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PROSITE entry PS00079


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General information about the entry

Entry name [info] MULTICOPPER_OXIDASE1
Accession [info] PS00079
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00076

Name and characterization of the entry

Description [info] Multicopper oxidases signature 1.
Pattern [info]
G-x-[FYW]-x-[LIVMFYW]-x-[CST]-x-{PR}-{K}-x(2)-{S}-x-{LFH}-G-[LM]-x(3)-
[LIVMFYW].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_03 which contains 571'609 sequence entries.


Total number of hits 249 in 193 different sequences
Number of true positive hits 203 in 147 different sequences
Number of 'unknown' hits 1
Number of false positive hits 45 in 45 different sequences
Number of false negative sequences 19
Number of 'partial' sequences 8
Precision (true positives / (true positives + false positives)) 81.85 %
Recall (true positives / (true positives + false negatives)) 91.44 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 3
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
147 sequences

ABR1_ASPFU  (Q4WZB4), ABR2_ASPFU  (E9RBR0), ASO_ARATH   (Q8LPL3), 
ASO_BRARP   (M4DUF2), ASO_CUCMA   (P24792), ASO_CUCPM   (P37064), 
ASO_CUCSA   (P14133), ASO_TOBAC   (Q40588), AURB_CHLAA  (P27197), 
AURL2_GIBZE (I1RF64), CERU_HUMAN  (P00450), CERU_MOUSE  (Q61147), 
CERU_RAT(P13635), CERU_SHEEP  (Q9XT27), COPA_PSESM  (P59571), 
COPA_PSEUB  (P12374), CTB12_CERBT (A0A2G5I8N8), ELCG_PHANO  (Q0UHZ8), 
FA5V_OXYMI  (Q58L90), FA5V_OXYSU  (Q58L91), FA5V_PSETE  (Q7SZN0), 
FA5_BOVIN   (Q28107), FA5_HUMAN   (P12259), FA5_MOUSE   (O88783), 
FA5_PIG (Q9GLP1), FA5_PSETE   (Q593B6), FA8_CANLF   (O18806), 
FA8_HUMAN   (P00451), FA8_MOUSE   (Q06194), FA8_PIG (P12263), 
FER1_USTMA  (Q4PIF8), FET3_CANAX  (P78591), FET3_CANGA  (Q96WT3), 
FET3_GIBZE  (I1RMG9), FET3_KLULA  (Q6CII3), FET3_YEAST  (P38993), 
FET5_YEAST  (P43561), FETC_ASPFU  (E9R598), FETC_EPIFE  (K7NCS2), 
FIO1_SCHPO  (Q09920), GEDJ_ASPTN  (Q0CCX6), GIP1_GIBZE  (I1RF62), 
GMC1_YEAST  (Q04399), GME65_PESMI (A0A5B8YWJ2), HEPHL_ACRMI (B3EWZ9), 
HEPH_HUMAN  (Q9BQS7), HEPH_MOUSE  (Q9Z0Z4), HEPH_RAT(Q920H8), 
HPHL1_HUMAN (Q6MZM0), HPHL1_MOUSE (Q3V1H3), LAC10_ARATH (Q6ID18), 
