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PROSITE entry PS00120


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General information about the entry

Entry name [info] LIPASE_SER
Accession [info] PS00120
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
08-NOV-2023 INFO UPDATE.
PROSITE Doc. [info] PDOC00110
Associated ProRule [info] PRU10037

Name and characterization of the entry

Description [info] Lipases, serine active site.
Pattern [info] 
[LIV]-{KG}-[LIVFY]-[LIVMST]-G-[HYWV]-S-{YAG}-G-[GSTAC].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2023_05 which contains 570'420 sequence entries.


Total number of hits 384 in 384 different sequences
Number of true positive hits 250 in 250 different sequences
Number of 'unknown' hits 27 in 27 different sequences
Number of false positive hits 107 in 107 different sequences
Number of false negative sequences 58
Number of 'partial' sequences 7
Precision (true positives / (true positives + false positives)) 70.03 %
Recall (true positives / (true positives + false negatives)) 81.17 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 7
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 250 sequences 

ATG15_AJECN (A6REI4), ATG15_ASPFU (Q4X180), ATG15_ASPNC (A2QGD9), 

ATG15_ASPTN (Q0CXU6), ATG15_CANAL (Q5A4N0), ATG15_CANGA (Q6FPI6), 
ATG15_CRYNB (P0CO61), ATG15_CRYNJ (P0CO60), ATG15_DEBHA (Q6BLM0), 
ATG15_EMENI (Q5B0L1), ATG15_EREGS (Q75EN3), ATG15_GIBZE (I1RFN8), 
ATG15_KLULA (Q6CU02), ATG15_LODEL (A5E567), ATG15_NEUCR (Q7RYY1), 
ATG15_PASFU (O13444), ATG15_PICAN (A7KAJ9), ATG15_PICGU (A5DC90), 
ATG15_PICST (A3LV34), ATG15_SCHPO (O13934), ATG15_USTMA (Q4PHZ2), 
ATG15_VANPO (A7TG13), ATG15_YARLI (Q6C2N7), ATG15_YEAS7 (A6ZTP2), 
ATG15_YEAST (P25641), BPHL_HUMAN  (Q86WA6), BPHL_MOUSE  (Q8R164), 
CLH0_CHEAL  (Q9LE89), CLH1_CITSI  (Q9MV14), CLH1_CITUN  (Q94LX1), 
DGLA_HUMAN  (Q9Y4D2), DGLA_MOUSE  (Q6WQJ1), DGLA_RAT(Q5YLM1), 
DGLB_HUMAN  (Q8NCG7), DGLB_MOUSE  (Q91WC9), DGLB_RAT(P0C1S9), 
EDS1C_ARATH (Q9SU72), EDS1L_ARATH (Q9XF23), EDSBC_ARATH (Q9SU71), 
ESTD_THEMA  (Q9WYH1), FAEA_ASPAW  (Q9P979), FAEA_ASPFN  (B8NIB8), 
FAEA_ASPNC  (A2QSY5), FAEA_ASPNG  (O42807), FAEA_ASPOR  (Q2UNW5), 
FAEA_ASPTN  (Q0CBM7), FAEA_ASPTU  (O42815), KRAK_DROME  (O18391), 
