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PROSITE entry PS00138


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General information about the entry

Entry name [info] SUBTILASE_SER
Accession [info] PS00138
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00125
Associated ProRule [info] PRU10082

Name and characterization of the entry

Description [info] Serine proteases, subtilase family, serine active site.
Pattern [info]
G-T-S-x-[SA]-x-P-x-{L}-[STAVC]-[AG].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_03 which contains 571'609 sequence entries.


Total number of hits 354 in 351 different sequences
Number of true positive hits 321 in 321 different sequences
Number of 'unknown' hits 0
Number of false positive hits 33 in 30 different sequences
Number of false negative sequences 6
Number of 'partial' sequences 7
Precision (true positives / (true positives + false positives)) 90.68 %
Recall (true positives / (true positives + false negatives)) 98.17 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 4
Site [info] active_site at position 3
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
321 sequences

AEP_YARLI   (P09230), AIR3_ARATH  (Q9ZSP5), ALP2_ASPFC  (B0Y473), 
ALP2_ASPFU  (P87184), ALP_HAPCH   (P29118), ALP_HYPAT   (Q03420), 
ALP_LECPS   (Q68GV9), APRX_BACSU  (O31788), AQL1_THEAQ  (P08594), 
ASES_SARSR  (R4IR27), ASPA_AERSA  (P31339), ASP_AERSO   (Q9L5A4), 
BLI4_CAEEL  (P51559), BLI_ONCVO   (A0A044RE18), BPRV_DICNO  (P42779), 
BPRX_DICNO  (P42780), C5AP_STRP1  (P58099), C5AP_STRP3  (P0DD34), 
C5AP_STRP6  (Q5X9R0), C5AP_STRP8  (Q8NZ80), C5AP_STRPQ  (P0DD35), 
C5AP_STRPY  (P15926), CH901_DAVTA (B7ZK61), CL401_COCLU (B3V0K8), 
CRSP_ARATH  (Q9LNU1), CUCM1_CUCME (Q39547), CUDP_METAN  (P29138), 
ELYA_ALKAL  (P27693), ELYA_BACYA  (P20724), ELYA_HALH5  (P41363), 
ELYA_SHOCL  (P41362), EPIP_STAEP  (P30199), EXPR_XANCP  (P23314), 
FIBR2_HEDJA (P86876), FKPC1_CAEEL (O17798), FLS_FERPE   (Q93LQ6), 
FUR11_DROME (P26016), FUR1C_DROME (P30430), FUR2_DROME  (P30432), 
FURI1_XENLA (P29119), FURIN_HUMAN (P09958), FURIN_MOUSE (P23188), 
