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PROSITE entry PS00139


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General information about the entry

Entry name [info] THIOL_PROTEASE_CYS
Accession [info] PS00139
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00126
Associated ProRule [info] PRU10088

Name and characterization of the entry

Description [info] Eukaryotic thiol (cysteine) proteases cysteine active site.
Pattern [info]
Q-{V}-x-{DE}-[GE]-{F}-C-[YW]-{DN}-x-[STAGC]-[STAGCV].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_03 which contains 571'609 sequence entries.


Total number of hits 297 in 297 different sequences
Number of true positive hits 280 in 280 different sequences
Number of 'unknown' hits 0
Number of false positive hits 17 in 17 different sequences
Number of false negative sequences 57
Number of 'partial' sequences 21
Precision (true positives / (true positives + false positives)) 94.28 %
Recall (true positives / (true positives + false negatives)) 83.09 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 7
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
280 sequences

361L_IIV6   (Q91FG3), ACTN_ACTCC  (P00785), ACTN_ACTDE  (A5HII1), 
ALEUL_ARATH (Q8RWQ9), ALEU_ARATH  (Q8H166), ALEU_HORVU  (P05167), 
ANAN_ANACO  (P80884), BHPC1_PLABA (A0A509APV9), BLH1_YEAS1  (B3LP78), 
BLH1_YEAS2  (C7GPC1), BLH1_YEAS6  (B5VQH0), BLH1_YEAS7  (A6ZRK4), 
BLH1_YEAS8  (C8ZFZ7), BLH1_YEAST  (Q01532), BLMH_CHICK  (P87362), 
BLMH_HUMAN  (Q13867), BLMH_MOUSE  (Q8R016), BLMH_RABIT  (P13019), 
BLMH_RAT(P70645), BROM1_ANACO (O23791), BROM2_ANACO (P14518), 
CAN10_HUMAN (Q9HC96), CAN10_MACFA (Q95LP4), CAN10_MOUSE (Q9ESK3), 
CAN10_RAT   (Q9ES66), CAN11_HUMAN (Q9UMQ6), CAN11_MOUSE (Q6J756), 
CAN11_RAT   (Q4V8Q1), CAN12_HUMAN (Q6ZSI9), CAN12_MOUSE (Q9ER56), 
CAN13_MOUSE (Q3UW68), CAN13_RAT   (Q5BK10), CAN14_HUMAN (A8MX76), 
CAN15_HUMAN (O75808), CAN15_MOUSE (Q9JLG8), CAN1_BOVIN  (Q27970), 
CAN1_HUMAN  (P07384), CAN1_MACFA  (Q9GLG2), CAN1_MOUSE  (O35350), 
CAN1_PIG(P35750), CAN1_PONAB  (Q5NVS7), CAN1_RAT(P97571), 
CAN2_BOVIN  (Q27971), CAN2_CHICK  (Q92178), CAN2_HUMAN  (P17655), 
CAN2_MACFA  (Q9GLG1), CAN2_MOUSE  (O08529), CAN2_RAT(Q07009), 
CAN3_BOVIN  (P51186), CAN3_CHICK  (Q92177), CAN3_HUMAN  (P20807), 
CAN3_MACFA  (Q9GLG7), CAN3_MOUSE  (Q64691), CAN3_PIG(P43368), 
CAN3_RAT(P16259), CAN3_SHEEP  (Q9TTH8), CAN5_CAEEL  (Q22036), 
CAN5_HUMAN  (O15484), CAN5_MOUSE  (O08688), CAN5_RAT(Q8R4C0), 