LCAT_GERGM  (O35840), LCAT_HUMAN  (P04180), LCAT_MOUSE  (P16301), 
LCAT_MYOGA  (O35502), LCAT_PAPAN  (Q08758), LCAT_RABIT  (P53761), 
LCAT_RAT(P18424), LDAH_DROME  (Q9W0H3), LDAH_HUMAN  (Q9H6V9), 
LDAH_MOUSE  (Q8BVA5), LDAH_PONAB  (Q5R7E8), LDAH_RAT(Q5HZX7), 
LDH1_YEAST  (P38139), LICH_CROAD  (J3SDX8), LICH_HUMAN  (P38571), 
LICH_MACFA  (Q4R4S5), LICH_MOUSE  (Q9Z0M5), LIH1_YEAST  (P47145), 
LIP1_ARATH  (Q71DJ5), LIP1_CAEEL  (Q9XTR8), LIP1_STAA8  (Q2FUU5), 
LIP1_STAAC  (Q5HCM7), LIP1_STAAM  (P65288), LIP1_STAAN  (P65289), 
LIP1_STAAR  (Q6GDD3), LIP1_STAAS  (Q6G604), LIP1_STAAW  (Q8NUI5), 
LIP2_ARATH  (Q67ZU1), LIP2_STAA8  (Q2G155), LIP2_STAAC  (Q5HJ48), 
LIP2_STAAM  (Q99WQ6), LIP2_STAAN  (Q7A7P2), LIP2_STAAR  (Q6GJZ6), 
LIP2_STAAS  (Q6GCF1), LIP2_STAAU  (P10335), LIP2_STAAW  (Q8NYC2), 
LIP3_DROME  (O46108), LIPA_PSEFL  (P26504), LIPA_SODAL  (P0CT91), 
LIPB_PSEFL  (P41773), LIPC_BOVIN  (Q3SZ79), LIPC_HUMAN  (P11150), 
LIPC_MOUSE  (P27656), LIPC_RABIT  (O46559), LIPC_RAT(P07867), 
LIPE_AERHY  (P40600), LIPE_CROAD  (J3RZ81), LIPF_BOVIN  (Q29458), 
LIPF_CANLF  (P80035), LIPF_HUMAN  (P07098), LIPF_MOUSE  (Q9CPP7), 
LIPF_RAT(P04634), LIPG_HUMAN  (Q9Y5X9), LIPG_MOUSE  (Q9WVG5), 
LIPG_RAT(Q8VBX1), LIPJ_HUMAN  (Q5W064), LIPK_HUMAN  (Q5VXJ0), 
LIPK_MOUSE  (Q8BM14), LIPL1_CAEEL (Q93789), LIPL3_CAEEL (O16956), 
LIPL5_CAEEL (O61866), LIPL_BOVIN  (P11151), LIPL_CAVPO  (P11153), 
LIPL_CHICK  (P11602), LIPL_FELCA  (P55031), LIPL_HUMAN  (P06858), 
LIPL_MOUSE  (P11152), LIPL_NEOVI  (O46647), LIPL_PAPAN  (P49060), 
LIPL_PIG(P49923), LIPL_RAT(Q06000), LIPL_SHEEP  (Q29524), 
LIPM_HUMAN  (Q5VYY2), LIPM_MOUSE  (Q8K2A6), LIPN_HUMAN  (Q5VXI9), 
LIPN_MOUSE  (Q3U4B4), LIPP_CAVPO  (P50903), LIPP_HORSE  (P29183), 
LIPP_HUMAN  (P16233), LIPP_ICTTR  (O88354), LIPP_MOUSE  (Q6P8U6), 
LIPP_MYOCO  (Q64425), LIPP_PIG(P00591), LIPP_RABIT  (Q02157), 
LIPP_RAT(P27657), LIPR1_CANLF (P06857), LIPR1_HUMAN (P54315), 
LIPR1_MOUSE (Q5BKQ4), LIPR1_RAT   (P54316), LIPR2_BOVIN (A5PK46), 
LIPR2_CAVPO (P81139), LIPR2_HUMAN (P54317), LIPR2_MOUSE (P17892), 
LIPR2_PIG   (D7EZN2), LIPR2_RAT   (P54318), LIPR3_HUMAN (Q17RR3), 
LIPV_MYCTU  (L0TC47), LIP_BURCE   (P22088), LIP_BURPL   (P0DUB8), 
LIP_PSEAE   (P26876), LIP_PSEFR   (P08658), LIP_PSEPS   (P0DUB9), 
