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PROSITE entry PS00105


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00105
Entry name [info] AA_TRANSFER_CLASS_1
Accession [info] PS00105
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00098

Name and characterization of the entry

Description [info] Aminotransferases class-I pyridoxal-phosphate attachment site.
Pattern [info] 
[GS]-[LIVMFYTAC]-[GSTA]-K-x(2)-[GSALVN]-[LIVMFA]-x-[GNAR]-{V}-R-[LIVMA]-
[GA].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 190 in 190 different sequences
Number of true positive hits 170 in 170 different sequences
Number of 'unknown' hits 0
Number of false positive hits 20 in 20 different sequences
Number of false negative sequences 112
Number of 'partial' sequences 6
Precision (true positives / (true positives + false positives)) 89.47 %
Recall (true positives / (true positives + false negatives)) 60.28 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] pyridoxal_phosphate at position 4
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 170 sequences 

1A111_ARATH (Q9S9U6), 1A112_ARATH (Q8GYY0), 1A11_ARATH  (Q06429), 

1A11_CUCMA  (P23599), 1A11_CUCPE  (P23279), 1A11_ORYSI  (A2XLL2), 
1A11_ORYSJ  (Q10DK7), 1A11_PRUMU  (Q9MB95), 1A12_ARATH  (Q06402), 
1A12_CUCMA  (Q00257), 1A12_CUCPE  (Q00379), 1A12_ORYSJ  (Q7XQ85), 
1A12_SOLLC  (P18485), 1A13_ORYSJ  (A0A0P0WIY3), 1A13_SOLLC  (Q42881), 
1A14_ARATH  (Q43309), 1A14_ORYSJ  (Q5W6F9), 1A14_SOLLC  (P29535), 
1A15_ARATH  (Q37001), 1A15_ORYSJ  (A0A0P0UZP7), 1A16_ARATH  (Q9SAR0), 
1A16_ORYSJ  (Q9SNN8), 1A17_ARATH  (Q9STR4), 1A18_ARATH  (Q9T065), 
1A19_ARATH  (Q9M2Y8), 1A1C_DIACA  (P27486), 1A1C_MALDO  (P37821), 
1A1C_SOYBN  (P31531), 1A1C_TOBAC  (Q07262), 1A1C_VIGRR  (Q01912), 
1A1L1_TAKRU (Q9W698), AAPAT_CHLTE (Q8KDS8), AAPAT_NITEU (Q82WA8), 
AAPAT_RHILP (O86459), AAPAT_RHIME (Q02635), AAPAT_RICBR (Q1RGV0), 
AAPAT_RICCN (Q92JE7), AAPAT_RICFE (Q4UND3), AAPAT_RICPR (Q9ZE56), 
AAPAT_RICTY (Q68XV9), AAPAT_THEAQ (O33822), AAPAT_THET8 (Q56232), 
AAT1_ARATH  (P46643), AAT1_BACSU  (P53001), AAT1_MEDSA  (P28011), 
AAT2_ARATH  (P46645), AAT3_ARATH  (P46644), AAT3_BACSU  (O07587), 
AAT4_ARATH  (P46646), AAT5_ARATH  (P46248), AATC_BOVIN  (P33097), 
AATC_CAEEL  (Q22067), AATC_CHICK  (P00504), AATC_DAUCA  (P28734), 
AATC_HORSE  (P08906), AATC_HUMAN  (P17174), AATC_MACFA  (Q4R5L1), 
AATC_MOUSE  (P05201), AATC_ORYSJ  (P37833), AATC_PANTR  (A5A6K8), 