CAN8_HUMAN  (A6NHC0), CAN8_MOUSE  (Q91VA3), CAN8_RAT(Q78EJ9), 
CAN9_HUMAN  (O14815), CAN9_MOUSE  (Q9D805), CAN9_RAT(O35920), 
CANA_DROME  (Q11002), CANB_DROME  (Q9VT65), CAND_DROME  (P27398), 
CANX_CHICK  (P00789), CAN_CAEEL   (P34308), CAN_SCHMA   (P27730), 
CAT7_MOUSE  (Q91ZF2), CAT7_RAT(D3ZZ07), CATB1_GIAIN (P92131), 
CATB2_ARATH (Q93VC9), CATB2_GIAIN (P92132), CATB3_ARATH (Q94K85), 
CATB3_GIAIN (P92133), CATB_BOVIN  (P07688), CATB_CHICK  (P43233), 
CATB_HUMAN  (P07858), CATB_MACFA  (Q4R5M2), CATB_MEDTR  (A0A072UTP9), 
CATB_MOUSE  (P10605), CATB_PIG(A1E295), CATB_PONAB  (Q5R6D1), 
CATB_RAT(P00787), CATB_SHEEP  (P83205), CATC_BOVIN  (Q3ZCJ8), 
CATC_CANLF  (O97578), CATC_HUMAN  (P53634), CATC_MACFA  (Q60HG6), 
CATC_MOUSE  (P97821), CATC_PONAB  (Q5RB02), CATC_RAT(P80067), 
CATF_HUMAN  (Q9UBX1), CATF_MOUSE  (Q9R013), CATH_BOVIN  (Q3T0I2), 
CATH_HUMAN  (P09668), CATH_MOUSE  (P49935), CATH_PIG(O46427), 
CATH_RAT(P00786), CATJ_MOUSE  (Q9R014), CATJ_RAT(Q63088), 
CATK_BOVIN  (Q5E968), CATK_CANLF  (Q3ZKN1), CATK_CHICK  (Q90686), 
CATK_HUMAN  (P43235), CATK_MACFA  (P61276), CATK_MACMU  (P61277), 
CATK_MOUSE  (P55097), CATK_PIG(Q9GLE3), CATK_RABIT  (P43236), 
CATK_RAT(O35186), CATL1_BOVIN (P25975), CATL1_CANLF (Q9GL24), 
CATL1_CHICK (P09648), CATL1_CHLAE (Q9GKL8), CATL1_HUMAN (P07711), 
CATL1_MOUSE (P06797), CATL1_PARTE (Q94714), CATL1_PIG   (Q28944), 
CATL1_RAT   (P07154), CATL1_SHEEP (Q10991), CATL2_BOVIN (Q5E998), 
CATL2_HUMAN (O60911), CATL2_PARTE (A0E358), CATLL_FASHE (Q24940), 
CATLL_PHACE (O97397), CATL_BRUPA  (O17473), CATL_DROME  (Q95029), 
CATL_SARPE  (Q26636), CATL_SCHMA  (Q26534), CATO_HUMAN  (P43234), 
CATO_MOUSE  (Q8BM88), CATS_BOVIN  (P25326), CATS_CANLF  (Q8HY81), 
CATS_HUMAN  (P25774), CATS_MOUSE  (O70370), CATS_RAT(Q02765), 
CATS_SAIBB  (Q8HY82), CATV_GVCPM  (O91466), CATV_GVXN   (Q9PYY5), 
CATV_NPVAC  (P25783), CATV_NPVAH  (Q80LP4), CATV_NPVAP  (Q91CL9), 
CATV_NPVBM  (P41721), CATV_NPVBS  (Q9YWK4), CATV_NPVCD  (Q6VTL7), 
CATV_NPVCF  (P41715), CATV_NPVEP  (Q91GE3), CATV_NPVHC  (Q9WGE0), 
CATV_NPVLD  (Q9YMP9), CATV_NPVMC  (Q8QLK1), CATV_NPVOP  (O10364), 
CATV_NPVR1  (Q8B9D5), CATV_NPVSE  (Q9J8B9), CATV_NPVST  (Q91BH1), 
CEP01_AMBAR (V5LU01), CEP1_ARATH  (Q9FGR9), CEP2_ARATH  (Q9STL4), 
CEP3_ARATH  (Q9STL5), CFAD_DICDI  (Q54TR1), CPGP2_ZINOF (P82474), 
CPL1_CAEEL  (O45734), CPP1_ENTH1  (Q01957), CPP2_ENTH1  (Q01958), 
CPP3_ENTH1  (P36184), CPR1_CAEEL  (P25807), CPR1_DROME  (Q9VN93), 
