PROSITE logo

PROSITE entry PS00138


View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission
General information about the entry

Entry name [info] SUBTILASE_SER
Accession [info] PS00138
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00125
Associated ProRule [info] PRU10082

Name and characterization of the entry

Description [info] Serine proteases, subtilase family, serine active site.
Pattern [info]
G-T-S-x-[SA]-x-P-x-{L}-[STAVC]-[AG].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_06 which contains 572'619 sequence entries.


Total number of hits 354 in 351 different sequences
Number of true positive hits 321 in 321 different sequences
Number of 'unknown' hits 0
Number of false positive hits 33 in 30 different sequences
Number of false negative sequences 6
Number of 'partial' sequences 7
Precision (true positives / (true positives + false positives)) 90.68 %
Recall (true positives / (true positives + false negatives)) 98.17 %

Comments [info]

Taxonomic range [info] Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 4
Site [info] active_site at position 3
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
321 sequences

AEP_YARLI   (P09230), AIR3_ARATH  (Q9ZSP5), ALP2_ASPFC  (B0Y473), 
ALP2_ASPFU  (P87184), ALP_HAPCH   (P29118), ALP_HYPAT   (Q03420), 
ALP_LECPS   (Q68GV9), APRX_BACSU  (O31788), AQL1_THEAQ  (P08594), 
ASES_SARSR  (R4IR27), ASPA_AERSA  (P31339), ASP_AERSO   (Q9L5A4), 
BLI4_CAEEL  (P51559), BLI_ONCVO   (A0A044RE18), BPRV_DICNO  (P42779), 
BPRX_DICNO  (P42780), C5AP_STRP1  (P58099), C5AP_STRP3  (P0DD34), 
C5AP_STRP6  (Q5X9R0), C5AP_STRP8  (Q8NZ80), C5AP_STRPQ  (P0DD35), 
C5AP_STRPY  (P15926), CH901_DAVTA (B7ZK61), CL401_COCLU (B3V0K8), 
CRSP_ARATH  (Q9LNU1), CUCM1_CUCME (Q39547), CUDP_METAN  (P29138), 
ELYA_ALKAL  (P27693), ELYA_BACYA  (P20724), ELYA_HALH5  (P41363), 
ELYA_SHOCL  (P41362), EPIP_STAEP  (P30199), EXPR_XANCP  (P23314), 
FIBR2_HEDJA (P86876), FKPC1_CAEEL (O17798), FLS_FERPE   (Q93LQ6), 
FUR11_DROME (P26016), FUR1C_DROME (P30430), FUR2_DROME  (P30432), 
FURI1_XENLA (P29119), FURIN_HUMAN (P09958), FURIN_MOUSE (P23188), 
