PROSITE entry PS00143

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General information about the entry

Entry name [info]	INSULINASE
Accession [info]	PS00143
Entry type [info]	PATTERN
Date [info]	01-APR-1990 CREATED; 01-NOV-1997 DATA UPDATE; 08-NOV-2023 INFO UPDATE.
PROSITE Doc. [info]	PDOC00130
Associated ProRule [info]	PRU10096

Name and characterization of the entry

Description [info]	Insulinase family, zinc-binding region signature.
Pattern [info]	G-x(8,9)-G-x-[STA]-H-[LIVMFY]-[LIVMC]-[DERN]-[HRKL]-[LMFAT]-x-[LFSTH]-x- [GSTAN]-[GST].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2023_05 which contains 570'420 sequence entries.

Total number of hits	75 in 75 different sequences
Number of true positive hits	75 in 75 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	40
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	65.22 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	1
Site [info]	zinc at position 6
Site [info]	active_site at position 9
Site [info]	zinc at position 10
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

75 sequences

AXL1_YEAST  (P40851), IDE1_ARATH  (O22941), IDE2_ARATH  (F4J3D9),

IDE_BOVIN   (Q24K02), IDE_DICDI   (Q54JQ2), IDE_DROME   (P22817), 
IDE_HUMAN   (P14735), IDE_MOUSE   (Q9JHR7), IDE_RAT (P35559), 
MPPA1_ARATH (Q9ZU25), MPPA2_ARATH (O04308), MPPA_BOVIN  (Q0P5M8), 
MPPA_HUMAN  (Q10713), MPPA_MOUSE  (Q9DC61), MPPA_NEUCR  (P23955), 
MPPA_PONAB  (Q5R513), MPPA_RAT(P20069), MPPA_SCHPO  (O94745), 
MPPA_SOLTU  (P29677), MPPA_YEAST  (P11914), MPPB_ARATH  (Q42290), 
MPPB_BOVIN  (Q3SZ71), MPPB_CAEEL  (Q23295), MPPB_DICDI  (Q4W6B5), 
MPPB_HUMAN  (O75439), MPPB_LENED  (Q9Y8B5), MPPB_MOUSE  (Q9CXT8), 
MPPB_NEUCR  (P11913), MPPB_PONAB  (Q5REK3), MPPB_RAT(Q03346), 
MPPB_SCHPO  (Q9P7X1), MPPB_YEAST  (P10507), MU138_SCHPO (O14077), 
NRDC_ARATH  (F4HNU6), NRDC_HUMAN  (O43847), NRDC_MOUSE  (Q8BHG1), 
NRDC_PONAB  (Q5R4H6), NRDC_RAT(P47245), PPQQE_HELPY (O25656), 
PQQF_KLEPN  (P27508), PQQF_PSEAE  (Q9I2D2), PQQF_PSEPH  (P55174), 
PQQF_PSEPK  (Q88QV3), PQQF_PSESM  (Q88A79), PQQL_ARATH  (Q9FJT9), 
PQQL_ECOLI  (P31828), PQQL_HAEIN  (P45181), PTRA_ECO57  (Q8X6M8), 
PTRA_ECOL6  (Q8CVS2), PTRA_ECOLI  (P05458), PTRA_SALTY  (Q8ZMB5), 
PTRA_SHIFL  (Q83QC3), QCR1_EUGGR  (P43264), QCR2_BOVIN  (P23004), 
QCR2_HUMAN  (P22695), QCR2_MOUSE  (Q9DB77), QCR2_RAT(P32551), 
QCR2_YARLI  (Q6C2E3), QCR2_YEAST  (P07257), SDP_EIMBO   (P42789), 
STE23_YEAST (Q06010), UCR1_CAEEL  (P98080), Y210_RICTY  (Q68XF0), 
Y219_RICPR  (O05945), Y2782_MYCTO (P9WHT4), Y2782_MYCTU (P9WHT5), 
Y2805_MYCBO (P0A5S9), Y293_RICCN  (Q92IX7), Y338_RICFE  (Q4UML9), 
Y4WA_SINFN  (P55679), Y522_RICBR  (Q1RJ61), Y5738_STRCO (O86835), 
Y855_MYCLE  (O32965), YMXG_BACSU  (Q04805), YQA4_CAEEL  (Q10040)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

