_SYNFM  (A0LJK2), 
MUTL_SYNWW  (Q0AYB2), MUTL_SYNY3  (P73349), MUTL_THEAB  (B7IHA2), 
MUTL_THEM4  (A6LL30), MUTL_THEMA  (P74925), MUTL_THENN  (B9K7B8), 
MUTL_THEP3  (B0K9L6), MUTL_THEPX  (B0K1A3), MUTL_THEYD  (B5YIZ6), 
MUTL_THIDA  (Q3SIQ5), MUTL_TOLAT  (C4L9N1), MUTL_TREPA  (O83325), 
MUTL_TRIL1  (B3E5Z2), MUTL_TRIV2  (Q3MEV6), MUTL_VIBC3  (A5F3L5), 
MUTL_VIBCH  (Q9KV13), MUTL_VIBCM  (C3LR77), MUTL_VIBPA  (Q87L05), 
MUTL_VIBVU  (Q8DCV0), MUTL_VIBVY  (Q7MH01), MUTL_WOLTR  (Q5GSP0), 
MUTL_WOLWR  (C0R515), MUTL_XANAC  (Q8PJX2), MUTL_XANC5  (Q3BSD0), 
MUTL_XANC8  (Q4UVP3), MUTL_XANCB  (B0RRZ8), MUTL_XANCP  (Q8P8E4), 
MUTL_XANOM  (Q2P295), MUTL_XANOP  (B2SHP8), MUTL_XANOR  (Q5GZ85), 
MUTL_XYLF2  (B2I9E6), MUTL_XYLFA  (Q9PFB8), MUTL_XYLFM  (B0U5C6), 
MUTL_XYLFT  (Q87AC9), MUTL_YERE8  (A1JIR3), MUTL_YERP3  (A7FMY1), 
MUTL_YERPA  (Q1C0Z8), MUTL_YERPB  (B2K202), MUTL_YERPE  (Q8ZIW4), 
MUTL_YERPG  (A9QYN3), MUTL_YERPN  (Q1CEF3), MUTL_YERPP  (A4TRP1), 
MUTL_YERPS  (Q66FB7), MUTL_YERPY  (B1JMP1), PM2P1_HUMAN (A4D2B8), 
PMS1_ARATH  (Q941I6), PMS1_DICDI  (Q54QA0), PMS1_HUMAN  (P54277), 
PMS1_SCHPO  (P54280), PMS1_YEAST  (P14242), PMS2_CHICK  (F1NQJ3), 
PMS2_HUMAN  (P54278), PMS2_MOUSE  (P54279)
» more

UniProtKB/Swiss-Prot
False negative sequences		 10 sequences 

MUTL_ANAD2  (B8J9F5), MUTL_ANADE  (Q2IIL0), MUTL_ANASK  (B4UCW3), 

MUTL_CYTH3  (Q11Z58), MUTL_MYXXD  (Q1D568), MUTL_STRGC  (A8AZU1), 
MUTL_STRSV  (A3CR14), MUTL_THEAQ  (P96082), MUTL_THET2  (Q72J22), 
MUTL_THET8  (Q9RA54)
» more

UniProtKB/Swiss-Prot
False positive sequences		 3 sequences 

S2542_HUMAN (Q86VD7), S2542_MOUSE (Q8R0Y8), S2542_RAT   (P0C546)


				
	

	

		PDB
[Detailed view]		
		
			25 PDB
			


			1B62; 1B63; 1BKN; 1EA6; 1H7S; 1H7U; 1NHH; 1NHI; 1NHJ; 3H4L; 4P7A; 5AKB; 
			
				5AKC; 5AKD; 5X9Y; 6LZI; 6LZJ; 6LZK; 6MFQ; 7AIB; 7AIC; 7P8V; 7RCB; 7RCI; 
				7RCK
			
			

			» more