PROSITE entry PS00136
View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission
General information about the entry
| Entry name [info] | SUBTILASE_ASP |
| Accession [info] | PS00136 |
| Entry type [info] | PATTERN |
| Date [info] |
01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00125 |
| Associated ProRule [info] | PRU10080 |
Name and characterization of the entry
| Description [info] | Serine proteases, subtilase family, aspartic acid active site. |
| Pattern [info] |
[STAIV]-{ERDL}-[LIVMF]-[LIVM]-D-[DSTA]-G-[LIVMFC]-x(2,3)-[DNH].
|
Numerical results [info]
| Total number of hits | 380 in 380 different sequences |
| Number of true positive hits | 185 in 185 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 195 in 195 different sequences |
| Number of false negative sequences | 7 |
| Number of 'partial' sequences | 6 |
| Precision (true positives / (true positives + false positives)) | 48.68 % |
| Recall (true positives / (true positives + false negatives)) | 96.35 % |
Comments [info]
| Taxonomic range [info] | Archaea, Eukaryotes, Prokaryotes (Bacteria) |
| Maximum number of repetitions [info] | 1 |
| Site [info] | active_site at position 5 |
| Version [info] | 1 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
185 sequences
AEP_YARLI (P09230), AEX5_CAEEL (P91863), ALP_FUSCU (P83610), ALP_HAPCH (P29118), ALP_HYPAT (Q03420), ALP_LECPS (Q68GV9), APRX_BACSU (O31788), AQL1_THEAQ (P08594), ASES_SARSR (R4IR27), ASPA_AERSA (P31339), ASP_AERSO (Q9L5A4), BLI4_CAEEL (P51559), BLI_ONCVO (A0A044RE18), BPRV_DICNO (P42779), BPRX_DICNO (P42780), C5AP_STRP1 (P58099), C5AP_STRP3 (P0DD34), C5AP_STRP6 (Q5X9R0), C5AP_STRP8 (Q8NZ80), C5AP_STRPQ (P0DD35), C5AP_STRPY (P15926), CUDP_METAN (P29138), ELYA_ALKAL (P27693), ELYA_BACYA (P20724), ELYA_HALH5 (P41363), ELYA_SHOCL (P41362), EPIP_STAEP (P30199), EXPR_XANCP (P23314), FKPC1_CAEEL (O17798), FLS_FERPE (Q93LQ6), FUR11_DROME (P26016), FUR1C_DROME (P30430), FUR2_DROME (P30432), FURI1_XENLA (P29119), FURIN_BOVIN (Q28193), FURIN_HUMAN (P09958), FURIN_MOUSE (P23188), FURIN_RAT (P23377), HETQ2_PODAS (P0DW09), ISP1_BACSU (P11018), ISP6_SCHPO (P40903), ISP_PAEPO (P29139), ISP_SHOCL (P29140), KEX1A_KLULA (P09231), KEX2_YEAST (P13134), KRP1_SCHPO (Q09175), MYCP2_MYCTU (O05458), MYCP4_MYCTU (I6YC58), MYCP5_MYCTU (O53945), NEC1_BOVIN (Q9GLR1), NEC1_HUMAN (P29120), NEC1_MOUSE (P63239), NEC1_MUSCO (P63240), NEC1_RAT(P28840), NEC2_BOVIN (Q9GLR0), NEC2_CAEEL (G5ECN9), NEC2_DROME (Q9VBC7), NEC2_HUMAN (P16519), NEC2_MOUSE (P21661), NEC2_PIG(Q03333), NEC2_PONAB (Q5REC2), NEC2_RAT(P28841), NECA_HYDVU (P29146), NECB_HYDVU (P29145), NISP_LACLL (Q07596), NVSP_ALIVI (P83433), ORYZ_ASPCL (A1CIA7), ORYZ_ASPFC (B0Y708), ORYZ_ASPFN (B8N106), ORYZ_ASPFU (P28296), ORYZ_ASPOR (P12547), ORYZ_EMENI (Q00208), ORYZ_NEOFI (A1CWF3), P1P_LACLC (P16271), P2P_LACLC (P15293), P2P_LACPA (Q02470), P3P_LACLS (P15292), PCSK4_HUMAN (Q6UW60), PCSK4_MOUSE (P29121), PCSK4_RAT (Q78EH2), PCSK5_HUMAN (Q92824), PCSK5_MOUSE (Q04592), PCSK5_RAT (P41413), PCSK6_HUMAN (P29122), PCSK6_RAT (Q63415), PIIS_ACHLY (P81719), PIMM2_PLABA (A0A509AKI1), PLS_PYRFU (P72186), PRCA_NOSS1 (Q59149), PRCA_TRIV2 (P23916), PROA_VIBAL (P16588), PRTB_YEAST (P09232), PRTK_PARAQ (P06873), PRTM_SHOC1 (Q99405), PRTR_PARAQ (P23653), PRTT_PARAQ (P20015), PSP3_SCHPO (Q9UTS0), RM201_RHOMI (Q32ZM1), RRT12_YEAST (P25381), SBT11_ARATH (Q84WS0), SBT14_ARATH (Q9LVJ1), SBT19_ARATH (Q9FHA4), SBT1_LOTJA (A9QY40), SBT21_ARATH (Q9SA75), SBT22_ARATH (Q9SUN6), SBT23_ARATH (Q9FI12), SBT24_ARATH (F4HYR6), SBT25_ARATH (O64481), SBT26_ARATH (Q9SZV5), SBT3G_ARATH (Q8GWX9), SBT3_LOTJA (A9QY39), SBT4E_ARATH (Q9LLL8), SBT4_LOTJA (A9QY38), SBT_MEDTR (G7KEU7), SBT_PETHY (A0A0M3R8G2), SEPR_THESR (P80146), SMP1_MAGPO (Q9Y778), SPAZ_ARTOA (G1X8P8), SPAZ_ORBOL (G3FNQ9), SPL1_ENCCU (Q8SQJ3), SUB10_ARTBC (D4AQG0), SUB10_TRIVH (D4DIS6), SUB1_PLAF7 (Q8I0V0), SUB1_PLAFA (O61142), SUB1_PLAFO (W7K9M0), SUB1_PSED2 (L8G6I7), SUB2A_COCP7 (C5P6D1), SUB2B_COCP7 (C5P906), SUB2C_COCP7 (C5NZ70), SUB2_ARTBC (D4AZ75), SUB2_ARTBE (Q64K35), SUB2_ARTGP (E4UZP9), SUB2_ARTOC (C5G168), SUB2_ARTOT (Q8J0D8), SUB2_PSED2 (L8FSM5), SUB2_TRIEQ (B6VA85), SUB2_TRIRU (Q69F57), SUB2_TRITO (B8XGQ5), SUB2_TRIVC (Q5VJ76), SUB2_TRIVH (D4DLI5), SUB3_PLAF7 (Q8I430), SUB3_PSED2 (L8GD75), SUB4B_COCP7 (C5NZT2), SUB5_ARTBC (D4B194), SUB5_ARTBE (Q64K32), SUB5_ARTGP (E4V2L6), SUB5_ARTOC (C5G1D1), SUB5_TRIEQ (B6VA87), SUB5_TRIRU (Q69F34), SUB5_TRITO (B8XGQ8), SUB5_TRIVC (Q5VJ73), SUB5_TRIVH (D4D0F5), SUB6_ARTBC (D4ALV9), SUB6_ARTBE (Q64K31), SUB6_ARTGP (E4V4J8), SUB6_ARTOC (C5FQI3), SUB6_TRIEQ (A1XIH0), SUB6_TRIRU (Q9UW97), SUB6_TRISD (A1XIH1), SUB6_TRISH (Q8J077), SUB6_TRITO (Q3ZEJ8), SUB6_TRIVC (Q5VJ72), SUB6_TRIVH (D4D5H3), SUB7A_COCP7 (C5PGK9), SUB7C_COCP7 (C5NZ69), SUB7D_COCP7 (C5P9H3), SUBB_LEDLE (P29599), SUBC_BACLI (P00780), SUBD_BACLI (P00781), SUBE_BACSU (P16396), SUBN_BACNA (P35835), SUBS_LEDLE (P29600), SUBT_BACAM (P00782), SUBT_BACPU (P07518), SUBT_BACS9 (P28842), SUBT_BACSA (P00783), SUBT_BACSU (P04189), SUBT_GEOSE (P29142), SUBV_BACSU (P29141), THES_BACSJ (Q45670), THET_THEVU (P04072), TKSP_THEKO (Q5JIZ5), TKSU_THEKO (P58502), XPR6_YARLI (P42781), YSP3_YEAST (P25036)» more
|
| UniProtKB/Swiss-Prot False negative sequences |
7 sequences
NALP_NEIMB (Q9JXM7), NALP_NEIMH (E6MVD9), SBT61_ARATH (Q0WUG6), SBTS_LOTJA (A9JQS7), SUB2_PLAF7 (Q8IHZ5), SUB2_PLAFA (O97364), SUB2_PLAFP (Q9Y008)» more |
| UniProtKB/Swiss-Prot 'Partial' sequences |
6 sequences
ASE2_ACRSP (P85157), CUDP_METCM (P80406), NCP3_COPCM (P83454), PRTE_HALME (P28308), SP01_SCEBO (Q10721), THEM_MALCI (P13858)» more |
| UniProtKB/Swiss-Prot False positive sequences |
195 sequences
ACDA1_ARCFU (O29165), AES1_THET4 (G2QJ27), AES1_THETO (T2FKR1), AGLU_TETPY (O00906), ALDO3_ARATH (Q7G9P4), ALT5_ALTAL (A0A3G9H9H1), AP1_KLULA (P56095), ARGC_CHRVO (Q7NRT5), ASL3_SARSH (A0A2U8U2L3), BAH_RHOER (Q8RSQ2), BTUB_PHOLL (Q7MYE3), CBID_PROMP (Q7V3N8), CHS1_CRYNH (O13356), CLS2_STAAC (Q5HEB2), CLS2_STAAR (Q6GEY7), CLS_STAAM (P63800), CLS_STAAN (P63801), CLS_STAAS (Q6G7M2), CLS_STAAW (P63802), COBT_DEIRA (Q9RYR8), CYAH_PSEI1 (E3JD18), DCL4_ORYSJ (A7LFZ6), DMXL1_HUMAN (Q9Y485), DMXL1_MOUSE (Q6PNC0), DNAG_NEIMA (P57028), DNAG_NEIMB (P57029), DNLJ1_STRGG (B1VUC2), DNLJ_FERNB (A7HJG6), DPFGA_GIBZE (I1RL11), DRD1_CARAU (P35406), EXOC1_DICDI (Q54NV1), EXOS5_ARATH (Q9LX74), FIXJ_AZOC5 (P26487), FLII_BUCBP (Q89AZ7), FMT_GEOSL (Q74GW4), FOLD2_ACIAD (Q6F8N7), FOLD_ACIBT (A3M846), FOLD_CALS4 (Q8RAD0), FOLD_MALP2 (Q8EV80), FOLD_PSYA2 (Q4FTX6), FOLD_PSYCK (Q1QD30), FOLD_RUTMC (A1AXA0), GLUQ_CUTAK (Q6A7Y1), GLYA_CUTAK (Q6AAU3), GLYA_MYCS2 (A0R2V7), GUAAB_PICTO (Q6L1Q1), GUAA_ASPOR (Q2UFN0), HEM1_RHORT (Q2RWE2), HIS5_ECOL6 (P60596), HIS5_ECOLI (P60595), HIS5_SHIBS (Q323I9), HIS5_SHIDS (Q32EF2), HIS5_SHIFL (Q83KJ5), HIS5_SHISS (Q3Z0G2), HLYE_ECO57 (Q9REB3), HLYE_ECOLI (P77335), HN1BA_DANRE (A1L1N5), HN1BB_DANRE (Q8UW00), HOA_PARPJ (B2T2S2), HOY1_YARLI (Q99160), HPS1_DOTSN (M2YKT6), IDA1_CAEEL (G5EGJ5), KATG2_ALKMQ (A6TV07), KATG_PHEZH (B4R8U3), KATG_SACD2 (Q21DT6), KUP3_RHIJ3 (Q1M651), LCAP_HUMAN (Q9UIQ6), LEC2_CYTSE (P22971), LEU3_BRUA2 (Q2YL58), LEU3_BRUAB (Q579B1), LEU3_BRUME (Q8YCX4), LEU3_BRUSU (Q8FVF3), LPXK_HELAH (Q17X64), LPXK_HELPH (Q1CUH3), LPXK_HELPJ (Q9ZMB1), LPXK_HELPY (O25095), LRC14_BOVIN (A5PJJ5), LRC14_HUMAN (Q15048), LRC14_MOUSE (Q8VC16), LRC14_RAT (Q569B5), LRRC3_DANRE (A8WHP9), MATK_GAGLU (Q9TMC8), MATK_ILLOL (A6MMS5), METL2_ARATH (Q8LFA9), METN1_PSEU2 (Q4ZZR8), MSTO1_BOVIN (A5D9D4), MSTO1_HUMAN (Q9BUK6), MSTO1_MACFA (Q4R681), MSTO1_MOUSE (Q2YDW2), MSTO1_PONPY (Q5RF82), MYO2_CAEEL (P12845), MZT1B_ARATH (Q9M0N8), NADE_SHEON (Q8EFF2), NADO2_ORYSJ (Q7G765), NCAP_CVM1 (P18446), NCAP_CVM2 (Q9PY96), NCAP_CVM3 (P18447), NCAP_CVMA5 (P03416), NCAP_CVMDV (Q83360), NCAP_CVMJH (P03417), NCAP_CVMS (P18448), NCAP_CVPV (P59713), NCAP_CVRNJ (Q9WCD0), NCAP_CVRSD (Q02915), NEMS_APIME (P85527), NOL6_DROME (Q8IH00), NOL6_DROSE (B4IBY3), NOL6_DROSI (B4QX57), NOL6_DROYA (B4PR18), NR2C1_BOVIN (A0JNE3), NR2C1_HUMAN (P13056), NR2C1_MACFA (Q95K90), NR2C1_MOUSE (Q505F1), NR2C1_PONAB (Q5RCZ5), NR2C1_RAT (Q8VIJ4), NR2C1_XENTR (Q28CK1), NUS1_ASPOR (P24021), OGR1_ORYSJ (B8YEK4), P2C28_ARATH (O64583), PA24A_BOVIN (A4IFJ5), PA24A_CHICK (P49147), PA24A_DANRE (P50392), PA24A_HORSE (O77793), PA24A_HUMAN (P47712), PA24A_MOUSE (P47713), PA24A_PONAB (Q5R8A5), PA24A_RABIT (Q9TT38), PA24A_RAT (P50393), PA24A_XENLA (Q7T0T9), PA24A_XENTR (B1WAZ6), PDAD_METKA (Q8TXD4), PEPQ_AERHH (A0KEL3), PEPQ_AERS4 (A4STF0), PGP_ARCFU (O29805), PILB_THET8 (Q5SLC9), PNP_FRAT1 (Q14IC9), PNP_FRATF (A7NDP3), PNP_FRATH (Q2A269), PNP_FRATM (B2SDK7), PNP_FRATN (A0Q5I9), PNP_FRATO (Q0BKU1), PNP_FRATT (Q5NGX7), PNP_FRATW (A4IZA6), PP263_ARATH (Q9M2A1), PPOC_ARATH (P55826), PRDE1_CAEEL (O17828), PURA_LEIDO (A7LBL2), PURA_LEIIN (A4HVP7), PURA_LEIMA (Q4QG35), PYRE_PHOLL (Q7MY25), PYRE_SHEON (Q8E9L5), PYRE_VIBCH (Q9KVD5), RNJ1_STAA3 (Q2FHZ1), RNJ1_STAA8 (Q2FZG9), RNJ1_STAAB (Q2YX35), RNJ1_STAAC (Q5HGZ5), RNJ1_STAAM (Q99V09), RNJ1_STAAN (Q7A682), RNJ1_STAAR (Q6GHZ6), RNJ1_STAAS (Q6GAC5), RNJ1_STAAW (Q7A171), RNJ1_STAEQ (Q5HQ80), RNJ1_STAES (Q8CT16), RNJ1_STAHJ (Q4L5A3), RNJ1_STAS1 (Q49WL3), RPOB_KORVE (Q1IHH4), RR2_THAPS (A0T0Q8), SC6_SCHCO (O74300), SECA_MYCPU (Q98RA6), SEY1_SCHPO (Q9UTE0), SMI1_SCHPO (O14362), STE13_YEAST (P33894), SYFB_THIDA (Q3SK29), T2S1_LACLC (O34104), TASS_HAPIR (A0A0F7GFS4), TEN1_HUMAN (Q9UKZ4), TEN1_MOUSE (Q9WTS4), TRP3_ARATH (Q9C7B1), VL2_HPV42 (P27235), XERS_LACLA (Q9CG78), XERS_LACLM (A2RKP9), XERS_LACLS (Q02YZ4), XOL1_CAEEL (Q23229), Y072_CHLTR (O84075), Y1273_MYCTU (P9WQJ1), Y1304_MYCBO (P0A4W5), Y1776_COREF (Q8FPK2), Y344_CHLMU (Q9PKW7), Y4KK_SINFN (P55529), Y5194_MYCGI (A4T1E2), Y973_METJA (Q58383), YFIB_BACSU (P54718), YQ02_CAEEL (Q17405), YSH1_EREGS (Q74ZC0), YSH1_YARLI (Q6C2Z7)» more |
| PDB [Detailed view] |
450 PDB
1A2Q; 1AF4; 1AH2; 1AK9; 1AQN; 1AU9; 1AV7; 1AVT; 1BE6; 1BE8; 1BFK; 1BFU; 1BH6; 1BJR; 1C3L; 1C9J; 1C9M; 1C9N; 1CNM; 1CSE; 1DBI; 1DUI; 1EGQ; 1GCI; 1GNS; 1GNV; 1HT3; 1IAV; 1IC6; 1JEA; 1LW6; 1MEE; 1MPT; 1NDQ; 1NDU; 1OT5; 1OYO; 1OYV; 1P7V; 1P7W; 1P8J; 1PEK; 1PFG; 1PJ8; 1PTK; 1Q5P; 1R0R; 1R64; 1R6V; 1S01; 1S02; 1SBC; 1SBH; 1SBI; 1SBN; 1SBT; 1SCA; 1SCB; 1SCD; 1SCJ; 1SCN; 1SEL; 1SIB; 1ST2; 1ST3; 1SUA; 1SUB; 1SUC; 1SUD; 1SUE; 1SUP; 1SVN; 1TEC; 1THM; 1TK2; 1TM1; 1TM3; 1TM4; 1TM5; 1TM7; 1TMG; 1TO1; 1TO2; 1UBN; 1V5I; 1VSB; 1WSD; 1XF1; 1Y1K; 1Y33; 1Y34; 1Y3B; 1Y3C; 1Y3D; 1Y3F; 1Y48; 1Y4A; 1Y4D; 1YJA; 1YJB; 1YJC; 1YU6; 2DP4; 