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PROSITE entry PS00080


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PURL: https://purl.expasy.org/prosite/signature/PS00080

Direct ScanProsite submission
General information about the entry

Entry name [info] MULTICOPPER_OXIDASE2
Accession [info] PS00080
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-OCT-1993 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00076

Name and characterization of the entry

Description [info] Multicopper oxidases signature 2.
Pattern [info] 
H-C-H-x(3)-H-x(3)-[AG]-[LM].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2026_01 which contains 574'627 sequence entries.


Total number of hits 132 in 132 different sequences
Number of true positive hits 129 in 129 different sequences
Number of 'unknown' hits 0
Number of false positive hits 3 in 3 different sequences
Number of false negative sequences 22
Number of 'partial' sequences 6
Precision (true positives / (true positives + false positives)) 97.73 %
Recall (true positives / (true positives + false negatives)) 85.43 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] copper_3 at position 1
Site [info] copper_1 at position 2
Site [info] copper_3 at position 3
Site [info] copper_1 at position 5
Site [info] copper_1 at position 8
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 129 sequences 

ABR1_ASPFU  (Q4WZB4), ABR2_ASPFU  (E9RBR0), ASO_ARATH   (Q8LPL3), 

ASO_BRARP   (M4DUF2), ASO_CUCMA   (P24792), ASO_CUCPM   (P37064), 
ASO_CUCSA   (P14133), ASO_TOBAC   (Q40588), AURL2_GIBZE (I1RF64), 
CCDJ_CHAGB  (Q2GPS9), CERU_HUMAN  (P00450), CERU_MOUSE  (Q61147), 
CERU_RAT(P13635), CERU_SHEEP  (Q9XT27), COPA_PSESM  (P59571), 
COPA_PSEUB  (P12374), CTB12_CERBT (A0A2G5I8N8), CUEO_ECO57  (Q8X947), 
CUEO_ECOLI  (P36649), CUEO_SALTI  (Q8Z9E1), CUEO_SALTY  (Q8ZRS2), 
CUEO_YERPE  (Q8ZBK0), ELCG_PHANO  (Q0UHZ8), FER1_MYCMD  (Q4PIF8), 
FET3_CANAX  (P78591), FET3_CANGA  (Q96WT3), FET3_GIBZE  (I1RMG9), 
FET3_KLULA  (Q6CII3), FET3_YEAST  (P38993), FET5_YEAST  (P43561), 
FETC_ASPFU  (E9R598), FETC_EPIFE  (K7NCS2), FIO1_SCHPO  (Q09920), 
GEDJ_ASPTN  (Q0CCX6), GIP1_GIBZE  (I1RF62), GMC1_YEAST  (Q04399), 
GME65_PESMI (A0A5B8YWJ2), HEPHL_ACRMI (B3EWZ9), HEPH_HUMAN  (Q9BQS7), 
HEPH_MOUSE  (Q9Z0Z4), HEPH_RAT(Q920H8), HPHL1_HUMAN (Q6MZM0), 
HPHL1_MOUSE (Q3V1H3), LAC10_ARATH (Q6ID18), LAC10_ORYSJ (Q10ND7), 
LAC11_ARATH (Q8VZA1), LAC11_ORYSJ (Q0DHL5), LAC12_ARATH (Q9FLB5), 
LAC12_ORYSJ (B9FJH4), LAC13_ARATH (Q9LYQ2), LAC13_ORYSJ (P0DKK6), 
LAC14_ARATH (Q9FY79), LAC14_ORYSJ (Q69L99), LAC15_ARATH (Q84J37), 
LAC15_ORYSJ (Q339K6), LAC16_ARATH (Q1PDH6), LAC16_ORYSJ (Q7XE50), 
LAC17_ARATH (Q9FJD5), LAC17_ORYSJ (Q2RBK2), LAC18_ORYSI (A2XCN6), 
LAC18_ORYSJ (Q53LU4), LAC19_ORYSI (A2Y9C5), LAC19_ORYSJ (Q2R0L2), 
LAC1_AGABI  (Q12541), LAC1_ARATH  (Q9LMS3), LAC1_ARTBC  (D4APX3), 
LAC1_BOTFU  (Q12570), LAC1_CRYPA  (Q03966), LAC1_EMENI  (P17489), 
LAC1_MELAO  (Q70KY3), LAC1_NEUCR  (P06811), LAC1_ORYSJ  (Q5ZCW1), 
LAC1_PLEOS  (Q12729), LAC20_ORYSI (A2Y9C2), LAC20_ORYSJ (Q2R0L0), 
LAC21_ORYSJ (Q2QZ80), LAC22_ORYSJ (Q0IQU1), LAC23_ORYSJ (Q2QYS3), 
LAC24_ORYSJ (Q2QUN2), LAC25_ORYSJ (Q0IP28), LAC2_AGABI  (Q12542), 
LAC2_ARATH  (O81081), LAC2_BOTFU  (Q96WM9), LAC2_ORYSJ  (Q8RYM9), 
LAC2_PLEOS  (Q12739), LAC2_PODAS  (P78722), LAC3_ANOGA  (A5YVV0), 
LAC3_ARATH  (Q56YT0), LAC3_BOTFU  (Q96UM2), LAC3_ORYSJ  (Q941X2), 
LAC3_TRAVI  (Q99049), LAC4_ARATH  (O80434), LAC4_ORYSJ  (Q5N9X2), 
LAC5_ARATH  (Q9SIY8), LAC5_ORYSJ  (Q5N9W4), LAC6_ARATH  (Q9ZPY2), 
LAC6_ORYSJ  (Q5N7A3), LAC7_ARATH  (Q9SR40), LAC7_ORYSJ  (Q5N7B4), 
LAC8_ORYSJ  (Q0JHP8), LAC9_ORYSJ  (Q6Z8L2), LMCO1_THET4 (G2QFD0), 
LPR1_ORYSJ  (Q9AWU4), LPR3_ORYSJ  (Q5ZE00), LPR4_ORYSJ  (Q7F757), 
LPR5_ORYSJ  (A2ZNT5), MCE_TALPI   (A0A1S7IUL2), MCO_STAAR   (Q6GIX3), 
MCO_STAAU   (Q69HT9), MCO_STAES   (Q8CQF6), MCO_STAHJ   (Q4LAB0), 
MLAC1_METAF (A0A0B4F1I0), MLAC1_METAN (C3SAH7), MLAC1_METAQ (E9E686), 
MLAC1_METAS (A0A0B2WJN5), MLAC1_METBS (A0A0B4F5S2), MLAC1_METGA (A0A0B4GLB5), 
MLAC1_METMF (A0A0B4HQH6), MLAC1_METRA (E9F648), MMCO_MYCTU  (I6WZK7), 
OPS5_BEAB2  (J5JH35), PCOA_ECOLX  (Q47452), PFMAD_PESFW (W3X7K0), 
PHSA_STRAT  (Q53692), TERE_ASPTN  (Q0D1P3), TPCJ_ASPFU  (Q4WQY8), 
USTL_USTVR  (A0A4Y6F0M8), VDTB1_BYSSP (A0A443HK79), VIOL_TRIRC  (F2SL83)
» more