LIP_PSES5   (P25275), LIP_PSEU0   (P26877), LIP_RHIMI   (P19515), 
LIP_RHINI   (P61871), LIP_RHIOR   (P61872), LIP_STAEP   (P0C0R3), 
LIP_STAEQ   (Q5HKP6), LIP_STAES   (P0C0R4), LIP_STAHY   (P04635), 
LIP_THELA   (O59952), LIP_VIBCH   (P15493), LPL1_YEAST  (Q08448), 
MDLA_PENCA  (P61870), MDLA_PENCY  (P61869), MES12_ARATH (Q940H7), 
MES14_ARATH (Q9FVW3), MES16_ARATH (O23512), MES1_ARATH  (Q8S8S9), 
MES2_ARATH  (O80476), MES3_ARATH  (O80477), MGLL_HUMAN  (Q99685), 
MGLL_MOUSE  (O35678), MGLL_RAT(Q8R431), PA11_DOLMA  (Q06478), 
PA11_POLDO  (Q6Q252), PA11_VESAF  (P0DMB4), PA12_DOLMA  (P53357), 
PA12_POLDO  (Q6Q251), PA12_VESAF  (P0DMB5), PA13_POLDO  (Q6Q250), 
PA14_POLDO  (Q6Q249), PA1_POLAN   (Q9U6W0), PA1_POLPI   (A2VBC4), 
PA1_SOLIN   (Q68KK0), PA1_VESBA   (A0A0M3KKW3), PA1_VESCR   (P0CH87), 
PA1_VESGE   (Q3ZU95), PA1_VESMC   (P51528), PA1_VESMG   (P0CH47), 
PA1_VESSQ   (P0CH86), PA1_VESVE   (C0HLL3), PA1_VESVU   (P49369), 
PAD4_ARATH  (Q9S745), PAFA2_BOVIN (P79106), PAFA2_HUMAN (Q99487), 
PAFA2_MOUSE (Q8VDG7), PAFA2_RAT   (P83006), PAFA_BOVIN  (Q28017), 
PAFA_CANLF  (Q28262), PAFA_CAVPO  (P70683), PAFA_CHICK  (Q90678), 
PAFA_HUMAN  (Q13093), PAFA_MOUSE  (Q60963), PHAZ_PSEOL  (P26495), 
PIR7A_ORYSI (A2WYS8), PIR7A_ORYSJ (Q0JG98), PIR7B_ORYSI (A2WYS7), 
PIR7B_ORYSJ (Q0JG99), PLA11_ARATH (Q948R1), PLA14_ARATH (O23522), 
PLA15_ARATH (Q941F1), PLA16_ARATH (Q3EBR6), PLA17_ARATH (Q9C8J6), 
PLA18_ARATH (Q9LNC2), PLA19_ARATH (O82274), PLA1A_HUMAN (Q53H76), 
PLA1A_MOUSE (Q8VI78), PLA1A_PONAB (Q5RBQ5), PLA1A_RAT   (P97535), 
PLA1_ORYSI  (A2WT95), PLA1_ORYSJ  (A2ZW16), PLA20_ARATH (Q9SJI7), 
PLA2_ORYSI  (A2WT96), PLA2_ORYSJ  (Q0JKT4), PLA3_ORYSI  (A2WTA0), 
PLA3_ORYSJ  (Q8RZ40), PLA4_ORYSJ  (B9EYD3), PLA6_ORYSJ  (Q6F358), 
PLA7_ORYSI  (A2Y7R2), PLA7_ORYSJ  (Q6F357), PLBAC_BACSU (O34705), 
PLIP3_ARATH (Q940L4), PPD_RAPSA   (Q2V0W1), PPME1_BOVIN (Q58DN4), 
PPME1_CAEEL (Q9BIB3), PPME1_DICDI (Q54TN3), PPME1_HUMAN (Q9Y570), 
PPME1_MOUSE (Q8BVQ5), PPME1_PONAB (Q5R4F9), PPT2_DROME  (Q9VKH6), 
ROG1_YEAST  (P53118), SABP2_TOBAC (Q6RYA0), TALLP_MESAU (Q3YBN2), 
VEST1_VESTR (P0DPT0), YD109_YEAST (Q12103), YD444_YEAST (Q04093), 
YDK2_SCHPO  (P87109), YJMD_SCHPO  (Q7LKZ6), YOR22_YEAST (Q12204), 
YP147_YEAST (Q06522)
» more