FURIN_RAT   (P23377), HLY_HALMT   (I3R794), HLY_NATA1   (P29143), 
ISP1_BACSU  (P11018), ISP6_SCHPO  (P40903), ISP_PAEPO   (P29139), 
ISP_SHOCL   (P29140), KEX1A_KLULA (P09231), KEX2_CANAW  (O13359), 
KEX2_YEAST  (P13134), KRP1_SCHPO  (Q09175), MBTP1_CRIGR (Q9Z2A8), 
MBTP1_HUMAN (Q14703), MBTP1_MOUSE (Q9WTZ2), MBTP1_RAT   (Q9WTZ3), 
MYCP4_MYCTU (I6YC58), NALP_NEIMB  (Q9JXM7), NALP_NEIMH  (E6MVD9), 
NEC1_BOVIN  (Q9GLR1), NEC1_HUMAN  (P29120), NEC1_MOUSE  (P63239), 
NEC1_MUSCO  (P63240), NEC1_RAT(P28840), NEC2_BOVIN  (Q9GLR0), 
NEC2_CAEEL  (G5ECN9), NEC2_DROME  (Q9VBC7), NEC2_HUMAN  (P16519), 
NEC2_MOUSE  (P21661), NEC2_PIG(Q03333), NEC2_PONAB  (Q5REC2), 
NEC2_RAT(P28841), NECA_HYDVU  (P29146), NECB_HYDVU  (P29145), 
NEP_NATMA   (Q5RLZ1), ORYZ_ASPCL  (A1CIA7), ORYZ_ASPFC  (B0Y708), 
ORYZ_ASPFL  (P35211), ORYZ_ASPFN  (B8N106), ORYZ_ASPFU  (P28296), 
ORYZ_ASPOR  (P12547), ORYZ_EMENI  (Q00208), ORYZ_NEOFI  (A1CWF3), 
P1P_LACLC   (P16271), P2P_LACLC   (P15293), P2P_LACPA   (Q02470), 
P3P_LACLS   (P15292), PCH13_PENCH (P9WEW4), PCH13_PENRB (P9WEW3), 
PCH18_PENCH (P9WEW6), PCH18_PENRB (P9WEW5), PCSK4_HUMAN (Q6UW60), 
PCSK4_MOUSE (P29121), PCSK4_RAT   (Q78EH2), PCSK5_BRACL (Q9NJ15), 
PCSK5_HUMAN (Q92824), PCSK5_MOUSE (Q04592), PCSK5_RAT   (P41413), 
PCSK6_HUMAN (P29122), PCSK6_RAT   (Q63415), PCSK7_HUMAN (Q16549), 
PCSK7_MOUSE (Q61139), PCSK7_RAT   (Q62849), PEN13_PENRB (Q9URR2), 
PEN18_PENRB (Q9P8G3), PENC1_PENCI (Q9Y749), PENC2_PENCI (Q9Y755), 
PEPC_ASPNG  (P33295), PLS_PYRFU   (P72186), POPC_MYXXD  (Q1DFT5), 
PRCA_NOSS1  (Q59149), PRCA_TRIV2  (P23916), PROA_VIBAL  (P16588), 
PRTB_YEAST  (P09232), PRTK_PARAQ  (P06873), PRTM_SHOC1  (Q99405), 
PRTR_PARAQ  (P23653), PRTS_SERMA  (P09489), PRTT_PARAQ  (P20015), 
PSP3_SCHPO  (Q9UTS0), RM201_RHOMI (Q32ZM1), RRT12_YEAST (P25381), 
SBT11_ARATH (Q84WS0), SBT12_ARATH (O64495), SBT13_ARATH (Q9FLI4), 
SBT14_ARATH (Q9LVJ1), SBT15_ARATH (Q9LUM3), SBT16_ARATH (O49607), 
SBT17_ARATH (O65351), SBT18_ARATH (Q9ZUF6), SBT19_ARATH (Q9FHA4), 
SBT1_SOYBN  (I1N462), SBT21_ARATH (Q9SA75), SBT22_ARATH (Q9SUN6), 
