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Entry: PS00136

General information about the entry

Entry name [info] SUBTILASE_ASP
Accession [info] PS00136
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE;
18-SEP-2019 INFO UPDATE.
PROSITE Doc. [info] PDOC00125
Associated ProRule [info] PRU10080

Name and characterization of the entry

Description [info] Serine proteases, subtilase family, aspartic acid active site.
Pattern [info]
[STAIV]-{ERDL}-[LIVMF]-[LIVM]-D-[DSTA]-G-[LIVMFC]-x(2,3)-[DNH].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2019_08 which contains 560'823 sequence entries.


Total number of hits 354 in 354 different sequences
Number of true positive hits 172 in 172 different sequences
Number of 'unknown' hits 0
Number of false positive hits 182 in 182 different sequences
Number of false negative sequences 0
Number of 'partial' sequences 6
Precision (true positives / (true positives + false positives)) 48.59 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] active_site at position 5
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
172 sequences

AEP_YARLI   (P09230    ), AEX5_CAEEL  (P91863    ), ALP_ACRCH   (P29118    ), 
ALP_FUSCU   (P83610    ), ALP_HYPAT   (Q03420    ), ALP_LECPS   (Q68GV9    ), 
APRX_BACSU  (O31788    ), AQL1_THEAQ  (P08594    ), ASES_SARSR  (R4IR27    ), 
ASPA_AERSA  (P31339    ), BLI4_CAEEL  (P51559    ), BLI_ONCVO   (A0A044RE18), 
BPRV_DICNO  (P42779    ), BPRX_DICNO  (P42780    ), C5AP_STRP1  (P58099    ), 
C5AP_STRP3  (P0DD34    ), C5AP_STRP6  (Q5X9R0    ), C5AP_STRP8  (Q8NZ80    ), 
C5AP_STRPQ  (P0DD35    ), C5AP_STRPY  (P15926    ), CUDP_METAN  (P29138    ), 
ELYA_BACAO  (P27693    ), ELYA_BACCS  (P41362    ), ELYA_BACHD  (P41363    ), 
ELYA_BACYA  (P20724    ), EPIP_STAEP  (P30199    ), EXPR_XANCP  (P23314    ), 
FKPC1_CAEEL (O17798    ), FLS_FERPE   (Q93LQ6    ), FUR11_DROME (P26016    ), 
FUR1C_DROME (P30430    ), FUR2_DROME  (P30432    ), FURI1_XENLA (P29119    ), 
FURIN_BOVIN (Q28193    ), FURIN_HUMAN (P09958    ), FURIN_MOUSE (P23188    ), 
FURIN_RAT   (P23377    ), ISP1_BACSU  (P11018    ), ISP6_SCHPO  (P40903    ), 
ISP_BACCS   (P29140    ), ISP_PAEPO   (P29139    ), KEX1A_KLULA (P09231    ), 
KEX2_YEAST  (P13134    ), KRP1_SCHPO  (Q09175    ), MYCP2_MYCTU (O05458    ), 
MYCP4_MYCTU (I6YC58    ), MYCP5_MYCTU (O53945    ), NEC1_BOVIN  (Q9GLR1    ), 
NEC1_HUMAN  (P29120    ), NEC1_MOUSE  (P63239    ), NEC1_MUSCO  (P63240    ), 
NEC1_RAT    (P28840    ), NEC2_BOVIN  (Q9GLR0    ), NEC2_CAEEL  (G5ECN9    ), 
NEC2_HUMAN  (P16519    ), NEC2_MOUSE  (P21661    ), NEC2_PIG    (Q03333    ), 
NEC2_PONAB  (Q5REC2    ), NEC2_RAT    (P28841    ), NECA_HYDVU  (P29146    ), 
NECB_HYDVU  (P29145    ), NISP_LACLL  (Q07596    ), NVSP_ALIVI  (P83433    ), 
ORYZ_ASPCL  (A1CIA7    ), ORYZ_ASPFC  (B0Y708    ), ORYZ_ASPFN  (B8N106    ), 