AATC_PIG(P00503), AATC_PONAB  (Q5R691), AATC_RAT(P13221), 
AATC_RHIME  (O87320), AATC_YEAST  (P23542), AATM_BOVIN  (P12344), 
AATM_CHICK  (P00508), AATM_DANRE  (Q7SYK7), AATM_DICDI  (Q55F21), 
AATM_HORSE  (P08907), AATM_HUMAN  (P00505), AATM_LUPAN  (P26563), 
AATM_MACFA  (Q4R559), AATM_MOUSE  (P05202), AATM_PIG(P00506), 
AATM_PONAB  (Q5REB0), AATM_RABIT  (P12345), AATM_RAT(P00507), 
AATM_SCHPO  (O94320), AATM_XENTR  (Q28F67), AATM_YEAST  (Q01802), 
AAT_BACY2   (P23034), AAT_ECOLI   (P00509), AAT_GEOSE   (Q59228), 
AAT_HAEIN   (P44425), AAT_METJA   (Q60317), AAT_MUSP7   (C6C2Z3), 
AAT_PSEAE   (P72173), AAT_PYRAB   (Q9V0L2), AAT_PYRHO   (O58489), 
AAT_RHIME   (P58350), AAT_RHIML   (Q06191), AAT_SACS2   (P14909), 
AAT_SALTI   (Q56114), AAT_SALTY   (P58661), AAT_STRAW   (Q82DR2), 
AAT_STRVG   (Q60013), AAT_SULAC   (Q4J8X2), AAT_SULTO   (Q972A2), 
AAT_SYNY3   (Q55128), AAT_THEKO   (O93744), AAT_THEMA   (Q9X0Y2), 
ARAT2_THELN (H3ZPU1), ARGM_STREL  (M1T1K4), ARUH_PSEAE  (Q9HUI9), 
ASDA_COMTE  (Q93QX0), ASDP_PSESP  (Q53IZ1), ATTY_BOVIN  (Q58CZ9), 
ATTY_DICDI  (Q54K95), ATTY_HUMAN  (P17735), ATTY_MOUSE  (Q8QZR1), 
ATTY_RAT(P04694), ATTY_RHIME  (Q02636), ATTY_TRYCR  (P33447), 
AVTA_MYCTU  (P96847), BACF_BACSU  (P39643), BNA3_YEAST  (P47039), 
C1436_CAMJE (Q0P8H8), COBC_PSEAE  (Q9I468), COBC_SINSX  (P21633), 
COBDQ_LEPIN (Q8EXQ7), COBD_SALTI  (Q8Z8H8), COBD_SALTY  (P97084), 
DAPAT_AQUAE (O66630), DAPAT_AZOPC (B6YRL2), DAPAT_CARHZ (Q3AC10), 
DAPAT_CHLMU (Q9PK04), DAPAT_CHLPN (Q9Z856), DAPAT_CHLT2 (B0B7W0), 
DAPAT_CHLTA (Q3KLW3), DAPAT_CHLTB (B0BC25), DAPAT_CHLTR (O84395), 
DAPAT_DEHM1 (Q3Z8H5), DAPAT_DEHMB (A5FRC5), DAPAT_DEHMC (Q3ZXC8), 
DAPAT_DESAP (B1I544), DAPAT_GLOVI (Q7NDX4), DAPAT_HALOH (B8CX89), 
DAPAT_LACP7 (A9KJ19), DAPAT_METJA (Q58786), DAPAT_METMP (Q6LX26), 
DAPAT_MOOTA (Q2RK33), DAPAT_NATTJ (B2A250), DAPAT_NITV2 (Q72BI1), 
DAPAT_NITV4 (A1VDD3), DAPAT_NITV9 (B8DJJ6), DAPAT_OLEA2 (Q30ZX9), 
DAPAT_SYNFM (A0LEA5), DAPT2_NOSS1 (Q8YP73), DAPT2_TRIV2 (Q3MDN5), 
DAPX_BACSU  (P16524), FRBH_STRR3  (Q0ZQ41), HIS82_HAEIN (Q57004), 
HSPAT_MYCBO (P63501), HSPAT_MYCTO (P9WQ88), HSPAT_MYCTU (P9WQ89), 
ISS1_ARATH  (Q9C969), MFNC_METJA  (Q58097), NOAT_STRMU  (Q8DTM1), 
OXYQ_STRRM  (Q3S8P9), PAT_ARATH   (Q9SIE1), PAT_PETHY   (E9L7A5), 
PAT_PINPS   (Q5F4K8), PHHC_PSEAE  (P43336), TYRB_ECOLI  (P04693), 
TYRB_KLEPN  (O85746), TYRB_SALTY  (P74861), UCDG_ASPUT  (A0A0C1E1D0), 
Y1178_MYCTU (O50434), YUGH_BACSU  (Q795M6)
» more

