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Entry: PS00143

General information about the entry

Entry name [info] INSULINASE
Accession [info] PS00143
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-NOV-1997 DATA UPDATE;
11-DEC-2019 INFO UPDATE.
PROSITE Doc. [info] PDOC00130
Associated ProRule [info] PRU10096

Name and characterization of the entry

Description [info] Insulinase family, zinc-binding region signature.
Pattern [info] 
G-x(8,9)-G-x-[STA]-H-[LIVMFY]-[LIVMC]-[DERN]-[HRKL]-[LMFAT]-x-[LFSTH]-x-
[GSTAN]-[GST].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2019_11 which contains 561'568 sequence entries.


Total number of hits 74 in 74 different sequences
Number of true positive hits 74 in 74 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 40
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 64.91 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] zinc at position 6
Site [info] active_site at position 9
Site [info] zinc at position 10
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 74 sequences 

AXL1_YEAST  (P40851    ), IDE1_ARATH  (O22941    ), IDE2_ARATH  (F4J3D9    ), 

IDE_BOVIN   (Q24K02    ), IDE_DICDI   (Q54JQ2    ), IDE_DROME   (P22817    ), 
IDE_HUMAN   (P14735    ), IDE_MOUSE   (Q9JHR7    ), IDE_RAT     (P35559    ), 
MPPA1_ARATH (Q9ZU25    ), MPPA2_ARATH (O04308    ), MPPA_BOVIN  (Q0P5M8    ), 
MPPA_HUMAN  (Q10713    ), MPPA_MOUSE  (Q9DC61    ), MPPA_NEUCR  (P23955    ), 
MPPA_PONAB  (Q5R513    ), MPPA_RAT    (P20069    ), MPPA_SCHPO  (O94745    ), 
MPPA_SOLTU  (P29677    ), MPPA_YEAST  (P11914    ), MPPB_ARATH  (Q42290    ), 
MPPB_BOVIN  (Q3SZ71    ), MPPB_CAEEL  (Q23295    ), MPPB_DICDI  (Q4W6B5    ), 
MPPB_HUMAN  (O75439    ), MPPB_LENED  (Q9Y8B5    ), MPPB_MOUSE  (Q9CXT8    ), 
MPPB_NEUCR  (P11913    ), MPPB_PONAB  (Q5REK3    ), MPPB_RAT    (Q03346    ), 
MPPB_SCHPO  (Q9P7X1    ), MPPB_YEAST  (P10507    ), MU138_SCHPO (O14077    ), 
NRDC_ARATH  (F4HNU6    ), NRDC_HUMAN  (O43847    ), NRDC_MOUSE  (Q8BHG1    ), 
NRDC_PONAB  (Q5R4H6    ), NRDC_RAT    (P47245    ), PQQF_KLEPN  (P27508    ), 
PQQF_PSEAE  (Q9I2D2    ), PQQF_PSEPH  (P55174    ), PQQF_PSEPK  (Q88QV3    ), 
PQQF_PSESM  (Q88A79    ), PQQL_ARATH  (Q9FJT9    ), PQQL_ECOLI  (P31828    ), 
PQQL_HAEIN  (P45181    ), PTRA_ECO57  (Q8X6M8    ), PTRA_ECOL6  (Q8CVS2    ), 
PTRA_ECOLI  (P05458    ), PTRA_SALTY  (Q8ZMB5    ), PTRA_SHIFL  (Q83QC3    ), 
QCR1_EUGGR  (P43264    ), QCR2_BOVIN  (P23004    ), QCR2_HUMAN  (P22695    ), 
QCR2_MOUSE  (Q9DB77    ), QCR2_RAT    (P32551    ), QCR2_YARLI  (Q6C2E3    ), 
QCR2_YEAST  (P07257    ), SDP_EIMBO   (P42789    ), STE23_YEAST (Q06010    ), 
UCR1_CAEEL  (P98080    ), Y210_RICTY  (Q68XF0    ), Y219_RICPR  (O05945    ), 
Y2782_MYCTO (P9WHT4    ), Y2782_MYCTU (P9WHT5    ), Y2805_MYCBO (P0A5S9    ), 
Y293_RICCN  (Q92IX7    ), Y338_RICFE  (Q4UML9    ), Y4WA_SINFN  (P55679    ), 
Y522_RICBR  (Q1RJ61    ), Y5738_STRCO (O86835    ), Y855_MYCLE  (O32965    ), 
YMXG_BACSU  (Q04805    ), YQA4_CAEEL  (Q10040    )
» more

