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PROSITE entry PS00080


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00080
Entry name [info] MULTICOPPER_OXIDASE2
Accession [info] PS00080
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-OCT-1993 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00076

Name and characterization of the entry

Description [info] Multicopper oxidases signature 2.
Pattern [info] 
H-C-H-x(3)-H-x(3)-[AG]-[LM].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 129 in 129 different sequences
Number of true positive hits 126 in 126 different sequences
Number of 'unknown' hits 0
Number of false positive hits 3 in 3 different sequences
Number of false negative sequences 22
Number of 'partial' sequences 6
Precision (true positives / (true positives + false positives)) 97.67 %
Recall (true positives / (true positives + false negatives)) 85.14 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] copper_3 at position 1
Site [info] copper_1 at position 2
Site [info] copper_3 at position 3
Site [info] copper_1 at position 5
Site [info] copper_1 at position 8
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 126 sequences 

ABR1_ASPFU  (Q4WZB4), ABR2_ASPFU  (E9RBR0), ASO_ARATH   (Q8LPL3), 

ASO_BRARP   (M4DUF2), ASO_CUCMA   (P24792), ASO_CUCPM   (P37064), 
ASO_CUCSA   (P14133), ASO_TOBAC   (Q40588), AURL2_GIBZE (I1RF64), 
CERU_HUMAN  (P00450), CERU_MOUSE  (Q61147), CERU_RAT(P13635), 
CERU_SHEEP  (Q9XT27), COPA_PSESM  (P59571), COPA_PSEUB  (P12374), 
CTB12_CERBT (A0A2G5I8N8), CUEO_ECO57  (Q8X947), CUEO_ECOLI  (P36649), 
CUEO_SALTI  (Q8Z9E1), CUEO_SALTY  (Q8ZRS2), CUEO_YERPE  (Q8ZBK0), 
ELCG_PHANO  (Q0UHZ8), FER1_MYCMD  (Q4PIF8), FET3_CANAX  (P78591), 
FET3_CANGA  (Q96WT3), FET3_GIBZE  (I1RMG9), FET3_KLULA  (Q6CII3), 
FET3_YEAST  (P38993), FET5_YEAST  (P43561), FETC_ASPFU  (E9R598), 
FETC_EPIFE  (K7NCS2), FIO1_SCHPO  (Q09920), GEDJ_ASPTN  (Q0CCX6), 
GIP1_GIBZE  (I1RF62), GMC1_YEAST  (Q04399), GME65_PESMI (A0A5B8YWJ2), 
HEPHL_ACRMI (B3EWZ9), HEPH_HUMAN  (Q9BQS7), HEPH_MOUSE  (Q9Z0Z4), 
HEPH_RAT(Q920H8), HPHL1_HUMAN (Q6MZM0), HPHL1_MOUSE (Q3V1H3), 
LAC10_ARATH (Q6ID18), LAC10_ORYSJ (Q10ND7), LAC11_ARATH (Q8VZA1), 
LAC11_ORYSJ (Q0DHL5), LAC12_ARATH (Q9FLB5), LAC12_ORYSJ (B9FJH4), 
LAC13_ARATH (Q9LYQ2), LAC13_ORYSJ (P0DKK6), LAC14_ARATH (Q9FY79), 
LAC14_ORYSJ (Q69L99), LAC15_ARATH (Q84J37), LAC15_ORYSJ (Q339K6), 
LAC16_ARATH (Q1PDH6), LAC16_ORYSJ (Q7XE50), LAC17_ARATH (Q9FJD5), 
LAC17_ORYSJ (Q2RBK2), LAC18_ORYSI (A2XCN6), LAC18_ORYSJ (Q53LU4), 
LAC19_ORYSI (A2Y9C5), LAC19_ORYSJ (Q2R0L2), LAC1_AGABI  (Q12541), 
LAC1_ARATH  (Q9LMS3), LAC1_ARTBC  (D4APX3), LAC1_BOTFU  (Q12570), 
LAC1_CRYPA  (Q03966), LAC1_EMENI  (P17489), LAC1_MELAO  (Q70KY3), 
LAC1_NEUCR  (P06811), LAC1_ORYSJ  (Q5ZCW1), LAC1_PLEOS  (Q12729), 
LAC20_ORYSI (A2Y9C2), LAC20_ORYSJ (Q2R0L0), LAC21_ORYSJ (Q2QZ80), 
LAC22_ORYSJ (Q0IQU1), LAC23_ORYSJ (Q2QYS3), LAC24_ORYSJ (Q2QUN2), 
LAC25_ORYSJ (Q0IP28), LAC2_AGABI  (Q12542), LAC2_ARATH  (O81081), 
LAC2_BOTFU  (Q96WM9), LAC2_ORYSJ  (Q8RYM9), LAC2_PLEOS  (Q12739), 
LAC2_PODAS  (P78722), LAC3_ARATH  (Q56YT0), LAC3_BOTFU  (Q96UM2), 
LAC3_ORYSJ  (Q941X2), LAC3_TRAVI  (Q99049), LAC4_ARATH  (O80434), 
LAC4_ORYSJ  (Q5N9X2), LAC5_ARATH  (Q9SIY8), LAC5_ORYSJ  (Q5N9W4), 
LAC6_ARATH  (Q9ZPY2), LAC6_ORYSJ  (Q5N7A3), LAC7_ARATH  (Q9SR40), 
LAC7_ORYSJ  (Q5N7B4), LAC8_ORYSJ  (Q0JHP8), LAC9_ORYSJ  (Q6Z8L2), 
LMCO1_THET4 (G2QFD0), LPR1_ORYSJ  (Q9AWU4), LPR3_ORYSJ  (Q5ZE00), 
LPR4_ORYSJ  (Q7F757), LPR5_ORYSJ  (A2ZNT5), MCE_TALPI   (A0A1S7IUL2), 
MCO_STAAR   (Q6GIX3), MCO_STAAU   (Q69HT9), MCO_STAES   (Q8CQF6), 
MCO_STAHJ   (Q4LAB0), MLAC1_METAF (A0A0B4F1I0), MLAC1_METAN (C3SAH7), 
MLAC1_METAQ (E9E686), MLAC1_METAS (A0A0B2WJN5), MLAC1_METBS (A0A0B4F5S2), 
MLAC1_METGA (A0A0B4GLB5), MLAC1_METMF (A0A0B4HQH6), MLAC1_METRA (E9F648), 
MMCO_MYCTU  (I6WZK7), OPS5_BEAB2  (J5JH35), PCOA_ECOLX  (Q47452), 
PFMAD_PESFW (W3X7K0), PHSA_STRAT  (Q53692), TERE_ASPTN  (Q0D1P3), 
TPCJ_ASPFU  (Q4WQY8), USTL_USTVR  (A0A4Y6F0M8), VDTB1_BYSSP (A0A443HK79)
» more

