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PROSITE entry PS00143


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PURL: https://purl.expasy.org/prosite/signature/PS00143

Direct ScanProsite submission
General information about the entry

Entry name [info] INSULINASE
Accession [info] PS00143
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-NOV-1997 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00130
Associated ProRule [info] PRU10096

Name and characterization of the entry

Description [info] Insulinase family, zinc-binding region signature.
Pattern [info] 
G-x(8,9)-G-x-[STA]-H-[LIVMFY]-[LIVMC]-[DERN]-[HRKL]-[LMFAT]-x-[LFSTH]-x-
[GSTAN]-[GST].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 75 in 75 different sequences
Number of true positive hits 75 in 75 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 40
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 65.22 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Site [info] zinc at position 6
Site [info] active_site at position 9
Site [info] zinc at position 10
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 75 sequences 

AXL1_YEAST  (P40851), IDE1_ARATH  (O22941), IDE2_ARATH  (F4J3D9), 

IDE_BOVIN   (Q24K02), IDE_DICDI   (Q54JQ2), IDE_DROME   (P22817), 
IDE_HUMAN   (P14735), IDE_MOUSE   (Q9JHR7), IDE_RAT (P35559), 
MPPA1_ARATH (Q9ZU25), MPPA2_ARATH (O04308), MPPA_BOVIN  (Q0P5M8), 
MPPA_HUMAN  (Q10713), MPPA_MOUSE  (Q9DC61), MPPA_NEUCR  (P23955), 
MPPA_PONAB  (Q5R513), MPPA_RAT(P20069), MPPA_SCHPO  (O94745), 
MPPA_SOLTU  (P29677), MPPA_YEAST  (P11914), MPPB_ARATH  (Q42290), 
MPPB_BOVIN  (Q3SZ71), MPPB_CAEEL  (Q23295), MPPB_DICDI  (Q4W6B5), 
MPPB_HUMAN  (O75439), MPPB_LENED  (Q9Y8B5), MPPB_MOUSE  (Q9CXT8), 
MPPB_NEUCR  (P11913), MPPB_PONAB  (Q5REK3), MPPB_RAT(Q03346), 
MPPB_SCHPO  (Q9P7X1), MPPB_YEAST  (P10507), MU138_SCHPO (O14077), 
NRDC_ARATH  (F4HNU6), NRDC_HUMAN  (O43847), NRDC_MOUSE  (Q8BHG1), 
NRDC_PONAB  (Q5R4H6), NRDC_RAT(P47245), PPQQE_HELPY (O25656), 
PQQF_KLEPN  (P27508), PQQF_PSEAE  (Q9I2D2), PQQF_PSEPH  (P55174), 
PQQF_PSEPK  (Q88QV3), PQQF_PSESM  (Q88A79), PQQL_ARATH  (Q9FJT9), 
PQQL_ECOLI  (P31828), PQQL_HAEIN  (P45181), PTRA_ECO57  (Q8X6M8), 
PTRA_ECOL6  (Q8CVS2), PTRA_ECOLI  (P05458), PTRA_SALTY  (Q8ZMB5), 
PTRA_SHIFL  (Q83QC3), QCR1_EUGGR  (P43264), QCR2_BOVIN  (P23004), 
QCR2_HUMAN  (P22695), QCR2_MOUSE  (Q9DB77), QCR2_RAT(P32551), 
QCR2_YARLI  (Q6C2E3), QCR2_YEAST  (P07257), SDP_EIMBO   (P42789), 
STE23_YEAST (Q06010), UCR1_CAEEL  (P98080), Y210_RICTY  (Q68XF0), 
Y219_RICPR  (O05945), Y2782_MYCTO (P9WHT4), Y2782_MYCTU (P9WHT5), 
Y2805_MYCBO (P0A5S9), Y293_RICCN  (Q92IX7), Y338_RICFE  (Q4UML9), 
Y4WA_SINFN  (P55679), Y522_RICBR  (Q1RJ61), Y5738_STRCO (O86835), 
Y855_MYCLE  (O32965), YMXG_BACSU  (Q04805), YQA4_CAEEL  (Q10040)
» more

