PROSITE entry PS00176
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General information about the entry
Entry name [info] | TOPOISOMERASE_I_EUK |
Accession [info] | PS00176 |
Entry type [info] | PATTERN |
Date [info] |
01-APR-1990 CREATED;
01-NOV-1997 DATA UPDATE; 08-NOV-2023 INFO UPDATE. |
PROSITE Doc. [info] | PDOC00159 |
Associated ProRule [info] | PRU10130 |
Name and characterization of the entry
Description [info] | Eukaryotic DNA topoisomerase I active site. |
Pattern [info] |
[DEN]-x(6)-[GS]-[IT]-S-K-x(2)-Y-[LIVM]-x(3)-[LIVM]. |
Numerical results [info]
Total number of hits | 27 in 27 different sequences |
Number of true positive hits | 25 in 25 different sequences |
Number of 'unknown' hits | 0 |
Number of false positive hits | 2 in 2 different sequences |
Number of false negative sequences | 3 |
Number of 'partial' sequences | 0 |
Precision (true positives / (true positives + false positives)) | 92.59 % |
Recall (true positives / (true positives + false negatives)) | 89.29 % |
Comments [info]
Taxonomic range [info] | Eukaryotes, Eukaryotic viruses |
Maximum number of repetitions [info] | 1 |
Site [info] | active_site at position 8 |
Version [info] | 1 |
Cross-references [info]
UniProtKB/Swiss-Prot True positive sequences |
25 sequences
TOP1A_ARATH (P30181), TOP1B_ARATH (Q9FJ79), TOP1M_HUMAN (Q969P6), TOP1M_PANTR (A9Q1D5), TOP1_CAEEL (O17966), TOP1_CANAR (A0A0L0P4F8), TOP1_CANAX (Q00313), TOP1_CHLAE (Q7YR26), TOP1_CRIGR (Q07050), TOP1_DAUCA (P93119), TOP1_DICDI (Q54RC3), TOP1_DROME (P30189), TOP1_HUMAN (P11387), TOP1_MONPV (A0A7H0DN83), TOP1_MOUSE (Q04750), TOP1_RAT(Q9WUL0), TOP1_RFVKA (P16472), TOP1_SCHPO (P07799), TOP1_USTMA (P41511), TOP1_VACCA (Q76ZS7), TOP1_VACCC (P68697), TOP1_VACCW (P68698), TOP1_VAR67 (P32989), TOP1_XENLA (P41512), TOP1_YEAST (P04786)» more
|
UniProtKB/Swiss-Prot False negative sequences |
3 sequences
TOP1E_MIMIV (Q7T6X9), TOP1M_MOUSE (Q8R4U6), TOP1M_RAT (Q6IM78) |
UniProtKB/Swiss-Prot False positive sequences |
2 sequences
L_DUGBA (Q66431), YE88_SCHPO (O14304) |
PDB [Detailed view] |
14 PDB
1A31; 1A41; 1K4S; 1K4T; 1NH3; 1RR8; 1RRJ; 1SC7; 1SEU; 1T8I; 1TL8; 2H7F; 2H7G; 3IGC » more |