ProRule PRU10096
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU10096 |
| Accession | PRU10096 |
| Dates | 16-OCT-2006 (Created)
19-NOV-2022 (Last updated, Version 7) |
| Data class | Domain; |
| Predictors |
PROSITE; PS00143; INSULINASE |
Name | Insulinase family, zinc-binding region |
| Function | Undefined |
| Scope(s) |
Eukaryota Bacteria |
| Example(s) | P27508 (PQQF_KLEPN); |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + AltName: Full=Pitrilysin; EC=3.4.24.55; |
Comments
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| CATALYTIC ACTIVITY | Reaction=Preferential cleavage of 16-Tyr-|-Leu-17 and 25-Phe-|-Tyr-26 bonds of oxidized insulin B chain. Also acts on other substrates of Mw less than 7 kDa such as insulin and glucagon.; EC=3.4.24.55; |
Features
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| From: PS00143 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 4 | 4 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
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| ACT_SITE | 7 | 7 | /note="Proton acceptor" | |||||||||
| BINDING | 8 | 8 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
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Additional information
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| Size range | unlimited amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [33] Eukaryota [82] All [ 115 ]
- Retrieve set of proteins with 3D structure for this domain