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PROSITE entry PS00133


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS00133
Entry name [info] CARBOXYPEPT_ZN_2
Accession [info] PS00133
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00123

Name and characterization of the entry

Description [info] Zinc carboxypeptidases, zinc-binding region 2 signature.
Pattern [info] 
H-[STAG]-{ADNV}-{VGFI}-{YAR}-[LIVME]-{SDEP}-x-[LIVMFYW]-P-[FYW].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 114 in 109 different sequences
Number of true positive hits 63 in 58 different sequences
Number of 'unknown' hits 0
Number of false positive hits 51 in 51 different sequences
Number of false negative sequences 83
Number of 'partial' sequences 2
Precision (true positives / (true positives + false positives)) 55.26 %
Recall (true positives / (true positives + false negatives)) 43.15 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 2
Site [info] zinc at position 1
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 58 sequences 

CBPA1_ANOGA (O02350), CBPA1_BOVIN (P00730), CBPA1_HUMAN (P15085), 

CBPA1_MOUSE (Q7TPZ8), CBPA1_PIG   (P09954), CBPA1_RAT   (P00731), 
CBPA2_HUMAN (P48052), CBPA2_MOUSE (Q504N0), CBPA2_RAT   (P19222), 
CBPA3_HUMAN (P15088), CBPA3_MOUSE (P15089), CBPA3_RAT   (P21961), 
CBPA4_HUMAN (Q9UI42), CBPA4_MOUSE (Q6P8K8), CBPA5_HUMAN (Q8WXQ8), 
CBPA5_MACFA (Q4R7R2), CBPA5_MOUSE (Q8R4H4), CBPA6_HUMAN (Q8N4T0), 
CBPA6_MOUSE (Q5U901), CBPB1_BOVIN (P00732), CBPB1_CANLF (P55261), 
CBPB1_HUMAN (P15086), CBPB1_PIG   (P09955), CBPB1_RAT   (P19223), 
CBPB_ASTAS  (P04069), CBPD_ANAPL  (Q90240), CBPD_DROME  (P42787), 
CBPD_HUMAN  (O75976), CBPD_LOPSP  (P83852), CBPD_MOUSE  (O89001), 
CBPD_RAT(Q9JHW1), CBPE_BOVIN  (P04836), CBPE_HUMAN  (P16870), 
CBPE_LOPAM  (P37892), CBPE_MACFA  (Q4R4M3), CBPE_MOUSE  (Q00493), 
CBPE_PANTR  (A5A6K7), CBPE_RAT(P15087), CBPM_HUMAN  (P14384), 
CBPM_MOUSE  (Q80V42), CBPM_PONAB  (Q5RFD6), CBPN_BOVIN  (Q2KJ83), 
CBPN_HUMAN  (P15169), CBPN_MOUSE  (Q9JJN5), CBPN_RAT(Q9EQV8), 
CBPS_STRGR  (P18143), CBPS_STRMP  (P39041), CBPT_THEVU  (P29068), 
CBPZ_CHICK  (Q8QGP3), CBPZ_HUMAN  (Q66K79), CBPZ_MOUSE  (Q8R4V4), 
CBPZ_RAT(O54858), CBPZ_SIMVI  (P42788), CPXM1_HUMAN (Q96SM3), 
CPXM1_MOUSE (Q9Z100), ECM14_YEAST (P38836), SOL1_ARATH  (Q9M9H7), 
SURO1_CAEEL (Q9XU75)
» more

