PROSITE entry PS00139
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PURL: https://purl.expasy.org/prosite/signature/PS00139
Direct ScanProsite submission
General information about the entry
Entry name [info] | THIOL_PROTEASE_CYS |
Accession [info] | PS00139 |
Entry type [info] | PATTERN |
Date [info] |
01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
PROSITE Doc. [info] | PDOC00126 |
Associated ProRule [info] | PRU10088 |
Name and characterization of the entry
Description [info] | Eukaryotic thiol (cysteine) proteases cysteine active site. |
Pattern [info] |
Q-{V}-x-{DE}-[GE]-{F}-C-[YW]-{DN}-x-[STAGC]-[STAGCV]. |
Numerical results [info]
Total number of hits | 299 in 299 different sequences |
Number of true positive hits | 282 in 282 different sequences |
Number of 'unknown' hits | 0 |
Number of false positive hits | 17 in 17 different sequences |
Number of false negative sequences | 57 |
Number of 'partial' sequences | 21 |
Precision (true positives / (true positives + false positives)) | 94.31 % |
Recall (true positives / (true positives + false negatives)) | 83.19 % |
Comments [info]
Taxonomic range [info] | Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses |
Maximum number of repetitions [info] | 1 |
Site [info] | active_site at position 7 |
Version [info] | 2 |
Cross-references [info]
UniProtKB/Swiss-Prot True positive sequences |
282 sequences
361L_IIV6 (Q91FG3), ACTN_ACTCC (P00785), ACTN_ACTDE (A5HII1), ALEUL_ARATH (Q8RWQ9), ALEU_ARATH (Q8H166), ALEU_HORVU (P05167), ANAN_ANACO (P80884), BHPC1_PLABA (A0A509APV9), BLH1_YEAS1 (B3LP78), BLH1_YEAS2 (C7GPC1), BLH1_YEAS6 (B5VQH0), BLH1_YEAS7 (A6ZRK4), BLH1_YEAS8 (C8ZFZ7), BLH1_YEAST (Q01532), BLMH_CHICK (P87362), BLMH_HUMAN (Q13867), BLMH_MOUSE (Q8R016), BLMH_RABIT (P13019), BLMH_RAT(P70645), BROM1_ANACO (O23791), BROM2_ANACO (P14518), CAN10_HUMAN (Q9HC96), CAN10_MACFA (Q95LP4), CAN10_MOUSE (Q9ESK3), CAN10_RAT (Q9ES66), CAN11_HUMAN (Q9UMQ6), CAN11_MOUSE (Q6J756), CAN11_RAT (Q4V8Q1), CAN12_HUMAN (Q6ZSI9), CAN12_MOUSE (Q9ER56), CAN13_MOUSE (Q3UW68), CAN13_RAT (Q5BK10), CAN14_HUMAN (A8MX76), CAN15_HUMAN (O75808), CAN15_MOUSE (Q9JLG8), CAN1_BOVIN (Q27970), CAN1_CAEEL (P34308), CAN1_HUMAN (P07384), CAN1_MACFA (Q9GLG2), CAN1_MOUSE (O35350), CAN1_PIG(P35750), CAN1_PONAB (Q5NVS7), CAN1_RAT(P97571), CAN2_BOVIN (Q27971), CAN2_CHICK (Q92178), CAN2_HUMAN (P17655), CAN2_MACFA (Q9GLG1), CAN2_MOUSE (O08529), CAN2_RAT(Q07009), CAN3_BOVIN (P51186), CAN3_CHICK (Q92177), CAN3_HUMAN (P20807), CAN3_MACFA (Q9GLG7), CAN3_MOUSE (Q64691), CAN3_PIG(P43368), CAN3_RAT(P16259), CAN3_SHEEP (Q9TTH8), CAN4_CAEEL (Q8IAA9), CAN5_CAEEL (Q22036), CAN5_HUMAN (O15484), CAN5_MOUSE (O08688), CAN5_RAT(Q8R4C0), CAN8_HUMAN (A6NHC0), CAN8_MOUSE (Q91VA3), CAN8_RAT(Q78EJ9), CAN9_HUMAN (O14815), CAN9_MOUSE (Q9D805), CAN9_RAT(O35920), CANA_DROME (Q11002), CANB_DROME (Q9VT65), CAND_DROME (P27398), CANX_CHICK (P00789), CAN_SCHMA (P27730), CAT7_MOUSE (Q91ZF2), CAT7_RAT(D3ZZ07), CATB1_GIAIN (P92131), CATB2_ARATH (Q93VC9), CATB2_GIAIN (P92132), CATB3_ARATH (Q94K85), CATB3_GIAIN (P92133), CATB_BOVIN (P07688), CATB_CHICK (P43233), CATB_HUMAN (P07858), CATB_MACFA (Q4R5M2), CATB_MEDTR (A0A072UTP9), CATB_MOUSE (P10605), CATB_PIG(A1E295), CATB_PONAB (Q5R6D1), CATB_RAT(P00787), CATB_SHEEP (P83205), CATC_BOVIN (Q3ZCJ8), CATC_CANLF (O97578), CATC_HUMAN (P53634), CATC_MACFA (Q60HG6), CATC_MOUSE (P97821), CATC_PONAB (Q5RB02), CATC_RAT(P80067), CATF_DROME (Q9VN93), CATF_HUMAN (Q9UBX1), CATF_MOUSE (Q9R013), CATH_BOVIN (Q3T0I2), CATH_HUMAN (P09668), CATH_MOUSE (P49935), CATH_PIG(O46427), CATH_RAT(P00786), CATJ_MOUSE (Q9R014), CATJ_RAT(Q63088), CATK_BOVIN (Q5E968), CATK_CANLF (Q3ZKN1), CATK_CHICK (Q90686), CATK_HUMAN (P43235), CATK_MACFA (P61276), CATK_MACMU (P61277), CATK_MOUSE (P55097), CATK_PIG(Q9GLE3), CATK_RABIT (P43236), CATK_RAT(O35186), CATL1_BOVIN (P25975), CATL1_CANLF (Q9GL24), CATL1_CHICK (P09648), CATL1_CHLAE (Q9GKL8), CATL1_DROME (Q95029), CATL1_HUMAN (P07711), CATL1_MOUSE (P06797), CATL1_PARTE (Q94714), CATL1_PIG (Q28944), CATL1_RAT (P07154), CATL1_SHEEP (Q10991), CATL2_BOVIN (Q5E998), CATL2_HUMAN (O60911), CATL2_PARTE (A0E358), CATLL_FASHE (Q24940), CATLL_PHACE (O97397), CATL_AEDAE (A0A1S4F2V5), CATL_BRUPA (O17473), CATL_SARPE (Q26636), CATL_SCHMA (Q26534), CATO_HUMAN (P43234), CATO_MOUSE (Q8BM88), CATS_BOVIN (P25326), CATS_CANLF (Q8HY81), CATS_HUMAN (P25774), CATS_MOUSE (O70370), CATS_RAT(Q02765), CATS_SAIBB (Q8HY82), CATV_GVCPM (O91466), CATV_GVXN (Q9PYY5), CATV_NPVAC (P25783), CATV_NPVAH (Q80LP4), CATV_NPVAP (Q91CL9), CATV_NPVBM (P41721), CATV_NPVBS (Q9YWK4), CATV_NPVCD (Q6VTL7), CATV_NPVCF (P41715), CATV_NPVEP (Q91GE3), CATV_NPVHC (Q9WGE0), CATV_NPVLD (Q9YMP9), CATV_NPVMC (Q8QLK1), CATV_NPVOP (O10364), CATV_NPVR1 (Q8B9D5), CATV_NPVSE (Q9J8B9), CATV_NPVST (Q91BH1), CEP01_AMBAR (V5LU01), CEP1_ARATH (Q9FGR9), CEP2_ARATH (Q9STL4), CEP3_ARATH (Q9STL5), CFAD_DICDI (Q54TR1), CPGP2_ZINOF (P82474), CPL1_CAEEL (O45734), CPP1_ENTH1 (Q01957), CPP2_ENTH1 (Q01958), CPP3_ENTH1 (P36184), CPR1_CAEEL (P25807), CPR3_CAEEL (P43507), CPR4_CAEEL (P43508), CPR5_CAEEL (P43509), CPR6_CAEEL (P43510), CRUST_PANBO (Q86GF7), CTSB_DICDI (Q54QD9), CYSEP_PHAVU (P25803), CYSEP_RICCO (O65039), CYSEP_VIGMU (P12412), CYSP1_DICDI (P04988), CYSP1_HAECO (P19092), CYSP1_HOMAM (P13277), CYSP1_HORVU (P25249), CYSP1_LEIPI (P35591), CYSP1_MAIZE (Q10716), CYSP1_ORYSJ (Q7XR52), CYSP1_OSTOS (P25802), CYSP1_VASCU (P32954), CYSP2_DICDI (P04989), CYSP2_HAECO (P25793), CYSP2_HOMAM (P25782), CYSP2_HORVU (P25250), CYSP2_LEIPI (Q05094), CYSP2_MAIZE (Q10717), CYSP2_VASCU (P32955), CYSP3_DICDI (Q23894), CYSP3_HOMAM (P25784), CYSP3_SOLLC (Q40143), CYSP3_VASCU (P32956), CYSP4_BRANA (P25251), CYSP4_DICDI (P54639), CYSP4_VASCU (P32957), CYSP5_DICDI (P54640), CYSP6_DICDI (Q94503), CYSP7_DICDI (Q94504), CYSPL_SOLLC (P20721), CYSP_BLOTA (A1KXI0), CYSP_HEMSP (P43156), CYSP_PEA(P25804), CYSP_SCHJA (P43157), CYSP_SCHMA (P25792), CYSP_THEPA (P22497), CYSP_TRYBB (P14658), CYSP_TRYCR (P25779), DEK1_ARATH (Q8RVL2), DEK1_MAIZE (Q8RVL1), DEK1_ORYSJ (Q6ZFZ4), ERVA_TABDI (A5YVK8), ERVB_TABDI (P60994), ERVC1_TABDI (P83654), ERVC2_TABDI (A8DS38), FPC1_PLAF7 (P25805), FPC2A_PLAF7 (Q8I6U4), FPC2B_PLAF7 (Q8I6U5), FPC3_PLAF7 (Q8IIL0), GMSA_DICDI (Q54ME1), LMCPA_LEIME (P25775), LMCPB_LEIME (P36400), MDO1_ANAMC (P83443), MEX1_JACME (P84346), MEX2_JACME (P84347), MUCIN_MUCPR (B2LSD2), ORYA_ORYSJ (P25776), ORYB_ORYSJ (P25777), ORYC_ORYSJ (P25778), PAPA1_CARPA (P00784), PAPA2_CARPA (P14080), PAPA3_CARPA (P10056), PAPA4_CARPA (P05994), PEPC_LACDL (Q48543), PEPC_LACHE (Q10744), PEPC_LACLA (Q9CEG3), PEPC_LACLC (Q04723), PEPC_LISIN (Q928V0), PEPC_LISMO (O69192), PEPC_STRTR (Q56115), PEPE_LACHE (P94870), PEPG_LACDL (P94869), PEPT1_DERFA (P16311), PEPT1_DERPT (P08176), PEPT1_EURMA (P25780), PEPW_LACDL (P94868), PVP1_PLAVN (P46102), RD19A_ARATH (P43296), RD19B_ARATH (P43295), RD19C_ARATH (Q9SUL1), RD19D_ARATH (Q8VYS0), RD21A_ARATH (P43297), RD21B_ARATH (Q9FMH8), RD21C_ARATH (Q9LT78), RDL1_ARATH (Q94B08), RDL2_ARATH (Q9LT77), RDL3_ARATH (Q9LXW3), REP1_ORYSJ (Q7F3A8), REPA_ORYSJ (Q7GDU7), SAG12_ARATH (Q9FJ47), SAG39_ORYSI (A2XQE8), SAG39_ORYSJ (Q7XWK5), SERA6_PLAF7 (Q9TY96), SERA6_PLAFA (Q26015), THPA_THADA (P21381), TPR_PORGI (P25806), VANSY_GLEHE (A0A068CNX1), VANSY_VANPL (A0A0F7G352), VF224_IIV3 (Q197D6), VF224_IIV6 (Q91FU7), VX1_PLAVS (P42666), XCP1_ARATH (O65493), XCP2_ARATH (Q9LM66)» more
