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PROSITE entry PS00074


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PURL: https://purl.expasy.org/prosite/signature/PS00074

Direct ScanProsite submission
General information about the entry

Entry name [info] GLFV_DEHYDROGENASE
Accession [info] PS00074
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-NOV-1997 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00071
Associated ProRule [info] PRU10011

Name and characterization of the entry

Description [info] Glu / Leu / Phe / Val dehydrogenases active site.
Pattern [info] 
[LIV]-x(2)-G-G-[SAG]-K-x-[GV]-x(3)-[DNST]-[PL].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 112 in 112 different sequences
Number of true positive hits 109 in 109 different sequences
Number of 'unknown' hits 0
Number of false positive hits 3 in 3 different sequences
Number of false negative sequences 14
Number of 'partial' sequences 3
Precision (true positives / (true positives + false positives)) 97.32 %
Recall (true positives / (true positives + false negatives)) 88.62 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 6
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 109 sequences 

DHE1_ARATH  (Q43314), DHE1_ORYSI  (A2XMV1), DHE1_ORYSJ  (Q852M0), 

DHE2_ARATH  (Q38946), DHE2_BACFR  (P94316), DHE2_BACSU  (P39633), 
DHE2_CLODI  (P27346), DHE2_CLOSY  (P24295), DHE2_HALSI  (P29051), 
DHE2_NEUCR  (P00365), DHE2_PEPAS  (P28997), DHE2_PORG3  (B2RKJ1), 
DHE2_PORGI  (P0C934), DHE2_SACS2  (P80053), DHE2_STAAC  (Q5HHC7), 
DHE2_STAAM  (Q99VD0), DHE2_STAAN  (Q7A6H8), DHE2_STAAR  (Q6GID0), 
DHE2_STAAS  (Q6GAW8), DHE2_STAAW  (Q7A1B9), DHE2_YEAST  (P33327), 
DHE3_AERPE  (Q9YC65), DHE3_ARATH  (Q9S7A0), DHE3_BACTN  (P94598), 
DHE3_BOVIN  (P00366), DHE3_CHICK  (P00368), DHE3_DICDI  (Q54KB7), 
DHE3_DROME  (P54385), DHE3_HUMAN  (P00367), DHE3_MAIZE  (Q43260), 
DHE3_MOUSE  (P26443), DHE3_ORYSJ  (Q6H3Y7), DHE3_PIG(P42174), 
DHE3_PYRAB  (Q47950), DHE3_PYREN  (Q47951), DHE3_PYRFU  (P80319), 
DHE3_PYRHO  (P0CL73), DHE3_PYRHR  (P0CL72), DHE3_RAT(P10860), 
DHE3_SOLLC  (P93541), DHE3_THEKO  (O59650), DHE3_THELN  (Q56304), 
DHE3_THEMA  (P96110), DHE3_THEPR  (O74024), DHE3_VITVI  (P52596), 
DHE4_AGABI  (P54387), DHE4_BOTFU  (O93934), DHE4_CHLSO  (P28998), 
DHE4_COREF  (Q8RQP4), DHE4_CORGL  (P31026), DHE4_ECOLI  (P00370), 
DHE4_EMENI  (P18819), DHE4_FUSFU  (Q96VJ7), DHE4_GIAIN  (P28724), 
DHE4_GORGO  (Q64I01), DHE4_HAEIN  (P43793), DHE4_HALSA  (Q9HRM7), 
DHE4_HALSI  (Q5MBG2), DHE4_HEBCY  (Q96UJ9), DHE4_HELPJ  (Q9ZKD8), 
DHE4_HELPY  (P55990), DHE4_HUMAN  (P49448), DHE4_HYLLA  (Q64HZ9), 
DHE4_LACBS  (P54388), DHE4_NEUCR  (P00369), DHE4_NEUIN  (Q9HGU4), 
DHE4_NEUSI  (Q9HGU3), DHE4_PANTR  (Q64HZ8), DHE4_PENCH  (Q9URS1), 
DHE4_PONPY  (Q64I00), DHE4_PSYT1  (Q9S1F9), DHE4_SACSH  (P39475), 
DHE4_SACU7  (Q8TFF6), DHE4_SALTI  (Q8Z6F6), DHE4_SALTY  (P15111), 
DHE4_SCHOC  (P29507), DHE4_SCHPO  (P78804), DHE4_SYNY3  (P54386), 
DHE4_TUBBO  (Q9HFR6), DHE4_UNKP   (P14657), DHE4_XYLRU  (P95544), 
DHE4_YEAST  (P07262), DHE5_YEAST  (P39708), DHEB_HALSA  (P0DMG4), 
DHEB_HALSI  (P0DMG3), DHEB_NICPL  (Q9LEC8), DHE_HALSA   (Q9HQE1), 
DHE_HALSI   (F2Z610), DHLE_BACCE  (P0A393), DHLE_BACCR  (P0A392), 
DHLE_BACLI  (Q53560), DHLE_BACSU  (P54531), DHLE_GEOSE  (P13154), 
DHLE_THEIN  (Q60030), DHPH_BACBA  (Q59224), DHPH_BACTR  (A0A0F5HSE8), 
DHPH_CALTT  (F5L9G2), DHPH_LYSSH  (P23307), DHPH_RHOJR  (Q0SG95), 
DHPH_SPOUR  (P97014), DHPH_THEIN  (P22823), GUDB_BACSU  (P50735), 
TRPDH_NOSP7 (B2IXH4), TRPDH_NOSPU (W8CV45), VDH_STRA4   (O69056), 
VDH_STRAM   (P42709), VDH_STRCO   (Q06539), VDH_STRFR   (P40176), 
VDH_STRVG   (Q53872)
» more