FURIN_RAT   (P23377), HLY_HALMT   (I3R794), HLY_NATA1   (P29143), 
ISP1_BACSU  (P11018), ISP6_SCHPO  (P40903), ISP_PAEPO   (P29139), 
ISP_SHOCL   (P29140), KEX1A_KLULA (P09231), KEX2_CANAW  (O13359), 
KEX2_YEAST  (P13134), KRP1_SCHPO  (Q09175), MBTP1_CRIGR (Q9Z2A8), 
MBTP1_HUMAN (Q14703), MBTP1_MOUSE (Q9WTZ2), MBTP1_RAT   (Q9WTZ3), 
MYCP4_MYCTU (I6YC58), NALP_NEIMB  (Q9JXM7), NALP_NEIMH  (E6MVD9), 
NEC1_BOVIN  (Q9GLR1), NEC1_HUMAN  (P29120), NEC1_MOUSE  (P63239), 
NEC1_MUSCO  (P63240), NEC1_RAT(P28840), NEC2_BOVIN  (Q9GLR0), 
NEC2_CAEEL  (G5ECN9), NEC2_DROME  (Q9VBC7), NEC2_HUMAN  (P16519), 
NEC2_MOUSE  (P21661), NEC2_PIG(Q03333), NEC2_PONAB  (Q5REC2), 
NEC2_RAT(P28841), NECA_HYDVU  (P29146), NECB_HYDVU  (P29145), 
NEP_NATMA   (Q5RLZ1), ORYZ_ASPCL  (A1CIA7), ORYZ_ASPFC  (B0Y708), 
ORYZ_ASPFL  (P35211), ORYZ_ASPFN  (B8N106), ORYZ_ASPFU  (P28296), 
ORYZ_ASPOR  (P12547), ORYZ_EMENI  (Q00208), ORYZ_NEOFI  (A1CWF3), 
P1P_LACLC   (P16271), P2P_LACLC   (P15293), P2P_LACPA   (Q02470), 
P3P_LACLS   (P15292), PCH13_PENCH (P9WEW4), PCH13_PENRB (P9WEW3), 
PCH18_PENCH (P9WEW6), PCH18_PENRB (P9WEW5), PCSK4_HUMAN (Q6UW60), 
PCSK4_MOUSE (P29121), PCSK4_RAT   (Q78EH2), PCSK5_BRACL (Q9NJ15), 
PCSK5_HUMAN (Q92824), PCSK5_MOUSE (Q04592), PCSK5_RAT   (P41413), 
PCSK6_HUMAN (P29122), PCSK6_RAT   (Q63415), PCSK7_HUMAN (Q16549), 
PCSK7_MOUSE (Q61139), PCSK7_RAT   (Q62849), PEN13_PENRB (Q9URR2), 
PEN18_PENRB (Q9P8G3), PENC1_PENCI (Q9Y749), PENC2_PENCI (Q9Y755), 
PEPC_ASPNG  (P33295), PLS_PYRFU   (P72186), POPC_MYXXD  (Q1DFT5), 
PRCA_NOSS1  (Q59149), PRCA_TRIV2  (P23916), PROA_VIBAL  (P16588), 
PRTB_YEAST  (P09232), PRTK_PARAQ  (P06873), PRTM_SHOC1  (Q99405), 
PRTR_PARAQ  (P23653), PRTS_SERMA  (P09489), PRTT_PARAQ  (P20015), 
PSP3_SCHPO  (Q9UTS0), RM201_RHOMI (Q32ZM1), RRT12_YEAST (P25381), 
SBT11_ARATH (Q84WS0), SBT12_ARATH (O64495), SBT13_ARATH (Q9FLI4), 
SBT14_ARATH (Q9LVJ1), SBT15_ARATH (Q9LUM3), SBT16_ARATH (O49607), 
SBT17_ARATH (O65351), SBT18_ARATH (Q9ZUF6), SBT19_ARATH (Q9FHA4), 
SBT1_SOYBN  (I1N462), SBT21_ARATH (Q9SA75), SBT22_ARATH (Q9SUN6), 