ORYZ_ASPFU  (P28296    ), ORYZ_ASPOR  (P12547    ), ORYZ_EMENI  (Q00208    ), 
ORYZ_NEOFI  (A1CWF3    ), P1P_LACLC   (P16271    ), P2P_LACLC   (P15293    ), 
P2P_LACPA   (Q02470    ), P3P_LACLS   (P15292    ), PCSK4_HUMAN (Q6UW60    ), 
PCSK4_MOUSE (P29121    ), PCSK4_RAT   (Q78EH2    ), PCSK5_HUMAN (Q92824    ), 
PCSK5_MOUSE (Q04592    ), PCSK5_RAT   (P41413    ), PCSK6_HUMAN (P29122    ), 
PCSK6_RAT   (Q63415    ), PIIS_ACHLY  (P81719    ), PLS_PYRFU   (P72186    ), 
PRCA_ANAVT  (P23916    ), PRCA_NOSS1  (Q59149    ), PROA_VIBAL  (P16588    ), 
PRTB_YEAST  (P09232    ), PRTK_PARAQ  (P06873    ), PRTM_BACSK  (Q99405    ), 
PRTR_PARAQ  (P23653    ), PRTT_PARAQ  (P20015    ), PSP3_SCHPO  (Q9UTS0    ), 
RM201_RHOMI (Q32ZM1    ), RRT12_YEAST (P25381    ), SBT11_ARATH (Q84WS0    ), 
SBT14_ARATH (Q9LVJ1    ), SBT19_ARATH (Q9FHA4    ), SBT21_ARATH (Q9SA75    ), 
SBT22_ARATH (Q9SUN6    ), SBT23_ARATH (Q9FI12    ), SBT24_ARATH (F4HYR6    ), 
SBT25_ARATH (O64481    ), SBT26_ARATH (Q9SZV5    ), SBT3G_ARATH (Q8GWX9    ), 
SBT4E_ARATH (Q9LLL8    ), SEPR_THESR  (P80146    ), SMP1_MAGPO  (Q9Y778    ), 
SPAZ_ARTOA  (G1X8P8    ), SPAZ_ARTOL  (G3FNQ9    ), SPL1_ENCCU  (Q8SQJ3    ), 
SUB10_ARTBC (D4AQG0    ), SUB10_TRIVH (D4DIS6    ), SUB1_PSED2  (L8G6I7    ), 
SUB2A_COCP7 (C5P6D1    ), SUB2B_COCP7 (C5P906    ), SUB2C_COCP7 (C5NZ70    ), 
SUB2_ARTBC  (D4AZ75    ), SUB2_ARTBE  (Q64K35    ), SUB2_ARTGP  (E4UZP9    ), 
SUB2_ARTOC  (C5G168    ), SUB2_ARTOT  (Q8J0D8    ), SUB2_PSED2  (L8FSM5    ), 
SUB2_TRIEQ  (B6VA85    ), SUB2_TRIRU  (Q69F57    ), SUB2_TRITO  (B8XGQ5    ), 
SUB2_TRIVC  (Q5VJ76    ), SUB2_TRIVH  (D4DLI5    ), SUB3_PSED2  (L8GD75    ), 
SUB4B_COCP7 (C5NZT2    ), SUB5_ARTBC  (D4B194    ), SUB5_ARTBE  (Q64K32    ), 
SUB5_ARTGP  (E4V2L6    ), SUB5_ARTOC  (C5G1D1    ), SUB5_TRIEQ  (B6VA87    ), 
SUB5_TRIRU  (Q69F34    ), SUB5_TRITO  (B8XGQ8    ), SUB5_TRIVC  (Q5VJ73    ), 
SUB5_TRIVH  (D4D0F5    ), SUB6_ARTBC  (D4ALV9    ), SUB6_ARTBE  (Q64K31    ), 
SUB6_ARTGP  (E4V4J8    ), SUB6_ARTOC  (C5FQI3    ), SUB6_TRIEQ  (A1XIH0    ), 
SUB6_TRIRU  (Q9UW97    ), SUB6_TRISD  (A1XIH1    ), SUB6_TRISH  (Q8J077    ), 
SUB6_TRITO  (Q3ZEJ8    ), SUB6_TRIVC  (Q5VJ72    ), SUB6_TRIVH  (D4D5H3    ), 
SUB7A_COCP7 (C5PGK9    ), SUB7C_COCP7 (C5NZ69    ), SUB7D_COCP7 (C5P9H3    ), 
SUBB_BACLE  (P29599    ), SUBC_BACLI  (P00780    ), SUBD_BACLI  (P00781    ), 
SUBE_BACSU  (P16396    ), SUBN_BACNA  (P35835    ), SUBS_BACLE  (P29600    ), 
SUBT_BACAM  (P00782    ), SUBT_BACPU  (P07518    ), SUBT_BACS9  (P28842    ), 
SUBT_BACSA  (P00783    ), SUBT_BACSU  (P04189    ), SUBT_GEOSE  (P29142    ), 
SUBV_BACSU  (P29141    ), THES_BACSJ  (Q45670    ), THET_THEVU  (P04072    ), 
TKSP_THEKO  (Q5JIZ5    ), TKSU_THEKO  (P58502    ), XPR6_YARLI  (P42781    ), 
YSP3_YEAST  (P25036    )
» more