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UniProtKB/Swiss-Prot False negative sequences |
57 sequences
CAN13_HUMAN (Q6MZZ7), CAN6_HUMAN (Q9Y6Q1), CAN6_MOUSE (O35646), CAN6_RAT(O88501), CAN7_HUMAN (Q9Y6W3), CAN7_MOUSE (Q9R1S8), CAN7_PIG(A0FKG7), CANC_DROME (Q9VXH6), CATB1_ARATH (F4HVZ1), CATC_SCHMA (Q26563), CATL3_PARTE (Q94715), CATM_MOUSE (Q9JL96), CATQ_RAT(Q9QZE3), CATR_MOUSE (Q9JIA9), CATV_NPVHZ (Q8V5U0), CATW_FELCA (Q9TST1), CATW_HUMAN (P56202), CATW_MOUSE (P56203), CATZ1_CAEEL (G5EGP8), CATZ_BOVIN (P05689), CATZ_HUMAN (Q9UBR2), CATZ_MOUSE (Q9WUU7), CATZ_RAT(Q9R1T3), CPGP1_ZINOF (P82473), CYSP_THEAN (P25781), DPAP1_PLAF7 (Q8IIJ9), ECPA_STAEP (P0C0P9), ECPA_STAEQ (Q5HKF6), ECPA_STAES (P0C0Q0), P34_SOYBN (P22895), PEPT1_PSOOV (Q1EIQ3), RDL4_ARATH (Q9SUT0), RDL5_ARATH (Q9SUS9), RDL6_ARATH (F4JNL3), SERA5_PLAF7 (Q9TY95), SERA5_PLAFD (P69193), SERA5_PLAFG (P69192), SILIC_PETFI (Q6YD92), SSPB_STAA8 (Q2FZL3), SSPB_STAAC (Q5HH36), SSPB_STAAM (Q99V46), SSPB_STAAN (Q7A6A7), SSPB_STAAR (Q6GI35), SSPB_STAAS (Q6GAG5), SSPB_STAAU (P0C1S6), SSPB_STAAW (Q8NX99), SSPP_STAA8 (Q2G2R8), SSPP_STAAC (Q5HEL3), SSPP_STAAM (P65825), SSPP_STAAN (P65826), SSPP_STAAR (Q6GFE8), SSPP_STAAS (Q6G824), SSPP_STAAU (P81297), SSPP_STAAW (Q8NVS9), TEST2_MOUSE (Q80UB0), TEST2_RAT (P15242), YCF2E_CAEEL (P90850)» more |
UniProtKB/Swiss-Prot 'Partial' sequences |
21 sequences
CAL1_CALGI (P20728), CAN1_RABIT (P06815), CAN2_PIG(P43367), CAN2_RABIT (P06814), CATB_COTJA (P81494), CATL1_FASHE (Q09093), CATL1_FELCA (P25773), CATL2_FASHE (P80342), CATL3_FASHE (P80532), CATL4_FASHE (P80528), CATL9_FASHE (P80533), CYSB_FASHE (P80529), CYSP3_OSTOS (Q06544), CYSP_TRIFO (P33403), CYSP_TRIVA (P33404), HP29_SARPE (P29184), KARA_BROPL (P22442), MDO2_ANAMC (P83447), PAPA5_CARPA (P05993), PEPT1_DERMI (P16312), PHIG1_PHIGI (P84789)» more |
UniProtKB/Swiss-Prot False positive sequences |
17 sequences
ACLI_ASPOR (Q2UPB9), CB042_BOVIN (Q3SYX3), CB042_HUMAN (Q9NWW7), CB042_MACFA (Q4R907), CB042_MOUSE (Q8R3C1), CCM2L_HUMAN (Q9NUG4), COBD_MYCBO (Q7VEN1), COBD_MYCTO (P9WP92), CRIM1_HUMAN (Q9NZV1), CSTN1_DANRE (F1R520), HEPA_HHV6U (P52375), IF172_CHLRE (Q5DM57), KIT_TAKRU (Q8AXC6), RK10_SPIOL (P82139), SCXD_CENLI (C0HK69), UNC71_CAEEL (G5EFD5), VM3VA_MACLB (Q4VM08)» more |
PDB [Detailed view] |
344 PDB