SBT23_ARATH (Q9FI12), SBT24_ARATH (F4HYR6), SBT25_ARATH (O64481), 
SBT26_ARATH (Q9SZV5), SBT31_ARATH (F4JJH4), SBT32_ARATH (Q9MAP4), 
SBT33_ARATH (Q9MAP5), SBT34_ARATH (F4HPF1), SBT35_ARATH (Q9MAP7), 
SBT36_ARATH (Q8L7I2), SBT37_ARATH (Q9SZY2), SBT38_ARATH (Q9SZY3), 
SBT39_ARATH (Q9ZSB0), SBT3A_ARATH (Q9ZSB1), SBT3B_ARATH (Q1PDX5), 
SBT3C_ARATH (F4JJH5), SBT3D_ARATH (Q8GUK4), SBT3E_ARATH (Q9SVT4), 
SBT3F_ARATH (F4JJL8), SBT3G_ARATH (Q8GWX9), SBT3H_ARATH (Q9C7U8), 
SBT3I_ARATH (Q9STQ2), SBT3_SOLLC  (O82777), SBT41_ARATH (F4IG09), 
SBT42_ARATH (O23357), SBT43_ARATH (Q9FIF8), SBT44_ARATH (Q9FGU3), 
SBT45_ARATH (F4JA91), SBT46_ARATH (Q9STF7), SBT47_ARATH (F4KGD4), 
SBT48_ARATH (Q9FIM6), SBT49_ARATH (Q9FIM5), SBT4A_ARATH (Q9FIM8), 
SBT4B_ARATH (Q9FIG1), SBT4C_ARATH (Q8L7D2), SBT4D_ARATH (Q9FIG2), 
SBT4E_ARATH (Q9LLL8), SBT4F_ARATH (Q9LZS6), SBT51_ARATH (F4HSQ2), 
SBT54_ARATH (F4JXC5), SBT55_ARATH (F4KEL0), SBT56_ARATH (Q9FK76), 
SBT61_ARATH (Q0WUG6), SBTS_LOTJA  (A9JQS7), SEPR_THESR  (P80146), 
SMP1_MAGPO  (Q9Y778), SPAZ_ARTOA  (G1X8P8), SPAZ_ORBOL  (G3FNQ9), 
SPL1_ENCCU  (Q8SQJ3), SPM1_PYRO7  (P58371), SSA1_MANHA  (P31631), 
SU11A_COCP7 (C5P1W9), SU11B_COCP7 (C5PFR5), SUB10_ARTBC (D4AQG0), 
SUB10_ARTOC (C5FX37), SUB10_TRIVH (D4DIS6), SUB12_ARTBC (D4AQA9), 
SUB12_ARTGP (E4UY04), SUB12_TRIVH (D4D1U5), SUB1_ARTBC  (D4AKU9), 
SUB1_ARTBE  (Q64K30), SUB1_ARTGP  (E4UPZ4), SUB1_ARTOC  (C5FPS1), 
SUB1_ARTOT  (Q8J0D9), SUB1_PLAF7  (Q8I0V0), SUB1_PLAFA  (O61142), 
SUB1_PLAFO  (W7K9M0), SUB1_PSED2  (L8G6I7), SUB1_TRIEQ  (B6VA84), 
SUB1_TRIRU  (Q69F58), SUB1_TRITO  (B8XGQ4), SUB1_TRIVC  (Q5VJ77), 
SUB1_TRIVH  (D4DIW9), SUB2A_COCP7 (C5P6D1), SUB2B_COCP7 (C5P906), 
SUB2C_COCP7 (C5NZ70), SUB2_ARTBC  (D4AZ75), SUB2_ARTBE  (Q64K35), 
SUB2_ARTGP  (E4UZP9), SUB2_ARTOC  (C5G168), SUB2_ARTOT  (Q8J0D8), 
SUB2_DEIRA  (Q9RYM8), SUB2_PLAF7  (Q8IHZ5), SUB2_PLAFA  (O97364), 
SUB2_PLAFP  (Q9Y008), SUB2_PSED2  (L8FSM5), SUB2_TRIEQ  (B6VA85), 
SUB2_TRIRU  (Q69F57), SUB2_TRITO  (B8XGQ5), SUB2_TRIVC  (Q5VJ76), 
SUB2_TRIVH  (D4DLI5), SUB3_ARTBC  (D4AWY5), SUB3_ARTBE  (Q64K34), 