UniProtKB/Swiss-Prot
'Partial' sequences
6 sequences

ASE2_ACRSP  (P85157    ), CUDP_METCM  (P80406    ), NCP3_COPCM  (P83454    ), 
PRTE_HALME  (P28308    ), SP01_SCEBO  (Q10721    ), THEM_MALCI  (P13858    )
» more

UniProtKB/Swiss-Prot
False positive sequences
182 sequences

ACDA1_ARCFU (O29165    ), AGLU_TETPY  (O00906    ), ALDO3_ARATH (Q7G9P4    ), 
AP1_KLULA   (P56095    ), ARGC_CHRVO  (Q7NRT5    ), BAH_RHOER   (Q8RSQ2    ), 
BTUB_PHOLL  (Q7MYE3    ), CBID_PROMP  (Q7V3N8    ), CHS1_CRYNH  (O13356    ), 
CLS2_STAAC  (Q5HEB2    ), CLS2_STAAR  (Q6GEY7    ), CLS_STAAM   (P63800    ), 
CLS_STAAN   (P63801    ), CLS_STAAS   (Q6G7M2    ), CLS_STAAW   (P63802    ), 
COBT_DEIRA  (Q9RYR8    ), DCL4_ORYSJ  (A7LFZ6    ), DMXL1_HUMAN (Q9Y485    ), 
DMXL1_MOUSE (Q6PNC0    ), DNAG_NEIMA  (P57028    ), DNAG_NEIMB  (P57029    ), 
DNLJ1_STRGG (B1VUC2    ), DNLJ_FERNB  (A7HJG6    ), DRD1_CARAU  (P35406    ), 
EXOC1_DICDI (Q54NV1    ), FIXJ_AZOC5  (P26487    ), FLII_BUCBP  (Q89AZ7    ), 
FMT_GEOSL   (Q74GW4    ), FOLD2_ACIAD (Q6F8N7    ), FOLD_ACIBT  (A3M846    ), 
FOLD_CALS4  (Q8RAD0    ), FOLD_MYCPE  (Q8EV80    ), FOLD_PSYA2  (Q4FTX6    ), 
FOLD_PSYCK  (Q1QD30    ), FOLD_RUTMC  (A1AXA0    ), GLUQ_CUTAK  (Q6A7Y1    ), 
GLYA_CUTAK  (Q6AAU3    ), GLYA_MYCS2  (A0R2V7    ), GUAAB_PICTO (Q6L1Q1    ), 
GUAA_ASPOR  (Q2UFN0    ), HEM1_RHORT  (Q2RWE2    ), HIS5_ECOL6  (P60596    ), 
HIS5_ECOLI  (P60595    ), HIS5_SHIBS  (Q323I9    ), HIS5_SHIDS  (Q32EF2    ), 
HIS5_SHIFL  (Q83KJ5    ), HIS5_SHISS  (Q3Z0G2    ), HLYE_ECO57  (Q9REB3    ), 
HLYE_ECOLI  (P77335    ), HN1BA_DANRE (A1L1N5    ), HN1BB_DANRE (Q8UW00    ), 
HOA_PARPJ   (B2T2S2    ), HOY1_YARLI  (Q99160    ), KATG2_ALKMQ (A6TV07    ), 
KATG_PHEZH  (B4R8U3    ), KATG_SACD2  (Q21DT6    ), KUP3_RHIL3  (Q1M651    ), 
LCAP_HUMAN  (Q9UIQ6    ), LEC2_CYTSE  (P22971    ), LEU3_BRUA2  (Q2YL58    ), 
LEU3_BRUAB  (Q579B1    ), LEU3_BRUME  (Q8YCX4    ), LEU3_BRUSU  (Q8FVF3    ), 
LPXK_HELAH  (Q17X64    ), LPXK_HELPH  (Q1CUH3    ), LPXK_HELPJ  (Q9ZMB1    ), 
LPXK_HELPY  (O25095    ), LRC14_BOVIN (A5PJJ5    ), LRC14_HUMAN (Q15048    ), 
LRC14_MOUSE (Q8VC16    ), LRC14_RAT   (Q569B5    ), LRRC3_DANRE (A8WHP9    ), 
MATK_GAGLU  (Q9TMC8    ), MATK_ILLOL  (A6MMS5    ), METL2_ARATH (Q8LFA9    ), 
METN1_PSEU2 (Q4ZZR8    ), MSTO1_BOVIN (A5D9D4    ), MSTO1_HUMAN (Q9BUK6    ), 
MSTO1_MACFA (Q4R681    ), MSTO1_MOUSE (Q2YDW2    ), MSTO1_PONPY (Q5RF82    ), 
MYO2_CAEEL  (P12845    ), MZT1B_ARATH (Q9M0N8    ), NADE_SHEON  (Q8EFF2    ), 
NADO2_ORYSJ (Q7G765    ), NCAP_CVM1   (P18446    ), NCAP_CVM2   (Q9PY96    ), 
