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annotation rule: PRU10096

General rule information [?]

Accession PRU10096
Dates 16-OCT-2006 (Created)
27-OCT-2018 (Last updated, Version 4)
Data class Domain
Predictors PROSITE; PS00143; INSULINASE
Name Insulinase family, zinc-binding region
Function Undefined.

Propagated annotation [?]


Description [?]

+ AltName: Full=Pitrilysin; EC=3.4.24.55;

Comments [?]

Catalytic activity Reaction=Preferential cleavage of 16-Tyr-|-Leu-17 and 25-Phe-|- Tyr-26 bonds of oxidized insulin B chain. Also acts on other substrates of Mw less than 7 kDa such as insulin and glucagon.; EC=3.4.24.55;.

Features [?]

From: PS00143
Key     From     To       Description   Tag   Condition   FTGroup
METAL     4     4       Zinc        
ACT_SITE     7     7       Proton acceptor        
METAL     8     8       Zinc        

Additional information [?]

Size range unlimited amino acids
Related rules None
Repeats 1
Topology Undefined
Example P27508 (PQQF_KLEPN)
Scope
Eukaryota
Bacteria

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]