ProRule PRU10130

General rule information [?]

Accession PRU10130
Dates 16-OCT-2006 (Created)
19-SEP-2023 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS00176; TOPO_IB_1
Name Topoisomerase (Topo) IB-type active site
Function The RKKRH/N "catalytic pentad", conserved in all members of the topo IB family, catalyzes the attack of the active site tyrosine nucleophile on the scissile phosphodiester.
Scope(s) Eukaryota
Example(s) Q76ZS7 (TOP1_VACCA);

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + AltName: Full=DNA topoisomerase;

Comments [?]

CATALYTIC ACTIVITY Reaction=ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.; EC=;

Features [?]

From: PS00176
Key From To Description Tag Condition FTGroup
ACT_SITE 6 6 /note="O-(3'-phospho-DNA)-tyrosine intermediate"

Additional information [?]

Size range unlimited amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

UniProtKB rule member sequences [?]