SBT23_ARATH (Q9FI12), SBT24_ARATH (F4HYR6), SBT25_ARATH (O64481), 
SBT26_ARATH (Q9SZV5), SBT31_ARATH (F4JJH4), SBT32_ARATH (Q9MAP4), 
SBT33_ARATH (Q9MAP5), SBT34_ARATH (F4HPF1), SBT35_ARATH (Q9MAP7), 
SBT36_ARATH (Q8L7I2), SBT37_ARATH (Q9SZY2), SBT38_ARATH (Q9SZY3), 
SBT39_ARATH (Q9ZSB0), SBT3A_ARATH (Q9ZSB1), SBT3B_ARATH (Q1PDX5), 
SBT3C_ARATH (F4JJH5), SBT3D_ARATH (Q8GUK4), SBT3E_ARATH (Q9SVT4), 
SBT3F_ARATH (F4JJL8), SBT3G_ARATH (Q8GWX9), SBT3H_ARATH (Q9C7U8), 
SBT3I_ARATH (Q9STQ2), SBT3_SOLLC  (O82777), SBT41_ARATH (F4IG09), 
SBT42_ARATH (O23357), SBT43_ARATH (Q9FIF8), SBT44_ARATH (Q9FGU3), 
SBT45_ARATH (F4JA91), SBT46_ARATH (Q9STF7), SBT47_ARATH (F4KGD4), 
SBT48_ARATH (Q9FIM6), SBT49_ARATH (Q9FIM5), SBT4A_ARATH (Q9FIM8), 
SBT4B_ARATH (Q9FIG1), SBT4C_ARATH (Q8L7D2), SBT4D_ARATH (Q9FIG2), 
SBT4E_ARATH (Q9LLL8), SBT4F_ARATH (Q9LZS6), SBT51_ARATH (F4HSQ2), 
SBT54_ARATH (F4JXC5), SBT55_ARATH (F4KEL0), SBT56_ARATH (Q9FK76), 
SBT61_ARATH (Q0WUG6), SBTS_LOTJA  (A9JQS7), SEPR_THESR  (P80146), 
SMP1_MAGPO  (Q9Y778), SPAZ_ARTOA  (G1X8P8), SPAZ_ORBOL  (G3FNQ9), 
SPL1_ENCCU  (Q8SQJ3), SPM1_PYRO7  (P58371), SSA1_MANHA  (P31631), 
SU11A_COCP7 (C5P1W9), SU11B_COCP7 (C5PFR5), SUB10_ARTBC (D4AQG0), 
SUB10_ARTOC (C5FX37), SUB10_TRIVH (D4DIS6), SUB12_ARTBC (D4AQA9), 
SUB12_ARTGP (E4UY04), SUB12_TRIVH (D4D1U5), SUB1_ARTBC  (D4AKU9), 
SUB1_ARTBE  (Q64K30), SUB1_ARTGP  (E4UPZ4), SUB1_ARTOC  (C5FPS1), 
SUB1_ARTOT  (Q8J0D9), SUB1_PLAF7  (Q8I0V0), SUB1_PLAFA  (O61142), 
SUB1_PLAFO  (W7K9M0), SUB1_PSED2  (L8G6I7), SUB1_TRIEQ  (B6VA84), 
SUB1_TRIRU  (Q69F58), SUB1_TRITO  (B8XGQ4), SUB1_TRIVC  (Q5VJ77), 
SUB1_TRIVH  (D4DIW9), SUB2A_COCP7 (C5P6D1), SUB2B_COCP7 (C5P906), 
SUB2C_COCP7 (C5NZ70), SUB2_ARTBC  (D4AZ75), SUB2_ARTBE  (Q64K35), 
SUB2_ARTGP  (E4UZP9), SUB2_ARTOC  (C5G168), SUB2_ARTOT  (Q8J0D8), 
SUB2_DEIRA  (Q9RYM8), SUB2_PLAF7  (Q8IHZ5), SUB2_PLAFA  (O97364), 
SUB2_PLAFP  (Q9Y008), SUB2_PSED2  (L8FSM5), SUB2_TRIEQ  (B6VA85), 
SUB2_TRIRU  (Q69F57), SUB2_TRITO  (B8XGQ5), SUB2_TRIVC  (Q5VJ76), 
SUB2_TRIVH  (D4DLI5), SUB3_ARTBC  (D4AWY5), SUB3_ARTBE  (Q64K34), 