CPR3_CAEEL  (P43507), CPR4_CAEEL  (P43508), CPR5_CAEEL  (P43509), 
CPR6_CAEEL  (P43510), CRUST_PANBO (Q86GF7), CTSB_DICDI  (Q54QD9), 
CYSEP_PHAVU (P25803), CYSEP_RICCO (O65039), CYSEP_VIGMU (P12412), 
CYSP1_DICDI (P04988), CYSP1_HAECO (P19092), CYSP1_HOMAM (P13277), 
CYSP1_HORVU (P25249), CYSP1_LEIPI (P35591), CYSP1_MAIZE (Q10716), 
CYSP1_ORYSJ (Q7XR52), CYSP1_OSTOS (P25802), CYSP1_VASCU (P32954), 
CYSP2_DICDI (P04989), CYSP2_HAECO (P25793), CYSP2_HOMAM (P25782), 
CYSP2_HORVU (P25250), CYSP2_LEIPI (Q05094), CYSP2_MAIZE (Q10717), 
CYSP2_VASCU (P32955), CYSP3_DICDI (Q23894), CYSP3_HOMAM (P25784), 
CYSP3_SOLLC (Q40143), CYSP3_VASCU (P32956), CYSP4_BRANA (P25251), 
CYSP4_DICDI (P54639), CYSP4_VASCU (P32957), CYSP5_DICDI (P54640), 
CYSP6_DICDI (Q94503), CYSP7_DICDI (Q94504), CYSPL_SOLLC (P20721), 
CYSP_BLOTA  (A1KXI0), CYSP_HEMSP  (P43156), CYSP_PEA(P25804), 
CYSP_SCHJA  (P43157), CYSP_SCHMA  (P25792), CYSP_THEPA  (P22497), 
CYSP_TRYBB  (P14658), CYSP_TRYCR  (P25779), DEK1_ARATH  (Q8RVL2), 
DEK1_MAIZE  (Q8RVL1), DEK1_ORYSJ  (Q6ZFZ4), ERVA_TABDI  (A5YVK8), 
ERVB_TABDI  (P60994), ERVC1_TABDI (P83654), ERVC2_TABDI (A8DS38), 
FPC1_PLAF7  (P25805), FPC2A_PLAF7 (Q8I6U4), FPC2B_PLAF7 (Q8I6U5), 
FPC3_PLAF7  (Q8IIL0), GMSA_DICDI  (Q54ME1), LMCPA_LEIME (P25775), 
LMCPB_LEIME (P36400), MDO1_ANAMC  (P83443), MEX1_JACME  (P84346), 
MEX2_JACME  (P84347), MUCIN_MUCPR (B2LSD2), ORYA_ORYSJ  (P25776), 
ORYB_ORYSJ  (P25777), ORYC_ORYSJ  (P25778), PAPA1_CARPA (P00784), 
PAPA2_CARPA (P14080), PAPA3_CARPA (P10056), PAPA4_CARPA (P05994), 
PEPC_LACDL  (Q48543), PEPC_LACHE  (Q10744), PEPC_LACLA  (Q9CEG3), 
PEPC_LACLC  (Q04723), PEPC_LISIN  (Q928V0), PEPC_LISMO  (O69192), 
PEPC_STRTR  (Q56115), PEPE_LACHE  (P94870), PEPG_LACDL  (P94869), 
PEPT1_DERFA (P16311), PEPT1_DERPT (P08176), PEPT1_EURMA (P25780), 
PEPW_LACDL  (P94868), PVP1_PLAVN  (P46102), RD19A_ARATH (P43296), 
RD19B_ARATH (P43295), RD19C_ARATH (Q9SUL1), RD19D_ARATH (Q8VYS0), 
RD21A_ARATH (P43297), RD21B_ARATH (Q9FMH8), RD21C_ARATH (Q9LT78), 
RDL1_ARATH  (Q94B08), RDL2_ARATH  (Q9LT77), RDL3_ARATH  (Q9LXW3), 
REP1_ORYSJ  (Q7F3A8), REPA_ORYSJ  (Q7GDU7), SAG12_ARATH (Q9FJ47), 
SAG39_ORYSI (A2XQE8), SAG39_ORYSJ (Q7XWK5), SERA6_PLAF7 (Q9TY96), 
SERA6_PLAFA (Q26015), THPA_THADA  (P21381), TPR_PORGI   (P25806), 
VANSY_GLEHE (A0A068CNX1), VANSY_VANPL (A0A0F7G352), VF224_IIV3  (Q197D6), 
VF224_IIV6  (Q91FU7), VX1_PLAVS   (P42666), XCP1_ARATH  (O65493), 
XCP2_ARATH  (Q9LM66)
» more