LAC10_ORYSJ (Q10ND7), LAC11_ARATH (Q8VZA1), LAC11_ORYSJ (Q0DHL5), 
LAC12_ARATH (Q9FLB5), LAC12_ORYSJ (B9FJH4), LAC13_ARATH (Q9LYQ2), 
LAC13_ORYSJ (P0DKK6), LAC14_ARATH (Q9FY79), LAC15_ARATH (Q84J37), 
LAC15_ORYSJ (Q339K6), LAC16_ARATH (Q1PDH6), LAC16_ORYSJ (Q7XE50), 
LAC17_ARATH (Q9FJD5), LAC17_ORYSJ (Q2RBK2), LAC18_ORYSI (A2XCN6), 
LAC18_ORYSJ (Q53LU4), LAC19_ORYSI (A2Y9C5), LAC19_ORYSJ (Q2R0L2), 
LAC1_AGABI  (Q12541), LAC1_ARATH  (Q9LMS3), LAC1_ARTBC  (D4APX3), 
LAC1_BOTFU  (Q12570), LAC1_CRYPA  (Q03966), LAC1_FOMSC  (S8FIE4), 
LAC1_MELAO  (Q70KY3), LAC1_NEUCR  (P06811), LAC1_ORYSJ  (Q5ZCW1), 
LAC1_PHLRA  (Q01679), LAC1_PLEOS  (Q12729), LAC1_PYCCI  (O59896), 
LAC1_THACU  (P56193), LAC1_TRAHI  (Q02497), LAC1_TRAMX  (D0VWU3), 
LAC1_TRAVI  (Q99044), LAC20_ORYSI (A2Y9C2), LAC20_ORYSJ (Q2R0L0), 
LAC21_ORYSJ (Q2QZ80), LAC22_ORYSJ (Q0IQU1), LAC23_ORYSJ (Q2QYS3), 
LAC2_AGABI  (Q12542), LAC2_ARATH  (O81081), LAC2_BOTFU  (Q96WM9), 
LAC2_FOMSC  (S8FGV1), LAC2_ORYSJ  (Q8RYM9), LAC2_PLEOS  (Q12739), 
LAC2_PODAS  (P78722), LAC2_THACU  (Q02075), LAC2_TRAVE  (Q12718), 
LAC2_TRAVI  (Q99046), LAC3_ARATH  (Q56YT0), LAC3_BOTFU  (Q96UM2), 
LAC3_ORYSJ  (Q941X2), LAC3_THACU  (Q02079), LAC3_TRAVI  (Q99049), 
LAC4_ARATH  (O80434), LAC4_ORYSJ  (Q5N9X2), LAC4_TRAVE  (Q12719), 
LAC4_TRAVI  (Q99055), LAC5_ARATH  (Q9SIY8), LAC5_ORYSJ  (Q5N9W4), 
LAC5_TRAVE  (Q12717), LAC5_TRAVI  (Q99056), LAC6_ARATH  (Q9ZPY2), 
LAC6_ORYSJ  (Q5N7A3), LAC7_ORYSJ  (Q5N7B4), LAC9_ORYSJ  (Q6Z8L2), 
LACF_GANAU  (C0HLV7), LACS_TRAHI  (C0HLV6), LMCO1_THET4 (G2QFD0), 
MCE_TALPI   (A0A1S7IUL2), MCO_STAAR   (Q6GIX3), MCO_STAAU   (Q69HT9), 
MCO_STAES   (Q8CQF6), MCO_STAHJ   (Q4LAB0), MLAC1_METAF (A0A0B4F1I0), 
MLAC1_METAN (C3SAH7), MLAC1_METAQ (E9E686), MLAC1_METAS (A0A0B2WJN5), 
MLAC1_METBS (A0A0B4F5S2), MLAC1_METGA (A0A0B4GLB5), MLAC1_METMF (A0A0B4HQH6), 
MLAC1_METRA (E9F648), MMCO_MYCTU  (I6WZK7), NRHAO_KUEST (P0DV45), 
PCOA_ECOLX  (Q47452), PFMAD_PESFW (W3X7K0), PFMAY_PESFW (W3X732), 
PHSA_STRAT  (Q53692), RUS1_ACIFR  (P23742), RUS2_ACIFI  (P0C918), 
RUS_ACIF2   (B7JAQ0), SOXE_SULAC  (Q53765), TERE_ASPTN  (Q0D1P3), 
TPCJ_ASPFU  (Q4WQY8), USTL_USTVR  (A0A4Y6F0M8), VDTB1_BYSSP (A0A443HK79)
» more