pdb_00001aec; pdb_00001aim; pdb_00001atk; pdb_00001au0; pdb_00001au2; pdb_00001au3; pdb_00001au4; pdb_00001ayu; pdb_00001ayv; pdb_00001ayw; pdb_00001bgo; pdb_00001bp4; pdb_00001bqi; pdb_00001by8; pdb_00001cb5; pdb_00001cpj; pdb_00001cqd; pdb_00001cs8; pdb_00001csb; pdb_00001cte; pdb_00001cvz; pdb_00001ewl; pdb_00001ewm; pdb_00001ewo; pdb_00001ewp; pdb_00001f29; pdb_00001f2a; pdb_00001f2b; pdb_00001f2c; pdb_00001fh0; pdb_00001gcb; pdb_00001gec; pdb_00001gmy; pdb_00001huc; pdb_00001icf; pdb_00001ito; pdb_00001iwd; pdb_00001jqp; pdb_00001k3b; pdb_00001kfu; pdb_00001kfx; pdb_00001khp; pdb_00001khq; pdb_00001m6d; pdb_00001me3; pdb_00001me4; pdb_00001meg; pdb_00001mem; pdb_00001mhw; pdb_00001ms6; pdb_00001nb3; pdb_00001nb5; pdb_00001nl6; pdb_00001nlj; pdb_00001npz; pdb_00001nqc; pdb_00001o0e; pdb_00001pad; pdb_00001pbh; pdb_00001pci; pdb_00001pe6; pdb_00001pip; pdb_00001pop; pdb_00001ppd; pdb_00001ppn; pdb_00001ppo; pdb_00001ppp; pdb_00001q6k; pdb_00001qdq; pdb_00001s4v; pdb_00001snk; pdb_00001sp4; pdb_00001stf; pdb_00001the; pdb_00001tl9; pdb_00001tlo; pdb_00001tu6; pdb_00001u9q; pdb_00001u9v; pdb_00001u9w; pdb_00001u9x; pdb_00001vsn; pdb_00001yal; pdb_00001yk7; pdb_00001yk8; pdb_00001yt7; pdb_00001yvb; pdb_00001zcm; pdb_00001ziv; pdb_00002act; pdb_00002aim; pdb_00002ary; pdb_00002as8; pdb_00002ato; pdb_00002aux; pdb_00002auz; pdb_00002bdl; pdb_00002bdz; pdb_00002cio; pdb_00002dc6; pdb_00002dc7; pdb_00002dc8; pdb_00002dc9; pdb_00002dca; pdb_00002dcb; pdb_00002dcc; pdb_00002dcd; pdb_00002djf; pdb_00002djg; pdb_00002dzy; pdb_00002dzz; pdb_00002e00; pdb_00002e01; pdb_00002e02; pdb_00002f1g; pdb_00002f7d; pdb_00002fo5; pdb_00002fq9; pdb_00002fra; pdb_00002frq; pdb_00002ft2; pdb_00002ftd; pdb_00002fud; pdb_00002fye; pdb_00002g6d; pdb_00002g7y; pdb_00002g8e; pdb_00002g8j; pdb_00002ghu; pdb_00002h7j; pdb_00002hh5; pdb_00002hhn; pdb_00002hxz; pdb_00002ipp; pdb_00002nqa; pdb_00002nqg; pdb_00002nqi; pdb_00002op3; pdb_00002oul; pdb_00002oz2; pdb_00002p0r; pdb_00002pad; pdb_00002pbh; pdb_00002pns; pdb_00002pre; pdb_00002r6n; pdb_00002r9c; pdb_00002r9f; pdb_00002r9m; pdb_00002r9n; pdb_00002r9o; pdb_00002xu1; pdb_00002xu3; pdb_00002xu4; pdb_00002xu5; pdb_00002yj2; pdb_00002yj8; pdb_00002yj9; pdb_00002yjb; pdb_00002yjc; pdb_00003ai8; pdb_00003bc3; pdb_00003bcn; pdb_00003bpf; pdb_00003bpm; pdb_00003bwk; pdb_00003c9e; pdb_00003e1z; pdb_00003h6s; pdb_00003h7d; pdb_00003h89; pdb_00003h8b; pdb_00003h8c; pdb_00003hd3; pdb_00003hha; pdb_00003hwn; pdb_00003i06; pdb_00003ima; pdb_00003iut; pdb_00003k9m; pdb_00003kfq; pdb_00003kku; pdb_00003kse; pdb_00003kw9; pdb_00003kwb; pdb_00003kwz; pdb_00003kx1; pdb_00003lfy; pdb_00003lxs; pdb_00003n3g; pdb_00003n4c; pdb_00003o0u; pdb_00003o1g; pdb_00003of8; pdb_00003of9; pdb_00003ovx; pdb_00003ovz; pdb_00003pbh; pdb_00003pdf; pdb_00004axl; pdb_00004axm; pdb_00004bpv; pdb_00004bqv; pdb_00004bs5; pdb_00004bs6; pdb_00004bsq; pdb_00004cdc; pdb_00004cdd; pdb_00004cde; pdb_00004cdf; pdb_00004dmx; pdb_00004dmy; pdb_00004klb; pdb_00004mzo; pdb_00004mzs; pdb_00004n79; pdb_00004n8w; pdb_00004oel; pdb_00004oem; pdb_00004p6e; pdb_00004p6g; pdb_00004pad; pdb_00004pi3; pdb_00004qh6; pdb_00004x6h; pdb_00004x6i; pdb_00004x6j; pdb_00004xui; pdb_00004yv8; pdb_00004yva; pdb_00005ef4; pdb_00005egw; pdb_00005f02; pdb_00005jt8; pdb_00005mae; pdb_00005maj; pdb_00005mbl; pdb_00005mbm; pdb_00005mqy; pdb_00005pad; pdb_00005t6u; pdb_00005tdi; pdb_00005tun; pdb_00005vcn; pdb_00005vco; pdb_00005vpg; pdb_00005vph; pdb_00005vpk; pdb_00005vpl; pdb_00006ash; pdb_00006ay2; pdb_00006bjd; pdb_00006bki; pdb_00006bkj; pdb_00006czk; pdb_00006ezp; pdb_00006ezx; pdb_00006f06; pdb_00006h8t; pdb_00006hgy; pdb_00006jw9; pdb_00006mis; pdb_00006n3s; pdb_00006o2x; pdb_00006okj; pdb_00006p3q; pdb_00006p4e; pdb_00006pad; pdb_00006pxf; pdb_00006qbs; pdb_00006ql8; pdb_00006qlm; pdb_00006qlw; pdb_00006qlx; pdb_00006qm0; pdb_00006tcx; pdb_00006ux6; pdb_00006y6l; pdb_00006ycb; pdb_00006ycc; pdb_00006ycd; pdb_00006yyn; pdb_00006yyo; pdb_00006yyp; pdb_00006yyq; pdb_00006yyr; pdb_00007ei0; pdb_00007juj; pdb_00007nxl; pdb_00007nxm; pdb_00007pck; pdb_00007qbl; pdb_00007qbm; pdb_00007qbn; pdb_00007qbo; pdb_00007qgw; pdb_00007qkb; pdb_00007qkc; pdb_00007qkd; pdb_00007s18; pdb_00007s19; pdb_00007v5l; pdb_00007w33; pdb_00007w34; pdb_00007w7o; pdb_00007x79; pdb_00007xf9; pdb_00007z3t; pdb_00007z58; pdb_00007zs7; pdb_00007zvf; pdb_00007zxa; pdb_00008a4u; pdb_00008a4v; pdb_00008a4w; pdb_00008a4x; pdb_00008a5b; pdb_00008ahv; pdb_00008b4f; pdb_00008b4t; pdb_00008b5f; pdb_00008c3d; pdb_00008c77; pdb_00008gt0; pdb_00008gt7; pdb_00008gx2; pdb_00008gx3; pdb_00008he9; pdb_00008hei; pdb_00008hen; pdb_00008het; pdb_00008hfv; pdb_00008ofa; pdb_00008oza; pdb_00008pch; pdb_00008pi3; pdb_00008prx; pdb_00008qkb; pdb_00008rnd; pdb_00008uac; pdb_00008v57; pdb_00008v58; pdb_00009gj2; pdb_00009pap » more |