SUB3_ARTGP  (E4UN97), SUB3_ARTOC  (C5FMY5), SUB3_ARTOT  (Q8J0D7), 
SUB3_PSED2  (L8GD75), SUB3_TRIEQ  (B6VA86), SUB3_TRIRU  (Q69F56), 
SUB3_TRITO  (B8XGQ6), SUB3_TRIVC  (Q5VJ75), SUB3_TRIVH  (D4DLA2), 
SUB4A_COCP7 (C5PCB1), SUB4C_COCP7 (C5P6L5), SUB4_ARTBC  (D4AXW3), 
SUB4_ARTBE  (Q64K33), SUB4_ARTGP  (E4UWA4), SUB4_ARTOC  (C5FXZ6), 
SUB4_TRIEQ  (A7UKV6), SUB4_TRIRU  (Q69F35), SUB4_TRITO  (B8XGQ7), 
SUB4_TRIVC  (Q5VJ74), SUB4_TRIVH  (D4D6Q4), SUB5_ARTBC  (D4B194), 
SUB5_ARTBE  (Q64K32), SUB5_ARTGP  (E4V2L6), SUB5_ARTOC  (C5G1D1), 
SUB5_TRIEQ  (B6VA87), SUB5_TRIRU  (Q69F34), SUB5_TRITO  (B8XGQ8), 
SUB5_TRIVC  (Q5VJ73), SUB5_TRIVH  (D4D0F5), SUB6_ARTBC  (D4ALV9), 
SUB6_ARTBE  (Q64K31), SUB6_ARTGP  (E4V4J8), SUB6_ARTOC  (C5FQI3), 
SUB6_TRIEQ  (A1XIH0), SUB6_TRIRU  (Q9UW97), SUB6_TRISD  (A1XIH1), 
SUB6_TRISH  (Q8J077), SUB6_TRITO  (Q3ZEJ8), SUB6_TRIVC  (Q5VJ72), 
SUB6_TRIVH  (D4D5H3), SUB7A_COCP7 (C5PGK9), SUB7B_COCP7 (C5PCX1), 
SUB7_ARTBC  (D4APA9), SUB7_ARTBE  (Q64K36), SUB7_ARTGP  (E4V2V9), 
SUB7_ARTOC  (C5FJA5), SUB7_TRIEQ  (A1XIH3), SUB7_TRIRU  (Q8NID9), 
SUB7_TRITO  (A1XIH4), SUB7_TRIVC  (Q5VJ71), SUB7_TRIVH  (D4CZQ4), 
SUB7_TRIVO  (A1XIH6), SUB8_ARTBC  (D4AX50), SUB8_ARTOC  (C5FII2), 
SUB8_COCP7  (C5P4Z8), SUB8_TRIVH  (D4DKQ4), SUB9_ARTBC  (D4B5N1), 
SUB9_ARTGP  (E4UTU7), SUB9_ARTOC  (C5FH27), SUB9_COCP7  (C5P5Q3), 
SUB9_TRIVH  (D4D674), SUBB_LEDLE  (P29599), SUBC_BACLI  (P00780), 
SUBD_BACLI  (P00781), SUBE_BACSU  (P16396), SUBF_BACSU  (P16397), 
SUBN_BACNA  (P35835), SUBS_LEDLE  (P29600), SUBT_BACAM  (P00782), 
SUBT_BACPU  (P07518), SUBT_BACS9  (P28842), SUBT_BACSA  (P00783), 
SUBT_BACSU  (P04189), SUBT_GEOSE  (P29142), SUBV_BACSU  (P29141), 
TAGB_DICDI  (P54683), TAGD_DICDI  (Q8T9W1), THES_BACSJ  (Q45670), 
THET_THEVU  (P04072), TKSP_THEKO  (Q5JIZ5), TKSU_THEKO  (P58502), 
TPP2_BOVIN  (A5PK39), TPP2_CAEEL  (Q09541), TPP2_DROME  (Q9V6K1), 
TPP2_HUMAN  (P29144), TPP2_MOUSE  (Q64514), TPP2_RAT(Q64560), 
TPP2_SCHPO  (Q9UT05), TPPII_ARATH (F4JVN6), TPPII_ORYSJ (Q6ESI7), 
WPRA_BACSU  (P54423), XPR6_YARLI  (P42781), YSP3_YEAST  (P25036)
» more