NCAP_CVM3   (P18447    ), NCAP_CVMA5  (P03416    ), NCAP_CVMDV  (Q83360    ), 
NCAP_CVMJH  (P03417    ), NCAP_CVMS   (P18448    ), NCAP_CVPV   (P59713    ), 
NCAP_CVRNJ  (Q9WCD0    ), NCAP_CVRSD  (Q02915    ), NEMS_APIME  (P85527    ), 
NOL6_DROME  (Q8IH00    ), NOL6_DROSE  (B4IBY3    ), NOL6_DROSI  (B4QX57    ), 
NOL6_DROYA  (B4PR18    ), NR2C1_BOVIN (A0JNE3    ), NR2C1_HUMAN (P13056    ), 
NR2C1_MACFA (Q95K90    ), NR2C1_MOUSE (Q505F1    ), NR2C1_PONAB (Q5RCZ5    ), 
NR2C1_RAT   (Q8VIJ4    ), NR2C1_XENTR (Q28CK1    ), NUS1_ASPOR  (P24021    ), 
OGR1_ORYSJ  (B8YEK4    ), PA24A_BOVIN (A4IFJ5    ), PA24A_CHICK (P49147    ), 
PA24A_DANRE (P50392    ), PA24A_HORSE (O77793    ), PA24A_HUMAN (P47712    ), 
PA24A_MOUSE (P47713    ), PA24A_PONAB (Q5R8A5    ), PA24A_RABIT (Q9TT38    ), 
PA24A_RAT   (P50393    ), PA24A_XENLA (Q7T0T9    ), PA24A_XENTR (B1WAZ6    ), 
PDAD_METKA  (Q8TXD4    ), PEPQ_AERHH  (A0KEL3    ), PEPQ_AERS4  (A4STF0    ), 
PGP_ARCFU   (O29805    ), PNP_FRAT1   (Q14IC9    ), PNP_FRATF   (A7NDP3    ), 
PNP_FRATH   (Q2A269    ), PNP_FRATM   (B2SDK7    ), PNP_FRATN   (A0Q5I9    ), 
PNP_FRATO   (Q0BKU1    ), PNP_FRATT   (Q5NGX7    ), PNP_FRATW   (A4IZA6    ), 
PP263_ARATH (Q9M2A1    ), PPOC_ARATH  (P55826    ), PURA_LEIDO  (A7LBL2    ), 
PURA_LEIIN  (A4HVP7    ), PURA_LEIMA  (Q4QG35    ), PYRE_PHOLL  (Q7MY25    ), 
PYRE_SHEON  (Q8E9L5    ), PYRE_VIBCH  (Q9KVD5    ), RNJ1_STAA3  (Q2FHZ1    ), 
RNJ1_STAA8  (Q2FZG9    ), RNJ1_STAAB  (Q2YX35    ), RNJ1_STAAC  (Q5HGZ5    ), 
RNJ1_STAAM  (Q99V09    ), RNJ1_STAAN  (Q7A682    ), RNJ1_STAAR  (Q6GHZ6    ), 
RNJ1_STAAS  (Q6GAC5    ), RNJ1_STAAW  (Q7A171    ), RNJ1_STAEQ  (Q5HQ80    ), 
RNJ1_STAES  (Q8CT16    ), RNJ1_STAHJ  (Q4L5A3    ), RNJ1_STAS1  (Q49WL3    ), 
RPOB_KORVE  (Q1IHH4    ), RR2_THAPS   (A0T0Q8    ), SC6_SCHCO   (O74300    ), 
SECA_MYCPU  (Q98RA6    ), SEY1_SCHPO  (Q9UTE0    ), SMI1_SCHPO  (O14362    ), 
STE13_YEAST (P33894    ), SYFB_THIDA  (Q3SK29    ), T2S1_LACLC  (O34104    ), 
TEN1_HUMAN  (Q9UKZ4    ), TEN1_MOUSE  (Q9WTS4    ), TRP3_ARATH  (Q9C7B1    ), 
VL2_HPV42   (P27235    ), XERS_LACLA  (Q9CG78    ), XERS_LACLM  (A2RKP9    ), 
XERS_LACLS  (Q02YZ4    ), XOL1_CAEEL  (Q23229    ), Y072_CHLTR  (O84075    ), 
Y1273_MYCTU (P9WQJ1    ), Y1304_MYCBO (P0A4W5    ), Y1776_COREF (Q8FPK2    ), 
Y344_CHLMU  (Q9PKW7    ), Y4KK_SINFN  (P55529    ), Y5194_MYCGI (A4T1E2    ), 
Y973_METJA  (Q58383    ), YFIB_BACSU  (P54718    ), YQ02_CAEEL  (Q17405    ), 
YSH1_ASHGO  (Q74ZC0    ), YSH1_YARLI  (Q6C2Z7    )
» more

