Due to scheduled maintenance work, this service may suffer downtimes today between
07:00 p.m. until
10:00 p.m.
CEST.
Apologies for the inconvenience.
Apologies for the inconvenience.
PROSITE entry PS00176
View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
PURL: https://purl.expasy.org/prosite/signature/PS00176
Direct ScanProsite submission
General information about the entry
| Entry name [info] | TOPO_IB_1 |
| Accession [info] | PS00176 |
| Entry type [info] | PATTERN |
| Date [info] |
01-APR-1990 CREATED;
01-NOV-1997 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00159 |
| Associated ProRule [info] | PRU10130 |
Name and characterization of the entry
| Description [info] | Topoisomerase (Topo) IB-type active site signature. |
| Pattern [info] |
[DEN]-x(6)-[GS]-[IT]-S-K-x(2)-Y-[LIVM]-x(3)-[LIVM]. |
Numerical results [info]
| Total number of hits | 27 in 27 different sequences |
| Number of true positive hits | 25 in 25 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 2 in 2 different sequences |
| Number of false negative sequences | 3 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 92.59 % |
| Recall (true positives / (true positives + false negatives)) | 89.29 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes, Eukaryotic viruses |
| Maximum number of repetitions [info] | 1 |
| Site [info] | active_site at position 8 |
| Version [info] | 1 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
25 sequences
TOP1A_ARATH (P30181), TOP1B_ARATH (Q9FJ79), TOP1M_HUMAN (Q969P6), TOP1M_PANTR (A9Q1D5), TOP1_CAEEL (O17966), TOP1_CANAR (A0A0L0P4F8), TOP1_CANAX (Q00313), TOP1_CHLAE (Q7YR26), TOP1_CRIGR (Q07050), TOP1_DAUCA (P93119), TOP1_DICDI (Q54RC3), TOP1_DROME (P30189), TOP1_HUMAN (P11387), TOP1_MONPV (A0A7H0DN83), TOP1_MOUSE (Q04750), TOP1_MYCMD (P41511), TOP1_RAT(Q9WUL0), TOP1_RFVKA (P16472), TOP1_SCHPO (P07799), TOP1_VACCA (Q76ZS7), TOP1_VACCC (P68697), TOP1_VACCW (P68698), TOP1_VAR67 (P32989), TOP1_XENLA (P41512), TOP1_YEAST (P04786)» more
|
| UniProtKB/Swiss-Prot False negative sequences |
3 sequences
TOP1E_MIMIV (Q7T6X9), TOP1M_MOUSE (Q8R4U6), TOP1M_RAT (Q6IM78) |
| UniProtKB/Swiss-Prot False positive sequences |
2 sequences
L_DUGBA (Q66431), YE88_SCHPO (O14304) |
| PDB [Detailed view] |
14 PDB
pdb_00001a31; pdb_00001a41; pdb_00001k4s; pdb_00001k4t; pdb_00001nh3; pdb_00001rr8; pdb_00001rrj; pdb_00001sc7; pdb_00001seu; pdb_00001t8i; pdb_00001tl8; pdb_00002h7f; pdb_00002h7g; pdb_00003igc » more |