PROSITE logo

ProRule PRU10096


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU10096
General rule information [?]

Accession PRU10096
Dates 16-OCT-2006 (Created)
19-NOV-2022 (Last updated, Version )
Data class Domain;
Predictors PROSITE; PS00143; INSULINASE
Name Insulinase family, zinc-binding region
Function Undefined
Scope(s) Eukaryota
Bacteria
Example(s) P27508;

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + AltName: Full=Pitrilysin;
                 EC=3.4.24.55;

Comments [?]

CATALYTIC ACTIVITY Reaction=Preferential cleavage of 16-Tyr-|-Leu-17 and 25-Phe-|-Tyr-26 bonds of oxidized insulin B chain. Also acts on other substrates of Mw less than 7 kDa such as insulin and glucagon.; EC=3.4.24.55;

Features [?]

From: PS00143
Key From To Description Tag Condition FTGroup
BINDING 4 4 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
ACT_SITE 7 7 /note="Proton acceptor"
BINDING 8 8 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"

Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]