UniProtKB/Swiss-Prot
False negative sequences		 14 sequences 

DHE2_ACHKL  (P41755), DHE2_HALED  (E1V4J5), DHE2_MYCS2  (A0R1C2), 

DHE2_MYCTU  (O53203), DHE2_ORYSI  (A2XW22), DHE2_ORYSJ  (Q33E23), 
DHE2_PSEAE  (Q9HZE0), DHE2_PYRCJ  (A3MUY9), DHE3_CHAAC  (P82264), 
DHE3_SINFN  (Q53199), DHE4_PYRCJ  (A3MWK6), DHEA_NICPL  (O04937), 
DHPH_RHOSO  (Q59771), GLUD2_DICDI (Q54VI3)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 3 sequences 

DHE2_THUTH  (P20016), DHE3_ELEEL  (P28270), DHE3_PYRWO  (Q09115)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			3 sequences
			


			
CHM4C_DANRE (Q6IQ73), IRC3_YEAST  (Q06683), SEC24_DICDI (Q54U61)


				
	

	

		PDB
[Detailed view]		
		
			86 PDB
			


			pdb_00001aup; pdb_00001b26; pdb_00001b3b; pdb_00001bgv; pdb_00001bvu; pdb_00001euz; pdb_00001gtm; pdb_00001hrd; pdb_00001hwy; pdb_00001k89; pdb_00001l1f; pdb_00001nqt; 
			
				pdb_00001nr1; pdb_00001nr7; pdb_00002tmg; pdb_00002yfh; pdb_00002yfq; pdb_00003etd; pdb_00003ete; pdb_00003etg; pdb_00003jcz; pdb_00003jd0; pdb_00003jd1; pdb_00003jd2; 
				pdb_00003jd3; pdb_00003jd4; pdb_00003k8z; pdb_00003k92; pdb_00003sbo; pdb_00004bht; pdb_00005b37; pdb_00005ijz; pdb_00005k12; pdb_00006dhd; pdb_00006dhk; pdb_00006dhl; 
				pdb_00006dhm; pdb_00006dhn; pdb_00006dhq; pdb_00006dqg; pdb_00006g2u; pdb_00006jn9; pdb_00006jna; pdb_00006jnc; pdb_00006jnd; pdb_00006yeh; pdb_00006yei; pdb_00007mft; 
				pdb_00007uzm; pdb_00007vda; pdb_00008ew0; pdb_00008hho; pdb_00008hiq; pdb_00008hiz; pdb_00008hj3; pdb_00008hj9; pdb_00008kgy; pdb_00008owm; pdb_00008own; pdb_00008sk8; 
				pdb_00008w4j; pdb_00008xco; pdb_00008xcp; pdb_00008xcq; pdb_00008xcr; pdb_00008xcs; pdb_00008xct; pdb_00008xcu; pdb_00008xcv; pdb_00008xcw; pdb_00008xcx; pdb_00008xcy; 
				pdb_00008xcz; pdb_00008xd0; pdb_00008xd1; pdb_00008xd2; pdb_00008xd3; pdb_00008xd4; pdb_00008xd5; pdb_00008xd6; pdb_00008zmu; pdb_00008znb; pdb_00008znc; pdb_00008znd; 
				pdb_00008zne; pdb_00008zng
			
			

			» more