UniProtKB/Swiss-Prot
False negative sequences
6 sequences

SBT1_LOTJA  (A9QY40), SBT3_LOTJA  (A9QY39), SBT4_LOTJA  (A9QY38), 
SBT_MEDTR   (G7KEU7), SBT_PETHY   (A0A0M3R8G2), SUB3_PLAF7  (Q8I430)
» more

UniProtKB/Swiss-Prot
'Partial' sequences
7 sequences

ASE2_ACRSP  (P85157), CUDP_METCM  (P80406), NCP3_COPCM  (P83454), 
NVSP_ALIVI  (P83433), PRTE_HALME  (P28308), SP01_SCEBO  (Q10721), 
THEM_MALCI  (P13858)
» more

UniProtKB/Swiss-Prot
False positive sequences
30 sequences

DCA11_CAEEL (P90794), FOSB_CANLF  (Q9TUB3), FOSB_HUMAN  (P53539), 
LIMD_DICDI  (Q9BIW4), MUCAP_PIG   (P12021), NU145_CHATD (G0SAK3), 
PAND_ALCBS  (Q0VSR5), PHYSA_PHYPO (Q8MZS4), PICP_PSESR  (P42790), 
SED1_ASPFU  (Q70DX9), SED2_ARTBC  (D4ANG0), SED2_ARTOC  (C5FBW2), 
SED2_ASPFU  (Q70J59), SED2_TRIVH  (D4DBH6), SED3_ARTBC  (D4AK75), 
SED3_ARTOC  (C5FTQ5), SED3_ASPFU  (Q70GH4), SED3_TRIVH  (D4D7N6), 
SED4_ARTBC  (D4AIK6), SED4_ARTOC  (C5FRX4), SED4_ASPFU  (Q4WQU0), 
SED4_TRIVH  (D4D9U2), SED5_ASPFU  (Q4WGU1), SPAST_DROWI (B4NBP4), 
TENS1_HUMAN (Q9HBL0), TPP1_DICDI  (Q55CT0), TTC8_CAEEL  (Q23049), 
UCR1_CAEEL  (P98080), XANP_XANS2  (Q60106), YL139_YARLI (P0C8L8)
» more