UniProtKB/Swiss-Prot
False negative sequences		 22 sequences 

COTA_BACIT  (A0A7T1FRB0), COTA_BACSU  (P07788), LAC1_PHLRA  (Q01679), 

LAC1_THACU  (P56193), LAC1_TRAHI  (Q02497), LAC1_TRAMX  (D0VWU3), 
LAC1_TRAVI  (Q99044), LAC2_THACU  (Q02075), LAC2_TRAVE  (Q12718), 
LAC2_TRAVI  (Q99046), LAC3_THACU  (Q02079), LAC4_THACU  (Q02081), 
LAC4_TRAVE  (Q12719), LAC4_TRAVI  (Q99055), LAC5_TRAVE  (Q12717), 
LAC5_TRAVI  (Q99056), LAC8_ARATH  (Q9LFD2), LAC9_ARATH  (Q9LFD1), 
LACC_HALVD  (D4GPK6), LPR1_ARATH  (F4I4K5), LPR2_ARATH  (Q949X9), 
LPR2_ORYSJ  (Q5ZE07)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 6 sequences 

LAC1B_CERUI (P85308), LAC1_GALSP  (P86351), LAC2D_CERUI (P85430), 

LAC2_CERUI  (P85149), LAC_AGAPC   (B3EWI3), MCOL1_ZINEL (P85414)
» more

UniProtKB/Swiss-Prot
False positive sequences		 3 sequences 

SNAI3_HUMAN (Q3KNW1), SNAI3_MOUSE (Q9QY31), TMUB1_DANRE (Q6P135)


				
	

	

		PDB
[Detailed view]		
		
			56 PDB
			


			pdb_00001aoz; pdb_00001aso; pdb_00001asp; pdb_00001asq; pdb_00001gw0; pdb_00001kcw; pdb_00001kv7; pdb_00001n68; pdb_00001pf3; pdb_00001zpu; pdb_00002fqd; pdb_00002fqe; 
			
				pdb_00002fqf; pdb_00002fqg; pdb_00002ih8; pdb_00002ih9; pdb_00002j5w; pdb_00002q9o; pdb_00002yxv; pdb_00002yxw; pdb_00003dkh; pdb_00003fu7; pdb_00003fu8; pdb_00003fu9; 
				pdb_00003gyr; pdb_00003nsd; pdb_00003nsf; pdb_00003nsy; pdb_00003od3; pdb_00003pau; pdb_00003pav; pdb_00003qpk; pdb_00003qqx; pdb_00004e9q; pdb_00004e9r; pdb_00004e9s; 
				pdb_00004e9t; pdb_00004ef3; pdb_00004ejx; pdb_00004enz; pdb_00004hak; pdb_00004hal; pdb_00004ner; pdb_00005b7e; pdb_00005b7f; pdb_00005b7m; pdb_00005n0k; pdb_00005n4l; 
				pdb_00005ys1; pdb_00005ys5; pdb_00006im7; pdb_00006im8; pdb_00006im9; pdb_00007f0v; pdb_00007f19; pdb_00007zn6
			
			

			» more