2DQK; 2DUJ; 2E1P; 2G4V; 2HD4; 2HPZ; 2ID4; 2ID8; 2PKC; 2PQ2; 2PRK; 2PWA; 2PWB; 2PYZ; 2SBT; 2SEC; 2SIC; 2SNI; 2ST1; 2TEC; 2V8B; 2WUV; 2WUW; 2Z2X; 2Z2Y; 2Z2Z; 2Z30; 2Z56; 2Z57; 2Z58; 2ZRQ; 2ZWO; 2ZWP; 3A3N; 3A3O; 3A3P; 3AFG; 3AJ8; 3AJ9; 3BX1; 3D9Q; 3DDZ; 3DE0; 3DE1; 3DE2; 3DE3; 3DE4; 3DE5; 3DE6; 3DE7; 3DVQ; 3DVR; 3DVS; 3DW1; 3DW3; 3DWE; 3DYB; 3EIF; 3F7M; 3GT3; 3GT4; 3HJR; 3I2Y; 3I30; 3I34; 3I37; 3L1K; 3OSZ; 3PRK; 3PTL; 3Q40; 3Q5G; 3QMP; 3SIC; 3TEC; 3UNX; 3VHQ; 3VSB; 3VV2; 3VYV; 3WHI; 3WIU; 3WIV; 3WQB; 4B5L; 4C3U; 4C3V; 4CFY; 4CFZ; 4CG0; 4DJ5; 4DWW; 4DZT; 4FON; 4JP8; 4LVN; 4LVO; 4MZD; 4OMC; 4OMD; 4RYD; 4WOB; 4WOC; 4Z2A; 4ZAR; 5AMX; 5AQE; 5ARB; 5ARC; 5ARD; 5AVJ; 5AVK; 5B1D; 5B1E; 5CW1; 5GL8; 5I9S; 5JMO; 5JXG; 5JXH; 5JXI; 5JXJ; 5K7S; 5KXU; 5KXV; 5MIM; 5MJL; 5OX2; 5ROC; 5ROD; 5ROE; 5ROF; 5ROG; 5ROH; 5ROI; 5ROJ; 5ROK; 5ROL; 5ROM; 5RON; 5ROO; 5ROP; 5ROQ; 5ROR; 5ROS; 5ROT; 5ROU; 5ROV; 5ROW; 5ROX; 5ROY; 5ROZ; 5RP0; 5RP1; 5RP2; 5RP3; 5RP4; 5RP5; 5RP6; 5RP7; 5RP8; 5RP9; 5RPA; 5RPB; 5RPC; 5RPD; 5RPE; 5RPF; 5RPG; 5RPH; 5RPI; 5RPJ; 5RPK; 5RPL; 5RPM; 5RPN; 5RPO; 5RPP; 5RPQ; 5RPR; 5RPS; 5RPT; 5RPU; 5RPV; 5RPW; 5RPX; 5RPY; 5RPZ; 5SIC; 5UVL; 5WHW; 5WJG; 5WJH; 5WRC; 6CL7; 6CL8; 6CL9; 6CLA; 6CLB; 6DWQ; 6EQV; 6EQW; 6EQX; 6FJS; 6HLB; 6HLD; 6HLE; 6HZA; 6HZB; 6HZC; 6HZD; 6J43; 6K2P; 6K2R; 6K2S; 6K2T; 6K2V; 6K2W; 6K2X; 6K8M; 6KKF; 6LAW; 6MH6; 6N4U; 6O44; 6PAK; 6PKJ; 6PKK; 6PKL; 6PKM; 6PKN; 6PKO; 6PKP; 6PKQ; 6PKR; 6PKS; 6PKT; 6PQ0; 6PQ4; 6PU4; 6PU5; 6QF1; 6QXV; 6RUG; 6RUH; 6RUK; 6RUN; 6RUW; 6RVE; 6RVG; 6RZP; 6TXG; 6V8R; 6Y5S; 6Y5T; 6YD2; 6YD3; 6YD4; 6YD7; 6ZET; 6ZEU; 6ZEV; 7A68; 7A9F; 7A9K; 7A9M; 7AM3; 7AM4; 7AM5; 7AM6; 7AM7; 7AM8; 7BJ3; 7C0P; 7JSY; 7LCU; 7LN7; 7LPT; 7LPU; 7LPV; 7LQ8; 7LQ9; 7LQA; 7LQB; 7LQC; 7LTD; 7LTI; 7LTV; 7LU0; 7LU1; 7LU2; 7LU3; 7NJJ; 7NP7; 7NPR; 7NPS; 7NUY; 7NUZ; 7O1U; 7O1W; 7O1Y; 7O20; 7O22; 7QXY; 7QXZ; 7QY0; 7QY1; 7QY2; 7S4Z; 7SKX; 7SVY; 7SVZ; 7SW0; 7SW1; 7SW2; 7SW3; 7SW4; 7SW5; 7SW6; 7SW7; 7SW8; 7SW9; 7SWA; 7SWB; 7SWC; 7YZX; 8B4V; 8B4W; 8B4X; 8E52; 8E53; 8F05; 8F06; 8F07; 8FYO; 8FYP; 8FYQ; 8FYR; 8FYS; 8OYH; 8POL; 8SDK; 8SOG; 8SOU; 8SOV; 8SPL; 8SQV » more |