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| annotation rule: PRU10096 |
General rule information
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| Accession | PRU10096 |
| Dates | 16-OCT-2006 (Created) 27-OCT-2018 (Last updated, Version 4) |
| Data class | Domain |
| Predictors | PROSITE; PS00143; INSULINASE |
| Name | Insulinase family, zinc-binding region |
| Function | Undefined. |
Propagated annotation
[?]
Description
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| + AltName: Full=Pitrilysin; EC=3.4.24.55; |
Comments
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| Catalytic activity | Reaction=Preferential cleavage of 16-Tyr-|-Leu-17 and 25-Phe-|- Tyr-26 bonds of oxidized insulin B chain. Also acts on other substrates of Mw less than 7 kDa such as insulin and glucagon.; EC=3.4.24.55;. |
Features
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| From: PS00143 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| METAL | 4 | 4 | Zinc | |||||||||
| ACT_SITE | 7 | 7 | Proton acceptor | |||||||||
| METAL | 8 | 8 | Zinc | |||||||||
Additional information
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| Size range | unlimited amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | P27508 (PQQF_KLEPN) |
| Scope | Eukaryota
Bacteria |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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UniProtKB/Swiss-Prot sets
Bacteria [32] Eukaryota [81] All [ 113 ]
- Retrieve set of proteins with 3D structure for this domain