Mismatch repair contributes to the overall fidelity of DNA replication [1]. It
involves the correction of mismatched base pairs that have been missed by the
proofreading element of the DNA polymerase complex. The sequence of some
proteins involved in mismatch repair in different organisms have been found to
be evolutionary related. These proteins are:
Escherichia coli and Salmonella typhimurium mutL protein [2]. MutL is
required for dam-dependent methyl-directed DNA repair.
Streptococcus pneumoniae hexB protein [3]. The Hex system is nick directed.
Human protein MLH1 [5] which is involved in a form of familial hereditary
nonpolyposis colon cancer (HNPCC).
As a signature pattern for this class of mismatch repair proteins we selected
a perfectly conserved heptapeptide which is located in the N-terminal section
of these proteins.
Nucleotide sequence of the Salmonella typhimurium mutL gene required for mismatch repair: homology of MutL to HexB of Streptococcus pneumoniae and to PMS1 of the yeast Saccharomyces cerevisiae.
Nucleotide sequence of the Streptococcus pneumoniae hexB mismatch repair gene: homology of HexB to MutL of Salmonella typhimurium and to PMS1 of Saccharomyces cerevisiae.
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see prosite_license.html.