UniProtKB/Swiss-Prot
False negative sequences		 58 sequences 

AT151_PHANO (Q0V1P1), ATG15_ASPCL (A1C6D6), ATG15_CHAGB (Q2H6M8), 

ATG15_COCIM (Q1DZE0), ATG15_NEOFI (A1DH10), ATG15_PENRW (A7KAM5), 
CSE_ARATH   (Q9C942), DSEL_ARATH  (O49523), EG1_ORYSI   (A2WY00), 
EG1_ORYSJ   (Q8S1D9), ESTA_BACSU  (P37957), ESTB_BACSU  (Q79F14), 
LCAT_CHICK  (P53760), LCAT_ELIQU  (O35573), LCAT_MICMN  (O35724), 
LDAH_CHICK  (Q5F477), LDAH_DICDI  (Q54LL8), LICH_RAT(Q64194), 
LIP1_DROME  (O46107), LIP1_MORS1  (P19833), LIP1_PSYIM  (Q02104), 
LIPHA_XENLA (Q6PA23), LIPHB_XENLA (Q641F6), LIPH_DANRE  (Q6DBU8), 
LIPH_HUMAN  (Q8WWY8), LIPH_MOUSE  (Q8CIV3), LIPH_RABIT  (Q9BDJ4), 
LIPH_RAT(Q32PY2), LIPH_XENTR  (Q5XGE9), LIPI_HUMAN  (Q6XZB0), 
LIPL4_CAEEL (Q94252), LIPR2_MYOCO (Q64424), LIP_BACSP   (Q5U780), 
MGLL_MYCTU  (O07427), OBL1_ARATH  (F4JFU8), OBL1_RICCO  (Q5VKJ7), 
OBL1_TOBAC  (A0A1S3ZP85), PA1_DINQU   (P0DSI2), PAFA_CAEEL  (Q22943), 
PETH1_AMYMS (P0DX29), PETH_IDESA  (A0A0K8P6T7), PHAZ_TALFU  (B2NHN2), 
PLA12_ARATH (Q9MA46), PLA13_ARATH (Q9SIN9), PLA1A_BOVIN (Q5E9H0), 
PLA1A_DANRE (Q6NYZ4), PLA5_ORYSI  (B8A8C9), PLA5_ORYSJ  (Q5NAI4), 
PLG7_SCHPO  (Q9URV1), PLIP1_ARATH (Q7Y220), PLIP2_ARATH (F4HXL0), 
TGCE1_SCHPO (O74430), TGCE2_SCHPO (P78898), TGCE3_SCHPO (O60095), 
TGL1_YEAST  (P34163), YE7A_SCHPO  (O14162), YEH1_YEAST  (Q07804), 
YEH2_YEAST  (Q07950)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 7 sequences 