SUB3_ARTGP  (E4UN97), SUB3_ARTOC  (C5FMY5), SUB3_ARTOT  (Q8J0D7), 
SUB3_PSED2  (L8GD75), SUB3_TRIEQ  (B6VA86), SUB3_TRIRU  (Q69F56), 
SUB3_TRITO  (B8XGQ6), SUB3_TRIVC  (Q5VJ75), SUB3_TRIVH  (D4DLA2), 
SUB4A_COCP7 (C5PCB1), SUB4C_COCP7 (C5P6L5), SUB4_ARTBC  (D4AXW3), 
SUB4_ARTBE  (Q64K33), SUB4_ARTGP  (E4UWA4), SUB4_ARTOC  (C5FXZ6), 
SUB4_TRIEQ  (A7UKV6), SUB4_TRIRU  (Q69F35), SUB4_TRITO  (B8XGQ7), 
SUB4_TRIVC  (Q5VJ74), SUB4_TRIVH  (D4D6Q4), SUB5_ARTBC  (D4B194), 
SUB5_ARTBE  (Q64K32), SUB5_ARTGP  (E4V2L6), SUB5_ARTOC  (C5G1D1), 
SUB5_TRIEQ  (B6VA87), SUB5_TRIRU  (Q69F34), SUB5_TRITO  (B8XGQ8), 
SUB5_TRIVC  (Q5VJ73), SUB5_TRIVH  (D4D0F5), SUB6_ARTBC  (D4ALV9), 
SUB6_ARTBE  (Q64K31), SUB6_ARTGP  (E4V4J8), SUB6_ARTOC  (C5FQI3), 
SUB6_TRIEQ  (A1XIH0), SUB6_TRIRU  (Q9UW97), SUB6_TRISD  (A1XIH1), 
SUB6_TRISH  (Q8J077), SUB6_TRITO  (Q3ZEJ8), SUB6_TRIVC  (Q5VJ72), 
SUB6_TRIVH  (D4D5H3), SUB7A_COCP7 (C5PGK9), SUB7B_COCP7 (C5PCX1), 
SUB7_ARTBC  (D4APA9), SUB7_ARTBE  (Q64K36), SUB7_ARTGP  (E4V2V9), 
SUB7_ARTOC  (C5FJA5), SUB7_TRIEQ  (A1XIH3), SUB7_TRIRU  (Q8NID9), 
SUB7_TRITO  (A1XIH4), SUB7_TRIVC  (Q5VJ71), SUB7_TRIVH  (D4CZQ4), 
SUB7_TRIVO  (A1XIH6), SUB8_ARTBC  (D4AX50), SUB8_ARTOC  (C5FII2), 
SUB8_COCP7  (C5P4Z8), SUB8_TRIVH  (D4DKQ4), SUB9_ARTBC  (D4B5N1), 
SUB9_ARTGP  (E4UTU7), SUB9_ARTOC  (C5FH27), SUB9_COCP7  (C5P5Q3), 
SUB9_TRIVH  (D4D674), SUBB_LEDLE  (P29599), SUBC_BACLI  (P00780), 
SUBD_BACLI  (P00781), SUBE_BACSU  (P16396), SUBF_BACSU  (P16397), 
SUBN_BACNA  (P35835), SUBS_LEDLE  (P29600), SUBT_BACAM  (P00782), 
SUBT_BACPU  (P07518), SUBT_BACS9  (P28842), SUBT_BACSA  (P00783), 
SUBT_BACSU  (P04189), SUBT_GEOSE  (P29142), SUBV_BACSU  (P29141), 
TAGB_DICDI  (P54683), TAGD_DICDI  (Q8T9W1), THES_BACSJ  (Q45670), 
THET_THEVU  (P04072), TKSP_THEKO  (Q5JIZ5), TKSU_THEKO  (P58502), 
TPP2_BOVIN  (A5PK39), TPP2_CAEEL  (Q09541), TPP2_DROME  (Q9V6K1), 
TPP2_HUMAN  (P29144), TPP2_MOUSE  (Q64514), TPP2_RAT(Q64560), 
TPP2_SCHPO  (Q9UT05), TPPII_ARATH (F4JVN6), TPPII_ORYSJ (Q6ESI7), 
WPRA_BACSU  (P54423), XPR6_YARLI  (P42781), YSP3_YEAST  (P25036)
» more