PDB
[Detailed view]
407 PDB

1A2Q; 1AF4; 1AH2; 1AK9; 1AQN; 1AU9; 1AV7; 1BE6; 1BE8; 1BFK; 1BFU; 1BH6; 1BJR; 1C3L; 1C9J; 1C9M; 1C9N; 1CNM; 1CSE; 1DBI; 1DUI; 1EGQ; 1GCI; 1GNV; 1HT3; 1IAV; 1IC6; 1JEA; 1LW6; 1MEE; 1MPT; 1NDQ; 1NDU; 1OT5; 1OYO; 1OYV; 1P7V; 1P7W; 1P8J; 1PEK; 1PFG; 1PJ8; 1PTK; 1Q5P; 1R0R; 1R64; 1R6V; 1S01; 1S02; 1SBC; 1SBH; 1SBI; 1SBN; 1SBT; 1SCA; 1SCB; 1SCD; 1SCN; 1SIB; 1ST2; 1ST3; 1SUE; 1SUP; 1SVN; 1TEC; 1THM; 1TK2; 1TM1; 1TM3; 1TM4; 1TM5; 1TM7; 1TMG; 1TO1; 1TO2; 1WSD; 1XF1; 1Y1K; 1Y33; 1Y34; 1Y3B; 1Y3C; 1Y3D; 1Y3F; 1Y48; 1Y4A; 1Y4D; 1YJA; 1YJB; 1YJC; 1YU6; 2DP4; 2DQK; 2DUJ; 2G4V; 2HD4; 2HPZ; 2ID4; 2ID8; 2PKC; 2PQ2; 2PRK; 2PWA; 2PWB; 2PYZ; 2SBT; 2SEC; 2SIC; 2SNI; 2ST1; 2TEC; 2V8B; 2WUV; 2WUW; 2Z2X; 3AJ8; 3AJ9; 3BX1; 3D9Q; 3DDZ; 3DE0; 3DE1; 3DE2; 3DE3; 3DE4; 3DE5; 3DE6; 3DE7; 3DVQ; 3DVR; 3DVS; 3DW1; 3DW3; 3DWE; 3DYB; 3EIF; 3F49; 3F7M; 3GT3; 3GT4; 3HJR; 3I2Y; 3I30; 3I34; 3I37; 3I6S; 3I74; 3L1K; 3LXU; 3OSZ; 3PRK; 3PTL; 3Q40; 3Q5G; 3QMP; 3SIC; 3TEC; 3UNX; 3VTA; 3VYV; 4B5L; 4C3U; 4C3V; 4CFY; 4CFZ; 4CG0; 4DJ5; 4DWW; 4DZT; 4FON; 4LVN; 4LVO; 4OMC; 4OMD; 4RYD; 4WOB; 4WOC; 4YN3; 4Z2A; 4ZAR; 5AMX; 5AQE; 5ARB; 5ARC; 5ARD; 5AVJ; 5AVK; 5B1D; 5B1E; 5CW1; 5GL8; 5I9S; 5JMO; 5JXG; 5JXH; 5JXI; 5JXJ; 5K7S; 5KXU; 5KXV; 5MIM; 5MJL; 5ROC; 5ROD; 5ROE; 5ROF; 5ROG; 5ROH; 5ROI; 5ROJ; 5ROK; 5ROL; 5ROM; 5RON; 5ROO; 5ROP; 5ROQ; 5ROR; 5ROS; 5ROT; 5ROU; 5ROV; 5ROW; 5ROX; 5ROY; 5ROZ; 5RP0; 5RP1; 5RP2; 5RP3; 5RP4; 5RP5; 5RP6; 5RP7; 5RP8; 5RP9; 5RPA; 5RPB; 5RPC; 5RPD; 5RPE; 5RPF; 5RPG; 5RPH; 5RPI; 5RPJ; 5RPK; 5RPL; 5RPM; 5RPN; 5RPO; 5RPP; 5RPQ; 5RPR; 5RPS; 5RPT; 5RPU; 5RPV; 5RPW; 5RPX; 5RPY; 5RPZ; 5SIC; 5UVL; 5WHW; 5WJG; 5WJH; 5WRC; 6CL7; 6CL8; 6CL9; 6CLA; 6CLB; 6EQV; 6EQW; 6EQX; 6FJS; 6HLB; 6HLD; 6HLE; 6HZA; 6HZB; 6HZC; 6HZD; 6J43; 6K2P; 6K2R; 6K2S; 6K2T; 6K2V; 6K2W; 6K2X; 6K8M; 6KKF; 6LAW; 6MH6; 6N4U; 6PKJ; 6PKK; 6PKL; 6PKM; 6PKN; 6PKO; 6PKP; 6PKQ; 6PKR; 6PKS; 6PKT; 6PQ0; 6PQ4; 6PU4; 6PU5; 6QF1; 6QXV; 6RUG; 6RUH; 6RUK; 6RUN; 6RUW; 6RVE; 6RVG; 6RZP; 6TXG; 6V8R; 6Y5S; 6Y5T; 6YD2; 6YD3; 6YD4; 6YD7; 6ZET; 6ZEU; 6ZEV; 7A68; 7A9F; 7A9K; 7A9M; 7C0P; 7JSY; 7LCU; 7LN7; 7LPT; 7LPU; 7LPV; 7LQ8; 7LQ9; 7LQA; 7LQB; 7LQC; 7LTD; 7LTI; 7LTV; 7LU0; 7LU1; 7LU2; 7LU3; 7NJJ; 7NUY; 7NUZ; 7O1U; 7O1W; 7O1Y; 7O20; 7O22; 7QXY; 7QXZ; 7QY0; 7QY1; 7QY2; 7S4Z; 7SKX; 7SVY; 7SVZ; 7SW0; 7SW1; 7SW2; 7SW3; 7SW4; 7SW5; 7SW6; 7SW7; 7SW8; 7SW9; 7SWA; 7SWB; 7SWC; 7YZX; 8B4V; 8B4W; 8B4X; 8E52; 8E53; 8E7F; 8F05; 8F06; 8F07; 8FYO; 8FYP; 8FYQ; 8FYR; 8FYS; 8SDK; 8SOG; 8SOU; 8SOV; 8SPL; 8SQV
» more