UniProtKB/Swiss-Prot
False negative sequences		 40 sequences 

ALBF_BACIU  (Q8RKH2    ), ALBF_BACSU  (P71006    ), CYM1_ASHGO  (Q759T9    ), 

CYM1_ASPFU  (Q4WP38    ), CYM1_ASPOR  (Q2UGN1    ), CYM1_CANAL  (Q5A301    ), 
CYM1_CANGA  (Q6FUI7    ), CYM1_DEBHA  (Q6BTC0    ), CYM1_EMENI  (Q5B6H7    ), 
CYM1_GIBZE  (Q4IA56    ), CYM1_KLULA  (Q6CWW6    ), CYM1_NEUCR  (Q7S7C0    ), 
CYM1_SCHPO  (O42908    ), CYM1_YARLI  (Q6C0U8    ), CYM1_YEAST  (P32898    ), 
MPPA_BLAEM  (P97997    ), PREP1_ARATH (Q9LJL3    ), PREP2_ARATH (Q8VY06    ), 
PREP_DANRE  (Q7ZVZ6    ), PREP_DROME  (Q9V9E3    ), PREP_HUMAN  (Q5JRX3    ), 
PREP_MOUSE  (Q8K411    ), PREP_PONAB  (Q5RDG3    ), PREP_XENLA  (Q6PF24    ), 
PREP_XENTR  (Q28BR5    ), PTRA_SALTI  (Q8Z418    ), QCR1_BOVIN  (P31800    ), 
QCR1_HUMAN  (P31930    ), QCR1_MOUSE  (Q9CZ13    ), QCR1_YEAST  (P07256    ), 
QCR2_EUGGR  (P43265    ), SPP_ARATH   (Q9FIH8    ), SPP_ORYSI   (B8B0E2    ), 
SPP_ORYSJ   (Q69TY5    ), SPP_PEA     (Q40983    ), Y4WB_SINFN  (P55680    ), 
YHJJ_ECOLI  (P37648    ), YHJJ_SALTI  (Q8Z286    ), YHJJ_SALTY  (P50335    ), 
YMFH_BACSU  (O31766    )
» more

PDB
[Detailed view]		 69 PDB

1BCC; 1BE3; 1BGY; 1EZV; 1HR6; 1HR7; 1HR8; 1HR9; 1KB9; 1KYO; 1L0L; 1L0N; 1NTK; 1NTM; 1NTZ; 1NU1; 1P84; 1PP9; 1PPJ; 1Q2L; 1QCR; 1SQB; 1SQP; 1SQQ; 1SQV; 1SQX; 2A06; 2BCC; 2FYU; 2IBZ; 2JG4; 2YBB; 3BCC; 3CX5; 3CXH; 3P7L; 3QZ2; 3TUV; 4D6T; 4D6U; 4DTT; 4IFH; 4IOF; 4PD4; 4RE9; 5KLV; 5LUF; 5NMI; 5OKD; 5UOE; 5XTE; 6B3Q; 6B70; 6B7Y; 6B7Z; 6BF6; 6BF7; 6BF8; 6BF9; 6BFC; 6FO0; 6FO2; 6FO6; 6GIQ; 6HAW; 6HU9; 6NHG; 6OFS; 6OFT
» more

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