ProRule PRU10130
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU10130 |
| Accession | PRU10130 |
| Dates | 16-OCT-2006 (Created)
19-SEP-2023 (Last updated, Version 8) |
| Data class | Domain; |
| Predictors |
PROSITE; PS00176; TOPO_IB_1 |
Name | Topoisomerase (Topo) IB-type active site |
| Function | The RKKRH/N "catalytic pentad", conserved in all members of the topo IB family, catalyzes the attack of the active site tyrosine nucleophile on the scissile phosphodiester. |
| Scope(s) |
Eukaryota Viruses |
| Example(s) | Q76ZS7 (TOP1_VACCA); |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + AltName: Full=DNA topoisomerase; EC=5.6.2.1; |
Comments
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| CATALYTIC ACTIVITY | Reaction=ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.; EC=5.6.2.1; |
Features
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| From: PS00176 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 6 | 6 | /note="O-(3'-phospho-DNA)-tyrosine intermediate" | |||||||||
Additional information
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| Size range | unlimited amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [21] Viruses [7] All [ 28 ]
- Retrieve set of proteins with 3D structure for this domain