UniProtKB/Swiss-Prot
False negative sequences
6 sequences

SBT1_LOTJA  (A9QY40), SBT3_LOTJA  (A9QY39), SBT4_LOTJA  (A9QY38), 
SBT_MEDTR   (G7KEU7), SBT_PETHY   (A0A0M3R8G2), SUB3_PLAF7  (Q8I430)
» more

UniProtKB/Swiss-Prot
'Partial' sequences
7 sequences

ASE2_ACRSP  (P85157), CUDP_METCM  (P80406), NCP3_COPCM  (P83454), 
NVSP_ALIVI  (P83433), PRTE_HALME  (P28308), SP01_SCEBO  (Q10721), 
THEM_MALCI  (P13858)
» more

UniProtKB/Swiss-Prot
False positive sequences
30 sequences

DCA11_CAEEL (P90794), FOSB_CANLF  (Q9TUB3), FOSB_HUMAN  (P53539), 
LIMD_DICDI  (Q9BIW4), MUCAP_PIG   (P12021), NU145_CHATD (G0SAK3), 
PAND_ALCBS  (Q0VSR5), PHYSA_PHYPO (Q8MZS4), PICP_PSESR  (P42790), 
SED1_ASPFU  (Q70DX9), SED2_ARTBC  (D4ANG0), SED2_ARTOC  (C5FBW2), 
SED2_ASPFU  (Q70J59), SED2_TRIVH  (D4DBH6), SED3_ARTBC  (D4AK75), 
SED3_ARTOC  (C5FTQ5), SED3_ASPFU  (Q70GH4), SED3_TRIVH  (D4D7N6), 
SED4_ARTBC  (D4AIK6), SED4_ARTOC  (C5FRX4), SED4_ASPFU  (Q4WQU0), 
SED4_TRIVH  (D4D9U2), SED5_ASPFU  (Q4WGU1), SPAST_DROWI (B4NBP4), 
TENS1_HUMAN (Q9HBL0), TPP1_DICDI  (Q55CT0), TTC8_CAEEL  (Q23049), 
UCR1_CAEEL  (P98080), XANP_XANS2  (Q60106), YL139_YARLI (P0C8L8)
» more

