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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU10130


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU10130
General rule information [?]

Accession PRU10130
Dates 16-OCT-2006 (Created)
19-SEP-2023 (Last updated, Version 9)
Data class Domain;
Predictors PROSITE; PS00176; TOPO_IB_1
Name Topoisomerase (Topo) IB-type active site
Function The RKKRH/N "catalytic pentad", conserved in all members of the topo IB family, catalyzes the attack of the active site tyrosine nucleophile on the scissile phosphodiester.
Scope(s) Eukaryota
Viruses
Example(s) Q76ZS7;

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + AltName: Full=DNA topoisomerase;
                 EC=5.6.2.1;

Comments [?]

CATALYTIC ACTIVITY Reaction=ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.; EC=5.6.2.1;

Features [?]

From: PS00176
Key From To Description Tag Condition FTGroup
ACT_SITE 6 6 /note="O-(3'-phospho-DNA)-tyrosine intermediate"

Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]