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| Entry: PS00139 |
General information about the entry
| Entry name [info] | THIOL_PROTEASE_CYS |
| Accession [info] | PS00139 |
| Entry type [info] | PATTERN |
| Date [info] |
01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE; 11-DEC-2019 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00126 |
| Associated ProRule [info] | PRU10088 |
Name and characterization of the entry
| Description [info] | Eukaryotic thiol (cysteine) proteases cysteine active site. |
| Pattern [info] |
Q-{V}-x-{DE}-[GE]-{F}-C-[YW]-{DN}-x-[STAGC]-[STAGCV].
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Numerical results [info]
| Total number of hits | 279 in 279 different sequences |
| Number of true positive hits | 267 in 267 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 12 in 12 different sequences |
| Number of false negative sequences | 57 |
| Number of 'partial' sequences | 21 |
| Precision (true positives / (true positives + false positives)) | 95.70 % |
| Recall (true positives / (true positives + false negatives)) | 82.41 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses |
| Maximum number of repetitions [info] | 1 |
| Site [info] | active_site at position 7 |
| Version [info] | 2 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
267 sequences
361L_IIV6 (Q91FG3 ), ACP1_ENTHI (P36184 ), ACP2_ENTHI (P36185 ), ACTN_ACTCC (P00785 ), ACTN_ACTDE (A5HII1 ), ALEUL_ARATH (Q8RWQ9 ), ALEU_ARATH (Q8H166 ), ALEU_HORVU (P05167 ), ANAN_ANACO (P80884 ), BLH1_YEAS1 (B3LP78 ), BLH1_YEAS2 (C7GPC1 ), BLH1_YEAS6 (B5VQH0 ), BLH1_YEAS7 (A6ZRK4 ), BLH1_YEAS8 (C8ZFZ7 ), BLH1_YEAST (Q01532 ), BLMH_CHICK (P87362 ), BLMH_HUMAN (Q13867 ), BLMH_MOUSE (Q8R016 ), BLMH_RABIT (P13019 ), BLMH_RAT (P70645 ), BROM1_ANACO (O23791 ), BROM2_ANACO (P14518 ), CAN10_HUMAN (Q9HC96 ), CAN10_MACFA (Q95LP4 ), CAN10_MOUSE (Q9ESK3 ), CAN10_RAT (Q9ES66 ), CAN11_HUMAN (Q9UMQ6 ), CAN11_MOUSE (Q6J756 ), CAN11_RAT (Q4V8Q1 ), CAN12_HUMAN (Q6ZSI9 ), CAN12_MOUSE (Q9ER56 ), CAN13_MOUSE (Q3UW68 ), CAN13_RAT (Q5BK10 ), CAN14_HUMAN (A8MX76 ), CAN15_HUMAN (O75808 ), CAN15_MOUSE (Q9JLG8 ), CAN1_BOVIN (Q27970 ), CAN1_HUMAN (P07384 ), CAN1_MACFA (Q9GLG2 ), CAN1_MOUSE (O35350 ), CAN1_PIG (P35750 ), CAN1_PONAB (Q5NVS7 ), CAN1_RAT (P97571 ), CAN2_BOVIN (Q27971 ), CAN2_CHICK (Q92178 ), CAN2_HUMAN (P17655 ), CAN2_MACFA (Q9GLG1 ), CAN2_MOUSE (O08529 ), CAN2_RAT (Q07009 ), CAN3_BOVIN (P51186 ), CAN3_CHICK (Q92177 ), CAN3_HUMAN (P20807 ), CAN3_MACFA (Q9GLG7 ), CAN3_MOUSE (Q64691 ), CAN3_PIG (P43368 ), CAN3_RAT (P16259 ), CAN3_SHEEP (Q9TTH8 ), CAN5_CAEEL (Q22036 ), CAN5_HUMAN (O15484 ), CAN5_MOUSE (O08688 ), CAN5_RAT (Q8R4C0 ), CAN8_HUMAN (A6NHC0 ), CAN8_MOUSE (Q91VA3 ), CAN8_RAT (Q78EJ9 ), CAN9_HUMAN (O14815 ), CAN9_MOUSE (Q9D805 ), CAN9_RAT (O35920 ), CANA_DROME (Q11002 ), CANB_DROME (Q9VT65 ), CAND_DROME (P27398 ), CANX_CHICK (P00789 ), CAN_CAEEL (P34308 ), CAN_SCHMA (P27730 ), CAT7_MOUSE (Q91ZF2 ), CAT7_RAT (D3ZZ07 ), CATB1_GIAIN (P92131 ), CATB2_ARATH (Q93VC9 ), CATB2_GIAIN (P92132 ), CATB3_ARATH (Q94K85 ), CATB3_GIAIN (P92133 ), CATB_BOVIN (P07688 ), CATB_CHICK (P43233 ), CATB_HUMAN (P07858 ), CATB_MACFA (Q4R5M2 ), CATB_MOUSE (P10605 ), CATB_PIG (A1E295 ), CATB_PONAB (Q5R6D1 ), CATB_RAT (P00787 ), CATC_BOVIN (Q3ZCJ8 ), CATC_CANLF (O97578 ), CATC_HUMAN (P53634 ), CATC_MACFA (Q60HG6 ), CATC_MOUSE (P97821 ), CATC_PONAB (Q5RB02 ), CATC_RAT (P80067 ), CATF_HUMAN (Q9UBX1 ), CATF_MOUSE (Q9R013 ), CATH_BOVIN (Q3T0I2 ), CATH_HUMAN (P09668 ), CATH_MOUSE (P49935 ), CATH_PIG (O46427 ), CATH_RAT (P00786 ), CATJ_MOUSE (Q9R014 ), CATJ_RAT (Q63088 ), CATK_BOVIN (Q5E968 ), CATK_CANLF (Q3ZKN1 ), CATK_CHICK (Q90686 ), CATK_HUMAN (P43235 ), CATK_MACFA (P61276 ), CATK_MACMU (P61277 ), CATK_MOUSE (P55097 ), CATK_PIG (Q9GLE3 ), CATK_RABIT (P43236 ), CATK_RAT (O35186 ), CATL1_BOVIN (P25975 ), CATL1_CANLF (Q9GL24 ), CATL1_CHICK (P09648 ), CATL1_CHLAE (Q9GKL8 ), CATL1_HUMAN (P07711 ), CATL1_MOUSE (P06797 ), CATL1_PARTE (Q94714 ), CATL1_PIG (Q28944 ), CATL1_RAT (P07154 ), CATL1_SHEEP (Q10991 ), CATL2_BOVIN (Q5E998 ), CATL2_HUMAN (O60911 ), CATL2_PARTE (A0E358 ), CATLL_FASHE (Q24940 ), CATLL_PHACE (O97397 ), CATL_BRUPA (O17473 ), CATL_DROME (Q95029 ), CATL_SARPE (Q26636 ), CATL_SCHMA (Q26534 ), CATO_HUMAN (P43234 ), CATO_MOUSE (Q8BM88 ), CATS_BOVIN (P25326 ), CATS_CANLF (Q8HY81 ), CATS_HUMAN (P25774 ), CATS_MOUSE (O70370 ), CATS_RAT (Q02765 ), CATS_SAIBB (Q8HY82 ), CATV_GVCPM (O91466 ), CATV_GVXN (Q9PYY5 ), CATV_NPVAC (P25783 ), CATV_NPVAH (Q80LP4 ), CATV_NPVAP (Q91CL9 ), CATV_NPVBM (P41721 ), CATV_NPVBS (Q9YWK4 ), CATV_NPVCD (Q6VTL7 ), CATV_NPVCF (P41715 ), CATV_NPVEP (Q91GE3 ), CATV_NPVHC (Q9WGE0 ), CATV_NPVLD (Q9YMP9 ), CATV_NPVMC (Q8QLK1 ), CATV_NPVOP (O10364 ), CATV_NPVR1 (Q8B9D5 ), CATV_NPVSE (Q9J8B9 ), CATV_NPVST (Q91BH1 ), CEP01_AMBAR (V5LU01 ), CEP1_ARATH (Q9FGR9 ), CEP2_ARATH (Q9STL4 ), CEP3_ARATH (Q9STL5 ), CFAD_DICDI (Q54TR1 ), CPGP2_ZINOF (P82474 ), CPL1_CAEEL (O45734 ), CPP1_ENTHI (Q01957 ), CPP2_ENTHI (Q01958 ), CPP3_ENTHI (Q06964 ), CPR1_CAEEL (P25807 ), CPR1_DROME (Q9VN93 ), CPR3_CAEEL (P43507 ), CPR4_CAEEL (P43508 ), CPR5_CAEEL (P43509 ), CPR6_CAEEL (P43510 ), CRUST_PANBO (Q86GF7 ), CTSB_DICDI (Q54QD9 ), CYSEP_PHAVU (P25803 ), CYSEP_RICCO (O65039 ), CYSEP_VIGMU (P12412 ), CYSP1_DICDI (P04988 ), CYSP1_HAECO (P19092 ), CYSP1_HOMAM (P13277 ), CYSP1_HORVU (P25249 ), CYSP1_LEIPI (P35591 ), CYSP1_MAIZE (Q10716 ), CYSP1_ORYSJ (Q7XR52 ), CYSP1_OSTOS (P25802 ), CYSP1_VASCU (P32954 ), CYSP2_DICDI (P04989 ), CYSP2_HAECO (P25793 ), CYSP2_HOMAM (P25782 ), CYSP2_HORVU (P25250 ), CYSP2_LEIPI (Q05094 ), CYSP2_MAIZE (Q10717 ), CYSP2_VASCU (P32955 ), CYSP3_DICDI (Q23894 ), CYSP3_HOMAM (P25784 ), CYSP3_SOLLC (Q40143 ), CYSP3_VASCU (P32956 ), CYSP4_BRANA (P25251 ), CYSP4_DICDI (P54639 ), CYSP4_VASCU (P32957 ), CYSP5_DICDI (P54640 ), CYSP6_DICDI (Q94503 ), CYSP7_DICDI (Q94504 ), CYSPL_SOLLC (P20721 ), CYSP_BLOTA (A1KXI0 ), CYSP_HEMSP (P43156 ), CYSP_PEA (P25804 ), CYSP_PLAFA (P25805 ), CYSP_PLAVN (P46102 ), CYSP_PLAVS (P42666 ), CYSP_SCHJA (P43157 ), CYSP_SCHMA (P25792 ), CYSP_THEPA (P22497 ), CYSP_TRYBB (P14658 ), CYSP_TRYCR (P25779 ), DEK1_ARATH (Q8RVL2 ), DEK1_MAIZE (Q8RVL1 ), DEK1_ORYSJ (Q6ZFZ4 ), ERVB_TABDI (P60994 ), ERVC_TABDI (P83654 ), GMSA_DICDI (Q54ME1 ), LMCPA_LEIME (P25775 ), LMCPB_LEIME (P36400 ), MDO1_ANAMC (P83443 ), MEX1_JACME (P84346 ), MEX2_JACME (P84347 ), ORYA_ORYSJ (P25776 ), ORYB_ORYSJ (P25777 ), ORYC_ORYSJ (P25778 ), PAPA1_CARPA (P00784 ), PAPA2_CARPA (P14080 ), PAPA3_CARPA (P10056 ), PAPA4_CARPA (P05994 ), PEPC_LACDL (Q48543 ), PEPC_LACHE (Q10744 ), PEPC_LACLA (Q9CEG3 ), PEPC_LACLC (Q04723 ), PEPC_LISIN (Q928V0 ), PEPC_LISMO (O69192 ), PEPC_STRTR (Q56115 ), PEPE_LACHE (P94870 ), PEPG_LACDL (P94869 ), PEPT1_DERFA (P16311 ), PEPT1_DERPT (P08176 ), PEPT1_EURMA (P25780 ), PEPW_LACDL (P94868 ), RD19A_ARATH (P43296 ), RD19B_ARATH (P43295 ), RD19C_ARATH (Q9SUL1 ), RD19D_ARATH (Q8VYS0 ), RD21A_ARATH (P43297 ), RD21B_ARATH (Q9FMH8 ), RD21C_ARATH (Q9LT78 ), RDL1_ARATH (Q94B08 ), RDL2_ARATH (Q9LT77 ), RDL3_ARATH (Q9LXW3 ), SAG12_ARATH (Q9FJ47 ), SAG39_ORYSI (A2XQE8 ), SAG39_ORYSJ (Q7XWK5 ), THPA_THADA (P21381 ), TPR_PORGI (P25806 ), VF224_IIV3 (Q197D6 ), VF224_IIV6 (Q91FU7 ), XCP1_ARATH (O65493 ), XCP2_ARATH (Q9LM66 )» more
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| UniProtKB/Swiss-Prot False negative sequences |
57 sequences
CAN13_HUMAN (Q6MZZ7 ), CAN6_HUMAN (Q9Y6Q1 ), CAN6_MOUSE (O35646 ), CAN6_RAT (O88501 ), CAN7_HUMAN (Q9Y6W3 ), CAN7_MOUSE (Q9R1S8 ), CAN7_PIG (A0FKG7 ), CANC_DROME (Q9VXH6 ), CATB1_ARATH (F4HVZ1 ), CATC_PLAF7 (Q8IIJ9 ), CATC_SCHMA (Q26563 ), CATL3_PARTE (Q94715 ), CATM_MOUSE (Q9JL96 ), CATQ_RAT (Q9QZE3 ), CATR_MOUSE (Q9JIA9 ), CATV_NPVHZ (Q8V5U0 ), CATW_FELCA (Q9TST1 ), CATW_HUMAN (P56202 ), CATW_MOUSE (P56203 ), CATZ1_CAEEL (G5EGP8 ), CATZ_BOVIN (P05689 ), CATZ_HUMAN (Q9UBR2 ), CATZ_MOUSE (Q9WUU7 ), CATZ_RAT (Q9R1T3 ), CPGP1_ZINOF (P82473 ), CYSP_THEAN (P25781 ), ECPA_STAEP (P0C0P9 ), ECPA_STAEQ (Q5HKF6 ), ECPA_STAES (P0C0Q0 ), P34_SOYBN (P22895 ), PEPT1_PSOOV (Q1EIQ3 ), RDL4_ARATH (Q9SUT0 ), RDL5_ARATH (Q9SUS9 ), RDL6_ARATH (F4JNL3 ), SERA_PLAF7 (Q9TY95 ), SERA_PLAFD (P69193 ), SERA_PLAFG (P69192 ), SILIC_PETFI (Q6YD92 ), SSPB_STAA8 (Q2FZL3 ), SSPB_STAAC (Q5HH36 ), SSPB_STAAM (Q99V46 ), SSPB_STAAN (Q7A6A7 ), SSPB_STAAR (Q6GI35 ), SSPB_STAAS (Q6GAG5 ), SSPB_STAAU (P0C1S6 ), SSPB_STAAW (Q8NX99 ), SSPP_STAA8 (Q2G2R8 ), SSPP_STAAC (Q5HEL3 ), SSPP_STAAM (P65825 ), SSPP_STAAN (P65826 ), SSPP_STAAR (Q6GFE8 ), SSPP_STAAS (Q6G824 ), SSPP_STAAU (P81297 ), SSPP_STAAW (Q8NVS9 ), TEST2_MOUSE (Q80UB0 ), TEST2_RAT (P15242 ), YCF2E_CAEEL (P90850 )» more |
| UniProtKB/Swiss-Prot 'Partial' sequences |
21 sequences