UniProtKB/Swiss-Prot
False negative sequences
19 sequences

COTA_BACIT  (A0A7T1FRB0), COTA_BACSU  (P07788), LAC14_ORYSJ (Q69L99), 
LAC1_EMENI  (P17489), LAC24_ORYSJ (Q2QUN2), LAC25_ORYSJ (Q0IP28), 
LAC4_THACU  (Q02081), LAC7_ARATH  (Q9SR40), LAC8_ARATH  (Q9LFD2), 
LAC8_ORYSJ  (Q0JHP8), LAC9_ARATH  (Q9LFD1), LACC_HALVD  (D4GPK6), 
LPR1_ARATH  (F4I4K5), LPR1_ORYSJ  (Q9AWU4), LPR2_ARATH  (Q949X9), 
LPR2_ORYSJ  (Q5ZE07), LPR3_ORYSJ  (Q5ZE00), LPR4_ORYSJ  (Q7F757), 
LPR5_ORYSJ  (A2ZNT5)
» more

UniProtKB/Swiss-Prot
'Partial' sequences
8 sequences

LAC1B_CERUI (P85308), LAC1_GALSP  (P86351), LAC2D_CERUI (P85430), 
LAC2_CERUI  (P85149), LACC1_CERUI (P86328), LACC2_CERUI (P86327), 
LAC_AGAPC   (B3EWI3), MCOL1_ZINEL (P85414)
» more

UniProtKB/Swiss-Prot
'Unknown' sequences
1 sequence

COPI_RUBGE  (W8FLH9)

		
UniProtKB/Swiss-Prot
False positive sequences
45 sequences

ACCD_CALFG  (Q7YIX5), AGRV1_DANRE (Q6JAN0), AL15_ASPFU  (O60022), 
AMP2_CAEEL  (Q22531), AUNC_ASPNA  (G3XSI4), AUNC_ASPNC  (A2QBE9), 
BFOC_ASPBC  (A0A1L9UQW4), BPT_GRABC   (Q0BTF8), CALI_BOVIN  (Q28068), 
CALI_HUMAN  (Q13939), CALI_MOUSE  (Q8CDE2), CALI_RAT(Q5XI58), 
DPO3A_STAEQ (Q5HNK2), DPO3A_STAES (Q8CNX0), DPOL1_SULOH (O50607), 
EXG1_YEAST  (P23776), EXG_SACU7   (Q876J3), FPOH_METAC  (Q8TQP1), 
HYAL4_HUMAN (Q2M3T9), HYAL_CONCN  (I0CME7), IMCL2_ORYSJ (Q5VNW5), 
MFS55_MYCLE (Q9CCP7), MGLA_CLOTE  (Q896Y2), NDVA_RHOP2  (Q2J0F4), 
NDVA_RHOPS  (Q13BH6), NUD17_ARATH (Q9ZU95), PEPT_PASMU  (Q9CP05), 
PTTBC_BACSU (P39794), RIR1_TRYBB  (O15909), S15A4_BOVIN (A6QQL0), 
S15A4_HUMAN (Q8N697), S15A4_MOUSE (Q91W98), S15A4_RAT   (O09014), 
S15A4_XENLA (Q68F72), SIM2_MOUSE  (Q61079), THII_COXBU  (Q83CD9), 
UT1_CAPHI   (D3INW7), UT1_HUMAN   (Q13336), UT1_MOUSE   (Q8VHL0), 
UT1_RAT (P97689), UT1_SHEEP   (C5MK33), UT2_HUMAN   (Q15849), 
UT2_MOUSE   (Q8R4T9), UT2_RAT (Q62668), Y3934_DICDI (Q54B29)
» more

PDB
[Detailed view]
57 PDB

1A3Z; 1A8Z; 1AOZ; 1ASO; 1ASP; 1ASQ; 1CUR; 1GW0; 1GY1; 1GY2; 1GYC; 1KCW; 1OV8; 1QHQ; 1RCY; 1SDD; 1ZPU; 2CAK; 2CAL; 2H5U; 2IH8; 2IH9; 2J5W; 2Q9O; 2R7E; 3CDZ; 3DIV; 3DKH; 3FU7; 3FU8; 3FU9; 3GYR; 3J2Q; 3J2S; 3QPK; 4BDV; 4BXS; 4EJX; 4ENZ; 5K8D; 5N0K; 5N4L; 6MF0; 6MF2; 7K66; 7KBT; 7KVE; 7KVF; 7KWO; 7KXY; 7TPP; 7TPQ; 7ZN6; 8FDG; 8G6I; 8TN9; 8TY1
» more