40 sequences

ALBF_BACIU  (Q8RKH2), ALBF_BACSU  (P71006), MPPA_BLAEM  (P97997),

PREP1_ARATH (Q9LJL3), PREP2_ARATH (Q8VY06), PREP_ASPFU  (Q4WP38), 
PREP_ASPOR  (Q2UGN1), PREP_CANAL  (Q5A301), PREP_CANGA  (Q6FUI7), 
PREP_DANRE  (Q7ZVZ6), PREP_DEBHA  (Q6BTC0), PREP_DROME  (Q9V9E3), 
PREP_EMENI  (Q5B6H7), PREP_EREGS  (Q759T9), PREP_GIBZE  (Q4IA56), 
PREP_HUMAN  (Q5JRX3), PREP_KLULA  (Q6CWW6), PREP_MOUSE  (Q8K411), 
PREP_NEUCR  (Q7S7C0), PREP_PONAB  (Q5RDG3), PREP_SCHPO  (O42908), 
PREP_XENLA  (Q6PF24), PREP_XENTR  (Q28BR5), PREP_YARLI  (Q6C0U8), 
PREP_YEAST  (P32898), PTRA_SALTI  (Q8Z418), QCR1_BOVIN  (P31800), 
QCR1_HUMAN  (P31930), QCR1_MOUSE  (Q9CZ13), QCR1_YEAST  (P07256), 
QCR2_EUGGR  (P43265), SPP_ARATH   (Q9FIH8), SPP_ORYSI   (B8B0E2), 
SPP_ORYSJ   (Q69TY5), SPP_PEA (Q40983), Y4WB_SINFN  (P55680), 
YHJJ_ECOLI  (P37648), YHJJ_SALTI  (Q8Z286), YHJJ_SALTY  (P50335), 
YMFH_BACSU  (O31766)

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PDB
[Detailed view]

122 PDB

1BCC; 1BE3; 1BGY; 1EZV; 1HR6; 1HR7; 1HR8; 1HR9; 1KB9; 1KYO; 1L0L; 1L0N; 1NTK; 1NTM; 1NTZ; 1NU1; 1P84; 1PP9; 1PPJ; 1Q2L; 1QCR; 1SQB; 1SQP; 1SQQ; 1SQV; 1SQX; 2A06; 2BCC; 2FYU; 2IBZ; 2JG4; 2YBB; 3BCC; 3CX5; 3CXH; 3P7L; 3QZ2; 3TUV; 4D6T; 4D6U; 4DTT; 4IFH; 4IOF; 4PD4; 4RE9; 5GPN; 5KLV; 5LUF; 5NMI; 5OKD; 5UOE; 5XTE; 5XTH; 5XTI; 6B3Q; 6B70; 6B7Y; 6B7Z; 6BF6; 6BF7; 6BF8; 6BF9; 6BFC; 6FO0; 6FO2; 6FO6; 6GIQ; 6HAW; 6HU9; 6NHG; 6OFS; 6OFT; 6T0B; 6T15; 6XVF; 6YMX; 6ZFS; 6ZFT; 6ZFU; 7DGQ; 7DGR; 7DGS; 7DKF; 7K1D; 7K1E; 7K1F; 7O37; 7O3C; 7O3E; 7O3H; 7R3V; 7RZE; 7RZF; 7RZG; 7RZH; 7RZI; 7TAY; 7TZ6; 8AB6; 8AB7; 8AB8; 8AB9; 8ABA; 8ABB; 8ABE; 8ABF; 8ABG; 8ABH; 8ABI; 8ABJ; 8ABK; 8ABL; 8ABM; 8AC3; 8AC4; 8AC5; 8BEP; 8BPX; 8BQ5; 8BQ6; 8E7S; 8EC0
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