UniProtKB/Swiss-Prot
False negative sequences
57 sequences

CAN13_HUMAN (Q6MZZ7), CAN6_HUMAN  (Q9Y6Q1), CAN6_MOUSE  (O35646), 
CAN6_RAT(O88501), CAN7_HUMAN  (Q9Y6W3), CAN7_MOUSE  (Q9R1S8), 
CAN7_PIG(A0FKG7), CANC_DROME  (Q9VXH6), CATB1_ARATH (F4HVZ1), 
CATC_SCHMA  (Q26563), CATL3_PARTE (Q94715), CATM_MOUSE  (Q9JL96), 
CATQ_RAT(Q9QZE3), CATR_MOUSE  (Q9JIA9), CATV_NPVHZ  (Q8V5U0), 
CATW_FELCA  (Q9TST1), CATW_HUMAN  (P56202), CATW_MOUSE  (P56203), 
CATZ1_CAEEL (G5EGP8), CATZ_BOVIN  (P05689), CATZ_HUMAN  (Q9UBR2), 
CATZ_MOUSE  (Q9WUU7), CATZ_RAT(Q9R1T3), CPGP1_ZINOF (P82473), 
CYSP_THEAN  (P25781), DPAP1_PLAF7 (Q8IIJ9), ECPA_STAEP  (P0C0P9), 
ECPA_STAEQ  (Q5HKF6), ECPA_STAES  (P0C0Q0), P34_SOYBN   (P22895), 
PEPT1_PSOOV (Q1EIQ3), RDL4_ARATH  (Q9SUT0), RDL5_ARATH  (Q9SUS9), 
RDL6_ARATH  (F4JNL3), SERA5_PLAF7 (Q9TY95), SERA5_PLAFD (P69193), 
SERA5_PLAFG (P69192), SILIC_PETFI (Q6YD92), SSPB_STAA8  (Q2FZL3), 
SSPB_STAAC  (Q5HH36), SSPB_STAAM  (Q99V46), SSPB_STAAN  (Q7A6A7), 
SSPB_STAAR  (Q6GI35), SSPB_STAAS  (Q6GAG5), SSPB_STAAU  (P0C1S6), 
SSPB_STAAW  (Q8NX99), SSPP_STAA8  (Q2G2R8), SSPP_STAAC  (Q5HEL3), 
SSPP_STAAM  (P65825), SSPP_STAAN  (P65826), SSPP_STAAR  (Q6GFE8), 
SSPP_STAAS  (Q6G824), SSPP_STAAU  (P81297), SSPP_STAAW  (Q8NVS9), 
TEST2_MOUSE (Q80UB0), TEST2_RAT   (P15242), YCF2E_CAEEL (P90850)
» more

UniProtKB/Swiss-Prot
'Partial' sequences
21 sequences

CAL1_CALGI  (P20728), CAN1_RABIT  (P06815), CAN2_PIG(P43367), 
CAN2_RABIT  (P06814), CATB_COTJA  (P81494), CATL1_FASHE (Q09093), 
CATL1_FELCA (P25773), CATL2_FASHE (P80342), CATL3_FASHE (P80532), 
CATL4_FASHE (P80528), CATL9_FASHE (P80533), CYSB_FASHE  (P80529), 
CYSP3_OSTOS (Q06544), CYSP_TRIFO  (P33403), CYSP_TRIVA  (P33404), 
HP29_SARPE  (P29184), KARA_BROPL  (P22442), MDO2_ANAMC  (P83447), 
PAPA5_CARPA (P05993), PEPT1_DERMI (P16312), PHIG1_PHIGI (P84789)
» more

UniProtKB/Swiss-Prot
False positive sequences
17 sequences

ACLI_ASPOR  (Q2UPB9), CB042_BOVIN (Q3SYX3), CB042_HUMAN (Q9NWW7), 
CB042_MACFA (Q4R907), CB042_MOUSE (Q8R3C1), CCM2L_HUMAN (Q9NUG4), 
COBD_MYCBO  (Q7VEN1), COBD_MYCTO  (P9WP92), CRIM1_HUMAN (Q9NZV1), 
CSTN1_DANRE (F1R520), HEPA_HHV6U  (P52375), IF172_CHLRE (Q5DM57), 
KIT_TAKRU   (Q8AXC6), RK10_SPIOL  (P82139), SCXD_CENLI  (C0HK69), 
UNC71_CAEEL (G5EFD5), VM3VA_MACLB (Q4VM08)
» more