UniProtKB/Swiss-Prot
False negative sequences		 112 sequences 

1A110_ARATH (Q9LQ10), 1A1L1_BOVIN (Q5E9H2), 1A1L1_HUMAN (Q96QU6), 

1A1L1_MOUSE (A2AIG8), 1A1L2_HUMAN (Q4AC99), 1A1L2_MOUSE (Q3UX83), 
AAPAT_AQUAE (O67781), AAPAT_CERS1 (A3PMF8), AATC2_BOVIN (Q2T9S8), 
AATC2_HUMAN (Q8NHS2), AATC2_MOUSE (Q7TSV6), AATC_DICDI  (Q54SF7), 
AATC_SCHPO  (O42652), ALAA_ECOL6  (P0A960), ALAA_ECOLI  (P0A959), 
ALAA_HAEIN  (P71348), ALAA_MYCBO  (P63499), ALAA_MYCTO  (P9WQ90), 
ALAA_MYCTU  (P9WQ91), ALAA_SHIFL  (P0A961), ALAC_ECOLI  (P77434), 
ARAT1_THELN (H3ZPL1), ASPAT_CORGL (Q8NTR2), ASPAT_MYCTU (O69689), 
DAPAT_ACAM1 (B0CDH5), DAPAT_ACET2 (A3DK17), DAPAT_AGARV (C4ZG66), 
DAPAT_ARATH (Q93ZN9), DAPAT_BACFN (Q5LC03), DAPAT_BACFR (Q64SY6), 
DAPAT_BACTN (Q8AAB8), DAPAT_CHLAB (Q5L6M0), DAPAT_CHLCV (Q824A4), 
DAPAT_CHLFF (Q253K9), DAPAT_CITBB (B5EGX2), DAPAT_CROS5 (B1WSG7), 
DAPAT_CYAP4 (B8HJY4), DAPAT_DESAH (C0QFJ4), DAPAT_DESDA (B8IZX8), 
DAPAT_DESHD (Q18T09), DAPAT_DESHY (Q24S01), DAPAT_DESOH (A8ZXV5), 
DAPAT_DESPS (Q6AL81), DAPAT_GEODF (B9M384), DAPAT_GEOMG (Q39Z65), 
DAPAT_GEOSL (Q74GT3), DAPAT_GEOSM (C6E9Q7), DAPAT_GEOUR (A5GD93), 
DAPAT_GLOC7 (B7KL61), DAPAT_HELMI (B0TA38), DAPAT_LACE2 (C4Z4Y1), 
DAPAT_LAWIP (Q1MR87), DAPAT_LEPBA (B0SEH8), DAPAT_LEPBJ (Q04UL5), 
DAPAT_LEPBL (Q04YV8), DAPAT_LEPBP (B0SMK7), DAPAT_LEPIC (Q72NJ3), 
DAPAT_LEPIN (Q8F814), DAPAT_MARSD (C6BUK3), DAPAT_METS3 (A5UN82), 
DAPAT_METST (Q2NFU1), DAPAT_METTH (O26158), DAPAT_MICAN (B0JUM0), 
DAPAT_NOSP7 (B2J2U3), DAPAT_PARD8 (A6L8U2), DAPAT_PARMW (Q7U4C3), 
DAPAT_PARUW (Q6MDE0), DAPAT_PELPD (A1ATI6), DAPAT_PHOV8 (A6L7E4), 
DAPAT_PICP2 (B1XKF6), DAPAT_PROM0 (A3PEY9), DAPAT_PROM1 (A2C4T7), 
DAPAT_PROM3 (A2CC97), DAPAT_PROM4 (A9BCJ1), DAPAT_PROM5 (A2BYM6), 
DAPAT_PROM9 (Q318P3), DAPAT_PROMA (Q7VA14), DAPAT_PROMM (Q7V4Z3), 
DAPAT_PROMP (Q7UZZ3), DAPAT_PROMS (A2BT75), DAPAT_PROMT (Q46IX2), 
DAPAT_RIPO1 (B7JVL5), DAPAT_SYNC1 (Q3A1U5), DAPAT_SYNE7 (Q31PY6), 
DAPAT_SYNJA (Q2JS04), DAPAT_SYNJB (Q2JLL9), DAPAT_SYNP6 (Q5N492), 
DAPAT_SYNPW (A5GIN1), DAPAT_SYNR3 (A5GW23), DAPAT_SYNS3 (Q0ID68), 
DAPAT_SYNS9 (Q3AW44), DAPAT_SYNSC (Q3AMU5), DAPAT_SYNY3 (Q55828), 
DAPAT_THEVB (Q8DH57), DAPAT_TRIEI (Q10ZC3), DAPAT_TRIL1 (B3E933), 
DAPT1_NOSS1 (Q8YM38), DAPT1_TRIV2 (Q3MAL4), GLII_ASPFU  (Q4WMJ9), 
HPGT_AMYOR  (O52815), LYSN_THET2  (Q72LL6), MRSB_PSESY  (D5FKJ2), 
MTNE_BACSU  (O31665), NAAT1_ORYSJ (A0A0P0VI36), NAATA_HORVU (Q9ST02), 
NAATB_HORVU (Q9ST03), SIRI_LEPMC  (Q6Q887), TCPI_CLAP2  (M1W859), 
TYRB_PARDE  (P95468), Y104_SACS2  (P95957), Y6286_MYCS2 (A0R5R7), 
YBDL_ECOLI  (P77806)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 6 sequences 