PDB
[Detailed view]
254 PDB

1A2Q; 1AF4; 1AH2; 1AK9; 1AQN; 1AU9; 1AV7; 1AVT; 1BE6; 1BE8; 1BFK; 1BFU; 1BH6; 1BJR; 1C3L; 1C9J; 1C9M; 1C9N; 1CNM; 1CSE; 1DBI; 1DUI; 1EGQ; 1GCI; 1GNS; 1GNV; 1HT3; 1IAV; 1IC6; 1JEA; 1LW6; 1MEE; 1MPT; 1NDQ; 1NDU; 1OT5; 1OYO; 1OYV; 1P7V; 1P7W; 1P8J; 1PEK; 1PFG; 1PJ8; 1PTK; 1Q5P; 1R0R; 1R64; 1R6V; 1S01; 1S02; 1SBC; 1SBH; 1SBI; 1SBN; 1SBT; 1SCA; 1SCB; 1SCD; 1SCJ; 1SCN; 1SEL; 1SIB; 1ST2; 1ST3; 1SUA; 1SUB; 1SUC; 1SUD; 1SUE; 1SUP; 1SVN; 1TEC; 1THM; 1TK2; 1TM1; 1TM3; 1TM4; 1TM5; 1TM7; 1TMG; 1TO1; 1TO2; 1UBN; 1V5I; 1VSB; 1WSD; 1XF1; 1Y1K; 1Y33; 1Y34; 1Y3B; 1Y3C; 1Y3D; 1Y3F; 1Y48; 1Y4A; 1Y4D; 1YJA; 1YJB; 1YJC; 1YU6; 2DP4; 2DQK; 2DUJ; 2E1P; 2G4V; 2HD4; 2HPZ; 2ID4; 2ID8; 2PKC; 2PQ2; 2PRK; 2PWA; 2PWB; 2PYZ; 2SBT; 2SEC; 2SIC; 2SNI; 2ST1; 2TEC; 2V8B; 2WUV; 2WUW; 2Z2X; 2Z2Y; 2Z2Z; 2Z30; 2Z56; 2Z57; 2Z58; 2ZRQ; 2ZWO; 2ZWP; 3A3N; 3A3O; 3A3P; 3AFG; 3AJ8; 3AJ9; 3BX1; 3D9Q; 3DDZ; 3DE0; 3DE1; 3DE2; 3DE3; 3DE4; 3DE5; 3DE6; 3DE7; 3DVQ; 3DVR; 3DVS; 3DW1; 3DW3; 3DWE; 3DYB; 3EIF; 3F7M; 3GT3; 3GT4; 3I2Y; 3I30; 3I34; 3I37; 3L1K; 3OSZ; 3PRK; 3PTL; 3Q40; 3Q5G; 3QMP; 3SIC; 3TEC; 3UNX; 3VHQ; 3VSB; 3VV2; 3VYV; 3WHI; 3WIU; 3WIV; 4B5L; 4C3U; 4C3V; 4CFY; 4CFZ; 4CG0; 4DJ5; 4DWW; 4DZT; 4FON; 4JP8; 4MZD; 4OMC; 4OMD; 4RYD; 4WOB; 4WOC; 4Z2A; 4ZAR; 5AMX; 5AQE; 5ARB; 5ARC; 5ARD; 5AVJ; 5AVK; 5B1D; 5B1E; 5CW1; 5GL8; 5I9S; 5JMO; 5JXG; 5JXH; 5JXI; 5JXJ; 5K7S; 5KXU; 5KXV; 5MIM; 5MJL; 5OX2; 5SIC; 5UVL; 5WHW; 5WJG; 5WJH; 5WRC; 6CL7; 6CL8; 6CL9; 6CLA; 6CLB; 6EQV; 6EQW; 6EQX; 6FJS; 6HLB; 6HLD; 6HLE; 6HZA; 6HZB; 6HZC; 6HZD; 6MH6; 6N4U; 6O44; 6QF1; 6RZP
» more

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