PDB
[Detailed view]
339 PDB

1AEC; 1AIM; 1ATK; 1AU0; 1AU2; 1AU3; 1AU4; 1AYU; 1AYV; 1AYW; 1BGO; 1BP4; 1BQI; 1BY8; 1CB5; 1CPJ; 1CQD; 1CS8; 1CSB; 1CTE; 1CVZ; 1EWL; 1EWM; 1EWO; 1EWP; 1F29; 1F2A; 1F2B; 1F2C; 1FH0; 1GCB; 1GEC; 1GMY; 1HUC; 1ICF; 1ITO; 1IWD; 1JQP; 1K3B; 1KFU; 1KFX; 1KHP; 1KHQ; 1M6D; 1ME3; 1ME4; 1MEG; 1MEM; 1MHW; 1MS6; 1NB3; 1NB5; 1NL6; 1NLJ; 1NPZ; 1NQC; 1O0E; 1PAD; 1PBH; 1PCI; 1PE6; 1PIP; 1POP; 1PPD; 1PPN; 1PPO; 1PPP; 1Q6K; 1QDQ; 1S4V; 1SNK; 1SP4; 1STF; 1THE; 1TL9; 1TLO; 1TU6; 1U9Q; 1U9V; 1U9W; 1U9X; 1VSN; 1YAL; 1YK7; 1YK8; 1YT7; 1YVB; 1ZCM; 1ZIV; 2ACT; 2AIM; 2ARY; 2AS8; 2ATO; 2AUX; 2AUZ; 2BDL; 2BDZ; 2CIO; 2DC6; 2DC7; 2DC8; 2DC9; 2DCA; 2DCB; 2DCC; 2DCD; 2DJF; 2DJG; 2DZY; 2DZZ; 2E00; 2E01; 2E02; 2F1G; 2F7D; 2FO5; 2FQ9; 2FRA; 2FRQ; 2FT2; 2FTD; 2FUD; 2FYE; 2G6D; 2G7Y; 2G8E; 2G8J; 2GHU; 2H7J; 2HH5; 2HHN; 2HXZ; 2IPP; 2NQA; 2NQG; 2NQI; 2OP3; 2OUL; 2OZ2; 2P0R; 2PAD; 2PBH; 2PNS; 2PRE; 2R6N; 2R9C; 2R9F; 2R9M; 2R9N; 2R9O; 2XU1; 2XU3; 2XU4; 2XU5; 2YJ2; 2YJ8; 2YJ9; 2YJB; 2YJC; 3AI8; 3BC3; 3BCN; 3BPF; 3BPM; 3BWK; 3C9E; 3E1Z; 3H6S; 3H7D; 3H89; 3H8B; 3H8C; 3HD3; 3HHA; 3HWN; 3I06; 3IMA; 3IUT; 3K9M; 3KFQ; 3KKU; 3KSE; 3KW9; 3KWB; 3KWZ; 3KX1; 3LFY; 3LXS; 3N3G; 3N4C; 3O0U; 3O1G; 3OF8; 3OF9; 3OVX; 3OVZ; 3PBH; 3PDF; 4AXL; 4AXM; 4BPV; 4BQV; 4BS5; 4BS6; 4BSQ; 4CDC; 4CDD; 4CDE; 4CDF; 4DMX; 4DMY; 4KLB; 4MZO; 4MZS; 4N79; 4N8W; 4OEL; 4OEM; 4P6E; 4P6G; 4PAD; 4PI3; 4QH6; 4X6H; 4X6I; 4X6J; 4XUI; 4YV8; 4YVA; 5EF4; 5EGW; 5F02; 5JT8; 5MAE; 5MAJ; 5MBL; 5MBM; 5MQY; 5PAD; 5T6U; 5TDI; 5TUN; 5VCN; 5VCO; 5VPG; 5VPH; 5VPK; 5VPL; 6ASH; 6AY2; 6BJD; 6BKI; 6BKJ; 6CZK; 6EZP; 6EZX; 6F06; 6H8T; 6HGY; 6JW9; 6MIS; 6N3S; 6O2X; 6OKJ; 6P3Q; 6P4E; 6PAD; 6PXF; 6QBS; 6QL8; 6QLM; 6QLW; 6QLX; 6QM0; 6TCX; 6UX6; 6Y6L; 6YCB; 6YCC; 6YCD; 6YYN; 6YYO; 6YYP; 6YYQ; 6YYR; 7EI0; 7JUJ; 7NXL; 7NXM; 7PCK; 7QBL; 7QBM; 7QBN; 7QBO; 7QGW; 7QKB; 7QKC; 7QKD; 7S18; 7S19; 7V5L; 7W33; 7W34; 7W7O; 7X79; 7XF9; 7Z3T; 7Z58; 7ZS7; 7ZVF; 7ZXA; 8A4U; 8A4V; 8A4W; 8A4X; 8A5B; 8AHV; 8B4F; 8B4T; 8B5F; 8C3D; 8C77; 8GT0; 8GT7; 8GX2; 8GX3; 8HE9; 8HEI; 8HEN; 8HET; 8HFV; 8OFA; 8OZA; 8PCH; 8PRX; 8QKB; 8UAC; 9PAP
» more