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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU10096


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU10096
General rule information [?]

Accession PRU10096
Dates 16-OCT-2006 (Created)
19-NOV-2022 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS00143; INSULINASE
Name Insulinase family, zinc-binding region
Function Undefined
Scope(s) Eukaryota
Bacteria
Example(s) P27508;

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + AltName: Full=Pitrilysin;
                 EC=3.4.24.55;

Comments [?]

CATALYTIC ACTIVITY Reaction=Preferential cleavage of 16-Tyr-|-Leu-17 and 25-Phe-|-Tyr-26 bonds of oxidized insulin B chain. Also acts on other substrates of Mw less than 7 kDa such as insulin and glucagon.; EC=3.4.24.55;

Features [?]

From: PS00143
Key From To Description Tag Condition FTGroup
BINDING 4 4 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
ACT_SITE 7 7 /note="Proton acceptor"
BINDING 8 8 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"

Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]