AAT1_PSEMZ  (P85906), AAT2_PSEMZ  (P85951), AATC_RABIT  (P12343), 

AATM_CATRO  (P85310), AAT_METEX   (P52069), AAT_STRGR   (P36692)
» more

UniProtKB/Swiss-Prot
False positive sequences		 20 sequences 

BAME1_ARATH (O49545), BAME2_ARATH (Q9M2Z1), CLP1_NEUCR  (Q7SAB7), 

DRB3_ORYSJ  (Q0DJA3), DRB7_ORYSJ  (Q0IV63), DRB8_ORYSJ  (Q0IQN6), 
HIS81_MANSM (Q65S79), HIS82_ARCFU (O28255), LR3E_METSD  (A0A172U6X0), 
MILK1_BOVIN (E1BBG2), MILK1_HUMAN (Q8N3F8), MILK1_MOUSE (Q8BGT6), 
MILK1_RAT   (D3ZQL6), RBKTP_CUPNH (Q0K3R9), RBKTP_CUPTR (B2AIF3), 
RGI5_ARATH  (C0LGF5), TDCD_YERE8  (A1JIM9), TRXR3_MOUSE (Q99MD6), 
WDR46_CANLF (Q5TJE7), WDR46_HUMAN (O15213)
» more

PDB
[Detailed view]		 180 PDB

1AAM; 1AAT; 1AAW; 1AHE; 1AHF; 1AHG; 1AHX; 1AHY; 1AJR; 1AJS; 1AMA; 1AMQ; 1AMR; 1AMS; 1ARG; 1ARH; 1ARI; 1ARS; 1ART; 1ASA; 1ASB; 1ASC; 1ASD; 1ASE; 1ASF; 1ASG; 1ASL; 1ASM; 1ASN; 1B4X; 1B5O; 1B5P; 1B8G; 1BJW; 1BKG; 1BQA; 1BQD; 1BW0; 1C9C; 1CQ6; 1CQ7; 1CQ8; 1CZC; 1CZE; 1G4V; 1G4X; 1G7W; 1G7X; 1GC3; 1GC4; 1GCK; 1IAX; 1IAY; 1IVR; 1IX6; 1IX7; 1IX8; 1LC5; 1LC7; 1LC8; 1LKC; 1M4N; 1M7Y; 1MAP; 1MAQ; 1O4S; 1OXO; 1OXP; 1QIR; 1QIS; 1QIT; 1SPA; 1TAR; 1TAS; 1TAT; 1TOE; 1TOG; 1TOI; 1TOJ; 1TOK; 1X28; 1X29; 1X2A; 1YAA; 1YNU; 1YOO; 2CST; 2D5Y; 2D61; 2D63; 2D64; 2D65; 2D66; 2D7Y; 2D7Z; 2Q7W; 2QA3; 2QB2; 2QB3; 2QBT; 2Z61; 2ZY2; 2ZY3; 2ZY4; 2ZY5; 3AAT; 3ASA; 3ASB; 3B46; 3DYD; 3FSL; 3HLM; 3II0; 3PD6; 3PDB; 3PDX; 3PIU; 3QN6; 3QPG; 3TAT; 3WZF; 3ZZJ; 3ZZK; 4A00; 4F5F; 4F5G; 4F5H; 4F5I; 4F5J; 4F5K; 4F5L; 4F5M; 5AX8; 5BJ3; 5BJ4; 5EAA; 5T4L; 5TON; 5TOQ; 5TOR; 5TOT; 5VJZ; 5VK7; 5VWQ; 5VWR; 5WMH; 5WMI; 5WMK; 5YHV; 6DNA; 6DND; 6F35; 6F5V; 6F77; 6L1L; 6L1N; 6L1O; 6LIG; 7AAT; 7DLW; 7DLY; 7TUR; 8AAT; 8E9C; 8E9D; 8E9J; 8E9K; 8E9L; 8E9M; 8E9N; 8E9O; 8E9P; 8E9Q; 8E9R; 8E9S; 8E9T; 8E9U; 8E9V; 8SKR; 9AAT
» more