PROSITE logo

PROSITE entry PS00176


View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission
General information about the entry

Entry name [info] TOPO_IB_1
Accession [info] PS00176
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-NOV-1997 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00159
Associated ProRule [info] PRU10130

Name and characterization of the entry

Description [info] Topoisomerase (Topo) IB-type active site signature.
Pattern [info] 
[DEN]-x(6)-[GS]-[IT]-S-K-x(2)-Y-[LIVM]-x(3)-[LIVM].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_04 which contains 571'864 sequence entries.


Total number of hits 27 in 27 different sequences
Number of true positive hits 25 in 25 different sequences
Number of 'unknown' hits 0
Number of false positive hits 2 in 2 different sequences
Number of false negative sequences 3
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 92.59 %
Recall (true positives / (true positives + false negatives)) 89.29 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 8
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 25 sequences 

TOP1A_ARATH (P30181), TOP1B_ARATH (Q9FJ79), TOP1M_HUMAN (Q969P6), 

TOP1M_PANTR (A9Q1D5), TOP1_CAEEL  (O17966), TOP1_CANAR  (A0A0L0P4F8), 
TOP1_CANAX  (Q00313), TOP1_CHLAE  (Q7YR26), TOP1_CRIGR  (Q07050), 
TOP1_DAUCA  (P93119), TOP1_DICDI  (Q54RC3), TOP1_DROME  (P30189), 
TOP1_HUMAN  (P11387), TOP1_MONPV  (A0A7H0DN83), TOP1_MOUSE  (Q04750), 
TOP1_RAT(Q9WUL0), TOP1_RFVKA  (P16472), TOP1_SCHPO  (P07799), 
TOP1_USTMA  (P41511), TOP1_VACCA  (Q76ZS7), TOP1_VACCC  (P68697), 
TOP1_VACCW  (P68698), TOP1_VAR67  (P32989), TOP1_XENLA  (P41512), 
TOP1_YEAST  (P04786)
» more

UniProtKB/Swiss-Prot
False negative sequences		 3 sequences 

TOP1E_MIMIV (Q7T6X9), TOP1M_MOUSE (Q8R4U6), TOP1M_RAT   (Q6IM78)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			2 sequences
			


			
L_DUGBA (Q66431), YE88_SCHPO  (O14304)


				
	

	

		PDB
[Detailed view]		
		
			14 PDB
			


			1A31; 1A41; 1K4S; 1K4T; 1NH3; 1RR8; 1RRJ; 1SC7; 1SEU; 1T8I; 1TL8; 2H7F; 
			
				2H7G; 3IGC
			
			

			» more