UniProtKB/Swiss-Prot
False negative sequences		 83 sequences 

CBPA1_DROME (Q9VL86), CBPA1_DROPS (Q29NC4), CBPB2_BOVIN (Q2KIG3), 

CBPB2_HUMAN (Q96IY4), CBPB2_MOUSE (Q9JHH6), CBPB2_RAT   (Q9EQV9), 
CBPC1_CAEEL (O76373), CBPC1_CHICK (E1C3P4), CBPC1_DANRE (Q4U2V3), 
CBPC1_HUMAN (Q9UPW5), CBPC1_MOUSE (Q641K1), CBPC1_XENLA (Q6DD21), 
CBPC1_XENTR (A9JRL3), CBPC2_DANRE (A6H8T7), CBPC2_HUMAN (Q5U5Z8), 
CBPC2_MACFA (Q4R632), CBPC2_MOUSE (Q8CDK2), CBPC2_XENTR (Q0P4M4), 
CBPC3_BOVIN (E1B9D8), CBPC3_HUMAN (Q8NEM8), CBPC3_MOUSE (Q8CDP0), 
CBPC4_HUMAN (Q96MI9), CBPC4_MOUSE (Q09M05), CBPC5_AILME (D2GXM8), 
CBPC5_BOVIN (Q58CX9), CBPC5_DANRE (Q68EI3), CBPC5_HUMAN (Q8NDL9), 
CBPC5_MOUSE (Q09M02), CBPC5_RAT   (B2GV17), CBPC5_XENTR (B0JZV4), 
CBPC6_CAEEL (Q09296), CBPC6_HUMAN (Q5VU57), CBPC6_MOUSE (Q09LZ8), 
CBPO_BOVIN  (Q0II73), CBPO_HUMAN  (Q8IVL8), CBPZ1_PLAF7 (Q8I2A6), 
CPXM2_HUMAN (Q8N436), CPXM2_MOUSE (Q9D2L5), ECM14_AJECG (C0NM08), 
ECM14_AJECH (C6H4F1), ECM14_AJECN (A6RCF5), ECM14_AJEDR (C5G6U8), 
ECM14_ARTBC (D4AKU7), ECM14_ARTGP (E4UPZ6), ECM14_ARTOC (C5FPR9), 
ECM14_ASPCL (A1CSU3), ECM14_ASPFC (B0XRS8), ECM14_ASPFN (B8NBP9), 
ECM14_ASPFU (Q4X1U0), ECM14_ASPNC (A2QZA2), ECM14_ASPOR (Q2TZK2), 
ECM14_ASPTN (Q0C9B4), ECM14_BLAGS (C5JZS0), ECM14_COCP7 (C5PHW9), 
ECM14_COCPS (E9DD69), ECM14_EMENI (Q5B011), ECM14_LEPMJ (E5A0U8), 
ECM14_NEOFI (A1DGH9), ECM14_PARBA (C1HE31), ECM14_PARBD (C1GDH9), 
ECM14_PARBP (C0SAI5), ECM14_PENRW (B6H233), ECM14_SCLS1 (A7EUC0), 
ECM14_TALMQ (B6Q972), ECM14_TALSN (B8M2K0), ECM14_TRIVH (D4DIW7), 
ECM14_UNCRE (C4JEE1), MCPAL_ARTBC (D4B5N0), MCPAL_ARTOC (C5FH26), 
MCPAL_TRIVH (D4D675), MCPA_ARTBC  (D4AS12), MCPA_ARTOC  (C5FVN6), 
MCPA_TRIEQ  (B8XGR3), MCPA_TRIRU  (A6XGK3), MCPA_TRITO  (B6V865), 
MCPA_TRIVH  (D4DL57), MCPB_ARTBC  (D4B1S6), MCPB_ARTOC  (C5FYJ7), 
MCPB_TRIEQ  (B8XGR2), MCPB_TRIRU  (A6XHF7), MCPB_TRITO  (B6V866), 
MCPB_TRIVH  (D4D4Z1), NNAD_DROME  (Q9VY99)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 2 sequences 

CBP1_SABMA  (P86516), CBPB_PROAT  (P19628)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			51 sequences
			