PDB
[Detailed view]
411 PDB

1A2Q; 1AF4; 1AH2; 1AK9; 1AQN; 1AU9; 1AV7; 1BE6; 1BE8; 1BFK; 1BFU; 1BH6; 1BJR; 1C3L; 1C9J; 1C9M; 1C9N; 1CNM; 1CSE; 1DBI; 1DUI; 1EGQ; 1GCI; 1GNV; 1HT3; 1IAV; 1IC6; 1JEA; 1LW6; 1MEE; 1MPT; 1NDQ; 1NDU; 1OT5; 1OYO; 1OYV; 1P7V; 1P7W; 1P8J; 1PEK; 1PFG; 1PJ8; 1PTK; 1Q5P; 1R0R; 1R64; 1R6V; 1S01; 1S02; 1SBC; 1SBH; 1SBI; 1SBN; 1SBT; 1SCA; 1SCB; 1SCD; 1SCN; 1SIB; 1ST2; 1ST3; 1SUE; 1SUP; 1SVN; 1TEC; 1THM; 1TK2; 1TM1; 1TM3; 1TM4; 1TM5; 1TM7; 1TMG; 1TO1; 1TO2; 1WSD; 1XF1; 1Y1K; 1Y33; 1Y34; 1Y3B; 1Y3C; 1Y3D; 1Y3F; 1Y48; 1Y4A; 1Y4D; 1YJA; 1YJB; 1YJC; 1YU6; 2DP4; 2DQK; 2DUJ; 2G4V; 2HD4; 2HPZ; 2ID4; 2ID8; 2PKC; 2PQ2; 2PRK; 2PWA; 2PWB; 2PYZ; 2SBT; 2SEC; 2SIC; 2SNI; 2ST1; 2TEC; 2V8B; 2WUV; 2WUW; 2Z2X; 3AJ8; 3AJ9; 3BX1; 3D9Q; 3DDZ; 3DE0; 3DE1; 3DE2; 3DE3; 3DE4; 3DE5; 3DE6; 3DE7; 3DVQ; 3DVR; 3DVS; 3DW1; 3DW3; 3DWE; 3DYB; 3EIF; 3F49; 3F7M; 3GT3; 3GT4; 3HJR; 3I2Y; 3I30; 3I34; 3I37; 3I6S; 3I74; 3L1K; 3LXU; 3OSZ; 3PRK; 3PTL; 3Q40; 3Q5G; 3QMP; 3SIC; 3TEC; 3UNX; 3VTA; 3VYV; 4B5L; 4C3U; 4C3V; 4CFY; 4CFZ; 4CG0; 4DJ5; 4DWW; 4DZT; 4FON; 4LVN; 4LVO; 4OMC; 4OMD; 4RYD; 4WOB; 4WOC; 4YN3; 4Z2A; 4ZAR; 5AMX; 5AQE; 5ARB; 5ARC; 5ARD; 5AVJ; 5AVK; 5B1D; 5B1E; 5CW1; 5GL8; 5I9S; 5JMO; 5JXG; 5JXH; 5JXI; 5JXJ; 5K7S; 5KXU; 5KXV; 5MIM; 5MJL; 5ROC; 5ROD; 5ROE; 5ROF; 5ROG; 5ROH; 5ROI; 5ROJ; 5ROK; 5ROL; 5ROM; 5RON; 5ROO; 5ROP; 5ROQ; 5ROR; 5ROS; 5ROT; 5ROU; 5ROV; 5ROW; 5ROX; 5ROY; 5ROZ; 5RP0; 5RP1; 5RP2; 5RP3; 5RP4; 5RP5; 5RP6; 5RP7; 5RP8; 5RP9; 5RPA; 5RPB; 5RPC; 5RPD; 5RPE; 5RPF; 5RPG; 5RPH; 5RPI; 5RPJ; 5RPK; 5RPL; 5RPM; 5RPN; 5RPO; 5RPP; 5RPQ; 5RPR; 5RPS; 5RPT; 5RPU; 5RPV; 5RPW; 5RPX; 5RPY; 5RPZ; 5SIC; 5UVL; 5WHW; 5WJG; 5WJH; 5WRC; 6CL7; 6CL8; 6CL9; 6CLA; 6CLB; 6EQV; 6EQW; 6EQX; 6FJS; 6HLB; 6HLD; 6HLE; 6HZA; 6HZB; 6HZC; 6HZD; 6J43; 6K2P; 6K2R; 6K2S; 6K2T; 6K2V; 6K2W; 6K2X; 6K8M; 6KKF; 6LAW; 6MH6; 6N4U; 6PKJ; 6PKK; 6PKL; 6PKM; 6PKN; 6PKO; 6PKP; 6PKQ; 6PKR; 6PKS; 6PKT; 6PQ0; 6PQ4; 6PU4; 6PU5; 6QF1; 6QXV; 6RUG; 6RUH; 6RUK; 6RUN; 6RUW; 6RVE; 6RVG; 6RZP; 6TXG; 6V8R; 6Y5S; 6Y5T; 6YD2; 6YD3; 6YD4; 6YD7; 6ZET; 6ZEU; 6ZEV; 7A68; 7A9F; 7A9K; 7A9M; 7C0P; 7JSY; 7LCU; 7LN7; 7LPT; 7LPU; 7LPV; 7LQ8; 7LQ9; 7LQA; 7LQB; 7LQC; 7LTD; 7LTI; 7LTV; 7LU0; 7LU1; 7LU2; 7LU3; 7NJJ; 7NUY; 7NUZ; 7O1U; 7O1W; 7O1Y; 7O20; 7O22; 7QXY; 7QXZ; 7QY0; 7QY1; 7QY2; 7S4Z; 7SKX; 7SVY; 7SVZ; 7SW0; 7SW1; 7SW2; 7SW3; 7SW4; 7SW5; 7SW6; 7SW7; 7SW8; 7SW9; 7SWA; 7SWB; 7SWC; 7YZX; 8B4V; 8B4W; 8B4X; 8E52; 8E53; 8E7F; 8F05; 8F06; 8F07; 8FYO; 8FYP; 8FYQ; 8FYR; 8FYS; 8OYH; 8POL; 8SDK; 8SOG; 8SOU; 8SOV; 8SPL; 8SQV; 8UW8; 8UWC
» more