CAL1_CALGI (P20728 ), CAN1_RABIT (P06815 ), CAN2_PIG (P43367 ), CAN2_RABIT (P06814 ), CATB_COTJA (P81494 ), CATL1_FASHE (Q09093 ), CATL1_FELCA (P25773 ), CATL2_FASHE (P80342 ), CATL3_FASHE (P80532 ), CATL4_FASHE (P80528 ), CATL9_FASHE (P80533 ), CYSB_FASHE (P80529 ), CYSP3_OSTOS (Q06544 ), CYSP_TRIFO (P33403 ), CYSP_TRIVA (P33404 ), HP29_SARPE (P29184 ), KARA_BROPL (P22442 ), MDO2_ANAMC (P83447 ), PAPA5_CARPA (P05993 ), PEPT1_DERMI (P16312 ), PHIG1_PHIGI (P84789 )» more |
| UniProtKB/Swiss-Prot False positive sequences |
12 sequences
CB042_BOVIN (Q3SYX3 ), CB042_HUMAN (Q9NWW7 ), CB042_MACFA (Q4R907 ), CB042_MOUSE (Q8R3C1 ), CCM2L_HUMAN (Q9NUG4 ), COBD_MYCBO (Q7VEN1 ), CRIM1_HUMAN (Q9NZV1 ), HEPA_HHV6U (P52375 ), IF172_CHLRE (Q5DM57 ), KIT_TAKRU (Q8AXC6 ), UNC71_CAEEL (G5EFD5 ), VM3VA_MACLB (Q4VM08 )» more |
| PDB [Detailed view] |
244 PDB
1AEC; 1AIM; 1ATK; 1AU0; 1AU2; 1AU3; 1AU4; 1AYU; 1AYV; 1AYW; 1BGO; 1BP4; 1BQI; 1BY8; 1CB5; 1CPJ; 1CQD; 1CSB; 1CTE; 1CVZ; 1EWL; 1EWM; 1EWO; 1EWP; 1F29; 1F2A; 1F2B; 1F2C; 1FH0; 1GCB; 1GEC; 1GMY; 1HUC; 1ICF; 1ITO; 1IWD; 1JQP; 1K3B; 1KFU; 1KFX; 1KHP; 1KHQ; 1M6D; 1ME3; 1ME4; 1MEG; 1MEM; 1MS6; 1NB3; 1NB5; 1NL6; 1NLJ; 1NPZ; 1NQC; 1O0E; 1PAD; 1PBH; 1PCI; 1PE6; 1PIP; 1POP; 1PPD; 1PPN; 1PPO; 1PPP; 1Q6K; 1QDQ; 1S4V; 1SNK; 1SP4; 1THE; 1TL9; 1TLO; 1TU6; 1U9Q; 1U9V; 1U9W; 1U9X; 1VSN; 1YK7; 1YK8; 1YT7; 1ZCM; 1ZIV; 2AIM; 2ARY; 2AS8; 2ATO; 2AUX; 2AUZ; 2BDL; 2BDZ; 2DC6; 2DC7; 2DC8; 2DC9; 2DCA; 2DCB; 2DCC; 2DCD; 2DJF; 2DJG; 2DZY; 2E00; 2F1G; 2F7D; 2FO5; 2FQ9; 2FRA; 2FRQ; 2FT2; 2FTD; 2FUD; 2FYE; 2G6D; 2G7Y; 2G8E; 2G8J; 2H7J; 2HH5; 2HHN; 2HXZ; 2IPP; 2NQA; 2NQG; 2NQI; 2OP3; 2OZ2; 2P0R; 2PAD; 2PBH; 2PNS; 2R6N; 2R9C; 2R9F; 2R9M; 2R9N; 2R9O; 2XU1; 2XU3; 2XU4; 2XU5; 2YJ2; 2YJ8; 2YJ9; 2YJB; 2YJC; 3AI8; 3C9E; 3D6S; 3E1Z; 3H7D; 3H89; 3H8B; 3HD3; 3HHA; 3HWN; 3I06; 3IUT; 3K9M; 3KKU; 3KW9; 3KWB; 3KWZ; 3KX1; 3LXS; 3N3G; 3N4C; 3O0U; 3O1G; 3OF8; 3OF9; 3OVX; 3OVZ; 3PBH; 3PDF; 3RVV; 3RVW; 3RVX; 4AXL; 4AXM; 4BPV; 4BQV; 4BS5; 4BS6; 4BSQ; 4CDC; 4CDD; 4CDE; 4CDF; 4DMX; 4DMY; 4KLB; 4MZO; 4MZS; 4N79; 4N8W; 4OEL; 4OEM; 4P6E; 4P6G; 4PAD; 4PI3; 4PP1; 4PP2; 4QH6; 4X6H; 4X6I; 4X6J; 4XUI; 4YV8; 4YVA; 5EF4; 5EGW; 5F02; 5MAE; 5MAJ; 5MQY; 5PAD; 5T6U; 5TDI; 5TUN; 5VCN; 5VCO; 5VPH; 5VPK; 5VPL; 6ASH; 6AY2; 6BJD; 6BKI; 6BKJ; 6EZP; 6EZX; 6F06; 6H8T; 6HGY; 6MIS; 6N3S; 6OKJ; 6PAD; 6QBS; 7PCK; 8PCH » more |
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