UniProtKB/Swiss-Prot
False negative sequences		 40 sequences 

ALBF_BACIU  (Q8RKH2), ALBF_BACSU  (P71006), MPPA_BLAEM  (P97997), 

PREP1_ARATH (Q9LJL3), PREP2_ARATH (Q8VY06), PREP_ASPFU  (Q4WP38), 
PREP_ASPOR  (Q2UGN1), PREP_CANAL  (Q5A301), PREP_CANGA  (Q6FUI7), 
PREP_DANRE  (Q7ZVZ6), PREP_DEBHA  (Q6BTC0), PREP_DROME  (Q9V9E3), 
PREP_EMENI  (Q5B6H7), PREP_EREGS  (Q759T9), PREP_GIBZE  (Q4IA56), 
PREP_HUMAN  (Q5JRX3), PREP_KLULA  (Q6CWW6), PREP_MOUSE  (Q8K411), 
PREP_NEUCR  (Q7S7C0), PREP_PONAB  (Q5RDG3), PREP_SCHPO  (O42908), 
PREP_XENLA  (Q6PF24), PREP_XENTR  (Q28BR5), PREP_YARLI  (Q6C0U8), 
PREP_YEAST  (P32898), PTRA_SALTI  (Q8Z418), QCR1_BOVIN  (P31800), 
QCR1_HUMAN  (P31930), QCR1_MOUSE  (Q9CZ13), QCR1_YEAST  (P07256), 
QCR2_EUGGR  (P43265), SPP_ARATH   (Q9FIH8), SPP_ORYSI   (B8B0E2), 
SPP_ORYSJ   (Q69TY5), SPP_PEA (Q40983), Y4WB_SINFN  (P55680), 
YHJJ_ECOLI  (P37648), YHJJ_SALTI  (Q8Z286), YHJJ_SALTY  (P50335), 
YMFH_BACSU  (O31766)
» more

PDB
[Detailed view]		 145 PDB

pdb_00001bcc; pdb_00001be3; pdb_00001bgy; pdb_00001ezv; pdb_00001hr6; pdb_00001hr7; pdb_00001hr8; pdb_00001hr9; pdb_00001kb9; pdb_00001kyo; pdb_00001l0l; pdb_00001l0n; pdb_00001ntk; pdb_00001ntm; pdb_00001ntz; pdb_00001nu1; pdb_00001p84; pdb_00001pp9; pdb_00001ppj; pdb_00001q2l; pdb_00001qcr; pdb_00001sqb; pdb_00001sqp; pdb_00001sqq; pdb_00001sqv; pdb_00001sqx; pdb_00002a06; pdb_00002bcc; pdb_00002fyu; pdb_00002ibz; pdb_00002jg4; pdb_00002ybb; pdb_00003bcc; pdb_00003cx5; pdb_00003cxh; pdb_00003p7l; pdb_00003qz2; pdb_00003tuv; pdb_00004d6t; pdb_00004d6u; pdb_00004dtt; pdb_00004ifh; pdb_00004iof; pdb_00004pd4; pdb_00004re9; pdb_00005gpn; pdb_00005klv; pdb_00005luf; pdb_00005nmi; pdb_00005okd; pdb_00005uoe; pdb_00005xte; pdb_00005xth; pdb_00005xti; pdb_00006b3q; pdb_00006b70; pdb_00006b7y; pdb_00006b7z; pdb_00006bf6; pdb_00006bf7; pdb_00006bf8; pdb_00006bf9; pdb_00006bfc; pdb_00006fo0; pdb_00006fo2; pdb_00006fo6; pdb_00006giq; pdb_00006haw; pdb_00006hu9; pdb_00006nhg; pdb_00006ofs; pdb_00006oft; pdb_00006t0b; pdb_00006t15; pdb_00006xvf; pdb_00006ymx; pdb_00006zfs; pdb_00006zft; pdb_00006zfu; pdb_00007dgq; pdb_00007dgr; pdb_00007dgs; pdb_00007dkf; pdb_00007k1d; pdb_00007k1e; pdb_00007k1f; pdb_00007o37; pdb_00007o3c; pdb_00007o3e; pdb_00007o3h; pdb_00007r3v; pdb_00007rze; pdb_00007rzf; pdb_00007rzg; pdb_00007rzh; pdb_00007rzi; pdb_00007tay; pdb_00007tz6; pdb_00008ab6; pdb_00008ab7; pdb_00008ab8; pdb_00008ab9; pdb_00008aba; pdb_00008abb; pdb_00008abe; pdb_00008abf; pdb_00008abg; pdb_00008abh; pdb_00008abi; pdb_00008abj; pdb_00008abk; pdb_00008abl; pdb_00008abm; pdb_00008ac3; pdb_00008ac4; pdb_00008ac5; pdb_00008bep; pdb_00008bpx; pdb_00008bq5; pdb_00008bq6; pdb_00008e7s; pdb_00008ec0; pdb_00008iao; pdb_00008iar; pdb_00008ib4; pdb_00008ib7; pdb_00008ib9; pdb_00008ibc; pdb_00008ibd; pdb_00008ibg; pdb_00008ic2; pdb_00008ic5; pdb_00008iuf; pdb_00008iuj; pdb_00008p65; pdb_00008pw5; pdb_00008pw6; pdb_00008pw7; pdb_00008q1b; pdb_00008uca; pdb_00008yhq; pdb_00008yin; pdb_00008zmt; pdb_00009etz; pdb_00009gcx
» more