			
AIM14_LACTC (C5E398), CARB_CLOAB  (Q97FT3), CR1L_HUMAN  (Q2VPA4), 

			
CTK1_SCHPO  (O14098), DUF2_ARATH  (F4I8W1), EXO5_ZYGRC  (C5DXZ1), 
GCH4_HALHL  (A1WYI8), GQ2_HHV6Z   (P0DOE1), GSH1_PECAS  (Q6D1T4), 
GTPBA_DANRE (Q6DHF7), HIR3_KLULA  (Q6CWI4), JANB_PENJA  (A0A0E3D8Q2), 
LIS1_PHATC  (B7FNU7), LPSA1_EPIFI (Q96V34), MAJIN_MOUSE (Q9D992), 
MATK_ARCUU  (Q71ML5), MURG_TRIEI  (Q119X8), MVP_BMV (P03603), 
NOL9_MOUSE  (Q3TZX8), NTE1_PICST  (A3LYZ4), PHK_NOCFA   (Q5Z066), 
PIMT_OPITP  (B1ZPF0), POTH_ECOLI  (P31135), PPE54_MYCTU (Q6MWY2), 
PRR33_HUMAN (A8MZF0), RAB7B_MOUSE (Q8VEA8), RDRP_SSDRV  (Q6YI57), 
RG1BB_DANRE (Q6DBW1), RK5_OSTTA   (Q0P3L4), RK5_PLETE   (A6YGC9), 
RSGA_AQUAE  (O66555), SYI_BUCBP   (Q89AU9), SYI_CAMJE   (P41257), 
SYI_CAMJR   (Q5HU41), SYS_MANSM   (Q65SK3), TGB2_SMYEA  (Q00842), 
TGM1_CANLF  (Q9GLK0), THIG_BURL3  (Q39KA4), THIG_BURMA  (Q62GC6), 
THIG_BURP1  (Q3JMY2), THIG_BURPS  (Q63Q73), THIG_BURTA  (Q2SU89), 
TRPA_GLOVI  (Q7NHC5), TSPO_ARCFU  (O28797), TTLL2_MOUSE (A4Q9E4), 
UXNAS_BACCN (A7GKX7), VIT_APIME   (Q868N5), YCF2_ACOCI  (A9LYE4), 
YCF2_ACOCL  (Q3V4Z0), YR229_MIMIV (Q5UQC4), ZSC4D_MOUSE (A7KBS4)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			111 PDB
			


			1ARL; 1ARM; 1AYE; 1BAV; 1CBX; 1CPB; 1CPS; 1CPX; 1DTD; 1EE3; 1ELL; 1ELM; 
			
				1F57; 1H8L; 1HDQ; 1HDU; 1HEE; 1IY7; 1KWM; 1M4L; 1NSA; 1OBR; 1PCA; 1PYT; 
				1QMU; 1UWY; 1YME; 1Z5R; 1ZG7; 1ZG8; 1ZG9; 1ZLH; 1ZLI; 2ABZ; 2BO9; 2BOA; 
				2CTB; 2CTC; 2JEW; 2NSM; 2PCU; 2PIY; 2PIZ; 2PJ0; 2PJ1; 2PJ2; 2PJ3; 2PJ4; 
				2PJ5; 2PJ6; 2PJ7; 2PJ8; 2PJ9; 2PJA; 2PJB; 2PJC; 2RFH; 2V77; 3CPA; 3FJU; 
				3FVL; 3FX6; 3GLJ; 3I1U; 3KGQ; 3MN8; 3PRT; 3QNV; 3V38; 3V7Z; 3WAB; 3WC5; 
				3WC6; 3WC7; 4A94; 4BD9; 4CPA; 4DJL; 4DUK; 4F8Z; 4GM5; 4IAV; 4IHM; 4IK2; 
				4UEE; 4UEZ; 4Z65; 5CPA; 5J1Q; 5JC6; 5LRG; 5LRJ; 5LRK; 5OM9; 5ZEQ; 6CPA; 
				6F6Q; 6F75; 6F79; 6GO2; 6I6Z; 6SN6; 6T9Y; 6TNK; 6Z28; 7AQP; 7ARU; 7CPA; 
				7Q87; 8CPA; 8QVO
			
			

			» more