UniProtKB/Swiss-Prot
False negative sequences		 22 sequences 

COTA_BACIT  (A0A7T1FRB0), COTA_BACSU  (P07788), LAC1_PHLRA  (Q01679), 

LAC1_THACU  (P56193), LAC1_TRAHI  (Q02497), LAC1_TRAMX  (D0VWU3), 
LAC1_TRAVI  (Q99044), LAC2_THACU  (Q02075), LAC2_TRAVE  (Q12718), 
LAC2_TRAVI  (Q99046), LAC3_THACU  (Q02079), LAC4_THACU  (Q02081), 
LAC4_TRAVE  (Q12719), LAC4_TRAVI  (Q99055), LAC5_TRAVE  (Q12717), 
LAC5_TRAVI  (Q99056), LAC8_ARATH  (Q9LFD2), LAC9_ARATH  (Q9LFD1), 
LACC_HALVD  (D4GPK6), LPR1_ARATH  (F4I4K5), LPR2_ARATH  (Q949X9), 
LPR2_ORYSJ  (Q5ZE07)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 6 sequences 

LAC1B_CERUI (P85308), LAC1_GALSP  (P86351), LAC2D_CERUI (P85430), 

LAC2_CERUI  (P85149), LAC_AGAPC   (B3EWI3), MCOL1_ZINEL (P85414)
» more

UniProtKB/Swiss-Prot
False positive sequences		 3 sequences 

SNAI3_HUMAN (Q3KNW1), SNAI3_MOUSE (Q9QY31), TMUB1_DANRE (Q6P135)


				
	

	

		PDB
[Detailed view]		
		
			56 PDB
			


			1AOZ; 1ASO; 1ASP; 1ASQ; 1GW0; 1KCW; 1KV7; 1N68; 1PF3; 1ZPU; 2FQD; 2FQE; 
			
				2FQF; 2FQG; 2IH8; 2IH9; 2J5W; 2Q9O; 2YXV; 2YXW; 3DKH; 3FU7; 3FU8; 3FU9; 
				3GYR; 3NSD; 3NSF; 3NSY; 3OD3; 3PAU; 3PAV; 3QPK; 3QQX; 4E9Q; 4E9R; 4E9S; 
				4E9T; 4EF3; 4EJX; 4ENZ; 4HAK; 4HAL; 4NER; 5B7E; 5B7F; 5B7M; 5N0K; 5N4L; 
				5YS1; 5YS5; 6IM7; 6IM8; 6IM9; 7F0V; 7F19; 7ZN6
			
			

			» more