LCAT_PIG(P30930), LIPP_FELCA  (P83629), LIPT_BURCE  (P29605), 

PA11_VESVE  (P0DMB6), PA12A_VESVE (P0DMB7), PA12B_VESVE (P0DMB8), 
PA1_POLGA   (P83542)
» more

UniProtKB/Swiss-Prot
'Unknown' sequences		 27 sequences 

AED3_ARATH  (O04496), ATR1_STEAL  (A0A8F4SKJ7), AXE1_HYPJE  (Q99034), 

BST1A_YARLI (Q6C2Z2), BST1B_YARLI (Q6BZU7), BST1C_YARLI (Q6CF60), 
BST1_ASPFU  (Q4WGM4), BST1_ASPOR  (Q2USI0), BST1_ASPTN  (Q0CIV4), 
BST1_CANAL  (Q59VP0), BST1_CHAGB  (Q2H102), BST1_COCIM  (Q1DWP9), 
BST1_DEBHA  (Q6BRG1), BST1_EMENI  (Q5AYC8), BST1_EREGS  (Q752Q2), 
BST1_KLULA  (Q6CIN9), BST1_NEUCR  (Q7SAM0), BST1_PHANO  (Q0UQV6), 
BST1_SCHPO  (Q9UT41), BST1_YEAST  (P43571), PGAP1_DROME (Q9W495), 
PGAP1_HUMAN (Q75T13), PGAP1_MOUSE (Q3UUQ7), PGAP1_RAT   (Q765A7), 
PGAP1_XENLA (Q66J01), YL4M_CAEEL  (Q8WT51), YR843_MIMIV (Q5URB6)
» more

UniProtKB/Swiss-Prot
False positive sequences		 107 sequences 

5MOAS_ASPTN (Q0CRQ5), AGIA_ASPFN  (B8NY88), ALTH1_PLAF7 (C6KTB7), 

ARGJ_DECAR  (Q47AB5), ASCC_ACREG  (A0A455R5P9), AXE2_TALPU  (O59893), 
CHEB2_CARHZ (Q3ADA6), CHEB3_RHORT (Q2RRX2), CHEB3_VIBCH (Q9KS59), 
CHEB_CALS4  (Q8RAZ3), CHEB_SALRD  (Q2RZD2), CUTI1_COPCI (B9U443), 
CUTI1_VERDA (A0A2J8C362), CUTI2_MAGO7 (G4MZV6), CUTI_BOTFU  (Q00298), 
CUTI_MONFR  (Q8TGB8), EAT1_ERECY  (G8JVR4), EAT1_KLULA  (Q6CLY8), 
EAT1_KLUMD  (W0T4A7), EAT1_WICAA  (A0A1E3P8S6), EAT1_WICCF  (K0KPV8), 
EAT2_CYBFA  (A0A061AYY2), EAT2_CYBJN  (A0A1E4S2N7), ESL2_MYCGE  (Q49418), 
ESL2_MYCPN  (P75311), ESL3_MYCGE  (Q49421), ESL3_MYCPN  (P75268), 
F135B_XENLA (Q641I1), GLU2A_ORYSJ (B9F676), ICT1_YEAST  (Q12385), 
KANL3_RAT   (Q3KR73), KFA_CANAL   (Q59ZV4), KFA_EREGS   (Q759T3), 
KFA_PICST   (A3GGU3), KFA_VANPO   (A7TJ85), KR231_HUMAN (A1A580), 
MCLN1_HUMAN (Q9GZU1), MCLN1_MACFA (Q60HE8), MCLN1_MOUSE (Q99J21), 
MEX67_SCHPO (Q9Y8G3), NUOH_FRAAA  (Q0RRW1), NUOH_FRACC  (Q2JFL3), 
PDAT_YEAST  (P40345), PDXD1_BOVIN (A7MBC2), PDXD2_HUMAN (Q6P474), 
PETH1_THEAE (D4Q9N1), PETH1_THECS (E9LVH8), PETH1_THEFU (G8GER6), 
PETH1_THEFY (Q47RJ7), PETH2_THEAE (F7IX06), PETH2_THECS (E9LVH9), 
PETH2_THEFU (Q6A0I4), PETH2_THEFY (Q47RJ6), PG043_MONPV (A0A7H0DN16), 
PHYLO_ARATH (Q15KI9), PIP_BREBN   (C0ZKI1), PIP_WEICA   (P46541), 
PKBA_EMENI  (Q5AZ32), PLSX_PSET1  (Q3IHD8), PMT2_CANAL  (Q5ADM9), 
PNAE_RAUSE  (Q9SE93), PPME1_ASPFU (Q4WKB2), PPME1_ASPOR (Q2URJ0), 
PPME1_CANAL (Q5ALW7), PPME1_CANGA (Q6FNL6), PPME1_CRYNB (P0CO63), 
PPME1_CRYNJ (P0CO62), PPME1_DEBHA (Q6BZG3), PPME1_EMENI (Q5BGN7), 
PPME1_EREGS (Q74Z47), PPME1_GIBZE (Q4IQC1), PPME1_KLULA (Q6CQZ5), 
PPME1_NEUCR (Q7SGG8), PPME1_RAT   (Q4FZT2), PPME1_SCHPO (Q9P7D2), 
PPME1_YARLI (Q6CGE1), PPME1_YEAST (P38796), PREU3_PREIS (P9WET6), 
PREU6_PREIS (P9WET2), RPOB_COXB2  (B6J270), RPOB_COXBN  (A9KD39), 
RPOB_COXBR  (A9NAL4), RPOB_COXBU  (P0C8S4), SFGH_YEAST  (P40363), 
SIDJ_ASPFU  (Q4WF56), SYE_AMOA5   (B3ERQ7), SYE_CARHZ   (Q3A9N9), 
SYE_DESAP   (B1I4Z1), SYE_DESRM   (A4J0Y7), SYE_HELMI   (B0TBU3), 
SYE_PELTS   (A5D5L8), SYE_SALRD   (Q2S1L8), TNR16_HUMAN (P08138), 
TNR16_MOUSE (Q9Z0W1), TNR16_RAT   (P07174), TRI12_FUSSP (Q9C1B3), 
TRI12_TRIAR (G0KYA8), UBE11_ARATH (P93028), UBE12_ARATH (P92974), 
Y193_HAEIN  (Q57427), Y2412_DICDI (Q54DA4), Y2715_MYCTO (P9WNH2), 
Y2715_MYCTU (P9WNH3), Y2734_MYCBO (P0A573), Y4KF_SINFN  (P55526), 
YELD_SCHPO  (O14244), YKM6_SCHPO  (Q9C0Y8)
» more

