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PROSITE entry PS00176


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General information about the entry

Entry name [info] TOPOISOMERASE_I_EUK
Accession [info] PS00176
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-NOV-1997 DATA UPDATE;
08-NOV-2023 INFO UPDATE.
PROSITE Doc. [info] PDOC00159
Associated ProRule [info] PRU10130

Name and characterization of the entry

Description [info] Eukaryotic DNA topoisomerase I active site.
Pattern [info] 
[DEN]-x(6)-[GS]-[IT]-S-K-x(2)-Y-[LIVM]-x(3)-[LIVM].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2023_05 which contains 570'420 sequence entries.


Total number of hits 27 in 27 different sequences
Number of true positive hits 25 in 25 different sequences
Number of 'unknown' hits 0
Number of false positive hits 2 in 2 different sequences
Number of false negative sequences 3
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 92.59 %
Recall (true positives / (true positives + false negatives)) 89.29 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 1
Site [info] active_site at position 8
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 25 sequences 

TOP1A_ARATH (P30181), TOP1B_ARATH (Q9FJ79), TOP1M_HUMAN (Q969P6), 

TOP1M_PANTR (A9Q1D5), TOP1_CAEEL  (O17966), TOP1_CANAR  (A0A0L0P4F8), 
TOP1_CANAX  (Q00313), TOP1_CHLAE  (Q7YR26), TOP1_CRIGR  (Q07050), 
TOP1_DAUCA  (P93119), TOP1_DICDI  (Q54RC3), TOP1_DROME  (P30189), 
TOP1_HUMAN  (P11387), TOP1_MONPV  (A0A7H0DN83), TOP1_MOUSE  (Q04750), 
TOP1_RAT(Q9WUL0), TOP1_RFVKA  (P16472), TOP1_SCHPO  (P07799), 
TOP1_USTMA  (P41511), TOP1_VACCA  (Q76ZS7), TOP1_VACCC  (P68697), 
TOP1_VACCW  (P68698), TOP1_VAR67  (P32989), TOP1_XENLA  (P41512), 
TOP1_YEAST  (P04786)
» more

UniProtKB/Swiss-Prot
False negative sequences		 3 sequences 

TOP1E_MIMIV (Q7T6X9), TOP1M_MOUSE (Q8R4U6), TOP1M_RAT   (Q6IM78)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			2 sequences
			


			
L_DUGBA (Q66431), YE88_SCHPO  (O14304)


				
	

	

		PDB
[Detailed view]		
		
			14 PDB
			


			1A31; 1A41; 1K4S; 1K4T; 1NH3; 1RR8; 1RRJ; 1SC7; 1SEU; 1T8I; 1TL8; 2H7F; 
			
				2H7G; 3IGC
			
			

			» more