PDB
[Detailed view]		 146 PDB

1BU8; 1CVL; 1DT3; 1DT5; 1DTE; 1DU4; 1EIN; 1ETH; 1EX9; 1GPL; 1HLG; 1HPL; 1HQD; 1K8Q; 1LGY; 1LPA; 1LPB; 1N8S; 1OIL; 1QGE; 1QOZ; 1RP1; 1TAH; 1TGL; 1TIA; 1TIB; 1TIC; 1USW; 1UWC; 1UZA; 1XKL; 1Y7H; 1Y7I; 1YS1; 1YS2; 2ES4; 2HIH; 2HL6; 2IX9; 2LIP; 2NW6; 2OCG; 2OCI; 2OCK; 2OXE; 2PPL; 2PVS; 3C5V; 3D59; 3D5E; 3F96; 3F97; 3F98; 3F9C; 3HJU; 3JW8; 3JWE; 3LIP; 3PE6; 3TGL; 4DYH; 4EA6; 4FLF; 4GBG; 4GHW; 4GI1; 4GLB; 4GWL; 4KJX; 4LIP; 4N8S; 4NFU; 4QNN; 4S0X; 4TGL; 4UUQ; 4X96; 4XWG; 4XX1; 4ZGB; 5AP9; 5BV7; 5CH8; 5HK8; 5I8P; 5I9I; 5JAD; 5JAH; 5JAL; 5JAN; 5JAO; 5JAP; 5JAR; 5JAS; 5JAT; 5JAU; 5LIP; 5LP1; 5LYY; 5LZ2; 5LZ4; 5LZ5; 5LZ7; 5LZ8; 5LZ9; 5TGL; 5TXF; 5YE7; 5YE8; 5YE9; 5YEA; 5ZUN; 6AX1; 6BQ0; 6E7K; 6HW1; 6I8G; 6I8H; 6M06; 6M07; 6M08; 6MVD; 6OAU; 6OAZ; 6OB0; 6OR3; 6Q6Z; 6QPP; 6QPR; 6U7M; 6V7N; 6XOK; 6XRV; 6XS3; 7APN; 7APP; 7L4T; 7L4U; 7L4W; 7L50; 7PRM; 7XDD; 7XEY; 7XJP; 7ZPG; 8ERL
» more